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Is There a Creativity Deficit In Science?

nerdyalien writes with this story that explores the impact of reduced science funding on innovation in science. "There’s a current problem in biomedical research,” says American biochemist Robert Lefkowitz, winner of the 2012 Nobel Prize for Chemistry. “The emphasis is on doing things which are not risky. To have a grant proposal funded, you have to propose something and then present what is called preliminary data, which is basically evidence that you’ve already done what you’re proposing to do. If there’s any risk involved, then your proposal won’t be funded. So the entire system tends to encourage not particularly creative research, relatively descriptive and incremental changes which are incremental advances which you are certain to make but not change things very much."...There is no more important time for science to leverage its most creative minds in attempting to solve our global challenges. Although there have been massive increases in funding over the last few decades, the ideas and researchers that have been rewarded by the current peer-review system have tended to be safer, incremental, and established. If we want science to be its most innovative, it's not about finding brilliant, passionate creative scientists; it's about supporting the ones we already have.

51 of 203 comments (clear)

  1. affirmative by Anonymous Coward · · Score: 4, Informative

    yes

    1. Re:affirmative by Z00L00K · · Score: 2

      Just look at some of the more successful companies - many of them have had a "skunk works" department where they could do the research and innovations in a less restricted area.

      And a lot of creative people are also less socially competent, which means that they have a harder time to get funding.

      --
      If builders built buildings the way programmers wrote programs, then the first woodpecker would destroy civilization.
    2. Re:affirmative by serviscope_minor · · Score: 4, Informative

      It's not as bad as all that, but it's still not great.

      Basically the way it works is this:

      A young, energetic research employed on grant A burns themself out moonlighting on project B.

      They then present the complete B as a proposal which might get funded.

      B gets funded and they use the money for B to work on C.

      Risky stuff does get done, and using exactly the same money but the funding bodies are entering into the fiction that they're involved in the risk. Of course they are since the money has to come from somewhere. It also involves a shitty life for the early career researcher.

      So, the funding bodies are idiots, but pretending risky stuff doesn't get done does a great disservice to those who actually do it.

      --
      SJW n. One who posts facts.
  2. Well of course by Anonymous Coward · · Score: 5, Insightful

    We're well past the innovation of the late 20th century, and we're on our way to the navel-gazing imploding Roman Empire stage of our Western civilization.

    More bureaucracy, more government, more universities, more requirements for simple jobs, more and more employees "required" for simple jobs, endless regulations and committees and civil servants and laws and rules and regulations...

    If the Apollo program were announced today, in 9 years we'd still be arguing over the color of the rocket by PhDs in colorometry.

    1. Re:Well of course by ShanghaiBill · · Score: 5, Interesting

      If the Apollo program were announced today, in 9 years we'd still be arguing over the color of the rocket by PhDs in colorometry.

      The Apollo program was successful because it had a clear goal (put a man on the moon, and return him safely to earth) and a hard deadline (before the decade is out). Modern scientists and engineers can do the same when given the same framework. The DARPA Grand Challenge and the Ansari X Prize are two examples where clear goals and hard deadlines in a competitive environment lead to rapid advances. Instead of doling out grants to people that write boring unambitious proposals, we should be setting bold and ambitious goals, and redirect the money to reward actual accomplishments. Pulling a string works a lot better than pushing it.

    2. Re:Well of course by Alomex · · Score: 2

      You left out the biggest factor: the end of the meritocracy.

      We are fast moving to a system where the person in charge, be it at a company or in government is no longer the most capable, but the one born in third base. Have a look at GW Bush, Mitt Romney, John McCain, Koch brothers, Donald Trump, etc.

      The repeal of the inheritance tax will only amplify this effect.

    3. Re:Well of course by jythie · · Score: 2

      It was also, by comparison, a fairly simple project. Innovation tends to come in bursts, something new and critical comes into scope (steam, transistors, atomic physics) and then society takes time figuring out all the new ways that discovery can be used. Over time though the lower fruit gets plucked and we are left with more and more difficult tasks with more and more incremental rewards. That is kinda the phase we are in right now, research is focusing on increasingly more difficult problems and discoveries are producing increasingly incremental improvements. Stuff that is risky, cheap, and has big payoffs has already been done for the most part.

    4. Re:Well of course by the+gnat · · Score: 2

      The Apollo program was successful because it had a clear goal. . . and a hard deadline

      And strategic significance (and potential dual-use technology) at a time when we were competing with another nuclear-armed superpower for global domination.

    5. Re:Well of course by DerekLyons · · Score: 2

      If the Apollo program were announced today, in 9 years we'd still be arguing over the color of the rocket by PhDs in colorometry.

      The Apollo program was successful because it had a clear goal (put a man on the moon, and return him safely to earth) and a hard deadline (before the decade is out).

