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"Secret Serum" Used To Treat Americans With Ebola
mrspoonsi (2955715) writes with news that the two Americans infected with Ebola in Liberia and transported to Atlanta for treatment were given an experimental drug, and their conditions appear to be improving. From the article: While some people do fight off the disease on their own, in the case of the two Americans, an experimental serum may have saved their lives. As Dr. Kent Brantly and missionary Nancy Writebol waited in a Liberian hospital, someone from the National Institutes of Health reached out to Samaritan's Purse, one of the two North Carolina-based Christian relief groups the two were working with, and offered to have vials of an experimental drug called ZMapp sent to Liberia, according to CNN's unnamed source. Although the Food and Drug Administration does allow experimental drugs to occasionally be distributed in life-threatening circumstances without approval under the expanded access or "compassionate use" conditions. It's not yet clear whether that approval was granted in this case or not. ... Brantly, who had been sick for nine days already ... [received] the first dose ... within an hour, he was able to breathe better and a rash on his body started to fade. The next day he was able to shower without help before boarding the air ambulance that flew him to Atlanta.
It's only "secret" in the sense that almost all pharmaceutical research is completely ignored by the media.
If you dig around you'll find some articles about ZMAPP in no-name low-impact journals like PNAS and Science.
"Secret"
[Fuck Beta]
o0t!
Odds are the so-called "secret-serum" is called ZMapp manufactured by a small biotech company called Mapp Biopharmaceutical...
Odds are this treatment is an optimized cocktail combining the best components of MB-003 and ZMAb (both appear to be three-mouse monoclonal antibody produced by exposing mice to fragments of the Ebola virus and extracting antibodies from their blood)...
Odds are these particular antibodies are actually manufactured in a plants, specifically Nicotiana, not extracted from animal blood.
Odds are you could find this information on this internet in less than 1 minute w/o suggesting or consulting a poorly researched, highly politicized book written in alarmist form.
Unfortunately, odds are many people are unable to use the internet effectively...
Here's a good, reliable page on Ebola, Reston variant: (this assumes you don't think Stanford is a cheesy school, or in on the vast conspiracy to supress all conspiracy theories, or whatever).
http://virus.stanford.edu/filo...
from this page
"twelve of the 186 people tested had serological evidence of infection with EBO-R. 22% of the workers at Ferlite Farms had positive IFAT (indirect fluorescent antibody test) titers, which was significantly higher than at the other three export facilities."
Those infection mumbers are low for a virus that normally attacks humans, like Ebola Marburg, in a setting with no precautions at all and lots of hosts, but the fact that humans have no significant symptoms from it says that the Reston variant virus does not colonize humans at all well, and so are at least marginal support for it being exceptionally likely to survive in the environment, compared to the more human lethal types. This just might indicate that Reston is airborne, but probably just indicates it survives a bit longer on surfaces or takes a little more exposure to some disinfectants to destroy than the commoner Ebola virus types. So you're halfway right about that - Reston is not presumed to have become air vectorable, it's just been raised as a possibility in discussion, and is still rated as less likely than some alternatives.
this particular shipment of nonhuman primates had a far larger number of deaths in Room F than would normally have been expected.
And there goes your record - Reston is deadly to simians, at least to cynomolgus macaques. Unless you want to stand on your obvious spelling error (yeah, it doesn't kill "semians" - I hear not even Kryptonite kills them), the poster you are "correcting" was correct.
Given a 25% accuracy rating and four spelling errors and two grammer errors in four sentences you would have a hard time persuading people to reject the conspiracy theory that Donald Trump's hairpiece is an Venusion Brainslug invader.
Who is John Cabal?
As a researcher in the pharma industry: You are an idiot.
Where can I find the tens to hundreds of millions in public money needed to fund clinicals for a single drug that will most likely not get approved? That money doesn't exist, and many promising drugs die because companies run out of money. So companies have to have major profits on the few drugs that succeed- you should think about it as if you were playing the lottery, but each ticket cost you 10+ mil. High risk-high reward.
Also, a lot of cost is added by FDA incompetence. Yes, they are needed. Yes, we need to make sure everything is safe to some reasonable statistical level. Unfortunately, old rules and test requirements are never removed, so a company has to do a barrage of tests on everything, of which 90% are redundant outdated tests that nobody uses anymore.
I don't really understand the hatred for drug companies. Why is it a problem to pay a few hundred bucks for a pill that will literally save your life, but not a problem to pay thousands for your car? We need new drugs to replace failing medicines, and cure untreatable diseases. If we want to solve the problem of these diseases, we need to give a reason for people to form companies in this area, and that isn't going to happen without an expectation to get the money spent back.