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Major Brain Pathway Rediscovered After Century-old Confusion, Controversy

vinces99 writes A couple of years ago a scientist looking at dozens of MRI scans of human brains noticed something surprising: A large fiber pathway that seemed to be part of the network of connections that process visual information that wasn't mentioned in any modern-day anatomy textbooks. "It was this massive bundle of fibers, visible in every brain I examined," said Jason Yeatman, a research scientist at the University of Washington's Institute for Learning & Brain Sciences. "... As far as I could tell, it was absent from the literature and from all major neuroanatomy textbooks.'"With colleagues at Stanford University, Yeatman started some detective work to figure out the identity of that mysterious fiber bundle. The researchers found an early 20th century atlas that depicted the structure, now known as the vertical occipital fasciculus. But the last time that atlas had been checked out was 1912, meaning the researchers were the first to view the images in the last century. They describes the history and controversy of the elusive pathway in a paper published Nov. 17 in the Proceedings of the National Academy of Sciences. You'd think that we'd have found all the parts of the human body by now, but not necessarily.

16 of 114 comments (clear)

  1. Clearly... by LordLimecat · · Score: 5, Funny

    "It was this massive bundle of fibers, visible in every brain I examined," said Jason Yeatman, a research scientist at the University of Washington's Institute for Learning & Brain Sciences. "... As far as I could tell, it was absent from the literature and from all major neuroanatomy textbooks.'

    Google's dark fiber really is everywhere.

  2. On the other hand. by fahrbot-bot · · Score: 5, Funny

    You'd think that we'd have found all the parts of the human body by now ...

    This is /. so I'm sure many of us have yet undiscovered parts of the human body...

    --
    It must have been something you assimilated. . . .
  3. From an old Unix fortune(6) by mi · · Score: 5, Funny

    The researchers found an early 20th century atlas that depicted the structure, now known as the vertical occipital fasciculus. But the last time that atlas had been checked out was 1912

    Ahh, those inquisitive — and well-funded — scientists... The following fortune-cookie came with BSD decades ago:

    Westheimer's Discovery:
    A couple of months in the laboratory can frequently save a couple of hours in the library.

    --
    In Soviet Washington the swamp drains you.
  4. Wait, what? by gstoddart · · Score: 3, Insightful

    So, for decades we've had med school people doing dissections, we've had autopsies, we've had people doing MRIs and all sorts of other things ... and we really had a situation where nobody ever put up their hand and said "umm, guys, WTF is this, it's not in the diagram?"

    That's just bizarre to me.

    However this reaffirms the necessity of good old fashioned paper libraries maintained by librarians.

    'Discovering' a piece of anatomy which had been forgotten about for a century isn't something you would do with throwing away your old books and digitizing the new ones.

    --
    Lost at C:>. Found at C.
    1. Re:Wait, what? by gstoddart · · Score: 4, Insightful

      If I gave you a diagram of an Intel processor and I gave you the schematics there are lots of little differences that only an engineer would notice.

      Dude, we're talking about doctors and neuroscientists here.

      So, I place them firmly in the set of people who should be able to navigate this and would be capable of reading the schematics.

      No one has the schematics for a human brain yet.

      Well, apparently stuff we used to know 100 years ago we no longer know.

      it's just hard to wrap my head around the notion that modern medicine just forgot about this, and haven't had it in their text books for that long.

      Surely at some point someone would have said "Hey, check this out".

      --
      Lost at C:>. Found at C.
    2. Re:Wait, what? by quantaman · · Score: 3, Insightful

      So, for decades we've had med school people doing dissections, we've had autopsies, we've had people doing MRIs and all sorts of other things ... and we really had a situation where nobody ever put up their hand and said "umm, guys, WTF is this, it's not in the diagram?"

      That's just bizarre to me.

      However this reaffirms the necessity of good old fashioned paper libraries maintained by librarians.

      'Discovering' a piece of anatomy which had been forgotten about for a century isn't something you would do with throwing away your old books and digitizing the new ones.

      I'm guessing a couple things happened.

      First I don't know how obvious it is when you're doing an investigation, I wonder if a lot of people probably simply thought it was part of something else.

      The second problem might be overspecialization, everyone focuses on their little section of the brain, and people aren't really doing the dissections poking at physical structures anymore. If it isn't even labelled no one even knows to look for it.

      Still you'd expect people working on surrounding structures to notice something was missing in the neighbourhood. I'm really curious to know what other researchers thought when they looked at the structure.

      --
      I stole this Sig
    3. Re:Wait, what? by Mashiki · · Score: 3, Insightful

      Those same neurologists are still trying to understand the basic problems of the brain. Like why do people develop MS, but mainly in the norther hemisphere of the world. Or why do we have headaches, why do some people have migraines that go away when they hit puberty and why do some people like me have migraines that get worse with age. I've hit a point where I can no longer function most days, and spend anywhere between 10-25 days on medications to keep the "omg brain exploding" to "omg, the pain...make it stop." It's bad enough that when I walk into emerg, the nurses know me on sight and know what I'm there for.

      It's not uncommon to "lose something" like this in a incredibly complex diagnostic field. Especially when it would have been taught as "common knowledge" and expecting that everyone already knows it. We see this in law too, especially common law where some things are so commonly known for a period that cases don't have to be cited. But then an oddball case comes up, and the original meaning of why xyz happened and is common was lost in the shuffle.