      You left out two other key factors... It was founded on a body of engineering, research, and development that was already in progress at the time President Kennedy announced it. And President Kennedy died in Dallas, allowing it to be pushed as his monument and temporarily stilling the debate over the stunning cost of the program.
       

      Modern scientists and engineers can do the same when given the same framework. The DARPA Grand Challenge and the Ansari X Prize are two examples where clear goals and hard deadlines in a competitive environment lead to rapid advances.

      It's no clear that either program lead to useful advances. I'm less knowledgeable about the DARPA Grand Challenge, but the X-Prize lead to an evolutionary dead end that's still grounded. Such prizes often do, as they tend to select for designs optimized to win the prize rather than for technology that's amenable to scaling or to wider introduction and use.
       

      Instead of doling out grants to people that write boring unambitious proposals, we should be setting bold and ambitious goals, and redirect the money to reward actual accomplishments. Pulling a string works a lot better than pushing it.

      Pulling a string is easy, because you know where to pull... that's not even remotely true of research.

    6. Re:Well of course by khallow · · Score: 2

      but the X-Prize lead to an evolutionary dead end that's still grounded.

      SpaceShipTwo has been test flying since October, 2010.

  3. Support our scientists ! by Anonymous Coward · · Score: 4, Insightful

    because the school systems are grinding the future brilliant, passionate creative scientists into drones.

    1. Re:Support our scientists ! by ShanghaiBill · · Score: 4, Interesting

      because the school systems are grinding the future brilliant, passionate creative scientists into drones.

      I have two kids in public school, and I have seen no evidence at all that the schools discourage creativity. In elementary school, my kids did an independent science fair project every year. They learned to do graphical programming in Scratch. The school had several teams that competed in robotic competitions. In high school, they have the full range of science classes, and students are encouraged to do original research or development as an independent study project with a mentor recruited from a research center or tech corporation. Last year, several students from my daughter's school competed in the Intel Science Talent Search. The public schools seem to be doing a much better job than they did when I was a kid.

    2. Re:Support our scientists ! by Rich0 · · Score: 3, Insightful

      In elementary school, my kids did an independent science fair project every year. They learned to do graphical programming in Scratch. The school had several teams that competed in robotic competitions.

      FYI that's not a normal public school.

      The problem with public education in the US is that it tends to be locally funded, so you get whatever your neighbors are willing to pay for. If you're into the "why should I have to pay money so that some poor kid in the local city can learn how to read" school of thought, you probably consider that a good thing. Likewise, if you live in the one progressive town in some red state then you probably appreciate not having to stock your science classroom with Bibles.

      On the whole, though, I think it hurts us.

    3. Re:Support our scientists ! by luis_a_espinal · · Score: 2

      In elementary school, my kids did an independent science fair project every year. They learned to do graphical programming in Scratch. The school had several teams that competed in robotic competitions.

      FYI that's not a normal public school.

      The problem with public education in the US is that it tends to be locally funded, so you get whatever your neighbors are willing to pay for.

      Capable of paying for. That is a more accurate statement.

  4. Re:evolution by Anonymous Coward · · Score: 2, Funny

    It might, however, take millions of years...

  5. Tenure-hunting discourages risk by Jack+Malmostoso · · Score: 4, Informative

    I have been working in research (chemistry) for 10 years, half in academia and half in industry. In my time in academia, it was all about putting together enough results to scrape a paper together, nevermind whether the "promising results" were benchmarked against shitty "state-of-the-art".

    In my current industry job, I have been asked to prepare a 5-year plan with high ambitions, and I am free to explore any path to the final goal without (reasonably at least) restrictions.

    Unfortunately until non-tenured researchers will need to publish as much as possible without actually delivering important results, this will not change.

    In my opinion the peer-review system is not perfect, but it's the best thing we have. I have found many reviewers whose comments have been genuinely beneficial to making my papers stronger. Others barely read the manuscript and rejected it because it encroached on their turf, or didn't cite them enough.

    In my opinion the peer-review should be changed to a double-blind system: the reviewer should not see name and affiliation of the authors, and judge the work as it would grade an undergrad paper (i.e. harshly). Like this I believe the signal-to-noise ratio in journals would increase, and only good papers would get published. At that point, I'd be willing to accept impact factor as a measure of worthiness of a publication. Until then, it's just friends judging friends, with nobody wanting to piss off anybody else. Minor revisions, congratulations, you're published.

    1. Re:Tenure-hunting discourages risk by jmv · · Score: 3, Insightful

      In my opinion the peer-review should be changed to a double-blind system: the reviewer should not see name and affiliation of the authors, and judge the work as it would grade an undergrad paper (i.e. harshly). Like this I believe the signal-to-noise ratio in journals would increase, and only good papers would get published.

