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Study Linking GM Maize To Rat Tumors Is Retracted

ananyo writes "Bowing to scientists' near-universal scorn, the journal Food and Chemical Toxicology has fulfilled its threat to retract a controversial paper which claimed that a genetically modified (GM) maize causes serious disease in rats after the authors refused to withdraw it. The paper, from a research group led by Gilles-Eric Séralini, a molecular biologist at the University of Caen, France, and published in 2012, showed 'no evidence of fraud or intentional misrepresentation of the data,' said a statement from Elsevier, which publishes the journal. But the small number and type of animals used in the study means that 'no definitive conclusions can be reached.' The known high incidence of tumors in the Sprague-Dawley rat 'cannot be excluded as the cause of the higher mortality and incidence observed in the treated groups,' it added. Today's move came as no surprise. Earlier this month, the journal's editor-in-chief, Wallace Hayes, threatened retraction if Séralini refused to withdraw the paper, which is exactly what he announced at a press conference in Brussels this morning. Séralini and his team remained unrepentant, and allege that the retraction derives from the journal's editorial appointment of biologist Richard Goodman, who previously worked for biotechnology giant Monsanto for seven years."

19 of 341 comments (clear)

  1. seems a bit strange by Trepidity · · Score: 5, Insightful

    Imo, withdrawing papers makes sense mainly if there is indeed, "evidence of fraud or intentional misrepresentation of the data". Faked data doesn't help advance science, and should be purged from the record.

    But merely questionable conclusions are another story. Science is a back-and-forth process: someone publishes a study purporting to show X, and then someone else criticizes their conclusions, re-analyzes their data, attempts to replicate it, etc. Then they publish their own conclusions, purporting to show not-X. Withdrawing the original study in this case doesn't make sense to me, if it was not fraudulent: we don't typically retroactively go into old journals and blank out the articles that have subsequently turned out to be wrong. We just write new articles with better analysis.

    1. Re:seems a bit strange by cranky_chemist · · Score: 4, Insightful

      You are correct.

      Weak science and insufficient sample sizes are matters for the journal's referees to suss out and, if necessary, recommend that the journal not publish the paper. The fact that the paper passed peer review should have the journal re-examining their editorial/peer-review policies.

      Ultimately, the decision to publish (and responsibility for publishing) a paper lies with the journal's editor in chief.

    2. Re:seems a bit strange by Anonymous Coward · · Score: 1, Insightful

      This only seems strange because you're viewing it through the logic of science, rather than the logic of Capitalism. Under the logic of Capitalism, this outcome is perfectly sensible: this study raises negative PR issues about a multi-billion-dollar industry, ergo is wrong and must be suppressed.

    3. Re:seems a bit strange by flaming+error · · Score: 2, Insightful

      I agree. If Elsevier thought the study was too weak, they shouldn't have published it.

      Asking the authors to retract it makes it look like they just wanted to save face by not doing it themselves. Didn't work.

      The "Nature" post says Elsevier bowed to "scientists' near-universal scorn"; I have no idea what that means. It suggests perhaps that the study was unconvincing. But it's Elsevier's job to screen for that. It's not their job to retroactively delete honest experiments with honest data which have been honestly reproduced and peer-reviewed because of negative letters to the editor.

    4. Re:seems a bit strange by gregor-e · · Score: 5, Insightful

      The case made for withdrawal bases its objections on bad science. The response from the authors was an ad-hominem attack against one of the editors.

    5. Re:seems a bit strange by Impy+the+Impiuos+Imp · · Score: 5, Insightful

      One cannot rule out the lesser-sized, but very real industry of trumping up faux problems for the purpose of becoming talking heads.

      --
      (-1: Post disagrees with my already-settled worldview) is not a valid mod option.
    6. Re:seems a bit strange by phantomfive · · Score: 5, Insightful

      Think of it this way, imagine someone did a study, where a single kid was vaccinated and later got autism. The authors of this study drew the conclusion that vaccines cause autism.

      Would you consider that to be poor science? Because that is essentially what happened here, there were obvious problems with the experiment, and the science was badly done. Elsevier was being kind by saying there was no evidence of fraud, because either it was fraud or incompetence that motivated these scientists to publish.

      What they should do is repeat the experiment with a better sample size.

