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Google Developing a Pill To Detect Cancer

An anonymous reader writes: The Google X research lab has unveiled a new project: developing a pill capable of detecting cancer, imminent heart attacks, and other diseases. According to the article, "the company is fashioning nanoparticles—particles about one billionth of a meter in width—that combine a magnetic material with antibodies or proteins that can attach to and detect other molecules inside the body." When a person ingests the pill, these particles interact with the particular markers for a given disease. Since they're magnetic, they can then be guided back to a particular spot where they can be scanned to determine if any interactions took place. Google X's head of life sciences, Andrew Conrad, said, "What we are trying to do is change medicine from reactive and transactional to proactive and preventative. Nanoparticles... give you the ability to explore the body at a molecular and cellular level."

58 comments

  1. Sooo... by Anonymous Coward · · Score: 0

    I can skip the next goddammed colonoscopy???

    1. Re:Sooo... by Anonymous Coward · · Score: 1

      Only if you have a google account. One account -- all of your body.

    2. Re:Sooo... by Anonymous Coward · · Score: 0

      I can skip the next goddammed colonoscopy???

      Only if you tell them to "Google my ass" :>

    3. Re: Sooo... by Anonymous Coward · · Score: 0

      I wouldn't. I skipped mine, and now I am dying from stage 4 colon cancer. Stage 4 means the cancer has metastasized. For colon cancer, that means you have a 50/50 chance of living two years beyond initial diagnosis, and a 6% chance you will be alive after 5 years.

      I was diagnosed 25 months ago. The doctor says I will most likely be dead by Christmas. He says it a lot nicer than that, of course. Ho, ho, ho...

      I would happily trade a monthly colonoscopy to be healthy again.

    4. Re: Sooo... by boristdog · · Score: 1

      Listen to this person.

      I got mine two years ago and they removed some stage 1 polyps. Had I waited a few years I might be in the same boat as this AC.

      Now I have to get colonoscopies every 3 years. But I am not complaining.

  2. Hype or real? by Chipmunk100 · · Score: 3, Interesting

    How do these particles avoid gut enzymes, once in the blood how do these particles avoid phagocytosis by macrophages, how can you expect that magnetic dragging of a number of these particles will not be deleterious, for example some of these got into cellular organelles being forcefully pulled out through their membranes etc. Either it is crazy or there is something ingenious about it.

    1. Re:Hype or real? by pepty · · Score: 1

      In other words:

      "WHY THE FUCK AREN'T YOU JUST TAKING A SAMPLE??"

      And I think I know the answer: avoiding all of the intellectual property surrounding running the exact same tests after taking a sample out of a human being. The number of patents on diagnostics based on these types of binding events is astounding. But they are almost all in vitro, not in vivo.

  3. Looks cloud-enabled. by Animats · · Score: 4, Insightful

    The pill transmits to a wrist sensor. Of course, that will transmit to an Android phone, which will upload the data to Google's servers. You'll need a Google account, of course. All that data will be available to you (and, of course, Google's "affiliates") via a newly reactivated Google Health.

    1. Re:Looks cloud-enabled. by JohnStock · · Score: 1

      How would you propose to do this, via telepathy?

    2. Re:Looks cloud-enabled. by Anonymous Coward · · Score: 0

      Through the wonders of MAGNETS!

    3. Re:Looks cloud-enabled. by Anonymous Coward · · Score: 0

      And it will in beta for years, before being slashed amid the cry of a few diehards.

    4. Re:Looks cloud-enabled. by Anonymous Coward · · Score: 1

      The pill transmits to a wrist sensor. Of course, that will transmit to an Android phone, which will upload the data to Google's servers. You'll need a Google account, of course. All that data will be available to you (and, of course, Google's "affiliates") via a newly reactivated Google Health.

      I'm sorry, but exactly how in the hell were you expecting a product from Google to work?

      Googling the cloud is an exercise in futility, since the entities are one in the same. They ARE the cloud.

    5. Re:Looks cloud-enabled. by Anonymous Coward · · Score: 0

      False dlemma is false.

    6. Re:Looks cloud-enabled. by angelbar · · Score: 1

      Where are my mod points? This need a Funny tag

      --
      -no sig today-
    7. Re:Looks cloud-enabled. by LessThanObvious · · Score: 1

      The tin-foil hat defeated by ingestible Google. Excuse me waiter, is this cheeseburger Google free?

    8. Re:Looks cloud-enabled. by ezelkow1 · · Score: 1

      Fucking Magnets! How do they work?