      Please no! The problem with this approach (and it's already happening) is that what will get published is boring papers that bring tiny improvements over the state of the art. They'll get accepted because the reviewers will find nothing wrong with the paper, not because there's much good in there. On the other hand, the really new and interesting stuff will inevitably be less rigorous and probably more controversial, so it's going to be rejected.

      Personally, I'd rather have 5% great papers among 95% of crap, than 100% papers that are neither great, nor crap, but just uninteresting. Reviews need to move towards positive rating (how many thing are interesting), away from negative ratings (how many issues you find in the paper). But it's not happening any time soon and it's one of the reasons I've mostly stopped reviewing (too often overruled by the associate editor to be worth my time).

    2. Re:Tenure-hunting discourages risk by martin-boundary · · Score: 2
      That's very wrong. Online comments have no scientific merit whatsoever, ratings systems are abitrary and error prone (who computes the ratings? is it an algorithm, or some full time secretarial type? Does he/she even have a degree?), and citation statistics are gameable, in similar ways that Google rankings are gameable in fact.

      Proper scientific reviews by qualified scientists with higher degrees are non negotiable, if we want science to remain a high quality human endeavour.

    3. Re:Tenure-hunting discourages risk by darthsteve · · Score: 4, Insightful

      but the whole system is geared to "publish or perish". Already thousands of scientists leave the field every year because they haven't produced sufficient publication churn to carry on working. Pubmed is a cesspit of junk, growing by tens of thousands of publications a day. In this hyper-competitive numbers game you have got to publish therefore you can't afford to do anything (anything at all) that could risk not being able to, which means safe, guaranteed data generation. Scientific discovery is secondary. Until there's a change from the all consuming obsession with numbers of publications being the single most important thing for a scientists career then things will remain just as they are, if not worsen.

  6. Re:10,000 Leagues by NoOneInParticular · · Score: 3, Funny

    Well, for starters, 10,000 leagues is a quite a bit over the circumference of the earth, so being so far under the sea is just simply impossible. If this Verne character is serious about his scientific ambitions, he shouldn't be three to four orders off with his approximations.

  7. Is there a science deficit in creativity? by Truth_Quark · · Score: 3, Interesting

    ... is the more salient question.

    Hollywood has turned against scientists again, and the anti-science hacks of antivax and climate change denial and creationism/intelligent design and alt-med are getting more and more air time.

    Uneducated intuition and magical thinking seem to be the respected characteristics in pop fiction, and well respected heroes like Sagan and David Attenborough have given way to more niche respected heroes like Hawkings, Cox and Tyson.

    1. Re:Is there a science deficit in creativity? by ChromeAeonium · · Score: 2

      Hollywood has turned against scientists again

      It irks me that so often science is make out the be the monster maker. I get that a movie called 'Another boring day in a genetic engineering lab where noting unusual happens' isn't going to be a big hit so they need to get their Frankenstein's monster somehow, but still, I don't like it.

      I really hate when there's some smug asshole in the movie who spends the first half of the film whining about playing God and 'toying with things you don't understand' and whatnot, and then gets vindicated when the monster inevitably attacks. I wonder if that influences movie goers' perceptions about science and scientists. The movie Contagion did a very good job at a positive portrayal of scientists, which I won't spoil, but if you haven't seen it you should.

    2. Re:Is there a science deficit in creativity? by the+gnat · · Score: 2

      I really hate when there's some smug asshole in the movie who spends the first half of the film whining about playing God and 'toying with things you don't understand' and whatnot, and then gets vindicated when the monster inevitably attacks

      I forget where I read this, but one writer pointed out that "Jurassic Park" was especially obnoxious in this regard. In the book, Ian Malcolm (the Jeff Goldblum character) keeps trying to explain that they've built a system that is far too complex and has far too many failure points to stay under their control - and of course he's right. In the movie, Malcolm is reduced to moralizing about the arrogance of scientists playing God.

      (Ironically, if Michael Chricton had written the book 15 years later, it probably would have been closer to the movie.)

  8. Absolutely correct; but what's the reason? by udippel · · Score: 4, Interesting

    This may sound strange, but it is a lack of trust.
    In the old days, which were not always good, a brilliant scientist/academician/professor would be granted tax payers' monies to pursue her dreams in science, at least as far as basic funding was concerned; that is not including expensive apparatuses.
    But then we, in the academic world, allowed the bean counters to take over. And they started to ask for ROI, at least in the number of patents, marketability, etc. Additionally, short funding terms made it into our world. 2 years, 3 years. Where I work, the latter is already the exemption. Therefore, as written by Lefkowitz, yes, we have to have results before we can ask for funding. Not only because the sponsors want to be on the safe side (of getting a return), but also not to embarrass ourselves by not being able to come up with what was envisaged. In the place were I used to be, the latter would give you a blacklisting.

    Or, the other way round, if the public is not willing to trust us, but wants us to produce off-the-shelf academic results (numbers of publications included; publications that might take away from our genuine research time), that's what the public gets.

