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Beware the Nocebo Effect

An article at the NY Times looks at research into the "nocebo" effect. Named after the placebo effect, it's the term for when patient expectations do harm, rather than good. "When a patient anticipates a pill’s possible side effects, he can suffer them even if the pill is fake." The article describes several instances of patients getting the placebo in a drug trial, but reporting the expected side effects of the drug, rather than the benefits or nothing at all. Quoting: "Consider the number of people in medical trials who, though receiving placebos, stop participating because of side effects. We found that 11 percent of people in fibromyalgia drug trials who were taking fake medication dropped out of the studies because of side effects like dizziness or nausea. Other researchers reported that the discontinuation rates because of side effects in placebo groups in migraine or tension drug trials were as much as 5 percent. Discontinuation rates in trials for statins ranged from 4 percent to 26 percent. ... In one remarkable case, a participant in an antidepressant drug trial was given placebo tablets — and then swallowed 26 of them in a suicide attempt. Even though the tablets were harmless, the participant's blood pressure dropped perilously low."

3 of 239 comments (clear)

  1. Re:The Mind is amazing by arth1 · · Score: 5, Insightful

    Drinks with HFCS give me migraines, for example. A sugar placebo would certainly have side effects not even considering the mind over matter aspect of the situation.

    I think you might be begging the question here - precluding a nocebo effect based on something that may very well be a nocebo effect.
    Or have you been through double blind tests?

  2. Re:No humans are weird by Anonymous Coward · · Score: 5, Insightful

    or that Chiropractic treatment works. Or homeopathy, crystals, accupunture, tiger penis soup, Sea Horse balls, etc ...

    And I once argued with a psychologist about their efficacy (for therapy). For the patient to get better, they have to want to change; then doesn't that make it a placebo?

    "No!" blah balh blah blah.

    "I see. But when I take a antibiotic, it either works or it doesn't. My belief or desire for it to work is irrelevant."

    And then there are the very compelling arguments with data of the efficacy of anti-depressants.

    Yeah, yeah, yeah, go ahead acuse me of being a Scientologist. But even kooks can be right sometimes for the wrong reasons. for example, Mormons. They say you can't drink alcohol.

  3. Re:No humans are weird by DMUTPeregrine · · Score: 5, Insightful

    Psychological therapy works by using a conscious desire for change to find subconscious causes of undesired behavior and eliminate them. It is arguably psychosomatic, but not all psychosomatic effects are placebo effects.

    --
    Not a sentence!