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Genetic Switches Behind 'Love' Identified In Prairie Voles

ananyo writes "Researchers have shown for the first time that the act of mating induces permanent chemical modifications in the chromosomes (epigenetic changes), affecting the expression of genes that regulate sexual and monogamous behavior in prairie voles. Prairie voles have long been of interest to neuroscientists and endocrinologists who study the social behavior of animals, in part because this species forms monogamous pair bonds — essentially mating for life. The voles' pair bonding, sharing of parental roles and egalitarian nest building in couples makes them a good model for understanding the biology of monogamy and mating in humans (abstract)."

28 of 102 comments (clear)

  1. Good model?!? by Anonymous Coward · · Score: 3, Insightful

    The voles' pair bonding, sharing of parental roles and egalitarian nest building in couples makes them a good model for understanding the biology of monogamy and mating in humans

    A good model for ideal human behavior, sure, but actual behavior?!? One wonders if the researchers have met any actual human couples.

    1. Re:Good model?!? by dragon-file · · Score: 4, Funny

      The voles' pair bonding, sharing of parental roles and egalitarian nest building in couples makes them a good model for understanding the biology of monogamy and mating in humans

      A good model for ideal human behavior, sure, but actual behavior?!? One wonders if the researchers have met any actual human couples.

      Of course they haven't met actually human couples. They're researchers.

      --
      Whenever a player quits EVE to go play WoW, the Average IQ of both games increase.
    2. Re:Good model?!? by Anonymous Coward · · Score: 3, Interesting

      My wife is the type that got turned on by me being with other women. While this sounds awesome, I quickly found that it was too much trouble dealing with one (both physically and mentally), let alone multiple women was not as good as being monogamous. I think people stray from their partners for immediate, temporary gratification because of hormones and the excitement. If this option was on the table, folks would learn quickly the value of having one person

    3. Re:Good model?!? by fuzzyfuzzyfungus · · Score: 4, Informative

      The voles' pair bonding, sharing of parental roles and egalitarian nest building in couples makes them a good model for understanding the biology of monogamy and mating in humans

      A good model for ideal human behavior, sure, but actual behavior?!? One wonders if the researchers have met any actual human couples.

      People like the vole model because prairie voles are(somewhat atypically) pair-bonded; but there is at least one closely related vole flavor that isn't. Makes narrowing down the elements involved (comparatively) pleasant and straightforward, by biology standards. Plus, 'vole' is pretty close to 'lab rat' in terms of size/cost/lifecycle-length/animal-rights-activists-setting-fire-to-your-lab, which makes it preferable to larger, more unwieldy, comparison animals.

    4. Re:Good model?!? by Immerman · · Score: 5, Interesting

      Indeed. Primate monogmay correlates fairly well with proportional testical size - by which measure humans fall about midway between gorillas (where the females will reject advances by anyone but their troop leader) and chimpanzees (who use sex for a wide variety of social purposes and demonstrate almost no prolonged sexual pair-bonding).

      I would be inclined to suggest that holding long-term monogamy as the "ideal" human behavior is itself the source of the vast majority of the problems our species encounters in that domain. There are (were?) considerably advantages to such an arrangement when trying to establish stable sociological institutions upon which empires can be built, but those advantages come at the expense of trying to distort our basic natures into something that they are, generally speaking, not inclined to be.

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      --- Most topics have many sides worth arguing, allow me to take one opposite you.
    5. Re:Good model?!? by lgw · · Score: 2

      All of society and culture is arguably "to distort our basic natures into something that they are, generally speaking, not inclined to be".

      Long-term monogamy is needed to establish a household for the raising and acculturating of children. Keeping a difficult relationship together for the sake of raising the kids benefits society as a whole to an extreme degree. Sure, there may be other approaches to raising kids, but none that have been proven effective.

      We have a real problem with culturally-accepted shortsighted selfishness right now, IMO - it's not all about what's best for you, today, in isolation. For enlightened self-interest the overall condition of the society you live in (primarily technology and social order) trumps simple short-term greed for maximizing long-term happiness.

      --
      Socialism: a lie told by totalitarians and believed by fools.
    6. Re:Good model?!? by dcollins · · Score: 3, Insightful

      So you support a society in which everyone is permanently miserable, because it serves to successfully perpetuate the permanently-miserable society.

      Well, you're certainly not alone.

      --
      We know where leadership by an anti-intellectual "strongman" who scapegoats minorities and likes boisterous rallies goes
    7. Re:Good model?!? by LateArthurDent · · Score: 2

      Keeping a difficult relationship together for the sake of raising the kids benefits society as a whole to an extreme degree.

      Holy crap, no, it really doesn't. Being a child to divorce parents really sucks, but if there's one thing that is worse is being a child in a household where the parents don't love each other, but remain together because of a misguided concept of responsibility. You can be perfectly responsible and a part of your child's life without being married to the other parent.

      Believe me, I know. I wish my parents had gotten divorced, but that's one of the things they cherry picked to follow in the catholic faith.