    I only wished that the public was cognizant of this interdependence.
     

    1. Re:Absolutely correct; but what's the reason? by Beck_Neard · · Score: 3, Insightful

      It's amazing how far removed scientific publishing has become from its original purpose. The original purpose of publishing a paper was to disseminate your results to the world. It was basically an open letter to other scientists (that's why so many journals have 'Letters' in the journal name). In the age of the internet, this has become redundant; you can just as easily (actually, much much more easily) communicate your results by writing them up in your blog. Once you have built up enough reputation on your blog, you might get requests from other scientists to feature their work on your blog. Voila - peer review and reputation.

      But now, publications are just indicators of penis size. The process of writing and peer review takes away valuable time from actual work. In the past 1-2 years I haven't done any more than a week or two of actual work; I've just been writing papers and talking to reviewers. I'm sure many other scientists are in the same boat. This is not the way it's supposed to be.

      --
      A fool and his hard drive are soon parted.
    2. Re:Absolutely correct; but what's the reason? by udippel · · Score: 2

      Second this! - When I started in academia, 1980, there were exactly 2 journals in our/my field worth reading. And, yes, they were worth reading; because the articles contained would often summarize the work of complete teams, mostly achieved over years of work. And nobody would be admonished for 'insufficient' publications. On the other hand, had someone at the age of 35 in those days told us, that she'd been 'doing some 135 peer-reviewed journal articles', we would have her failed the job interview. We would have said "that's the least we're interested in".
      Few years ago, someone popping up in the interview and saying exactly that was set on a tenure-track professorship.
      And today, there are around 70 journals in our/my field. And most articles are lousy enough to wipe one's dirty shoes. But i don't blame the authors. I blame the science community overall not to rebuke the bean counters, the MBAs, the admin people, when those became jealous, and insecure, having to somehow evaluate the 'return' of our work. We ought to have offered them a cold shower instead by pointing out that our work usually does not come in tangible returns. But in intellectual returns; something in the realms that those people were lacking in.

    3. Re:Absolutely correct; but what's the reason? by Beck_Neard · · Score: 2

      > maybe that's because the taxpayers' money was used to fund bizarre, esoteric research that nobody would use in a million years,

      This is a very concerning attitude. Would you call research on, say, the Big Bang, 'esoteric' and 'useless'? If so, then you're wrong. If not, then could you cite some examples of what you mean?

      And how would you know in advance whether something would turn out to be useful? The nature of scientific funding is that you fund a lot of projects knowing that most of them will probably fail, but if one succeeds it could cause a major paradigm shift.

      > Too many scientists look down on the less intelligent and don't think they should have to answer to anyone.

      Most scientists I know tend to be very humble people. At least, much more humble than, say, businessmen. I haven't seen anything less than scientists JUMPING at the opportunity to explain their work to others. If anything, it's the laypeople that seem to have zero interest in what the scientists are doing.

      --
      A fool and his hard drive are soon parted.
    4. Re:Absolutely correct; but what's the reason? by BVis · · Score: 3, Insightful

      Hmm, maybe that's because the taxpayers' money was used to fund bizarre, esoteric research that nobody would use in a million years

      Are you qualified to make that determination? Have you read any of these papers beyond the sensationalized headline on some hideously inaccurate post on some web site? Is it possible that these "bizarre, esoteric" topics have more relevance to scientific inquiry than you think? Can you really look at one of these studies and say "well, no useful research here whatsoever"?

      When you take money, you owe something in return.

      Congratulations, you're part of the problem. It seems that you expect all research funded in this way to have immediate, practical applications. Science does not work that way. All scientific research builds on the work that has gone before it; it's possible that studying the mating habits of gibbons will aid in finding a cure for cancer in some way. I think the point here is that the (relatively) uneducated people are making the decisions about what to fund and what not to fund, and it should be scientists who are in a position to know what the fuck they're talking about that should be making that call. Yes, sometimes these studies fail, and nothing is accomplished. Welcome to science, where failure is not only a fact of life, it's necessary for the process to succeed. Without the freedom to fail, we may as well just let the evangelists take over and abandon science altogether.

      --
      Never underestimate the power of stupid people in large groups.
    5. Re:Absolutely correct; but what's the reason? by Rich0 · · Score: 2

      Well said.

      If you really want to pay for breakthrough research, you're inevitably going to spend a LOT of money on things that don't pan out. You can't just look at some breakthrough in isolation and say, "those guys discovered foo with only $bar in funding!" You have to look at the other 47 guys that were also given $bar in funding and they came up with nothing.

      If you could predict ahead of time whose research was going to pan out, then it wouldn't really be research, and you certainly wouldn't need to use tax dollars to fund it since every venture capitalist in town would already be funding it themselves.

