Researchers Discover Breakthrough Drug Delivery Method By Changing Shape of Pill

ErnieKey writes: Researchers at the UCL School of Pharmacy, University College London have found a way to change the rate of dissolution within medication via a 3D printing method. Researchers used MakerBot's water- soluble filament, cut it into tiny pieces and mixed in acetaminophen. They then used the Filabot extruder to extrude a drug infused filament. With this filament they printed odd shaped pills and tested them to see what effect different shapes had on the speed at which they dissolved. What they concluded was that these odd shaped pills allowed for different rates of absorption, enabling custom medications for patients.

Comments

Surface area to volume

[Anonymous Coward]

Surface area to volume ratio found to affect rate of dissolution, details at 11.

So which dissolves faster?

[fustakrakich]

Fred or Dino?

Re:fast-acting and slow release combined?

[spasm]

That's how most of the '-contin' formulations work (eg oxycontin). You make tiny pellets of the analgesic, add a thin layer of wax to some, a thicker layer to some, a thicker yet layer to some, then make up a pill containing some pellets with no coating, and some with each of the increasingly thicker layers of wax. When you swallow the pill, the stuff with no layer goes into immediate effect (so you get fast acting relief). The acid in your stomach starts dissolving the wax around the rest, with the different thicknesses of wax acting to give a continuous release of the remaining analgesic. Different formulations have differing amounts of the initial uncoated analgesic.