    8. Re:Good model?!? by lgw · · Score: 2

      You can be perfectly responsible and a part of your child's life without being married to the other parent.

      Living together does not require marriage. Baby daddies are not fathers. Not that you specifically need a biological mother and father, but two live-in caregivers seems to be the key.

      Sure, sometimes having two caregivers living with a child still doesn't work out well, but on average it's the best system people have found. I think extended families probably help too, but I suspect that's about simply having a larger network from which to select those two caregivers.

      --
      Socialism: a lie told by totalitarians and believed by fools.
    9. Re:Good model?!? by Anonymous Coward · · Score: 2, Interesting

      Actually, prairie voles may be modeling humans a little better than you might think. Even within the mated pairs, some of them are "deadbeat dads" that have to be forced by the female to spend time with the pups. Some others also occasionally cheat on their partners.

    10. Re:Good model?!? by lgw · · Score: 3, Interesting

      So you think that for a society in which there are two live-in caregivers the normal state is misery? Wow, you must be pretty unhappy.

      I think the big problem was that, for lack of reliable birth control, "sex for fun" got tangled up with "raising children". Spending 20 years with someone just because you had sex with them no doubt makes for much unhappiness. OTOH, waiting to have kids until you're ready to commit long term (as opposed to waiting to have sex until you're ready to commit long term) has proven itself a good strategy for the kids.

      --
      Socialism: a lie told by totalitarians and believed by fools.
  2. Or the opposite by cellocgw · · Score: 3, Insightful

    Somehow I strongly doubt that any such epigenetic (or other) monogamy-influencing event takes place when humans mate.

    --
    https://app.box.com/WitthoftResume Code: https://github.com/cellocgw
    1. Re:Or the opposite by ananyo · · Score: 2

      On what evidence? It seems pretty obvious that -some- sort of epigenetic changes happen in the human brain too on -some- occasions. I doubt the researchers are arguing that human pair-bonding happens in exactly the same way as in prairie voles - just that there are some parallels. In any case, the cool thing is that they've shown epigenetic changes behind pair-bonding for the first time. (There's plenty of evidence that epigenetic changes influence other forms of complex human behaviour (eg see http://www.nature.com/news/2010/100908/full/467146a.html). No reason I can see for sex/love to be different.)

    2. Re:Or the opposite by mu22le · · Score: 2

      Somehow I strongly doubt that any such epigenetic (or other) monogamy-influencing event takes place when humans mate.

      Tell that to your oxytocin receptors (http://en.wikipedia.org/wiki/Sexual_motivation_and_hormones#Oxytocin_and_vasopressin)

    3. Re:Or the opposite by Immerman · · Score: 4, Informative

      There is minimal evidence to suggest that humans are biologically predsposed to long-term pair bonding at all, in fact there's considerable evidence to the contrary. Oxytocin does however seem to be a significant agent in the amount of pair-bonding we are predisposed to.

      The problem is that researchers like these try to use species that are biologically inclined to long-term monogamy as models for an unrelated species (us) that are sociologically biased towards it. Because the basic fact is that sociological behaviors operate on an almost completely different set of rules, and changes on timescales that genetics can't hope to respond to effectively.

      So how about for a change instead of trying to shoehorn human behavior into some sort of arbitrary "moral ideal", we instead take a good hard look at what we actually are, and adjust our sociological and moral norms to be in line with our basic natures. Socially enforced monogamy was a useful solution to support child-rearing as our societies grew beyond the scale where tribalism was effective, but it was hardly the *only* solution, and irrationally clinging to it as the ideal today, when pretty much everything else about our society has been utterly transformed, is intellectually questionable at best.

      --
      --- Most topics have many sides worth arguing, allow me to take one opposite you.
  3. NIMH by Antipater · · Score: 4, Funny

    "This is a study I myself wanted to do years ago,” says Thomas Insel, who heads the US National Institute of Mental Health in Bethesda, Maryland. “...This study for me really is the first experimental demonstration that the epigenetic change would be necessary for the long-term change in behaviour.”

    Insel continued. "Unfortunately, due to a scandalous bit of contrived fiction, we here at NIMH have been prohibited from doing this kind of work for decades. Every attempt to work on a rodent model is sabotaged, with a Frisbee left at the scene and the words 'REMEMBER NICODEMUS' spray-painted on the wall. Police never found a suspect, and eventually Congress pulled the funding. Hopefully our colleagues at Florida State can continue this valuable work without such interference!"

    --
    Everything is better with chainsaws.
  4. Bonobos by dcollins · · Score: 4, Interesting

    "a good model for understanding the biology of monogamy and mating in humans"

    Are humans that close to prairie voles? Because bonobos, our closest actual relation evolutionary speaking, are highly sexualized and totally polygamous.

    http://brembs.net/bonobos.html

    Of course, if one is seeking to bolster some culturally-determined myth of monogamy (so as to uphold property rights and inheritance, perhaps) then you've got to look pretty far afield for examples of monogamous species.