      --
      Om, nomnomnom...
    4. Re:Wait, what? by AthanasiusKircher · · Score: 4, Informative

      Still you'd expect people working on surrounding structures to notice something was missing in the neighbourhood. I'm really curious to know what other researchers thought when they looked at the structure.

      Nothing was "missing." I'm not an expert in neuroanatomy, but just like most press releases from university research labs, this "rediscovery" appears to be quite exaggerated.

      The thing they claim to have "rediscovered" is Wernicke's "vertical occipital fasciculus" (or VOF). Just out of curiosity, I just did a quick search in Google Scholar for this term, and it popped up dozens of articles, starting in the 1940s, quite a few in the late 1970s, some in the 1980s, some in the 1990s, and some in the 2000s.

      For something that was supposedly "unknown" for a century, it has shown up quite a few times in the literature, particularly since the 1970s. So, it looks like some people "know" about it, and have known about it... and have discussed it in papers. A number of these studies clearly also mention processing of visual information, so it's not like these were just mentioning some old anatomical term for a structure nobody knew the purpose of either.

      Granted, I haven't done a full literature search, and I don't know how influential these dozens of papers were/are, but claiming like the last time any scientist noted this part of the brain or its function was a century ago appears to be absolute nonsense. Maybe it deserves to be better known. Maybe it deserves a more prominent place in textbooks.

      But clearly SOME scientists have known about it before this "rediscovery."

  5. A cautionary tale ... by jamesl · · Score: 4, Insightful

    It's bad enough that everything we know is wrong (Firesign Theater), and that we don't know everything (even though there are those who think they do). It turns out that there's lots of important stuff that we used to know and have forgotten.

    Now, where did I leave my keys?

  6. Link to PNAS article by Idarubicin · · Score: 5, Informative

    Direct link to PNAS abstract.

    Why, why, why is it that Slashdot always reports on new scientific discoveries with a link to a lay press summary or a press release, and never gives us the useful link to the actual papers with the real words by actual scientists? Aaaargh.

    --
    ~Idarubicin
    1. Re:Link to PNAS article by Trailer+Trash · · Score: 3, Insightful

      Direct link to PNAS abstract.

      Why, why, why is it that Slashdot always reports on new scientific discoveries with a link to a lay press summary or a press release, and never gives us the useful link to the actual papers with the real words by actual scientists? Aaaargh.

      Hey, at least it wasn't Bennet Haselton telling us about it.

  7. Re:reflexes? by ScienceofSpock · · Score: 4, Interesting

    I watched a show a few months back, one of those shows where they talk about people with different/special abilities, synesthesia, a German guy who was blind from birth, but could understand and draw perspective, etc.

    There was one study they talked about where they had a group of people who were blind in one eye, but the blindness was the result of a brain injury or defect, not a problem with their actual eyes. In the study, the subjects had their sighted eye covered, and were shown pictures of faces with various emotions/expressions to the blind eye. They found that even though they were blind in that eye, they could still "see" the emotion in the faces and would mimic it on their own face.

    Basically, they were saying that the visual signals were getting into the brain and were being interpreted on some level by an unknown part of the brain before getting lost in the damaged visual cortex. I wonder if this has something to do with it?

  8. Debunked? by Anonymous Coward · · Score: 5, Informative

    "it was absent from the literature". A simple Google search shows many articles discussing the "vertical occipital fasciculus" - 265,000 for me:

    The article referenced here: http://www.pnas.org/content/ea...

    Some other references:
    2012: http://www.ncbi.nlm.nih.gov/pu...
    http://www.nan.upol.cz/neuro/c...
    1943 reference: http://psycnet.apa.org/index.c...

    There were a lot more. Something seems fishy here.

    1. Re:Debunked? by crunchygranola · · Score: 4, Insightful

      Mod parent up!

      Yes indeed. This seems to be making mountain out of a molehill. Here is the operative phrase I think: "wasn't mentioned in any modern-day anatomy textbooks". This may well be the case - are every know structure commonly included in anatomy textbooks? They aren't, you know, atlases or encyclopedias of neuroanatomy that might be expected to contain everything.

      As AC shows, the bit about "absent from the literature" seems to have been hype.

      --
      Second class citizen of the New Gilded Age
  9. Re:reflexes? by Jason+Levine · · Score: 4, Interesting

    My mother likely has a damaged visual cortex. She was born with double vision and had surgery to correct this. Unfortunately, even though the surgery successfully fixed her eyes, she still sees double. She'll see one image up and slightly to the side of the other - all blended together. Don't ask me how she drives, reads, or even maneuvers around. I wouldn't know which objects (seeing two of everything) to avoid but she has adapted and is used to it. She has said that, to her, it seems natural to see 2 of everything since you have two eyes and seeing one just sounds foreign. (3D movies don't work for her, thanks to this though.)

    --
    My sci-fi novel, Ghost Thief, is now available from Amazon.com.
  10. Re:reflexes? by ScienceofSpock · · Score: 3, Interesting

    I was going to post something to the effect of:

    "If 3D movies don't work on her, she probably has limited or no depth perception, which is a huge problem for driving"

    BUT

    A cursory google search shows stereo vision or depth perception doesn't seem to be a requirement for a driver license, at least in some areas. Only "sufficient vision" and a regular field of view are required. People can get a driver license with only one eye.

    Personally, *I* wouldn't feel comfortable driving with limited depth perception, or only one eye, but I'm speaking from the perspective of having both of those things all of my life. I wouldn't feel comfortable doing ANYTHING without depth perception or only having one eye.