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Scientists Show Human Aging Rates Vary Widely

HughPickens.com writes: Ever notice at your high school reunions how some classmates look ten years older than everybody else — and some look ten years younger. Now BBC reports that a study of people born within a year of each other has uncovered a huge gulf in the speed at which human bodies bodies age. The report tracked traits such as weight, kidney function and gum health and found that some of the 38-year-olds in the study were aging so badly that their "biological age" was on the cusp of retirement. "They look rough, they look lacking in vitality," says Prof Terrie Moffitt. The study says some people had almost stopped aging during the period of the study, while others were gaining nearly three years of biological age for every twelve months that passed. "Any area of life where we currently use chronological age is faulty, if we knew more about biological age we could be more fair and egalitarian," says Moffitt. The researchers studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. They developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. According to Moffit the science of healthspan extension may be focused on the wrong end of the lifespan; rather than only studying old humans, geroscience should also study the young. "Eventually if we really want to slow the process of ageing to prevent the onset of disease we're going to have to intervene with young people."

38 of 285 comments (clear)

  1. Colour me suprised by amalcolm · · Score: 4, Insightful

    What you do/experience when you are young (smoking, drinking to much, too little sleep, bad excercise, bad housing ... etc. ) comes back to haunt you.

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    Time for bed, said Zebedee - boing
    1. Re:Colour me suprised by Chrisq · · Score: 5, Funny

      What you do/experience when you are young (smoking, drinking to much, too little sleep, bad excercise, bad housing ... etc. ) comes back to haunt you.

      Not always. Jeanne Calment was once asked what the secret of her long life was and she said that she thought that cutting down her smoking at the age of 96 had a lot to do with it.

    2. Re:Colour me suprised by AthanasiusKircher · · Score: 4, Interesting

      Not always. Jeanne Calment was once asked what the secret of her long life was and she said that she thought that cutting down her smoking at the age of 96 had a lot to do with it.

      Uh, I know you were trying to be funny -- but the very article you linked explains that she stopped smoking at age 117. Wikipedia doesn't say why, but I recall reading an article years ago which said it was because she had gone blind and was unable to light her own cigarettes -- and was too vain to ask others to do it for her.

    3. Re:Colour me suprised by TWX · · Score: 2

      On the other hand there are some disease processes that can be reversed, like some forms of Diabetes, when the individual starts taking better care of themselves. If I knew a guy that was probably close to 400lb by the time he graduated high school, and looked every bit as bad as one could expect. He literally decided to do something about it one day, changing his diet, changing his habits, exercising more, and within about four years he was down probably half his body weight. He did it slowly enough that he didn't really have skin issues either. It was honestly astounding; I hadn't seen him during the transition so when he stopped in to visit his mom I did not recognize him at first.

      --
      Do not look into laser with remaining eye.
    4. Re:Colour me suprised by sgunhouse · · Score: 3

      I look younger than my younger brother, yet I smoke and drink moderately (and him not at all) and had a job which required irregular hours sleeping for about 5 years. However, he's always had a high metabolism while mine is slow, and it shows.

    5. Re:Colour me suprised by nine-times · · Score: 4, Insightful

      From the article:

      The team said the next step was to discover what was affecting the pace of ageing.

      So common wisdom might tell you that this is all caused by smoking, drinking, lack of sleep, lack of exercise, etc., but scientifically we don't know. We might study this and discover that the effect of some of those things in minor when compared to... I don't know what. Genetics? Childhood trauma? Stress? Sitting too much?

  2. Re:Methamphetamines age you prematurely. by Anonymous Coward · · Score: 5, Funny

    I have some old friends that are meth addicts that look like my grandparents.

    Are your grandparents on meth?