  9. One of countless problems by s.petry · · Score: 2

    What you mention is I believe symptom of other problems, not a problem by itself. To run down why science is currently being operated this way would be rather extensive so I'll cover the biggies.

    1) IP Laws have allowed certain entities to own ideas, and patent trolls to buy patents in bulk for no other purpose than to milk innovators if a product becomes successful. Remember that success can also include causing damage to a competing product, so the "success" is related to the patent owner and not society or the science. This has dissuaded sharing of science (collaboration) that up until very recent times was very normal and healthy for progress.

    2) Massive government and bureaucratic control of public funding. This has allowed "pet" project funding in place of what benefits society. In fact many projects are only to benefit the bureaucrats at the detriment of society.

    3) Same massive government does not understand science to uses measures which are invalid and unrealistic to maintain science programs.

    Everyone else including Universities are playing the games. There are many motives for this, and in many cases playing along is the only way to get funding.

    --

    -The wise argue that there are few absolutes, the fool argues that there are no probabilities.

    1. Re:One of countless problems by gtall · · Score: 2

      "3) Same massive government does not understand science to uses measures which are invalid and unrealistic to maintain science programs."

      I think this is a much bigger problem than you indicate. The reason: because bureaucrats do not understand science, they and their managers are being rewarded for successful science which they fund. They, being almost but not quite entirely stupid, have just enough on the ball to realize that if they narrow their funding targets to those they can be reasonably certain will succeed (namely because the researchers are only promising incremental advances), then they (the bureaucrats) will be rewarded with pay raises and more vacation time.

      The fellow up above had it correct, do the research first so you can point to it, then ask for funding for it promising some incremental improvements which, if you are on the ball, you've already done but not published, and then use the money to work on your next line of research. This notion of how to do research has been a running joke ever since I started in research lo' those many years ago, and I'm am not young.

      Essentially, it is the victory of the bean counters. These bureaucrats have no appreciable skills other than bean counting. They work in an environment that rewards them for counting the most of the correctly colored beans. Their ultimate bosses, the politicians, are even worse. The bureaucrats actually believe science is valuable even if they don't understand it. The politicians have no use for science because it cannot be spun very easily. They think of scientists as part of a big dodge who are colluding to prevent the pols from dictating how the world works...or worse, dictating how their god tells everyone else how it works.

  10. Re:Not just a biomedical, but a general problem... by Anonymous Coward · · Score: 2, Insightful

    Now the best way to resolve this is to increase basic research funding to college labs and lone researchers who go through a vetting process.

    The problem with trying to do research in a University setting is that there is a strong tendency to rely on graduate students to do the lab work - rather than career scientists. This means that a typical tenured science professor graduates another new science PhD every couple years. So the tenured professor could easily graduate a dozen or so PhDs over their career before retiring to create one single solitary job opening for those dozen PhDs.

    And that creates a problem in funding lone researchers. The number of people with science PhDs would would love to be paid to go off on their own and research a big question is orders of magnitude greater than the available funding. There's this huge pool of people who are all capable of major creative breakthroughs in science - but no way to know who is more or less likely to actually succeed if you fund them.

    And in addition to this a certain percentage of the funding should be earmarked for experimental research that doesn't have any immediate payoff.

    Of course, all other things being equal more funding is better. But when it comes to cutting edge outside-the-box scientific research I'd be in favor of keeping the government out of it almost entirely - don't make any attempt to judge the research itself.

    Instead, what I would propose is part-time arrangement. Pay a scientist a decent salary, say, $75K/year, to do six months of work that requires specialized skill and creativity but is relatively well defined - giving lectures in science, DNA sequencing more diverse organisms, etc. Then for the other six months let the scientists work on whatever they want - without any restriction aside from subject/patient ethics. If the tax payers absolutely insisted, the scientists could be required to keep a basic accounting of their time to show that they were, in fact, doing something scientific with their time (wrote code for molecular dynamics simulation in morning, researched replica exchange algorithms in afternoon, etc.).

    But the key point would be to not impose bureaucratic restrictions on the areas of science to be explored.

  11. Re:It All Comes Down to FAT CATS by ClickOnThis · · Score: 3, Insightful

    Neither you nor the GP offer any evidence to back up your claims. I'm not interested in preparing a thesis about the correlation of political orientation and intelligence. I'll just offer this,

    http://www.psychologytoday.com...

    and share my own personal experience, which us that there are smart and dumb people across the political spectrum.

    --
    If it weren't for deadlines, nothing would be late.
  12. Tenure-hunting discourages risk by Anonymous Coward · · Score: 2, Interesting

    In some areas, e.g. for SIGGRAPH, the review is double-blind; only the paper committee knows the identity of the authors so that they can assign reviews who do not have a conflict of interest. However, this only really works for areas that are being hotly pursued by many different research groups; diction (often researchers will have different terms for the same thing based on what research group they are in), writing style and illustrations will often give away at least one of the authors, if not the first author.

