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Genes and Ancient Remedies May Help Fight Antibiotic Resistance

szczys writes: We've been hearing about it for years; bacteria are developing resistance to antibiotics and evolving into what are called superbugs. Some forecast the end of our ability to combat infection, but humanity has a knack for making breakthroughs that carry everyone forward. Dan Maloney looked at what is being done to combat antibiotic-resistance and the answer combines new technology with old remedies. It turns out that there are many ancient cures that successfully combat infections (video); they're just mixed in among a lot of cruft. More modern efforts focus on attacking bacteria on the genetic level which is a research area just getting itself up to speed now.

30 comments

  1. If your penis is itchy, soak it in vodka? by Anonymous Coward · · Score: 0

    So is this like the old Russian remedy of soaking an itchy, STD-infested penis in vodka?

    1. Re:If your penis is itchy, soak it in vodka? by Anonymous Coward · · Score: 0

      That's not a remedy, it's a recipe. Hey, people get cold and hungry in those Siberian winters.

  2. Selective Poisons by Anonymous Coward · · Score: 0

    Antibiotics are basically selective poisons, but there are many non-selective metal salts that kill almost everything such as copper, gold, silver, potassium, manganese, sulphur, zinc and titanium. If salts of these metals are used at a level low enough that it doesn't kill a big fat human being, then it can still kill the little bugs. So there are lots of treatments in our arsenal.

  3. A good example by Gonoff · · Score: 3, Insightful

    This is a good example of why all forms of information should be retained and studied.
    We have history going back ever further. Who know what might be found in ancient maths, astronomy, cooking, animal husbandry or whatever.

    What other useful things might be pulled out when the right to people sit down together in the cafeteria. It is the best of blue sky thinking and a great reason to keep those non STEM subjects going.

    Lets see about stopping the destruction of ancient history in Syria. Maybe we can find again how to make Damascus steel. (Something to keep the conservatives feeling positive there.)

    --
    I'll see your Constitution and raise you a Queen.
    1. Re:A good example by Tempest_2084 · · Score: 1

      This needs serious research! I only need two more Damascus Steel to get Matchless Steel. Tournesol will be mine!

    2. Re:A good example by Agent0013 · · Score: 1

      I am pretty sure we have figured out how to make Damascus steel. I watched a documentary on a guy doing the analysis and recreating the steel using the old techniques. In addition, I have a paring knife made of Damascus steel from Lehmans.com. When they compared it to the original steel under a high powered microscope the make up of the newly made steel matched that of the ancient steel.

      --

      -- ssoorrrryy,, dduupplleexx sswwiittcchh oonn.. -Quote found on actual fortune cookie.
    3. Re: A good example by Anonymous Coward · · Score: 0

      No.
      The science is settled.

    4. Re:A good example by Gonoff · · Score: 1

      How about Greek fire then? I'm sure that napalm isn't as good.

      --
      I'll see your Constitution and raise you a Queen.
  4. Mostly dupe article by tomhath · · Score: 4, Insightful

    The ancient cure was covered here on /. about six months ago; it's a poison so of course it kills bacteria (among other things).

    Regarding the genetic research, it is indeed a major area of diagnosis and treatment. At this point it's mostly diagnosis - if you can identify the resistance genes a bacteria has you can select the appropriate antibiotic much sooner.

    1. Re:Mostly dupe article by tuxgeek · · Score: 1

      There are many more real and working ancient remedies than you know.
      The main problem limiting your access to, or knowledge of them, depends on whether the Multi-National-Pharma giants can own and profit from something anyone can get for free. All you have to do is know where to look, what to pick, and how to prepare.

      For example, I've been using golden seal root for years and have killed off intestinal parasites and pretty much any bug that makes me ill, all in very short order.
      You can buy the stuff at any health store but your Big Uncle Pharma can't own and patent it. No advertising, no marketing, something that works well but few know about.

      Imagine a news break about a common plant or a common sense lifestyle that could put the multi-billion dollar flu shot industry out of business. Oh the horror!!!
      Nope, that wouldn't fly ..

      --
      "Suppose you were an idiot...and suppose you were a member of Congress...but I repeat myself." