Artificial Spleen Removes Ebola, HIV Viruses and Toxins From Blood Using Magnets

concertina226 writes Harvard scientists have invented a new artificial spleen that is able to clear toxins, fungi and deadly pathogens such as Ebola from human blood, which could potentially save millions of lives. When antibiotics are used to kill them, dying viruses release toxins in the blood that begin to multiply quickly, causing sepsis, a life-threatening condition whereby the immune system overreacts, causing blood clotting, organ damage and inflammation. To overcome this, researchers have invented a "biospleen", a device similar to a dialysis machine that makes use of magnetic nanobeads measuring 128 nanometres in diameter (one-five hundredths the width of a single human hair) coated with mannose-binding lectin (MBL), a type of genetically engineered human blood protein.

Comments

Poor source

[Anonymous Coward]

This summary is a butchered summary of a far more interesting article. Here is a far better source! http://www.nature.com/news/artificial-spleen-cleans-up-blood-1.15917 I'm quite surprised at IBT's lack of knowledge. Viruses killed by antibiotics? Toxins Multiplying?

What ? That's not biologically possible

[aepervius]

"When antibiotics are used to kill them, dying viruses release toxins in the blood that begin to multiply quickly, causing sepsis, a life-threatening condition whereby the immune system overreacts, causing blood clotting, organ damage and inflammation."

Toxin are released by bacteria not virus, and antibiotic do diddly squat against virus, they are used against bacteria. For example Staphylococcus (when not resistant...) is killed antibiotic, and Clostridium botulinum release a toxin which can be deadly (look up botulism). On the other hand HIV laugh at your antibiotic, as well as any rhinovirus or any virus. Vitrus hijack our cells reproduction system to instead generate more virus. I won't even go into the difference among viruses. That summary is extremly poorly written. Especially when the article summary mention bacteria. Also it could not have killed to mention this use magnetofection (associating amino acid or protein with a magnetic nanoparticle and afterward direct it to or from a place).

Re:What ? That's not biologically possible

[Megane]

Toxin are released by bacteria not virus, and antibiotic do diddly squat against virus, they are used against bacteria.

The original article gets this right. You were expecting a clickbait peddler like IBT to even copypasta it correctly?

Much better article in _Nature_

[steveha]

http://www.nature.com/news/artificial-spleen-cleans-up-blood-1.15917

Key points:

* The coating on the nanobeads binds to many different things, so it's useful even if you don't know in advance what is making the patient sick.

The device uses a modified version of mannose-binding lectin (MBL), a protein found in humans that binds to sugar molecules on the surfaces of more than 90 different bacteria, viruses and fungi, as well as to the toxins released by dead bacteria that trigger the immune overreaction in sepsis.

* The device can process about 1 litre of blood per hour; compare with about 5 litre blood volume for a typical human, thus this should be able to completely process a person's blood about once every 5 hours. If a faster rate is needed, multiple devices could be used in parallel.

* This has been successfully tested on rats. They infected rats with bacteria and 89% of the rats treated with the "artificial spleen" survived, while only 14% of the control group survived.

* This could move to human clinical trials relatively soon.

Nigel Klein, an infection and immunity expert at University College London, says that the biospleen could also allow diagnosticians to collect samples of a pathogen from the blood and then culture it to identify it and determine what drugs will best treat it. As blood transfusion and filtration are already common practices, he expects that the biospleen could move into human clinical trials within a couple of years.

Read the whole article. It's not long and all of it is interesting.

Re:Antibiotics and Viruses

[SlowGenius]

Sooo many things wrong with this. For starters, viruses aren't even really alive, even though they interact with living things. So they don't really die, although it is possible to destroy them. For nexters, viruses don't have any ribosomes, so they can't possibly make (let alone release) toxins or anything else. Somebody doesn't have a f***ing clue what he/she is talking about. Magnets. Um, yeah, right.

Re:Antibiotics and Viruses

[Guy Harris]

Makes me want to go to Harvard.

Makes me not want to read the International Business Times, but to, instead, read the news article from Nature , as suggested in another post.

Re:Antibiotics and Viruses

[SlowGenius]

Uh, yeah. The massive die-off you're talking about is called a Jarisch-Herxheimer reaction. It can happen with any gram-negative bacteria (which has endotoxin/lipopolysaccharide), and can easily throw somebody into septic shock. It's also a particularly common problem with spirochetes (syphilis, Lyme).

Re:Woohoo!!

[MattskEE]

The nanoparticles are magnetic, not magnets, which is an important different. It means that the nanoparticles will be attracted to an external magnetic field when it is applied, but they will not be attracted to each other.

Buckyballs were banned because if you swallow permanent magnets they can attract each other and could potentially pinch two parts of your intestine together, or other such unpleasant things which would be bad for you.

Swallowing permanent magnets: Bad idea.
Swallowing magnetic nanoparticles: Good idea assuming it passes the relevant medical trials for safety and effectiness.