Medical Milestone: Scientists Reset Human Stem Cells

SternisheFan sends news that researchers from the University of Cambridge have made a breakthrough in the production of human pluripotent stem cells. The goal when developing this kind of stem cell is to have them as early in the cell's lifecycle as possible, so that they're more like true embryonic stem cells and can fulfill whatever role is needed. But all of them made so far are advanced slightly down their developmental pathway. The new work, published in the journal Cell (abstract), has found a way to "reset" the cells by introducing two genes that induce a developmental "ground state."

Comments

Re:hoooray

[Idou]

This is absolutely right, and I would go further to say that this kind of technology cannot be perfected without mass adoption. For instance, there is priceless value to the smart phone industry of having billions of "testers," an expansive variety of users that drives a healthy community of app developers, and a high enough density of adoption to justify wireless infrastructure investment. In the end, the economic value of the combined smart-phone user base is probably many times more than whatever resources the 1%ers could pool together to invent a technology that only they would use.

Now, consider the fact that medical treatment carries significantly more intrinsic risk to the user than smart-phone usage (though user born risk varies. . .), and it is hard to see why 1%ers would try to monopolize this technology. On the contrary, I think any rational person with significant wealth and interest would invest in ways to bring this technology to a large enough population in order to ensure related treatments could be confirmed safe at a statistical level.

Re:Replacement Organs

[jbeaupre]

It will be a lot more expensive than that. Harvesting from a donor means using a "free" kidney. Free in that no one had to be paid to make it. Here are some prices of dissimilar items:

I work with several biomedical companies. A simple metal part can cost $10k. And that's not gouging. Getting that metal part to clinical trials took millions of dollars and 15 years. The amount of testing and paperwork are outrageous. But easier to make than a kidney.

An artificial leg for above the knee amputation can cost $50k and up. Those guys are gouging. But easier to make than a kidney.

I would expect a lab grown kidney to go for $50k-$100k, not including implantation costs. And that's IF they figure out a cheap way to make them.

And ironically, your wife would probably be denied insurance coverage for it. Because she already has a kidney.

(On a related side note, I worked on a non-sterile dialysis system that was so cheap, we couldn't figure out how to make money from it. A few hundred bucks a year, could be done at home, 0% risk of infection. We donated the research and $100k to a research hospital.)