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MIT Researchers Discover "Metabolic Master Switch" To Control Obesity

New submitter ahbond writes: The meme of the chubby nerd alone in the basement may be a thing of the past. Well, at least the chubby part, if recent work at MIT pans out and we're able to use a biological "master switch" to "dial-in" a persons metabolic rate. “Obesity has traditionally been seen as the result of an imbalance between the amount of food we eat and how much we exercise, but this view ignores the contribution of genetics to each individual’s metabolism,” said senior author Manolis Kellis, a professor of computer science and a member of MIT’s Computer Science and Artificial Intelligence Laboratory and of the Broad Institute.

4 of 381 comments (clear)

  1. Re:Metabolic rate doesn't vary that much by Anonymous Coward · · Score: 5, Insightful

    Why is parent modded down? He made a good point, one that most people have seen with their own eyes.

    Next door to me lives a sixty-year old man who is rail thin despite living the good life (especially with food) and never exercising. I'm not talking about merely not overweight, this guy is really skinny. His twenty-something daughter is already pretty hefty, not fat yet but will be by the time she's thirty. Same lifestyle, half of the same genes, different results.

  2. Re:I volunteer as tribute. by cfalcon · · Score: 5, Insightful

    > No, they cure it 100% of the time. The problem is few people actually follow a proper regimen.

    If 98% of people can't "follow the proper regimen", then it's not a proper regimen, and it's quite obviously not at all what thin people are doing. That's the fucking point.

    Hey, side question- you know that study where the poop transplants make people skinny, or fat? How about you round up your "proper regiment" bros- people who agree with your general side of this coin- and get the poop transplant from the really fat dudes? Put your body where your mouth is. If it's all about diet and exercise, I imagine 100% of the diet-and-exercise-is-panacea team will stay their original weight, no prob at all.

    Call me when that happens. Until then... lolzors bro.

  3. Re:Not ignored by nine-times · · Score: 5, Insightful

    Yeah, but just look at the responses here. Suggesting that people have different metabolic rates is a weird 3rd rail on the Internet. If you say, "Two people of the same age, weight, height, and sex can have different metabolic rates," you're pretty much inviting a flame war where people accuse you of being fat, and just trying to defend your lazy, overeating habits.

    I'm not always sure why people get so angry about it, but my guess is that some of those people must be clinging on really tightly to their superiority over fat people, and saying that their other factors threatens their self-esteem. Like they're thinking, "I'm a total piece of shit, but at least I'm not fat! I'm better than everyone who weighs more than me!" so if you suggest that their low weight might be at least partially due to genetics, it really freaks them out. That's my only guess.

    Because otherwise, why get so angry about what's basically settled science? The statement "Some people have a harder time controlling their weight than others," shouldn't be so upsetting.

  4. Re:I volunteer as tribute. by sjames · · Score: 5, Insightful

    Try this, breathe less. No, I didn't make an oblique reference to suicide, I mean breathe less. Just wait a little bit after you start feeling the breathing urge. Each time. For the rest of your life.

    That is, make everything all about your breathing, or the lack thereof. Be sure to measure the amount of each breath. You wouldn't want to be a weak willed overbreather, would you?