      --
      "First they came for the slanderers and i said nothing."
    7. Re:seems a bit strange by AlphaWolf_HK · · Score: 4, Insightful

      Indeed let's look at it from that perspective: I'm sure you'd be rather suspect of any study that has received most of its funding from Monsanto. Likewise, would you be in favor of retracting any that reached a very shaky conclusion?

      On that same token, would you be suspect of any research study that was funded by any one (or several) companies in the organic lobby? The organic industry is massively profitable, and in fact enjoys much higher profit margins than conventional farming. The organic lobby also dumps all kinds of money into trying to prove that GM crops are harmful, and this particular study was in fact one of those they funded, in addition to this one:

      http://www.marklynas.org/2013/06/gmo-pigs-study-more-junk-science/

      Seralini is himself an anti-GMO activist who is setting out from the get-go to try to kill GMO farming. This is like having a scientist who also happens to be a catholic minister publishing a study proving that Intelligent Design is true and Evolution is false. Of course I'd retract it. And besides, it isn't even just the publisher who wants it retracted, numerous other independent researchers want the same thing because Seralini himself tried to derail the peer review process:

      http://en.wikipedia.org/wiki/S%C3%A9ralini_affair

      --
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    8. Re:seems a bit strange by PopeRatzo · · Score: 2, Insightful

      One cannot rule out the lesser-sized, but very real industry of trumping up faux problems for the purpose of becoming talking heads.

      When you say "lesser-sized" you don't really give any indication of the scale of difference.

      The agribusiness industry spends more on public relations than the entire independent research community spends overall. One cannot rule out a very large bias in favor of suppressing anything that might endanger profits. Almost all independent researchers are part of non-profits.

      but very real industry of trumping up faux problems for the purpose of becoming talking heads.

      I find no mention of this "very real" industry you speak of on any of the world's stock exchanges. Are you sure you're not just making it up? I assume you have a list of the "faux problems", and I also assume that it reflects your political opinion more than it does any real "industry".

      How much you think a "talking head" from the scientific community makes, anyway? I'll bet there are executive secretaries at Monsanto that are making 5 times what the highest-paid "talking head" of the type you describe could possibly make.

      Do you think there's more money to be had making up science for Monsanto or for nongmoproject.org?

      --
      You are welcome on my lawn.
  2. 'no definitive conclusions can be reached' by gstoddart · · Score: 1, Insightful

    Funny how Monsanto isn't required to definitively prove their crap is safe, but everyone else is required to definitely prove that it isn't.

    So basically we've got an evidentiary double-standard where Monsanto et al get to say "perfectly safe until proven otherwise", and we don't get to say "prove it". And then we all get to be the test subjects in the long-term studies.

    And, more importantly, having worked at Monsanto should automatically exclude you from being considered from holding an editorial position like this. You mostly have to assume these guys are going to be paid shills who have already made up their mind that it's safe, and he's basically just demonstrated that Food and Chemical Toxicology isn't interested in objective science.

    --
    Lost at C:>. Found at C.
    1. Re:'no definitive conclusions can be reached' by Anonymous Coward · · Score: 5, Insightful

      It's very easy to prove that something is unsafe; you simply show meaningful and reproducible examples of harm caused

      You can't prove that something is safe because you can't say beyond a doubt that something will never ever cause harm in the future. What you *can* do is show multiple studies that were looking for harm and could not meaningfully find any.

      What we know about GMOs is that there are no known examples of harm caused by them that can be reproduced by scientific peers.

    2. Re:'no definitive conclusions can be reached' by khallow · · Score: 4, Insightful

      Funny how Monsanto isn't required to definitively prove their crap is safe, but everyone else is required to definitely prove that it isn't.

      It's not that way for either party and shouldn't be ("definitively prove" is a ludicrously high threshold). This was apparently half-assed research which didn't "prove" anything.

    3. Re:'no definitive conclusions can be reached' by Samantha+Wright · · Score: 5, Insightful

      Like it or not, even big companies are innocent until proven guilty. Pending FDA approval, anyway.