  3. take care of yourself and you will look good by known_coward_69 · · Score: 2, Informative

    i'm 41. and people who meet me for the first time think i'm in my mid 20's. same with my wife. don't drink more than once or twice a month, exercise, avoid eating out all the time and avoid processed foods. stay away from milk, sugar and gluten. cook for yourself and don't buy the prepared foods

    1. Re:take care of yourself and you will look good by IgnitusBoyone · · Score: 2, Interesting

      I was with you until the Milk part. My ancestors worked hard at animal husbndry and shoving milk down thier guys to ensure I was lactose tolarante. Ok to be fair they didn't care about me they just wanted to surivive, but its a niec side effect at any rate, ...

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      Momento Mori
    2. Re:take care of yourself and you will look good by hippo · · Score: 4, Funny

      I'll just stick with the painting in my attic thanks.

    3. Re: take care of yourself and you will look good by Anonymous Coward · · Score: 5, Funny

      The trick is to avoid processed milk. Just suck it right from the cow. But, make sure you find a cow and not a bull. The bull won't like it. I know that seems counterintuitive, but trust me on this one.

    4. Re:take care of yourself and you will look good by smooth+wombat · · Score: 4, Informative

      stay away from milk, sugar and gluten.

      You were doing pretty well right up until you mentioned gluten. This near fanaticism with avoiding gluten is approaching the same level of thinking organic foods are more nutritious.

      Gluten comes from certain grains. Despite this fact, I have seen products, including fruit itself, labeled as "gluten free" which do not use grain in their production. This article spells it out very nicely:

      The researchers noted that many symptoms attributed to gluten may actually be caused by sensitivity to other components of wheat flour or other ingredients found in wheat-based foods like bread, pasta, and breakfast cereals.

      Symptoms that have been attributed to gluten sensitivity include diarrhea, abdominal cramping, bloating, headaches, fatigue, and even those associated with attention deficit hyperactivity disorder (ADHD).

      Di Sabatino and Corazza write that some people may experience these symptoms when they eat foods containing gluten simply because they believe these foods will make them sick.

      They conclude that common sense must prevail to "prevent a gluten preoccupation from evolving into the conviction that gluten is toxic for most of the population."

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      We will bankrupt ourselves in the vain search for absolute security. -- Dwight D. Eisenhower
    5. Re:take care of yourself and you will look good by NatasRevol · · Score: 3, Informative

      generally eating gluten free is better for your digestive system,

      What utter unscientific bullshit*.

      *unless you have actual celiac disease.

      --
      There are two types of people in the world: Those who crave closure
    6. Re:take care of yourself and you will look good by TWX · · Score: 2

      Ah, the Internet. Where the men are men, the women are men, and the teenage girls are FBI agents...

      --
      Do not look into laser with remaining eye.
    7. Re:take care of yourself and you will look good by Ol+Olsoc · · Score: 2

      You were doing pretty well right up until you mentioned gluten. This near fanaticism with avoiding gluten is approaching the same level of thinking organic foods are more nutritious.

      A restaraunt my wife frequents has completely separate grills and utensils for gluten free cooking. That's pretty much fanaticism.

      Gluten has replaced peanut allergies as the allergy du jour. If you have celiac disease, you have a real gluten allergy. If not, not as likely

      Gluten comes from certain grains.

      Specifically, it's the protein portion of the seed. And each version of gluten is a little different. Anin in an ironic twist, is one of the meat substitutes for vegans.

      Despite this fact, I have seen products, including fruit itself, labeled as "gluten free" which do not use grain in their production.

      I saw a bottle of spring water that was labeled as "gluten free" As the wise man once said "No shit?"

      Symptoms that have been attributed to gluten sensitivity include diarrhea, abdominal cramping, bloating, headaches, fatigue, and even those associated with attention deficit hyperactivity disorder (ADHD).

      Sounds like a night of drinking cheap wine will cause a gluten allergy.

      A real gluten allergy like Celiac disease will have some of those symptoms you described, certainly people with celiac know something is really off within themselves.

      But it isn't common at all.

      I'm more inclined to think that some people who eliminate processed wheat products from their diets might be eating better in general, might have taken off a few pounds, and if a person is overweight, taking off a bit is a great way to feel better.