  13. The Trouble with Physics by DrJimbo · · Score: 3, Informative

    Lee Smolin's brilliant book The Trouble with Physics discussed this issue eight years ago. The book also includes the best introduction to string theory for a scientifically oriented non-physicist I have ever seen.

    Smolin concluded the "trouble with physics" is the problem discussed in the article: the current system rewards small incremental steps over creative leaps. He discusses the risk to payoff ratios. He says the current system drums out most truly creative people.

    --
    We don't see the world as it is, we see it as we are.
    -- Anais Nin
  14. maybe it has just moved out of university by Sad+Loser · · Score: 4, Informative

    I work in biomedical research and yes - a lot of money is diverted into research with incremental benefits - me-too drugs.

    remember that big pharma spend more on marketing than on research.

    The interesting stuff has effectively been outsourced to start-ups that find compounds, do some basic work and then sell to a pharma to commercialise. That way at least the people doing the creating get some benefit.

    What hasn't happened in its stead is any good research at delivering and applying a lot of the knowledge/ practice we do have, and this is where we could get a lot of bang for our buck and we could be a lot more creative - just by doing what we know works correctly.
    This is particularly true in fields where there is not currently much research (because there is no big drugs market)

    --
    Humorous signatures are over-rated.
    1. Re:maybe it has just moved out of university by Rich0 · · Score: 2

      I work in biomedical research and yes - a lot of money is diverted into research with incremental benefits - me-too drugs.

      I don't buy into this line of argument. What you say is obviously true, but the implied argument is that this money is wasted. Every antibiotic since pennicilian is in a sense a me-too drug, but I hear doctors always going on about how we don't invest enough in antibiotics because there isn't a big market for new ones (and it doesn't help that we squander the ones that we have).

      You never want just one drug to treat a particular condition. You don't even want one drug that has a particular mechanism to treat a particular condition. The problem is that while only one drug can statistically be the best treatment for a problem, when it comes down to individuals you have a lot of variance. Maybe drug A is the drug with the best outcomes for a condition you have, but you take it and after two days you have hives breaking out everywhere. Drug B might be a me-too drug that doesn't even work as well, but if you can't take drug A without suffocating then drug B is probably a lot better than take some aspirin for the pain until the disease kills you.

      Research into me-too drugs is already self-limiting. If somebody comes up with another statin that only works 5% better than the current ones, they'll have very little market - the extra competition will depress prices on all the branded treatments, and the generic ones are already out there and will always be far cheaper.

      Also, often the me-too drugs are drugs that were 80% through development when somebody beat them to the market. At that point a company can either just cancel the program and eat the sunk costs, or spend incrementally more to bring the drug to market and at least recover some of those costs. Often the math works out better to move ahead, and patients are better for having an extra option.

      remember that big pharma spend more on marketing than on research.

      Very true, but that is also true of just about every industry out there. Pharma actually spends a lot more on R&D than most companies do.

      I'm all for getting rid of the non-value-add marketing, but that requires a change in consumer behavior. If people stop buying whatever the Hollywood actors tell them to buy, then companies will stop paying those actors to hawk their products.

  15. Science is unpredictable and unprofitable by v(*_*)vvvv · · Score: 4, Insightful

    You cannot predict what you do not know, and to measure how long something takes, it turns out you need to know it pretty darn well. So if anyone claiming to be a scientist claims they need x dollars to get you something amazing in y days, they are talking straight out of their ass. All they have is their curiosity and a hunch. The journey is unknown, and so are the results. To know you will succeed, you have had to have succeeded already. This isn't to be confused with engineering. Engineering is different because you already know the technology and have the tools. You can simulate what you're building before you build it. But the science that gives way to technology no one can predict. If anyone should admit to this, it should be the scientists. The only reason they can't is for political and financial reasons.

  16. Re:10,000 Leagues by techno-vampire · · Score: 2

    Is 10,000 Leagues Under the Sea considered science?

    I don't know; I've never heard of it. By any chance are you referring to Twenty Thousand Leagues Under the Sea? If so, most definitely, because the book accurately predicted a number of features that later became standard on submarines.

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  17. We don't need that many super brilliants. by 140Mandak262Jamuna · · Score: 2
    The creativity distribution obeys a very strong version of the power law [*1]. What it means almost all the brilliant scientific breakthrough comes from very few scientists. Creating incentives for creativity will make the scientists use all that creativity in getting the incentives, innovative proposals, truly genius grant applications etc. Take for example, the true innovation in understanding the "evolution of cooperation". On the face of it "survival of the fittest" and "nature red in tooth and claw" would seem to discourage cooperation between individuals. But many species including our own are highly cooperative. How come? The ground work was done by one guy (Maynard Smith?) in "Evolutionarily Stable Strategies". One guy conducted a tournament of strategies in 1980s in U Mich (Axelrod?). One guy won it, (Anatol?) tit-fot-tat. I think Richard Dawkins played a catalyst by bringing together a biologist and an economist. They were both working on the same cooperation problem but were unaware of each other's work because they used different terminologies. Then a whole bevy of scientists refine the understanding of Iterative Prisoners Dilemma problem to the present level where we can explain how cooperation evolved.