      In this case it looks like the researchers were out for blood and let their dislike for Monsanto get in the way of doing the science properly—not only did they use cancer-prone rats like it says in the summary, but they didn't do enough replicates to determine if the results were actually statistically significant: the control group definitely got fewer tumours, but given the unreliability of the rat breed's tumour-forming rate it's hard to say that it wasn't just a coincidence. (And using a cancer-prone rat isn't exactly realistic to begin with; tumours grow faster whenever they get cheap and easy nutrients.)

      The paper was under close scrutiny immediately when it was published, and not just from Elsevier or Monsanto.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    4. Re:'no definitive conclusions can be reached' by stenvar · · Score: 5, Insightful

      Funny how Monsanto isn't required to definitively prove their crap is safe, but everyone else is required to definitely prove that it isn't.

      That's because it is reasonable to assume that it is safe based on what we know about biology. Furthermore, there are no real-world indications that it is not. At this point, if you want to claim it's unsafe, you better have some strong data to back it up.

      he's basically just demonstrated that Food and Chemical Toxicology isn't interested in objective science.

      According to objective science, every widely used organism produced by genetic manipulation is safe to consume.

    5. Re:'no definitive conclusions can be reached' by iluvcapra · · Score: 3, Insightful

      You say "there are no known examples of harm" --- but that's because nearly no one has looked

      Hardly no one looks for examples of harm from non-GMO corn either. All corn, really all agricultural products, are heavily genetically engineered, the difference is some is engineered with selective breeding and hybridization, and the other by resequencing. The only reason we pay attention to the latter is there's a contingent of motivated believers who think that "natural" food contains Maggi Health Fairies, and that Big Science and Corporations kill the fairies by Playing God(!!1!@1!). it's really hard to get funding to try studying anything against Big Ag's corporate profit interests

      "It's impossible to disprove Darwinism, because the Darwin lobby controls all granting in the life sciences!" "It's impossible to disprove general relativity, because the government suppresses that truth!"

      --
      Don't blame me, I voted for Baltar.
    6. Re:'no definitive conclusions can be reached' by phantomfive · · Score: 3, Insightful

      the kind of thing you might have big a-priori safety concerns about, above and beyond genetic modification to speed along selective breeding processes for traits not directly related to dumping massive amounts of toxins onto food products. So, yes, humans have been doing "genetic engineering" for a long time, but less so for capabilities to saturate fields with weird shit that kills all the other plants.

      Interestingly, they've been dumping actual shit on plants for a long time before that, which is probably more dangerous than the glyphosate that you are (for some unknown reason) afraid of.

      --
      "First they came for the slanderers and i said nothing."
  3. Re:The US isn't always wrong. by phantomfive · · Score: 3, Insightful

    Fortunately, in this case, it's ok to be annoyed by both sides: Elsevier and the guys who did the study. Both are bad.

    --
    "First they came for the slanderers and i said nothing."
  4. Re:Monsanto Fanboys? by Anonymous Coward · · Score: 0, Insightful

    They're not Monsanto fanboys - simply ignorance haters. Monsanto might be corrupt, but they're nowhere near as evil as hippie conspiracy theorists think.

  5. Wrong issues with GMOs by presidenteloco · · Score: 4, Insightful

    Direct health effects of GMO foods are IMHO only the third most important potential concern with GMOs.

    The first concern is that whatever you have engineered, it is self-reproducing and could potentially take over a niche in a whole ecosystem, displacing other species or naturually adapted varieties, and you in general could not stop this if it happened. So eco-systems then become fully the responsibility of human biology tweakers.
    This seems generally unwise. The consequences of such ecosystem shifts is too complex to be predicted.

    A second concern is that each genetic engineering modification needs to be fully assessed separately from all others, due to the complexity of the systems into which they are being inserted. Or at least, very narrow equivalence classes of modifications need each to be individually, and in combination, re-tested for long term effects, viability, viability and effects of likely mutations of the tweak etc, each time they are tweaked.
    The cost of such repeated and long term safety testing is well beyond the capability of the companies producing the products, so we can be sure that such rigorous, long term, and repeated (when product is varied) testing is not being done.
    Instead, smaller numbers of specific tests on a subset of engineered varieties are generalized in alleged applicability and conclusion, to save money.

    So there is still a lot of know unknown and unknown unknown out there, and it is the kind of product that in general, self-reproduces and also expands in range.

    --

    Where are we going and why are we in a handbasket?