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Transfusions Reverse Aging Effects On Hearts In Mice
symbolset writes "Research published yesterday in the journal Cell (abstract) by Richard Lee and Amy Wagers of Harvard has isolated GDF-11 as a negative regulator of age-associated cardiac hypertrophy. 'When the protein ... was injected into old mice, which develop thickened heart walls in a manner similar to aging humans, the hearts were reduced in size and thickness, resembling the healthy hearts of younger mice.' Through a type of transfusion called parabiotic or 'shared circulation' in mice — one old and sick, the other young and well — they managed to reverse this age-associated heart disease. From there, they isolated an active agent, GDF-11, present in the younger mouse but absent in the older, which reverses the condition when administered directly. They are also using the agent to restore other aged/diseased tissues and organs. Human applications are expected within six years. Since the basis for the treatment is ordinary sharing of blood between an older ill, and younger healthy patient, we can probably expect someone to start offering the transfusion treatment somewhere in the world, soon, to those with the means to find a young and healthy volunteer."
Find me the blood of a young boy, Smithers... quickly...
Now I know why Vampires live so long!!!
I really didn't mean all those things I said about young people.
You can hang out on my lawn.
Faster! Faster! Faster would be better!
That blood sacrifices of the young made a come back. They've been out of fashion for much too long...
You are fired. I don't want to get any younger!
- Professor Farnsworth.
Sure, they used reverse transfusions to figure out what was going on, but then they isolated the active agent and were able to reproduce the effect with just that. They may continue using reverse transfusions as a research tool, but actual therapies are just going to be pills or shots, probably of chemicals produced by engineered bacteria.
Hopefully they also monitored effects on the younger mouse. Twould be a shame if people started doing these experiments on humans, and then find out that it accelerates aging in the donor.
"New, from Almay, our all new hemoceutical line...containing pure bionutrient yb1, found in young and healthy blood. Make your face look up to 10 years younger in just four weeks..."
"Because you're worth it"
Great warrior...hrmph! Wars not make one great.
Human applications are expected within six years.
Ha ha ha no. Sure, perhaps 6 years until the first Phase II clinical trials report safety and proof of concept efficacy. But 6 years until you can go to a clinic and have this done? No way. Drug development takes about a decade.
But this does sound like an interesting approach.
Seriously, science, I love you.
If we colonize Mars, it won't be the World Wide Web anymore. UWW?
Didn't Heinlein predict this as what people did to mimic the Howard families longevity? I think he wrote about it in "Time Enough For Love"
Maybe the Countess was not so crazy?
Repeal the 17th Amendment TODAY! Also Please Read http://www.gnu.org/philosophy/right-to-read.html
You mean like the Umbrella corporation? Or are they still called Monsanto?
Is that Vampirism works?
It looks like it's $335 for 10 micrograms... http://www.rndsystems.com/product_results.aspx?m=1508
Ray Seyfarth, ray.seyfarth@gmail.com, http://rayseyfarth.blogspot.com
For anyone who doesn't subscribe to the journal, here's an interesting extract from the full text, describing early phase human testing of the procedure on a Romanian subject:
"There lay the Count, but looking as if his youth had been half renewed, for the white hair and moustache were changed to dark iron-grey; the cheeks were fuller, and the white skin seemed ruby-red underneath. The mouth was redder than ever, for on the lips were gouts of fresh blood, which trickled from the corners of the mouth and ran down over the chin and neck. Even the deep, burning eyes seemed set amongst swollen flesh, for the lids and pouches underneath were bloated. It seemed as if the whole awful creature were simply gorged with blood. He lay like a filthy leech, exhausted with his repletion."
Since the basis for the treatment is ordinary sharing of blood between an older ill, and younger healthy patient, we can probably expect someone to start offering the transfusion treatment somewhere in the world, soon, to those with the means to find a young and healthy volunteer.
Volunteer? People give blood because they want to help someone who they usually envision as having a horrible illeness not because they want some rich, old guy to live longer than the norm.
I think there will more likely be a blood trade where the young (or criminal organ harvesters) sell blood to the old. Either that or some sort of blood Ponzi scheme similar to Social Security where you pay blood in when you are young that is immediately used by the old and recieve blood from the young when you are old. Of course, everything breaks down when the previous generation becomes smaller than they current one. Although, I would not be surprised if by that time there would be synthetic blood that would serve the same purpose.
We've found an awful lot of candidate treatments that work well in mice that work poorly or not at all in humans.
Why would you do that?
Help stamp out iliturcy.
How long before we farm transfusions from a donor critter or lab grown spleen vat.
Never.
It's a protein. Just splice the appropriate sequence into a plasmid, inject it into an e-coli bacterium (of an "enfeebled" strain to keep it from going feral)), and grow its offspring by the vatload, producing purified product by the gallon.
This procedure is one of the earliest commercialized pieces of genetic engieering.
Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way