    9. Re:Looks cloud-enabled. by stonedead · · Score: 0

      Google could invest all this money into buying a basketball team or something if they wanted. Instead they choose to do something good which could potentially save hundreds of thousands of lives every year. And I wonder why /. geeks would view this in a negative way.

    10. Re:Looks cloud-enabled. by buybuydandavis · · Score: 1

      Works for me, and I'd pay for it. I'd pay for it a lot more if Google and I were *free* to do whatever we thought made medical sense. Google over medicare/medicaid/Obamacare any time.

    11. Re:Looks cloud-enabled. by AmiMoJo · · Score: 1

      Do you not have any laws regarding the use of medical data in the US? In most of Europe businesses that handle medical data are controlled very strictly, and not allowed to share it with "affiliates" unless there is a medical need and you give your consent.

      --
      const int one = 65536; (Silvermoon, Texture.cs)
      SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
    12. Re:Looks cloud-enabled. by tlhIngan · · Score: 1

      Do you not have any laws regarding the use of medical data in the US? In most of Europe businesses that handle medical data are controlled very strictly, and not allowed to share it with "affiliates" unless there is a medical need and you give your consent.

      In theory yes. However, this is Google we're talking about, and this sensor isn't being developed from the goodness of Google's heart. No, Google makes money gathering information and knowing as much as possible about you. (It's interesting people think Facebook is worse, even though most of the data on Facebook was provided voluntarily by users of it. Google, OTOH, collects data involuntarily by your actions and by how big Google is ("too big to fail" anyone?)).

      At the very least, Google will datamine your health information and suggest its affiliates target ads towards you, perhaps for ways to ensure your insurance premiums don't go up (and I'm sure Google would love to provide insurance companies with information on who saw that kind of service...). Or maybe show you ads for fitness equipment or something.

      Add in a hack of the CurrentC system for its health data (and you can bet insurance companies would buy that data off hackers "off the books") and by the time the law comes around, it's too late.

  4. Ads by Anonymous Coward · · Score: 0

    So they giving this away too? Do some of the particles send subliminal ads straight to your brain?

    Or they notice you have cancer and sell your info to drug companies

    1. Re:Ads by NotInHere · · Score: 1

      Simple. They control the nanodevices, so they control the apps to control the nanodevices. They add ads to the apps. They profit!

  5. So Many Questions by Anonymous Coward · · Score: 5, Interesting

    So, once the antibody attaches to something, how do you get it to detach so that it can go to the rendezvous point?
    So you inject a thousand different particles, how do you "read" which ones interacted with something?
    Hmm, you also have to have a marker for each disease - a marker that is extraordinarily specific. These don't exist either.

    While I hope it works, I suspect that this project this project will go nowhere. BTW - antibodies are about 14 nm long, 9 nm wide, probably about 4 nm in smallest dimension (possibly much larger, depending on the type of antibody) which is significantly larger than the story implies. I'll believe it when I see it.

    Sounds to me like someone has done some creative writing to get their project funded.

    1. Re:So Many Questions by Chipmunk100 · · Score: 1

      Dont worry, Google has plenty of money to wash down the drain.

    2. Re:So Many Questions by wierd_w · · Score: 2

      antibodies are special proteins generated by your body to attach to, and then neutralize foreign bodies for elimination either in the liver, or via excretion through the renal system.

      This means the bodies are fully free-floating in the circulatory system, and are much smaller in size than are red or white corpuscles. These are basically just large molecules, compared to WHOLE GODDAMN CELLS you have suspended in your blood plasma. (For a reasonable comparison, compare a golfball to a semi truck. An antibody is the size of a golfball, and the blood cell is the size of the semi truck.)

      The antibody is tethered to a magnetic nanoparticle, which means that it will get stuck in soft tissues where a magnetic field is applied. So, wear a magnet on the wrist, and underneath that magnet, the nanoparticles will be held by the penetrating field lines, and they will accumulate in the soft tissue there. They can then be statistically sampled using a simple needle biopsy of this soft tissue at the collection site.

      The antibodies will also stick to biproducts of certain diseases, and serve as a means to concentrate these biproducts at the collection site for effective diagnosis, even when disease is in early stages, and these biproducts would be in nearly undetectable levels in the blood serum otherwise.

      The issue they need to address is what risks do the remaining aggregated particles have on the health of the patient, (Since they may not get cleared by the body after the magnetic trap is removed, and may stick around and contribute to a local pathology) and are there any histological implications of adding synthetic antibodies to the patient. (Not everyone will respond well to having synthetic antibodies introduced. Let alone a large assortment of them, all at once. What happens when these antibodies bind strongly to cellular receptor sites, but then cant or wont let go, etc.)