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    We know where leadership by an anti-intellectual "strongman" who scapegoats minorities and likes boisterous rallies goes
    1. Re:Bonobos by fuzzyfuzzyfungus · · Score: 2

      Voles are a good model because they relatively neatly elucidate the mechanism: you have access to both pair-bonding voles and (quite similar) non-bonding species, which narrows the search space considerably. Plus, bonobos are big, relatively rare, and have fairly long lifecycles, which makes doing potentially invasive and dangerous research(like determining that you've found the correct switch by patching a vole to change its behavior) without dedicating a decade or two, a substantial amount of money, and some unpleasant little chats with the IRB.

    2. Re:Bonobos by dcollins · · Score: 2

      "There are plenty of reasons to strongly suspect that humans are somewhat monogamous - eg human males and females are around the same size - for various reasons, strongly polygamous species tend to have larger males, smaller females."

      How is that size ratio different from the polygamous bonobos? Humans and bonobos both have about the same size between genders (among other similarities in sex organs). Perhaps you're thinking of gorillas that have a 2:1 size difference and a polygynous (alpha male mates with all females) nature.

      --
      We know where leadership by an anti-intellectual "strongman" who scapegoats minorities and likes boisterous rallies goes
  5. Re:Except... by Anonymous Coward · · Score: 3, Funny

    By definition, no. Any mistakes perceived by the vole would be removed by the chemical modifications.

    Praire voles have permanent beer-goggles.

  6. Re:Except... by cellocgw · · Score: 2

    Just because biology is talking, doesn't mean you have to listen.

    Now you've done it: cue the "free will" flame wars...

    --
    https://app.box.com/WitthoftResume Code: https://github.com/cellocgw
  7. Re:Except... by femtobyte · · Score: 3, Insightful

    Humans aren't entirely monogamous, but along the spectrum observed in other species --- from rigid monogamy to "mate with anything that moves" --- humans are at least semi-monogamous; frequently pair-bonding, if not for life, at least for the relatively long period for offspring to be born and reach self-sufficient maturity. Understanding the biological mechanisms backing "strongly monogamous" mammalian behavior may also provide information about what biological mechanisms contribute to humans' less total tendencies towards monogamy.

  8. Re:Except... by MightyYar · · Score: 3, Insightful

    Just because biology is talking, doesn't mean you have to listen.

    If that's your strategy, you probably are destined for disappointment. IMHO, it's best to learn how to identify and avoid situations that force you to confront your biology.

    --
    W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
  9. Already disproven by ThatsNotPudding · · Score: 2

    Ask any woman and they will tell you that all men are not voles, but are in fact, pigs.

  10. Re:Hypergamy Cure? by femtobyte · · Score: 2

    or you end up with a very stratified society where virtually nobody marries anyone outside their current socio-economic caste.

    Well, at least in the US, "very stratified society" is a fairly apt description. Some basic statistics are available in the Wikipedia article on US social mobility. While not "officially" enforced as in a caste system, the US has many institutions that discourage inter-class mixing. People of considerably different economic status generally grow up in different neighborhoods, go to different schools, and end up in a formally class-stratified workplace (with distinct "labor" vs. "management" roles, corresponding to large differentials in salary and social interaction). The US displays a combination of high inequality and low mobility generally only exceeded by considerably less developed nations.

  11. Re:Hypergamy Cure? by femtobyte · · Score: 3, Informative

    One can hardly call this "human nature" when pretty much every other developed country has higher equality and social mobility --- if anything, the US is bucking the trend of human nature to seek higher ideals of equality and freedom once technological development allows the satisfaction of lower needs. Of course, the key is not convincing more rich white male rich guys to marry their Mexican maids despite a complete lack of shared culture, but to create a society where there is a sense of shared culture and humanity between people in all walks of life. For example, having a robust and high-quality public education system so both the kids of millionaires and janitors grow up socializing together is a key component in more egalitarian societies. So to is having high minimum wage standards and social safety nets, so that even maids can have time/access to hobbies and culture and forming relationships outside of a depressed community of grinding poverty. When living on a lower quintile income isn't a death sentence for your children's hopes and dreams and future, then there is much less of a barrier to marrying for love across income lines.

  12. Humans aren't monogamous though by GodfatherofSoul · · Score: 3, Interesting

    Culturally maybe, but not biologically. I just read an article a few months back about why our penises are shaped the way they are. Basically, the head is optimized to siphon another male's semen out of a woman during the thrusting action. That slightly uncomfortable sensitivity you feel after orgasm is nature's way to stop your thrusting so you don't accidentally siphon out your own semen.

    --
    I swear to God...I swear to God! That is NOT how you treat your human!
  13. Re:Except... by MightyYar · · Score: 2

    Yes, you got it...

    I was thinking more along the lines of: if you are married, don't go out for drinks with the cute girl from work :)

    And yes, that does make me slightly more boring - but that's rather the point! Not all kinds of excitement are good - get to know yourself and your weaknesses.

    --
    W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.