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Stem Cells Used To Grow Miniature Human Livers In Mice

ananyo writes "Transplanting tiny 'liver buds' constructed from human stem cells restores liver function in mice, researchers have found. Although preliminary, the results offer a potential path towards developing treatments for the thousands of patients awaiting liver transplants every year. The liver buds, approximately 4 mm across, staved off death in mice with liver failure, the researchers report this week in Nature (abstract.). The transplanted structures also took on a range of liver functions — secreting liver-specific proteins and producing human-specific metabolites. But perhaps most notably, these buds quickly hooked up with nearby blood vessels and continued to grow after transplantation."

3 of 59 comments (clear)

  1. Re:Not that I would try it by JanneM · · Score: 5, Interesting

    Well... You eat your own cells all the time, and in practice you probably get a serving of other peoples' sloughed-off cells with every meal you have. I guess it's really more a matter of intent: If you're not getting the stuff from a human body (or arrange for the human to become "body" in the first place) then you may well decide this is not really cannibalism no matter what DNA the cells happen to contain. It comes from a mouse, so it's basically a mouse liver.

    Why you'd want to eat mouse livers is another question of course, though chicken liver is delicious, so why not?

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  2. I'm sure they'd love to try it in a dying human by Ungrounded+Lightning · · Score: 5, Insightful

    As usual, any kind of clinical use of this stem cell stuff is "ten years away". These guys are as bad as fusion researchers.

    I'm sure they'd love to try it in a human dying of liver disease. But between the FDA regs, the self-appointed Medical Ethics czars, and the malpractice ambulance-chasers there's a lot of hurdles to jump before they MIGHT be allowed to try it (let alone deploy it as a regular procedure).

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  3. Re:By the way: With Obamacare... by lxs · · Score: 5, Funny

    He's right you know. Here in Europe we're so backward that we still marvel at the germ theory of disease. Only last week I had to miss work due to the Black Death. Luckily for me it was only a mild case and I'm up and running again. well hopping really, what with the gangrenous leg and all.