Effects of Parkinson's-Disease Mutation Reversed In Cells

An anonymous reader sends this quote from a press release at Eurekalert: "UC San Francisco scientists working in the lab used a chemical found in an anti-wrinkle cream to prevent the death of nerve cells damaged by mutations that cause an inherited form of Parkinson's disease. A similar approach might ward off cell death in the brains of people afflicted with Parkinson’s disease, the team suggested in a study reported online in the journal Cell on August 15 (abstract). ... Mutations that cause malfunction of the targeted enzyme, PINK1, are directly responsible for some cases of early-onset Parkinson’s disease. Loss of PINK1 activity is harmful to the cell’s power plants, called mitochondria, best known for converting food energy into another form of chemical energy used by cells, the molecule ATP. In Parkinson’s disease, poorly performing mitochondria have been associated with the death of dopamine-producing nerve cells in a region of the brain called the substantia nigra, which plays a major role in control of movement. Loss of these cells is a hallmark of Parkinson’s disease and the cause of prominent symptoms including rigidity and tremor. A UCSF team led by Shokat, a Howard Hughes Medical Institute Investigator, used the chemical, called kinetin, to increase mutant PINK1 enzyme activity in nerve cells to near normal levels. 'In light of the fact that mutations in PINK1 produce Parkinson’s disease in humans, the finding that kinetin can speed mutated PINK1 activity to near normal levels raises the possibility that kinetin may be used to treat these patients,' Shokat said."

Comments

Coming soon to theaters

[dkleinsc]

Back to the Future IV - Great Scott!

Re:The confusing wordings of TFA

[Nidi62]

Since English isn't my mother tongue, there are times I find myself struggling to understand things others have written.

I have read, and re-read the following, which I copied from TFA:

'In light of the fact that mutations in PINK1 produce Parkinsonâ(TM)s disease in humans, the finding that kinetin can speed mutated PINK1 activity to near normal levels ...'

I dunno about you, but the more times I re-read the above the more confused I got

Well, it talks about the mitochondria "perform poorly". My guess is that the mutation somehow slows down the operation of the mitochondria, which would have been linked to Parkinsons. So my takeaway is that the kinetin speeds back up the operation of the mitochondria to close to non-mutated levels. But yes the summary is worded rather poorly.

Virgin coconut oil contains kinetin

[sonamchauhan]

See this site for some of the benefits of coconut oil: (Parkinson's is mentioned)
http://m.naturalnews.com/news/039388_coconut_oil_dementia_alzheimers_disease.html

Re:Virgin coconut oil contains kinetin

[pnagel]

This comment is actually much more relevant to the OP than it may seem.

As the OP says, Parkinsonson's is essentially a fuel crisis of the brain due to impaired mitochondrial function.

One way to fix this would be to repair the mitochondrial function, as the OP article tries to.

But another way would be to find an alternative fuel source for the brain.

Those who promote coconut oil point of that it it specifically the metabolism of glucose that is impaired in Parkinson's (hence the modern trend of calling it Type III Diabetes). But there are many other energy substrates used my mitochondria, and ketones is one type that brain cells can also make use of.

Coconut oil is high in MCTs (medium-chain triglycerides), which have the unique property of being immediately converted to ketones in the liver. Thus the point of the coconut oil is to give the starving brain something else to run on.

Another way to raise ketones is by using a ketogenic diet (hence the name), as was the standard effective treatment for epilepsy early last century before drugs became available (and ketogenic diets have been making a comeback as alternative treatment when drugs don't help).

In a ketogenic diet, the vast majority of one's energy is derived from fat sources, not carbohydrates. As a side effect of metabolising fat for energy all over the body, ketones are released at a much higher level than otherwise, and these ketones themselves are then available as fuel for the brain (and other tissues).

"shows potential"... "promising"... "possibly".

[mark-t]

In other words... they don't *actually* have any good news. They're just particularly hopeful that they will.

Sounds like somebody is using a particularly optimistic phrasing in order to get funding for more research.

Not to belittle such research, but until that research actually bears real fruit, it feels to me like they are deliberately trying to mislead people into thinking that a practical cure or treatment is basically here already (even though they don't actually come right out and say so), and to me that's not any better than the conmen who travelled from village to village in the 1700's selling "snake oil".

Energy-restoring protoocols are effective for many

[Eukariote]

This is not the first time that a protocol that restores energy metabolism, or protects it, has been found effective. And not just in early-onset Parkinson's. See for example the work of Birkmeyer who developed a protocol around NADH and Co-enyme Q10 (both co-enzymes active in glucose metabolism). Or the use of coconut oil (for the lauric acid contained therein) as a dietary addition to provide ketones as an alternative for glucose to energize cells: also found effective for many Alzheimers patients.

The ketogenic approach is easy to try as coconut oil is readily available. The Birkmeyer protocol requires a few supplements, in particular stablized NADH to be taken on an empty stomach.

Re:Atkins for Parkinson's

[pnagel]

The induction phase of the Atkins diet is mostly a ketogenic diet. For the treatment of epilepsy, there are now a handful of variations on the original ketogenic diet used since the 1920s, one of these is known as the "Modified Atkins".

However, there are stricter metabolic goals when on a ketogenic diet and special things to watch out for (too much protein can knock one out of ketosis, for example), so it is best to approach a ketogenic diet as a specialty topic in its own right rather than as something that a different low-carb diet may or may not achieve as a side effect.

There is a lot of recent research on the neuroprotective properties of a ketogenic diet, not just for Alzheimer's, but also for Parkinsons and stroke. See http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367001/ for example.