    All I am saying is this emphasis on leadership and creativity is a little too much. Leads to "All Chiefs and no Indians" problem. Good, strong, independent thinking followers are as important to science as leaders. And we need an order of magnitude more followers. If anything we should reduce the incentives for creativity so that only truly creative people shine through.

    [*1] Power Law: aka 80-20 law. 80% income by top 20% of earners, 80% of crime by 20% of criminals etc.

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  18. If you want to fix science.... by Beck_Neard · · Score: 4, Insightful

    It's not that hard to see what you have to do. Provide a funding system that reflects how science actually works. Provide longer-term grants that are accepting of minor failures or changes in research direction. Cut down on the bureaucracy and the committees. Realize that not all research falls into the domain of 'big name' journals and instead focus on more realistic metrics of progress. Some funding agencies are already starting to move in this direction.

    Non-risky science is a big problem, but there's an even bigger problem. You know how news outlets have a focus on churning out news that is sensationalist and overhyped to whore for views and attention? Well, sadly, it's starting to look like that in science. Nowadays the most 'successful' labs are the ones that hype their output the most and shout loudest over the din of everyone else. This is aided and encouraged by both grant agencies and 'big name' journals like Nature.

    As a result, we now have an entire self-sustaining system for producing bullshit, where bullshit goes through the cycle of hype and publication, leading to grant money, leading to even more bullshit. Some of these big labs become black holes for funding, consuming millions upon millions and then ten years later everyone wonders why their miraculous cancer cure turned out to be a dud.

    I don't know when it got this way, or if it's always been this way. Hell, I'm just a newcomer. But I have a hard time imagining that this system would produce people like Einstein or Crick. People like Fleischmann and Pons, more likely.

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  19. Re:It All Comes Down to FAT CATS by dbIII · · Score: 2

    True. Some people are quite intelligent but pretend to be stupid in order to fit in with a bunch of luddite extremists, especially if there is a chance of money or power on the table.

  20. Overhead by mdsolar · · Score: 2

    NASA, for example, does not allow grant funding to be used to write grants. So, this preliminary data thing sounds like a different model. Where did the money come from to obtain the preliminary data? With regard to NASA, grants can cover administrative overhead. And, most institutions have support for new grant writing efforts. Doubtless, some NASA grant money that goes to overhead ends up providing support for that kind of effort so new grants do get written. It is just murky.

    In any case, all that work to find out if an idea is technically feasible enough to make a good grant proposal gets paid for somehow to persuade peers that a proposal is viable. So, really, the originality of new grant proposals has something to do with how well faculty are supported in exploring new ideas. That would seem to be the place to ensure that peer reviews get to see exciting and not just competent proposals. Are the institutions hiring the most creative postdocs, for example? Are junior faculty getting good seed money? Is there time set aside for use of laboratories for pursuit of hunches? So, if granting institutions want to see more creative proposals, they'll have to look at the institutional culture grant overhead supports.

  21. Well yeah by Drethon · · Score: 2

    Creativity tends to go a different direction with mainstream. When peer-review is important do you really want to contradict or say something different from your peers?

  22. Innovation goes faster than ever by GuB-42 · · Score: 4, Insightful

    It may look like scientists nowadays are less creative. I don't think it's the case, they just communicate more.
    Research is always made in small steps. The thing is that now, with sites like arXiv and search engines, we see all these small steps instead of just the end result. It is probably why it looks more incremental.
    Another factor is that we have pretty much nailed down most of the human scale phenomena. Science now needs to address high level of accuracy or work at the nano or cosmic scales. Our brains are not made to deal with this, as a result, a lot of rigor is required and most wonderfully creative ideas end up flat out wrong when compared to the actual data. Because of this, when someone comes up with a creative idea, we need to make sure that he is ready to deal with high precision observations.

  23. Not a Public Education Issue by luis_a_espinal · · Score: 2

    In elementary school, my kids did an independent science fair project every year. They learned to do graphical programming in Scratch. The school had several teams that competed in robotic competitions.

    FYI that's not a normal public school.

