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Detritus From Cancer Cells May Infect Healthy Cells

bmahersciwriter writes Tiny bubbles of cell membrane — called exosomes — are shed by most cells. Long thought to be mere trash, researchers had recently noticed that they often contain short, regulatory RNA molecules, suggesting that exosomes may be one way that cells communicate with one another. Now, it appears that RNA in the exosomes shed by tumor cells can get into healthy cells and 'transform' them, putting them on the path to becoming cancerous themselves.

9 of 46 comments (clear)

  1. Assumptions... by curious.corn · · Score: 3, Interesting

    Isn't it great when decades old assumptions are challenged and new research and understanding avenues open up? Can't beat science...

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    Mi domando chi à il mandante di tutte le cazzate che faccio - Altan
    1. Re:Assumptions... by gunner_von_diamond · · Score: 2

      "Yeah! Science Bitch!" -Jesse Pinkman

  2. Re:Long thought to be mere trash by Wild_dog! · · Score: 2

    And you published your own research into the subject when exactly AC? It is easier to criticize the bus driver from the back of the bus.

  3. Re:Long thought to be mere trash by Njorthbiatr · · Score: 2

    These "pretentious arrogant twats" have known that exosomes can carry mRNA and miRNA and what exactly as early as 2007. Further, we knew that tumor cells used them to manipulate its environment and how as early as 2010.

    And we've known about them since a study published in 1987. It seemed to just carry obsolete proteins from cells called reticulocytes. But we've known for well over a decade that they're used as a form of intercellular transport, especially within the immune system. No legitimate scientist was going, "Hey this does this one thing for this specific type of cell under certain conditions, I bet it does that exact same thing for all other cells in the body."

    In fact scientists noticed that platelets were also using exosomes and it was a mystery as to why.

    It's funny because you're the one who doesn't seem to be understanding basic microbiology, like the difference between a protein and mRNA.

  4. Re:Long thought to be mere trash by Gr8Apes · · Score: 2

    At risk of feeding the troll, biologists would most likely be the first to tell you that they do not know everything in their field, nor that the field answers any of the fundamental questions, since that's what just about every story related to biology seems to be about lately - new understandings of something previously not considered or even dismissed, much as this case. Biology's understanding at the current time is much like giving you windows 10 today and asking you about it. You understand some of the externally visible pieces, but you don't have a clue how the library dependency structure works exactly, nor what will happen if you replace or remove this one particular file. In any case, understanding yet one more piece of the puzzle should be exciting, not a time to demean those working hard to solve the puzzle.

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    The cesspool just got a check and balance.
  5. There is no "trash". by digsbo · · Score: 2

    Either in the DNA or any other part of the body's systems. We just made a lot of simplifying assumptions to get a handle on some extremely complex systems (i.e. genes are the only place inheritable traits are carried). Now we have to start addressing the complexity behind those simplifying assumptions.

  6. How is this different from a virus? by pz · · Score: 3, Interesting

    A small encapsulatory structure containing a fragment of RNA. I'm not a microbiologist, so can someone tell me how these things are different from a virus?

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    Put my fist through my alarm clock with its ding-dong death inside my ear. - The Blackjacks.
    1. Re:How is this different from a virus? by oodaloop · · Score: 2

      Probably because they don't self-replicate?

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      Tic-Tac-Toe, Global Thermonuclear War, and relationships all have the same winning move.
    2. Re:How is this different from a virus? by pz · · Score: 2

      And that should have been part of my posting above that asked the question -- these fragments dock with other cells, inject the RNA, and that RNA causes the cells to become cancerous, which, in turn creates more of these little RNA capsulettes.

      I'm sure there are some differences between these and classical virus structure, in some way, but given my ignorance of the subject, they walk and talk like viruses.

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      Put my fist through my alarm clock with its ding-dong death inside my ear. - The Blackjacks.