      It's a neat idea, but I want to see LOTS of animal model studies and considerable cultured tissue in vitro studies as well before this gets anywhere near a human.

    3. Re:So Many Questions by Anonymous Coward · · Score: 0

      So, once the antibody attaches to something, how do you get it to detach so that it can go to the rendezvous point?
      So you inject a thousand different particles, how do you "read" which ones interacted with something?

      The antibody doesn't have to detach. When the wrist device is used, you'll see a deficit of returning magnetic particles with IDs that match to the antibodies that are MIA.

      Whether or not leaving nano-magnetised antibodies trapped in the body is a good idea is for another debate.

      If antibody/nano magnets stay bound to a target, I could see a potential for targeted delivery of payloads. Once all non-bound AB/beads are removed from the body, the in-place magnet-attached antibodies could be used as a sequestering system for nano-magnet attached payload particles. Or nano-magnet attached medical grade radiolabels (for CT scanning to determine location). Or both.

      This hypothetical has a very large proviso. It could only be used **IF** the antibodies don't bind off target. If they do bind off target, all hell could break loose biologically if sending payloads to those incorrectly targeted sites.
      Whether each "test" is for a single ailment/disease (easiest to do), or for a group (multiplexing the test), is something for Google to elaborate on and they would require methods.
      I think the language that Andrew Conrad uses in TFA is lay terminology for the rest of google and the world.

  6. Ten years from now: by pushing-robot · · Score: 5, Funny

    "I'm not sure I have cancer, but based on the ads I've been seeing lately..."

    --
    How can I believe you when you tell me what I don't want to hear?
    1. Re:Ten years from now: by PJ6 · · Score: 1

      "I'm not sure I have cancer, but based on the ads I've been seeing lately..."

      This idea would make for a good near-future science fiction short story, riffing off what's already happened to pregnant teens.

  7. Is it reuseable? by Anonymous Coward · · Score: 0

    I'm sure some folks would want to know...

  8. Please create or login to your Google+ account... by Anonymous Coward · · Score: 2, Funny

    ..in order to view your upcoming heart attacks and your terminal diseases. Share the news with your circles so they can +1 you for support!

  9. Preventative medicine by ISoldat53 · · Score: 2

    My doctors don't believe in doing any tests that aren't indicated by an existing condition. Why cause concern if something is found? What about false positives? Is it going to cost a lot of money? Will insurance pay for it? Once a condition is diagnosed then insurance will pay for it but not before. Prventative medicine is not practices here.

    1. Re:Preventative medicine by Anonymous Coward · · Score: 2, Insightful

      My doctors don't believe in doing any tests that aren't indicated by an existing condition. Why cause concern if something is found? What about false positives? Is it going to cost a lot of money? Will insurance pay for it? Once a condition is diagnosed then insurance will pay for it but not before. Prventative medicine is not practices here.

      You must not be in America. Here the doctor is sure to test your blood for cholesterol and write you a prescription for a statin, because that's what the drug reps tell them to do.

    2. Re:Preventative medicine by Anonymous Coward · · Score: 1

      Only cholesterol? I get two blood screenings per year, 100% covered by insurance, each covers almost 40 different things. At the comfort of my work during a paid break, I get to sit down with a nurse and go over my results and talk about my general health. They'll even set me up with an on-site nutritionist for free.

  10. kind of a misnomer by Anonymous Coward · · Score: 1

    Google X is a data company, not a nanomaterials company. They've had some success combining existing tech into a paltform like the self driving cars, but nanoparticles are still in the lab-phase and trying hard to transition to an application phase. So i feel like it's inaccurate to say Google is developing this, especially when the article says they're looking for partners. The partner is the one to develop this.

    The right guy, who's also just a stone's throw away from Google, is Bell Biosystems, they have some really cool technology. http://www.bellbiosystems.com/Technology

    There are several other promising nanoparticle candidates, but unfortunately a lot of the data shows there's still a lot of control work to be done.

  11. Magnetic clot by Anonymous Coward · · Score: 1

    If all the nanoparticles end up sticking together and blocking an artery they can just stick you in a big degausser to get them to break up.

  12. Ok by TheDarkener · · Score: 3, Funny

    "...the company is fashioning nanoparticles—particles about one billionth of a meter in width"

    Because traditionally, measurements in the ingredients of pills are in meters.

    --
    It is pitch black. You are likely to be eaten by a grue.
    1. Re:Ok by fahrbot-bot · · Score: 4, Funny

      "...the company is fashioning nanoparticles—particles about one billionth of a meter in width"

      Because traditionally, measurements in the ingredients of pills are in meters.

