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Researchers Crack Major HIV Mystery
mrspoonsi sends this news from Scientific American:
"The difference between HIV infection and full-blown AIDS is, in large part, the massive die-off of the immune system's CD4 T-cells. But researchers have only observed the virus killing a small portion of those cells, leading to a longstanding question: What makes the other cells disappear? New research shows that the body is killing its own cells in a little-known process. What's more, an existing, safe drug could interrupt that self-destruction, thereby offering a way to treat AIDS. The destructive process has caught scientists by surprise. 'We thought HIV infects a cell, sets up a virus production factory and then the cell dies as a consequence of being overwhelmed by virus. But there are not enough factories to explain the massive losses,' says Warner Greene, director of virology and immunology at the Gladstone Institutes, whose team published two papers today in Science and Nature describing the work. Greene estimates 95 percent of the cells that die in HIV infections are killed through pyroptosis, so the findings raise hope for a new type of treatment that could prevent HIV from progressing into AIDS. 'Inhibiting activation of the immune system is not a new concept, but this gives us a new pathway to target,' says Robert Gallo. And in fact, a drug already exists that can block pyroptosis."
This is how you milk science. I won't contest that it is incredibly useful, but the decision to publish in *both* Nature and Science shows the direction science is heading in. All for papers.
Every experiment which ends in a big bang is a good experiment.
Lesbians, by this logic, are God's chosen, since female-to-female transmission of HIV is extremely rare.
Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
As much as I hate to burst your "boo pharma, yay me!" bubble, the current batch of drugs, when taken properly(and that is the key) are almost as effective as condoms in preventing HIV transmission, and if used in conjunction with condoms, prevent probably about 99.9% of all infections. So yeah, obviously big pharma is trying to give everyone HIV. You cracked the case!
Monstar L
It inhibits Caspase 3, necessary for apoptosis... I believe Caspase 1 is necessary for pyroptosis.
Happiness in intelligent people is the rarest thing I know.
Ernest Hemingway
HIV only kills ~5% of the T-cells.
Newly discovered pyroptosis pathway kills the other 95%
This is a radical departure from the accepted mechanisms of how HIV works. Pyroptosis can be triggered by a boatload of different inflammatory processes, I'll be looking forward to their smoking gun that HIV is the cause.
With all the research money poured into HIV research, it's taken them 20 years to notice this?
Face it, God hates fags.
Skin cancer is prove that God hates Scandinavians.
Current society is prove that God hates women.
Diabetes is prove that God hates chocolate.
Your comment is prove that God hates people.
Epidemiology by itself isn't a junk science. It crosses into junk science when someone leaps from observed statistical associations on non-randomized samples to wishfully ($$$) declaring causal relations. Such associations are at best a hint that there may be causal relation, but one needs hard science, such as randomized trials or animal/human experiments to find out what kind of links (e.g. causal or protective/therapeutic) connect those correlated variables.
That's how it is done in normal science, you use statistical hint to make hypothesis that is followed up with hard science. But antismoking "science" is stuck on the same hint since 1950.
And it is not for lack of trying hard science. There were thousands of experiments done since then. The problem was that they all went the "wrong" way -- the smoking animals live longer, perform better on cognitive tasks, get cancers less often, etc. What can poor scientific mercenaries do, when their bosses want the opposite result, but stick with what works, parrot the statistical hints disguised as "science." This was so unusual pattern that already in 1958, the father of modern statistical methods, famous British mathematician R. A. Fisher noticed it and wrote (pdf; this article also contains a very readable exposition of the sample randomization topic):
"Most of us thought at the time, on hearing the nature of evidence, which I hope to make clear a little later, that a good prima facie case had been made for further investigation. But the time has passed, and although further investigation, in a sense, has taken place, it has consisted largely of the repetition of observations of the same kind as those which Hill and his colleagues called attention to several years ago. I read a recent article to the effect that nineteen different investigations in different parts of the world had all concurred in confirming Dr. Hill's findings. I think they had concurred, but I think they were mere repetitions of evidence of the same kind..."
Yet, the antismoking "science" still rests its case squarely on the same kind of soft/junk science that Fisher objected to over half a century ago.
I know about Helena's play thing called the Council of Nicaea. Most of the crap we get spewed out of Christians' mouths are from Leviticus though so 3000 years is accurate though the written part is a little off since it was not written down until the Jewish exile to Babylon.