    It is if you are middle class. And it is not just a public school issue. It is also an income issue. My girl will have a greater chance of success given that

    1. I can afford pouring her with educational activities,
    2. and that I can afford having one of us parents stay at home to help her with homework,
    3. and that I can afford keeping her busy with extra curricular activities,
    4. and that both of us are college educated

    compared to another kid of the same age and talent potential whose parents

    1. cannot afford pouring her with the same amount of educational activities
    2. cannot afford for one of them to stay home for them,
    3. will inevitably spend more idle time because of that

    Neither situation implies guarantee success for my girl nor failure for the hypothetical kid in the comparison. But the conditions and disparities are real, and amount and accrue to tilt the odds one way. No amount of public education the way it is funded nowadays can change that.

    We know how to teach. We simply allow a system that permits the existence of school districts better funded than others.

    The problem people are discussing here is not about the school system per say, but the system that funds public education which is a) highly local, and b) relies heavily on real state taxes. If there were true state and federal level public education funding systems and/or if we were to diversify local public education funding away from real state taxes, you would see a change.

    You can have a great brain surgeon or a world class oncologist, but he will not do his magic if you pay him crap, you only give him a Neolithic stone dagger and a bag of aspirins to do his work, and you measure his performance under such conditions. It is not a problem with his professional potential, but the system that funds him and deploys him.

    This is very obvious. So why do we examine public education on a different light? It is not our public education system that is doing this or that. It is the system that funds it, and our culture's ethos regarding the role of state and federal government that are a) vital to our society and b) whose support systems are fundamentally broken.

    Either we get Fed/big government involved, or we get local governments to find more equitative (cue morons screaming "socialism!"), more diversified sources of funding away from things that are purely a function of economic brackets/classes (real state taxes.)

    We do not want big government involved, but at the same time, we do not do shit to properly fund public education across all income brackets and neighborhoods? How the hell does that make sense? How the hell does this become a fault of our public education system?

  24. Re:Who bears the risk? by Actually,+I+do+RTFA · · Score: 2

    Risky to who, exactly?

    The research bearing fruit. No one is suggesting removing protections from actual subjects. The article is about funders wanting to fund "successful" (that is, hypothesis affirming) and "publishable" (that is, less contraversial) experiments.

    His goal is to somehow shift the funder's incentives so high sucessful completion risk/high reward (either in basic knowledge or specific benefit) stuff gets made.

    And I agree. The shit that gets funded at any real level is often piecemeal and uninteresting. Hell, even "we want money to try a similar study with N>35 so we can test a lot of spin off research of this promising study" get shot down for being too out there.%lt;/rant>

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  25. It's about Kuhn by thrig · · Score: 2

    Nary a word about Kuhn's Structure of Scientific Revolutions, in particular the distinction between the puzzle solving of normal science and the different conditions of revolutions in thinking? Oh, the revolutionary thinkers face an uphill battle (like they always have)? I am shocked, shocked, at this sorry state of not learning from the history of science.

  26. I know people. The biochemist is right. by bussdriver · · Score: 2

    I know some people in academic research; retired and current.
    The system is fucked up; to use the expression of the youngest one.

    In pursuit of "perfection" we have so much worrying about oversight to prevent waste and corruption that was already lower than everywhere else that we continually clamp down and harm the system more every "reform." This extends into the publishing system which also has a "gold stars" approach where it's all about quantity and not quality. A big earth shattering research paper is foolish; you milk it for dozens of lesser papers almost nobody reads (and creates more research work.) So now we need IBM to device an AI to handle the volume when it probably could go down by a factor of 100 (that said, active topics are still too much for a human to keep up with.)

    Creative science isn't even required-- we just need to fund wasteful stuff that politicians ignorantly rail against as being pointless. Some marine biologist wasting time studying some creature we don't eat... like sharks... finding out why bacteria don't cling to their skin like other creatures might be a total waste; however, that led to super anti bacterial coverings (which you don't see because somebody was allowed a trivial patent on publicly funded research... the real invention was the "pointless" research.)

  27. Funding what we know by LongearedBat · · Score: 2

    If we don't know what we don't know, then we don't know if there's value in knowing whatever it is that we don't yet know. That's when we should fund research, to find out if the funding was worth the price of knowing whatever it is we don't know... and if there is something to know, whether it is worth knowing.

    But if we research what we already know, then because we already know most of what we want to know about, we will know only a little more about what we know much about rather than know much more about what we know little about.

    Isn't that pretty clear?

  28. Re:Not just a biomedical, but a general problem... by david_thornley · · Score: 2

    In some fields, letting scientists go half-time with whatever scientific thing they wanted would work, more or less. In others, it's necessary to work in teams with a whole lot of capital costs.

    Assume somebody wants to do some neat experiments in particle physics, with a possibility of major breakthroughs but likely confirming what we already know. That person is likely to need access to the LHC, which is more than the person's going to be able to afford on $75K/year. (BTW, that is not an impressive salary for somebody with a Ph.D. in a technical field.) Biological experiments are going to require quite a few specimens, and some of them are fairly expensive.

    This plan would impose considerable restrictions on the areas of science to be explored.

    --
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