      But I fear you have opened a floodgate of criticism, we'll hear about how gluten allergies are caused by (insert trendy bugaboo word here) and that you're being an insensitive clod, and a ton of testimonial on how someone cured their gluten allergy, and will live forever because of it.

      But don't worry, they'll move on to the next ailment du jour shortly.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
  4. Sometimes being fair requires ignoring differences by ciaran2014 · · Score: 4, Interesting

    From the summary: "Any area of life where we currently use chronological age is faulty, if we knew more about biological age we could be more fair and egalitarian,"

    That depends. Should people with a higher biological age retire earlier? Kinda unfair to people who looked after themselves.

    Of course I can also see ways to make good use of this: It would be interesting to see if certain jobs are linked to people ageing faster. Maybe (maybe) people in those jobs should be give the option of retiring earlier, with pensions adjusted somehow.

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  5. Re:Methamphetamines age you prematurely. by cayenne8 · · Score: 5, Interesting
    Most of my friends that married and had kids, look MUCH older than I do. Hair fell out early, and turned gray long ago. Faces are more wrinkled too.

    I guess raising kids takes a toll on your health as well as your bank account.

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    Light travels faster than sound. This is why some people appear bright until you hear them speak.........
  6. Re:Methamphetamines age you prematurely. by TWX · · Score: 4, Interesting

    I've heard a theory that once one's biological imperative is met, one's body may indeed start to change. This could be just an old wives' tale, but on the other hand if the 'family unit' tends to make for physiological changes in both parents (as opposed to the male leaving after conception) then maybe there's a bit of truth to it.

    We really don't have enough information at this point though.

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    Do not look into laser with remaining eye.
  7. Re:Sometimes being fair requires ignoring differen by TWX · · Score: 2

    Well even if you are allowed to retire earlier, you would make less money than a person who was healthy enough to work another decade. So I feel that there is a built in incentive there.

    Unless one adjusts for that too, giving preferential treatment to those who age faster, giving them greater fianancial benefits in retirement.

    Mind you, I don't agree with that, mainly since in my experiences with my extended family (my paternal grandparents had a LOT of children) there's huge variation in how people have aged, so it's clearly not simply a matter of biology. Choice plays a rather large part and those that have engaged in fewer self-destructive habits have generally aged better.

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    Do not look into laser with remaining eye.
  8. try facebooking with friends when you're 40+ by Trailer+Trash · · Score: 4, Insightful

    Getting back in touch with high-school classmates was a huge eye-opener for me. I'm 47 now, graduated in 1986. Many of my classmates look like they're in their 60s. I'm not exaggerating. It's just amazing to me how differently people age.

    1. Re:try facebooking with friends when you're 40+ by Trailer+Trash · · Score: 2

      Is it just you?
      Once I visited home and walked around with my dad, and ran into my friend's dad, Bill.
      All I could think was "two old men having an old-man conversation".
      Afterwards my dad told he he was surprised how much Bill had aged, while he himself had barely aged at all!

      Good question, but no, it's not just me. Admittedly I look young for my age, as does my wife. We're both commonly mistaken for being 10 years younger than we are. What stuck out in my facebook friends list isn't "me" vs. "other people", it's "some of my friends" vs. "some of my other friends". If you saw their pictures without knowing who they were you would have trouble believing they were all the same age. Some look to be my age and others look 20+ years older. I know one guy who's 50 who looks to be my mother's age (she's 72).

      The point is that when you see all of these people side-by-side in photos those differences are really noticeable. I've noticed that those who age quickest don't tend to show up at the class reunions so I didn't notice before.

      Another odd effect is that some of the girls who were babes in high school turned out to be average looking by age 30. I don't mean "fat" - I mean their beautiful face became average. At the same time some girls who weren't terribly pretty in high school are now very pretty.

      It's strange how people change throughout life, and it's not something you notice until you've lived like 50 years.

