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The Man With the Golden Blood

First time accepted submitter Torontoman points out this story of a man with one of the rarest blood types in the world. Forty years ago, when ten-year-old Thomas went into the University Hospital of Geneva with a routine childhood infection, his blood test revealed something very curious: he appeared to be missing an entire blood group system. There are 35 blood group systems, organized according to the genes that carry the information to produce the antigens within each system. The majority of the 342 blood group antigens belong to one of these systems. The Rh system (formerly known as ‘Rhesus’) is the largest, containing 61 antigens. The most important of these Rh antigens, the D antigen, is quite often missing in Caucasians, of whom around 15 per cent are Rh D negative (more commonly, though inaccurately, known as Rh-negative blood). But Thomas seemed to be lacking all the Rh antigens. If this suspicion proved correct, it would make his blood type Rhnull – one of the rarest in the world, and a phenomenal discovery for the hospital hematologists.

3 of 75 comments (clear)

  1. Re:Tell me why I should care. by Kurrelgyre · · Score: 5, Informative

    It *is* a summary failure--just indicating that it's rare doesn't make it newsworthy. Mentioning that it's more universally applicable as donor blood than Type O would have been a good idea since we're not all hemotologists.

  2. Re:rare or just not looked for? by dmr001 · · Score: 5, Informative
    In the US, when you donate blood, you'll be tested for ABO/Rh, and some of the more "minor" blood antigens (minor insofar as they are less frequently implicated in transfusion reactions and pregnancy-related alloimmunization. Most pregnant women will get, in addition to ABO and Rh-D testing, tested with an antibody screen for sensitivity to antigens from other alleles on the Rh locus, Rh-C and Rh-E. The antibody screen also tests for anti-Kell (anti-K, typically the worst of the more minor antigens; we're taught "Kell kills"), anti-Duffy (Fy(a) and Fy(b)), and sometimes anti-Kidd antigens, and once in a while you'll see anti-P, anti MNS, and anti-Lewis, which typically cause little or no harm. (See this Medscape article for a few details.)

    The deal is if you are (say) an Rh positive fetus in an Rh negative mom who was previously exposed to another fetus's D antigens (and D is often the culprit) you can get your blood cells nailed by mom's previously-formed anti-D antibodies. You get anemia, jaundice as well, and the potential various bad side effects therefrom (heart damage, brain damage, swelling all over[may not be safe for work]). Similar havoc ensues with anti-K. Preventive therapy with RhoGAM is available to prevent anti-D disease; it's a soup of anti-D antibodies that scavenge any fetal Rh-D positive blood cells that happen to find their way into mom's circulation. It's produced from pooled human blood plasma, though even most Jehovah's Witnesses (since a 1974 church opinion) and Jews (because there's an escape hatch in kashrut for saving human life) find it acceptable for treatment in order to prevent this fairly terrifying surprise G-d had in store for a few unlucky babies.

  3. Re:Tell me why I should care. by Stolpskott · · Score: 3, Informative

    The question of the GP was probably not so outlandish. I, for one, was wondering the same. Ok, it's interesting that he's got some oddity in his blood. But ... what does that mean? Can it be used to find out something about our blood in general? Is he something like the "perfect donor"? Does it somehow express itself in his being or behaviour? Does it affect his life?

    In a nutshell, his blood is the universal blood for people with rare Rh blood types (but not truly universal blood that can be given to absolutely anyone, as I understand it). It makes his blood a backup for quite a few rare blood types, but perversely his blood type is so much rarer than those others that supplies of his blood type are more tightly controlled than other rare types.
    There is a hint in the article that people with his blood type are expected to be short-tempered (probably not just because of the constant requests to give blood), but there are no proven links between blood type and personality traits, afaik.

    One interesting point is that this guy's blood is incredibly rare (and therefore also potentially valuable for both research and direct medical use), but it actually costs him money - when he is asked to donate blood, usually by going to the center that needs the blood instead of his local donation center (helps keep the blood fresh, but mainly to avoid the bureaucratic headaches of transporting blood across borders), he has to take time off work and arrange his own transport unless something unofficial is provided - the blood donors in most Eurpoean countries receive no financial compensation at all, even to out-of-pocket expenses.