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Study Ties High Blood Sugar To Dementia

A study published last week in the New England Journal suggests that blood sugar levels may be a more important indicator than previously realized for non-diabetics: high blood sugar levels were linked by the study's authors with increased risk of dementia (summary free; full article paywalled). The study followed more than 2,000 elderly participants, and found a positive correlation between blood glucose levels and development of dementia, both for patients with and without diabetes.

6 of 157 comments (clear)

  1. Where have I heard this before? by pellik · · Score: 5, Informative
    1. Re:Where have I heard this before? by mpe · · Score: 3, Informative

      There are already five forms of diabetes. Type 1 (early onset, no pancreatic function, incurable); Type 1.5 (Late onset, no pancreatic function, incurable); Pre Type 2 Diabetes (insulin resistance building, possibly curable); Type 2 (late onset, insulin resistance, some pancreatic function, incurable); and Gestational Diabetes (hormonal imbalance create insulin resistance, temporary).

      Actually you have three groups.
      Auto-immune: T1 and T1.5 (LADA).
      Insulin resistant: Pre-Diabetes, T2 and Gestational Diabetes.
      Mitochondial malfunction: Very misleadingly called Mature Onset Diabetes of the Young (MODY). N.B. it is possible for young people, especially women with PCOS, to have insulin resistance diabetes.

      Only insulin resistant diabetes can be reversed (cured). Only in some cases, the degree & length of time of the insulin resistance along with injury to beta cells and liver due to glucotoxicity being possible factors here.

  2. Brain diabetes by DeathGrippe · · Score: 5, Informative

    This is particularly interesting because alzheimer's is now thought, by many researchers, to be a form of "brain diabetes."

    There are clinical data which demonstrate that alzheimer's can be reversed to some extent with medium chain triglycerides, which are absorbed by cells directly and provide energy which isn't dependent on glucose uptake.

    See: http://www.doctoroz.com/videos/alzheimers-diabetes-brain and http://w.numedica.net/literature/Reger%202004.pdf for more info.

  3. Re:Proves Bloomberg correct. by tlambert · · Score: 2, Informative

    I don't know about that. People stupid enough to drink a 52 oz, 1000+ calorie drink packed with sugar might not have the best brain to begin with and probably have all around terrible health practices as well.

    The study was about Glucose; the predominant sugar in soda drinks is Fructose, at least in the U.S., and because it lends itself to plumbing-based manufacturing of junk food rather than requiring auger gears to move powdered sweetener around, it's gaining ground in other countries junk food as well.

  4. Re:evils of sugar by Samantha+Wright · · Score: 4, Informative

    Sugar is the most basic kind of energy source. It's extremely important to your body, but as with everything, there are limits on what intake is healthy. (As Stephen Fry once said, 'Well of course too much is bad for you, that's what "too much" means you blithering twat. If you had too much water it would be bad for you, wouldn't it?')

    Don't worry about the dementia thing too much. While it's a very strong correlation, it only increases the risk of developing dementia to 120% of normal for nondiabetics and 140% of normal for diabetics, which is still only about 1-2% of the people in their study.

    As for the other consequences, it may help to understand them a bit better:

    Tooth decay is caused by sugar left on your teeth. You can consume a ton of sugar and never have any tooth issues if you brush aggressively. Cavities are caused by bacteria in your mouth breaking down food left on your teeth, which causes them to release acidic byproducts. Starches like potatoes, corn, and bread are actually much more of a problem, however, and are the primary cause of cavities.

    Gaining weight happens because the human body isn't prepared, evolutionarily, to regulate its own food intake very well. We have a high inclination toward absorbing and storing extra energy because that gives us the best chance of surviving a famine. Because sugar is the most basic kind of food, the body uses it as a clue to say "it's time to absorb nutrients!", hence sugary foods make you gain weight even faster. This is part of the normal purpose of the hormone insulin.

    Diabetes isn't only caused by high sugar intake; it can be inherited too. Technically it's an inability to recognize sugar and absorb it, which (amongst other things) causes gradual starvation if not managed properly. Sugar causes it only if you consume a great deal for a long period of time, which makes your body start to ignore insulin. Diabetes can also be caused by pancreatic damage (type 1) or temporarily by pregnancy.

    Acne is a weird issue; it's also caused by bacteria, in this case sitting on the skin. The immediate cause is a spike in testosterone, which can be induced by a number of sources, because it roughens up the surface of the skin. Sugar is one of those sources, but simply having overactive hormones as a teenager is probably a more dominant issue.

    And as Slew said, sugar isn't acidic, it's just the breakdown of it that gets to be that way. This doesn't really have much of an effect on your body unless you're already suffering from acidosis (acidic blood), and you'd die very quickly if it stopped entirely, so don't worry about it.

    --
    Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
  5. Re:Proves Bloomberg correct. by smaddox · · Score: 4, Informative

    Fructose (which is one half of sucrose - basically the same as high fructose corn syrup) is actually much worse than glucose precisely because it is metabolized by the liver. The metabolic process is very similar to that of ethanol, and the chronic effects are also almost identical. Here's a great presentation by Prof. Robert H. Lustig, MD about the link between sugar consumption and obesity: http://www.youtube.com/watch?v=dBnniua6-oM