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Assembling a Micro-scale Biochemistry Lab Like Snapping LEGOs Together

An anonymous reader writes: Microfluidic systems promise to bring the same level of precision and control seen in the electronics industry to chemistry and the life sciences. Typically, devices are fabricated at substantial cost and using borrowed techniques from the semiconductor industry. Researchers at the USC Viterbi School of Engineering have invented a system of discrete microfluidic elements akin to those found in electronic board design. It was inspired by the ease with which LEGO bricks are assembled into a larger structure, and finally allows for the rapid prototyping of "Lab-on-Chip" devices. The original paper is published in the Proceedings of the National Academy of Science.

11 of 26 comments (clear)

  1. Don't care by viperidaenz · · Score: 1

    I'm waiting for Lego-On-Chip

  2. Ah, fluidics by 50000BTU_barbecue · · Score: 1

    When I was a kid my parents had a collection of very old Britannica supplements from the 1960s. Some sort of yearly book for each year after the main books came out.

    Anyways, when I was a kid I was always impressed by the pictures and the descriptions. One of the articles was about fluidics, the pictures of plates of metal with holes, piled up and bolted together and doing logic operations with boiling liquids and what not.

    I'm just wool gathering, but it seems like the 1960s were unusually fertile in all fields and it's fun to see one of these "anything goes"-type technologies still being useful after so long.

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    Mostly random stuff.
    1. Re:Ah, fluidics by ShanghaiBill · · Score: 2

      One of the articles was about fluidics, the pictures of plates of metal with holes, piled up and bolted together and doing logic operations with boiling liquids and what not.

      That is not quite the same, since the goal was logic, rather than chemistry. Fluid/pneumatic logic was used in early embedded ICBM targeting and control systems, because it could withstand a thousand times as much radiation as an electronic circuit of that era.

  3. Re:Hey, NERDS! by rmdingler · · Score: 1

    Ask yourselves but one question... do you see a single thread, such as this, over there, promoting both sides of the argument equally without censure? There is but one true great nerd site. I'm posting on it.

    --
    Happiness in intelligent people is the rarest thing I know.

    Ernest Hemingway

  4. Re: Hey, NERDS! by Fwipp · · Score: 1

    I have no idea what you're trying to say.

  5. "FPGA" chemistry on a chip=Star trek replicator by sg_oneill · · Score: 1

    "Make this drug on a chip" is kind of awesome, but the next step is the "FPGA" equivilent where novel compounds can be downloaded to it and have it assemble them from base compounds up. What might be implausible industrially due to having too many steps becomes plausible on the very small scale. From here we have the ability to have standard chemical inputs generate any given chemical output and we're on the way to 3D printers that can print almost anything. Thinking futuristically here, but thats your first step to a genuine star trek replicator without having to resort to imaginary quantum woo

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    Excuse the Unicode crap in my posts. That's an apostrophe, and slashdot is busted.
  6. The grammar of Lego by GrahamCox · · Score: 1

    Lego is the building material as a whole, therefore it's already a collective noun. So there's no such thing as "a lego", it's "a lego brick", and by extension there's no such thing as Legos.

    1. Re:The grammar of Lego by Hognoxious · · Score: 1

      Plus it's not an acronym.

      --
      Confucius say, "Find worm in apple - bad. Find half a worm - worse."
  7. Only sheeps say legos. by Anonymous Coward · · Score: 1

    'nuff said.

  8. No it's not by Hognoxious · · Score: 1

    It's more like bolting meccanoes together.

    --
    Confucius say, "Find worm in apple - bad. Find half a worm - worse."
  9. I'm not sure how I feel about this... by jeffb+(2.718) · · Score: 1

    As a chemistry hobbyist, I always wanted one of those big organic-labware sets with pluggable components -- you could build a multi-stage vacuum still, controlled-atmosphere reactor and separator, whatever you wanted -- but true micro- or nano-scale chemistry never seemed as appealing.

    By analogy, I always thought playing with discrete components or small-scale logic chips was a lot more engaging than wiring up a microcontroller and loading it with canned or slightly-modified firmware.

    On the other hand, you can unquestionably get a lot more done with the canned-complex-parts approach. I'll be fascinated to see where this leads.