      Sure, only about one billionth of a meter in width, but the pills are *really* long ...

      • Prof. Farnsworth: This is chance for Fry to test out my experimental Google Pill.
        [He pulls out a huge black pill.]
      • Fry: I can't swallow that.
      • Prof. Farnsworth: Well then good news! It's a suppository.
      --
      It must have been something you assimilated. . . .
    2. Re:Ok by pepty · · Score: 1

      Particles about one billionth of a meter in width are smaller than the antibodies that are supposed to be coating them. Even an ScFV (useful fragment derived from an antibody) is over 3 nm.

  13. BLOWED UP real good! by Anonymous Coward · · Score: 0

    Virginia is for lovers, but not for NASA!

  14. What about control? by Anonymous Coward · · Score: 0

    If you can explore at a molecular and cellular level - you can certainly CONTROL the same.

    Sounds like the X-Files... Still scares the hell out of me

  15. The Red Pill or the Blue Pill? by tquasar · · Score: 1

    One pill makes you larger And one pill makes you small And the ones that mother gives you Don't do anything at all Go ask Alice, when she's ten feet tall - Grace Slick Or...The Matrix version: https://www.youtube.com/watch?... Med research stuff takes a decade to go through trials, endless approval and patent stuff, etc. It's like Conan and Andy said, "In the year 2000..."

    1. Re:The Red Pill or the Blue Pill? by Anonymous Coward · · Score: 0

      I dare you to make less sense.

  16. Subtle Diagnosis by FrankDrebin · · Score: 2

    "Hey, why did the | I'm Feeling Lucky | button disappear?"

    --
    Anybody want a peanut?
    1. Re:Subtle Diagnosis by Anonymous Coward · · Score: 0

      They also need an "I'm Feeling Very Lucky" button for when you don't type anything into the search box.

  17. A google pill? by Anonymous Coward · · Score: 0

    I hope it doesn't leave an __utm tracker particle inside me if I take it...

  18. Google Y by Mister+Liberty · · Score: 1

    "Proactive and preventative", eh. Let's say Google wants a larger percentage of the population
    to be apt at programming. Would be nice to have a pill that would proactively and preventatively
    aborts unneeded foetuses -- those with relatively limited perspective -- in Google's programmatic,
    programmed, proactive, preventative world.
    /p?

    1. Re:Google Y by Zynder · · Score: 1

      There's obviously madness in your method.

  19. Even if Google found a cure for cancer ... by linuxguy · · Score: 1

    Google: We have found a cure for cancer
    Typical Slashdotter: Nah. If I have cancer, I will live with it. I don't want to risk you showing me ads relevant to cancer survivors. I much prefer the ads for tampons I see now.

  20. If it doesn't detect cancer... by Anonymous Coward · · Score: 1

    the nanoparticles will cause it.

  21. Seriously folks? by Anonymous Coward · · Score: 0

    I expect Google is peeing in our collective boots. Again.

  22. This is fantasy by rbc76 · · Score: 2

    Far and away the biggest challenge here is to figure out a "marker of a given disease". If the "marker" is something circulating in the blood, then this project is basically developing a chemistry test that can be ingested as a pill, absorbed into the blood, run autonomously in the bloodstream, collected magnetically and interpreted on the spot. Alternatively, you could do a simple blood draw and send the tube to the lab. Right now, we don't have any effective cancer screening based on this approach. If the "marker" is bound to a cell, this gets even harder. Presumably, the "marker" would be something that doesn't belong on the cell. However, your immune system is an expert at detecting what should and should not be on a cell surface. The nanoparticle must be able to figure out that the cell surface "marker" doesn't belong there, and do this more efficiently than your own immune system. That's a tall order. If Google wants to make a major contribution, forget the nanoparticle. Just figure out the markers. It would easily be worth a Nobel prize (possibly several).

    1. Re:This is fantasy by Cyberax · · Score: 1

      Correction: we know markers for several cancer types ( http://www.cancer.gov/cancerto... ). But it doesn't look like there are universal markers applicable for each cancer type.

  23. Good start, Google by Anonymous Coward · · Score: 0

    This, Google. This is what you should be doing instead of spying on our files and communications. Remember "Do No Evil"? This is the kind of thing they wanted you to do instead.

  24. Nanoparticles? by ThatsNotPudding · · Score: 1

    You mean the particles so tiny, they can easily pass thru the blood / brain barrier and do unimaginable neurological damage? Those particles? #WhatCouldPossiblyGoWrong

    1. Re:Nanoparticles? by Anonymous Coward · · Score: 0

      #whatcouldpossiblygowrong? ThatsNotPudding, it's your mushed up brain!