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Nobel Prize In Chemistry Awarded To Trio For Microscope Advancement
The 2014 Nobel Prize in Chemistry has been awarded to Eric Betzig, Stefan W. Hell, and William E. Moerner for their work in bypassing the limits of traditional optical microscopy. Hell developed a method called Simulated Emission Depletion microscopy, which uses one laser beam to cause a collection of molecules to fluoresce, and another laser beam to cancel out that fluorescence everywhere other than a nanometer-sized volume. Repeating this process over an entire sample provides nanometer resolution for the resulting image. Betzig and Moerner did important work on Single-Molecule microscopy. "The method relies upon the possibility to turn the fluorescence of individual molecules on and off. Scientists image the same area multiple times, letting just a few interspersed molecules glow each time. Superimposing these images yields a dense super-image resolved at the nanolevel." The three scientists' work was pivotal to enabling nano-scale microscopy and allowing detailed study of objects at the molecular level.
The distinction between the three science related fields is not as clear as they were when Alfred Nobel wrote his will.