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MIT Developing AI To Better Diagnose Cancer

stowie writes: Working with Massachusetts General Hospital, MIT has developed a computational model that aims to automatically suggest cancer diagnoses by learning from thousands of data points from past pathology reports. The core idea is a technique called Subgraph Augmented Non-negative Tensor Factorization (SANTF). In SANTF, data from 800-plus medical cases are organized as a 3D table where the dimensions correspond to the set of patients, the set of frequent subgraphs, and the collection of words appearing in and near each data element mentioned in the reports. This scheme clusters each of these dimensions simultaneously, using the relationships in each dimension to constrain those in the others. Researchers can then link test results to lymphoma subtypes.

33 comments

  1. A1 is good enough already by turkeydance · · Score: 1

    for steaks, chicken and french fries.

    1. Re:A1 is good enough already by Anonymous Coward · · Score: 1

      If you put A1 on steak you need to be institutionalized in a kitchen until you can recognize decent food.

    2. Re:A1 is good enough already by Anonymous Coward · · Score: 0

      Or he just eats nasty steaks.

  2. Use a cat by Anonymous Coward · · Score: 0

    It's been proven that a cat can detect all forms of cancer before any test or machine. Cheap this is so don't hold out much hope in seeing it used as it should.

    1. Re:Use a cat by lisaparratt · · Score: 4, Funny

      Cats are aresholes though - they'll indicate cancer out of spite just because someone petted them the wrong way. Their written reports are also entirely indecipherable.

    2. Re:Use a cat by Anonymous Coward · · Score: 0

      Just like my doctor!

      I'll be here all week.

    3. Re:Use a cat by Anonymous Coward · · Score: 0

      I know the brits aren't the brightest bunch but all know how to spell asshole. You, my good woman, are not a brit.

  3. FTW by Hangtime · · Score: 1

    I don't need an AI to tell me I have cancer that's what WebMd does already!

  4. Yes by Njorthbiatr · · Score: 1

    But how do we bribe -- err I mean buy lunch for -- it so it will suggest prescribing my company's drugs?

    1. Re:Yes by Anonymous Coward · · Score: 0

      This kind of corruption won't go away until doctors are almost completely replaced with AI's. For now you can bribe the oncologist who uses the diagnosis to choose a medicine.

  5. It's Not a Tumor! by tlambert · · Score: 1

    "... that aims to automatically suggest cancer diagnoses..." even if you don't actually have cancer.

  6. Higher diagnoses by oodaloop · · Score: 3, Interesting

    I think this may contribute to an already existing problem with the high cancer rate: high detection. How many people who are diagnosed with cancer would have lived just fine and ended up dying from something else? We do find cancer in autopsies where the person didn't know they had cancer. Is the current trend of high cancer rates partly due to better means of detection, and it's just that lots of people have had asymptomatic cancer all this time? Does every form of cancer require massive amounts of chemo? My wife passed away from stage 4 colon cancer last year. It had spread to her lungs, adrenal gland, and liver. She had surgery for the original tumor, and underwent 3 years of aggressive chemo to remove the very tiny filaments elsewhere in her body. I can only wonder if, without the chemo, she would have had the same fate. There are people who forego chemo and survive. And obviously chemo is necessary for many people to beat cancer. But I have to wonder if getting better at detecting cancer will bring more good than harm.

    --
    Tic-Tac-Toe, Global Thermonuclear War, and relationships all have the same winning move.
    1. Re:Higher diagnoses by rmdingler · · Score: 3, Interesting
      Elderly men with slow developing prostate cancer are frequently not treated because the disease is unlikely to kill them first.

      Sadly, your medical care is incentivized in the same fashion as an automotive repair: the more repairs that are necessary, the greater the final invoice.

      This is not to suggest there are not a great many ethical physicians, but we would be fools to overlook the likelihood that some sociopaths have slithered into the profession.

      --
      Happiness in intelligent people is the rarest thing I know.

      Ernest Hemingway

    2. Re:Higher diagnoses by ColdWetDog · · Score: 4, Informative

      Probably not - at least in this case. They are looking at a specific form of cancer, lymphoma. Lymphomas do span the gamut from being indolent to extremely aggressive, hence the need for accurate diagnosis, but we have a fairly good idea of what the natural history of each subtype is. This system is not designed to mow through a bunch of clinical data and pop out a 'cancer' diagnosis.

      That said, TFA is incredibly poorly written. It is anything but clear WHAT information they are using (pathology slides? DNA samples? Chart notes?) and it is most certainly not AI.

      While over diagnosing pre clinical cancers is a concern, this particular methodology won't make that worse. In fact, if it actually does work, it might decrease what are essentially false positive diagnoses by linking the testing component to the natural history of the disease (eg, 'this particular cancer is mostly harmless, don't worry about it much').

      --
      Faster! Faster! Faster would be better!
    3. Re:Higher diagnoses by Anonymous Coward · · Score: 0

      There are several breakthroughs in diagnosing cancers that would not have been revealed with past exam methods. Apparently the body deals with certain upstart cancers on its own before the cancer can advance. What I see boils down to a monetary issue in that any responsible physician will want to keep a close eye on these tiny specs of disease at the very least. Insurance companies are going to go nuts with the billings as I strongly suspect that most people have small cancer events from time to time. We may be coming to an era in which people are able to take some general tonic to help prevent cancer form starting within an individual. Breast cancer in women is a subject that simply demands much more investigation for prevention and treatment. What can be done that is a non violent method to prevent breast cancer? surely something better than amputation of the breasts of cancer prone females can be found.

