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Long-Lasting Enzyme Chews Up Cocaine

MTorrice (2611475) writes "Despite cocaine's undeniable destructiveness, there are no antidotes for overdoses or medications to fight addiction that directly neutralize cocaine's powerful effects. A natural bacterial enzyme, cocaine esterase, could help by chopping up cocaine in the bloodstream. But the enzyme is unstable in the body, losing activity too quickly to be a viable treatment. Now, using computational design, researchers tweaked the enzyme (full paper, PDF) to simultaneously increase stability and catalytic efficiency. Mice injected with the engineered enzyme survive daily lethal doses of cocaine for an average of 94 hours."

2 of 73 comments (clear)

  1. Re:Daily lethal doses by gstoddart · · Score: 4, Funny

    They're a special breed of mouse, called the Charlie Sheen mouse. They inject them with tiger blood.

    'Cuz that's how they roll, banging 7 gram rocks. ;-)

    checks google, yes, banging rocks, that's what he said.

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    Lost at C:>. Found at C.
  2. Re:Hmmm .... by gstoddart · · Score: 4, Funny

    I don't have a secretary you insensitive clod. ;-)

    And, no, I have no interest whatsoever in trying cocaine.

    However, I will concede to the more generalized 'motorboating'. :-P

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    Lost at C:>. Found at C.