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The Biohacking Movement and Open Source Insulin

Posted by timothy on from the raw-milk-and-handcrafted-biologicals dept.

szczys writes: Since early last century, insulin has been produced from the pancreas of animals. In the late 1970s we figured out how to synthesize insulin using bacteria or yeast. As the biohacking movement has grown, insulin production has been a common target, but for some reason we're not there yet. Dan Maloney looked into the backstory (including the amazing story of the Saxl family who produced life-saving insulin during WWII) and a new startup that is trying to get Biohackers working on the problem. Update: 07/30 21:56 GMT by T : That's WWII above, not WWI; mea culpa.

6 of 66 comments (clear)

  1. Re:Biohacking? by ColdWetDog · · Score: 2

    You don't use tin hats in biology. You need to keep in tune with Gai's resonances. Tin foil hats are strictly for computer types.

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  2. Sounds Great by kwiecmmm · · Score: 3, Informative

    As a type 1 diabetic I am all for this. Currently a vial (500 units) of insulin costs between $250 and $400 (before insurance). Since this was done originally in 1978, there shouldn't be a patent to worry about. And since diabetics need this to live, I really don't care too much about the profits of the drug manufacturer, when it probably costs them less than $5 to make a vial.

    1. Re:Sounds Great by Andy+Dodd · · Score: 4, Informative

      Um, no, a 1000 unit vial (10 mL of U-100) costs $25 for regular and NPH insulins. (If you're paying more than this, blame the pharmacy. This is one of the few cases where I root for Walmart - they've managed to get Novo onboard with selling Novolin R and N for $25/vial)

      Unless you're purchasing Lantus or Novolog/Humalog (which most diabetics including myself are), which are MUCH newer than 1978 and still have active patents. (Some of Lantus' are about to expire or recently expired, but Novartis played some legal games to manage to block generic Lantus from the market until late 2016...) Even after "generics" of the "designer" insulins launch, the FDA's rules on "biosimilars" are going to slow down this market. (IIRC, generic Lantus IS available in India at significantly reduced prices.)

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      retrorocket.o not found, launch anyway?
    2. Re: Sounds Great by bill_mcgonigle · · Score: 3, Interesting

      If anybody wants to spend 45 minutes reviewing the data on whether the FDA's current regulatory regime helps or hinders, this talk is quite good.

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  3. not there yet by Anonymous Coward · · Score: 3, Informative

    As the biohacking movement has grown, insulin production has been a common target, but for some reason we're not there yet

    I'd guess it because of patents and greedy pharmaceutical companies. Plus, manufacturing your own drugs and giving them to other people probably runs afoul of a few laws.

    Here's a kicker. I was diagnosed as a Type 1 in 1997. Back then, a 10ml vial (U-100) of Eli Lilly's Humulin R or NPH costs--I'm not making this up-- $17.00. Today, without insurance, the same vial goes for $99. And this is for insulin made from recombinant DNA tech that has been around since the '70's like the article mentions. It's a fucking crime that pharmaceuticals have jacked up the price of the only types of insulin that can be bought over-the-counter.

  4. Re:Biohacking? by ArmoredDragon · · Score: 2

    Basically. The food religion says GMO is bad until one of them happens to need insulin and also happens to be allergic to "natural" cow insulin, then GMO produced humulin (secreted by a genetically modified e. coli bacterium to be chemically similar to human insulin) is a miracle.

    Which by the way, this particular GMO has been in use for 32 years now.