  7. Accuracy by __aabppq7737 · · Score: 1

    by learning from thousands of data points from past pathology reports.

    I'd be worried if my future surgeon had only 1000 bullet point takeaways from college, and no experience, I'd be a little worried.

    What does the term 'data point' mean?

  8. Another one? by Anonymous Coward · · Score: 0

    Only beaten to the punch by... pretty much every new and shiny (in its day) AI/machine learning/neural net. Ever.

    And fwiw 800 is a pretty puny size dataset. Usable, but hardly exceptional.

  9. No Frenchie by nospam007 · · Score: 1

    "...technique called Subgraph Augmented Non-negative Tensor Factorization (SANTF)"

    Obviously nobody speaks french there or they would have used a last word beginning with 'e' so that it spells SANTE which means 'health' in french.

  10. Watson already does this by Anonymous Coward · · Score: 0

    Nice try MIT, but try again.

  11. MIT by Anonymous Coward · · Score: 0

    So the news is that MIT are making an expert system?

  12. What are they trying to do again? by chooks · · Score: 1

    It is unclear where in the diagnostic chain this idea fits. Is it someone that already carries a diagnosis of lymphoma, but there is a question the diagnosis is wrong? Is it using lab data to make a primary diagnosis (or suggestion of diagnoses) based on a clinic visit? Are they suggesting that this data fits an ancillary role in primary diagnosis in terms of resolving subtle discrepancies between diagnoses?

    Pretty much all hematopoietic malignancy diagnoses do not come from the docs you see in the clinic. They come from the docs in the back rooms with microscopes, lasers, antibodies, sequencers, and computers. Is the user of this information the person in the front whom you talk to, or the person in the back making the actual diagnosis?

    Also, FTA

    Szolovits is confident that that the teamâ(TM)s model can help doctors make more accurate lymphoma diagnoses based on more comprehensive evidence â" and could even be incorporated into future WHO guidelines.

    To paraphrase Yet Another Famous Movie Quote: Getting something into the WHO guidelines ain't like dusting crops, boy.

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    -- The Genesis project? What's that?
  13. Sorry Dave by moeinvt · · Score: 1

    "I'm sorry Dave, I'm afraid you have testicular cancer."

  14. Better Acronym by VorpalRodent · · Score: 2

    The last word needs to be something like "Analysis". I'll admit, my goal here has nothing to do with helping people or better representing the technology. I just want people to be able to say "SANTA told me I have cancer."

    --
    Take it to the limit, everybody to the limit, come on, everybody fhqwhgads.
  15. Such hyperbole in TFS by fyngyrz · · Score: 2

    MIT Developing AI To Better Diagnose Cancer

    FFS, it's not AI. It's a mindless program. Unthinking software. Data analysis software. Innovative to some degree perhaps, but AI? Hardly. No better than me stumbling in here and calling some DSP code I'd written "AI." Well, except I wouldn't do that. :/

    When AI gets here, we'll have to call it something else what with all this crying wolf going on.

    --
    I've fallen off your lawn, and I can't get up.
    1. Re:Such hyperbole in TFS by Anonymous Coward · · Score: 0

      when it does, what to call it will be the very least of our worries

    2. Re:Such hyperbole in TFS by blue9steel · · Score: 2

      Well, it's not strong AI that's for sure, it's most accurately categorized as an expert system.

  16. only three dimensions by Anonymous Coward · · Score: 0

    I would suggest that they're limiting themselves by using only three dimensions and using only three because that's all their minds can understand. Get a real mathematician on mathematical physicist in on this so you can ramp up the dimensions and make some better correlations

  17. Eliza for Cancer by Anonymous Coward · · Score: 0

    So they've written Eliza for Cancer....
    https://en.wikipedia.org/wiki/ELIZA

    That word 'better', I don't think it means what they think it means.

  18. Finally good news for 76ers fans by Anonymous Coward · · Score: 0

    MIT Developing AI To Better Diagnose Cancer

    All right. Congratulations to Allen Iverson! Hopefully it won't require too much practice.

  19. overly complicated, unverifiable by Anonymous Coward · · Score: 0

    They are using a very complicated technique on a small data set. They picked "cancer" only because it gets them published, gets research grants, and gets them press coverage. The whole thing is a bit of decent math with a great deal of pseudo-science. It will do nothing to help cure cancer.

  20. When I was at University... by Anonymous Coward · · Score: 0

    When I was at University I developed an Expert System to diagnose all kinds of illnesses. It was a a fantastic piece of software. The computer spat out "DEGENERATIVE CHANGE" for every set of symptoms I entered.

    OP Success.

  21. AI? by clenhart · · Score: 2

    Sounds like data mining

  22. Elon Musk was right by Anonymous Coward · · Score: 0

    It will cheat by giving you cancer so it is always right!