  9. Re:Methamphetamines age you prematurely. by DigiShaman · · Score: 5, Insightful

    It's stress; be it from the hard work in raising a family or a single person pushing 60+ hours a day with 5 hours of sleep or less. This kills the body, literally! Mental stress also shrinks the brain. I'm in my late 30s, and I can tell how much work related stress (you either have a job, or don't. There's no fucking balance in this world anymore to pay the mortgage/rent) has altered my health. I feel I've aged twice what I should have. I'm the only one in my family that has a few gray hairs early. 10 years go, people thought I was under 21.

    FUCK!

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    Life is not for the lazy.
  10. Unsupported assertions by sjbe · · Score: 4, Informative

    generally eating gluten free is better for your digestive system

    There is no credible scientific study I am aware of that supports this statement. If you wish to assert this you need to provide non-anecdotal evidence, preferably in the form of a double blind study supporting this assertion. I am not aware of any evidence that gluten is measurably harmful to individuals without celiac disease, an allergy or other form of gluten sensitivity. This is a very small portion of the population (somewhere between 0.5% and 1%) that is known to be affected. The best available evidence appears to clearly show that if your aren't part of that population then avoiding gluten is a waste of effort.

    if you want to stay young, avoid as many processed foods as you can.

    Again you are asserting that "staying young" is linked to avoiding processed foods. While there is evidence to support that processed foods are frequently harmful if consumed regularly over time, you cannot automatically generalize this to link it to biological aging (versus chronological aging) without evidence. There may very well be a link but it is unproven at this time. I understand that it sounds reasonable but lots of things sound reasonable that aren't actually true.

    1. Re:Unsupported assertions by Alioth · · Score: 2

      I suspect processed foods are not harmful. A raw food diet is a lot likely to be less optimal (basically, cooking - which is processing food - is what made us human: processing our food allowed us to break it down a bit meaning a simpler, more efficient digestive process, allowing us to have larger brains).

      If you cook from fresh ingredients, guess what you're still eating processed food. Just because the food processing happened in your home, doesn't mean it's not processed food. It doesn't matter where the processing occurred - in your home, in a factory, or wherever, so long as the food doesn't contain excessive quantities of crap. I think the real answer is avoid crap foods. Foods with large quantities of refined sugar for example. I think the main things of home cooking (processed foods processed in your home) is that you know what went into the process so it's easier to avoid the crap simply by not adding it to the recipe.

  11. Re:ANTIOXIDANTS! by DarkOx · · Score: 2

    I don't doubt it. Ask anyone in rural Maine. The farmers are all perfectly healthy right up into they decide to retire and get a place in town. Then they go down fast. Being up and moving a large part of each day clearly is good for longevity. At least for most people.

    --
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  12. Re:Methamphetamines age you prematurely. by war4peace · · Score: 3, Interesting

    *raises hand* I'd like to join your congregation.
    Father of two, sole income-maker in my family, average sleep time is 6 hours a day. I work more than it's healthy, and that's because I have no choice. Still, many people think I'm younger than I actually am. I guess at some point I'll start aging really fast, like it's often seen in Asian people. This year they look like they're 25, next year they look like they're 50 and their actual age is 35-36.

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    ...gis sdrawkcab (usually not responding to ACs; don't bother posting as AC)
  13. Re:Methamphetamines age you prematurely. by blazer1024 · · Score: 3, Insightful

    It's stress; be it from the hard work in raising a family or a single person pushing 60+ hours a day with 5 hours of sleep or less.

    That is a long freaking day.

  14. Re:Methamphetamines age you prematurely. by drinkypoo · · Score: 2

    How the heck does a mans body know when his imperative is met?

    Pheromones? If the women around him have had their imperative met? As plausible as any other made-up bullshit, probably moreso

    --
    "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
  15. Re:Lifestyle Differences by ChrisMaple · · Score: 2

    An extreme case is the genetic disease progeria, which causes very rapid aging and early death. It seems reasonable that there are other genetic defects that speed aging to a lesser degree.

