Long-Lasting Enzyme Chews Up Cocaine

MTorrice (2611475) writes "Despite cocaine's undeniable destructiveness, there are no antidotes for overdoses or medications to fight addiction that directly neutralize cocaine's powerful effects. A natural bacterial enzyme, cocaine esterase, could help by chopping up cocaine in the bloodstream. But the enzyme is unstable in the body, losing activity too quickly to be a viable treatment. Now, using computational design, researchers tweaked the enzyme (full paper, PDF) to simultaneously increase stability and catalytic efficiency. Mice injected with the engineered enzyme survive daily lethal doses of cocaine for an average of 94 hours."

Comments

Re:Hmmm ....

[iluvcapra]

And, this will do nothing at all to fight addiction.

Nope, but it will save lives from overdoses.

There's a line of reasoning that's somewhat common, it goes: "We should never do anything altruistic ever, because it will create a moral hazard, and the mere potential of moral hazard is always worse than concrete good." Similar arguments are used against drugs that treat opiate overdoses, and relatedly, drugs used to fight alcoholism. Some of this is bound up in the idea that addiction is a moral or character failing, or strictly a psychological disorder that can only be treated with therapy and "getting to the real problem," and anything else we do is simply palliative and forestalls treating the "real" problem.

To your point, what needs to be done is a real epidemiological study, to see if people really end up taking more drugs, or if the trauma of OD'ing, being revived by the paramedics and spending a week in the ER with heroic interventions isn't sufficient to make some people hit bottom and scare them straight.