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Newly Developed RNA-Based Vaccine Could Offer Lifelong Protection From the Flu
An anonymous reader writes "A new experimental flu vaccine made out of messenger RNA that may work for life is now being developed. German researchers said on Sunday that the vaccine, made of the genetic material that controls the production of proteins, protected animals against influenza and, unlike traditional vaccines, it may work for life and can potentially be manufactured quickly enough to stop a pandemic (abstract)."
Mutate you into some sort of strange half-man/half-flu monstrosity. 50/50. Could go either way.
Are we seriously trying to bring about the zombie apocalypse now?
In Finland (and possibly the other Nordic countries whose welfare states served as a model for Finland's) you don't get a sick day unless you visit your neighbourhood's clinic in the morning and get a doctor to sign off on the sick day. On the plus side, you get paid for the day.
Unfortunately, some of the more abusive low level employers still require a doctor's note anyway. One notorious telemarketing company in my town almost didn't give a dude his sick days because he didn't call in every day he was sick - the guy was in the hospital. It was only when the guy got the hospital itself off that they grudgingly gave him his time.
Compare this to my current office, where if you so much as sneeze the boss looks at you with narrowed eyes and asks if you'd rather telecommute that day, rather than risk infecting the entire office.
Occasionally living proof of the Ballmer peak.
This is why it is being done in Germany. Countries with socialized health care systems are putting a lot of funding into permanent cures.
It is why when I graduate I will probably end up going to another country to work for a while. If you want to want to do permanent cures for disease then the USA is not currently the place to do it, the profit motive of medicine in the USA basically works against it happening.
The guys that sell the current vaccines, sure. Their competitors, not so much. Permanent cures are good business because they're high-value products. You can charge a lot for them, you can get a lot of people to buy them, you can get the state to mandate them, you can get the state to pay for them, etc. The current flu vaccines aren't some endless gravy train -- they require a lot of work every year to actually get out the door and people (and governments) get pissy when you're late on delivery. A develop-once vaccine that's you can almost guarantee a sale of to each new person born is nice business, especially if it lets you screw your competitor out of yearly flu vaccine sales.
The pharma industry isn't some monolithic ideal conspiracy. They have joint goals, but they're also made up of competing entities.
If your claim was true, we wouldn't see companies continuing to sell vaccines and develop new vaccines that provide cures to diseases. But we do.
If the vaccine works in people,
That is the catch. It has not worked so far in people, or animals for that matter. But $scientist speculates it might. Till more data comes through we should soak the RNA in snake oil before freeze drying it.
I wouldn't be so quick to dismiss it. I've been following this for a while now and the approach is sound. The standard ways viruses develop resistance simply won't work with this approach. It'd be a non specific antiviral so if should work on any virus. Sadly prions would likely be immune but not viruses. It's at least a decade off and maybe more but there is a lot of promise. There's reason to think viruses and bacterial infections will be treatable or preventable within the next 20 years. In the meantime we are loosing the war so we need out of the box thinking because millions will die while we are waiting for real treatments to be developed.
I can't really see how this technique could offer lifelong protection from the flu, the current encarnation currently does not and it's not clear how it would all work.
First of all, the vaccine they developed is a "hardened" mRNA that encodes the manufacture of a particular varient one of the two proteins (hemagglutinin or HA) that are found on the surface of a flu virus (the other one is neuraminidase or NA). In this case they chose the recent H1 part of the H1N1 varient was recently going around. This mRNA tricks the host's own cells to produce this H1 protein which triggers the immune response. In contrast, the "traditional" flu shot just has HA and NA proteins (usually made from dead flu viruses grown in eggs, but sometimes made in labs) in it along with some other "stuff" like adjuvents, to amp up the immune response.
Unfortunatly this particular vaccine is like traditional vaccines in that it primes the immune system to look for HA/NA proteins, and these are the flu proteins that mutate all the time, so it would just provide life-line protection for one particular strain (and some close relatives), kinda like the current flu shot.
The current breakthrough was in "hardening" the mRNA so that it isn't dissolved in you blood. These researchers discovered a protein called protamine can bind with the mRNA so that it can make it into enough cells so that the cellular mechanims can transcribe it into the encoded protein into H1.
There is some promise that this technique could be easily adapted to target part of the flu surface proteins that don't mutate as much (whereas the current technique is mostly about refining HA/NA proteins so might not be applicable to something else) but that lifelong protection from the flu using a technique like this seems like a dream. I don't think anyone knows how to do that yet, although many folks are working on it and most of them aren't just relying on just stimulating a human immune response.
On the other hand, as with most hype, there is a kernel of something there. The current crop of modern flu-treatments (like tamiflu) target the NA part of the flu virus (technically they are neuraminidase inhibitors, so they interfere with part of the virus reproduction cycle). Unfortuantly the NA part is the faster mutating protein and there have been cases where mutation in the NA part of the virus can circumvent these modern treatments. The HA part mutates more slowly and as I mentioned above, this particular treatment has been steered to target the HA part. Who knows, maybe you'd get a vaccine with mRNA for every HA subtype they know about***. Of course that is until there is another mutation. I'm guessing that on this basis they've annointed this new thing as having the potential "lifelong" protection from the flu. As for how this would be significantly different than just giving someone a regular flu shot with all the known HA subtypes, I don't see it. Seems like a bit of hype to me compared to what other folks are working on (e.g., specific artificial antibodies that target all HA subtypes).
*** AFAIK, there are 17 types of HA, although viruses that infect humans don't appear to have that many variations, so maybe you could get away with just H1, H2, H3, H5 (the ones known to infect humans).