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  16. Re:Color me suprised by NotQuiteReal · · Score: 2

    Health nuts are going to feel stupid someday, lying in hospitals dying of nothing.

    - Redd Foxx

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    This issue is a bit more complicated than you think.
  17. Re:Methamphetamines age you prematurely. by allcoolnameswheretak · · Score: 2

    Not sure about that. One of my best friends leads a very relaxed lifestyle in Berlin. Only works 4hrs a day, 4 days a week, no kids, no family, just his very own, slow-paced life and hobbies. He manages that because he lives in a cheap room in a shared appartment without a car and has in general a very frugal lifestyle. He is two years younger than me, in his early thirties but he has lost almost all of his hair, and what is left around the sides has turned grey.

  18. Re:Methamphetamines age you prematurely. by cayenne8 · · Score: 2, Insightful

    Step one to not aging so fast: Don't be white trash.

    Seriously, every white trash friend I've ever had ended up looking 10-20 years older than their age by the time they're in their 30's. I've seen 20-something white trash who looking like they were middle-aged.

    White Trash is basically the Caucasian equivalent of nigger, right?

    Why is that post not getting down modded as fast as this one is...to be due to the utterance of the dreaded "N" word?

    --
    Light travels faster than sound. This is why some people appear bright until you hear them speak.........
  19. Re:Methamphetamines age you prematurely. by rubycodez · · Score: 2

    Really, it's the opposite at my class reunion, the single people who led "hard life" (excessive drugs and boozing and other types of 'partying') looking the oldest

    I'd rather think taking care of one's' self plays the biggest factor

  20. Re:Methamphetamines age you prematurely. by irrational_design · · Score: 2

    An opposite anecdote. My wife and I have 7 children, and people are always commenting on how young we look (most say we look about 10 years younger than we are) and are shocked when they find out we have any children, much less 7. Of course, other than the children themselves we don't have too much stress. I have a fantastic well paying job, we have great health insurance, we have little to no debt, we live in a great community in the beautiful Pacific Northwest, etc.

  21. Extrapolating from anecdotes by sjbe · · Score: 2

    Yankees first baseman just gave up milk as well and says he's never felt better.

    Good for him. That has nothing to do with me or millions of other people. I drink milk daily and I feel great. Times when I've gone without it had no effect on me positive or negative. So what exactly am I to learn from your anecdote?

    even if you're not allergic to milk like I am, it's not very good for you after a while

    And your evidence for this is what exactly? Unless you have a specific digestion problem with dairy (and many people do) every bit of evidence suggests it is a fine part of a balanced diet. It's on the food pyramid and every dietician I've ever met will tell you dairy is just fine. We're mammals so milk is one of the things that sort of defines us. It's basically the perfect food for a mammal nutrition-wise so long as you can digest it safely.

  22. Re:Methamphetamines age you prematurely. by RabidReindeer · · Score: 2

    Grandparents manufacture the meth. Sell it to friends.

  23. Re:Methamphetamines age you prematurely. by Moridineas · · Score: 2

    Seven! That's such a rarity now... If you don't mind my asking, how do you like it? My wife and I both came from two-child households, and we have three kids (all under the age of 6). Our parents all thought it was bizarre and that we were crazy to have three kids. I kind of want more while my wife--who admittedly has to do most of the work of creating the child!--is not so sure right now. I'm always curious to hear other people's takes.

  24. Shift already occurring in scientific research by WillAffleckUW · · Score: 2

    In our latest studies on various diseases associated with aging, many are now following younger subjects. The major problem is that annual followups tend not to work as well, since younger people are busy, so you have to go from an annual cycle to an every 2-3 year cycle. However, this makes changes more noticeable. Following subjects when they're very young is more difficult, as they tend to move a lot more. So most studies now are shifting to a 35-40 lower age range.

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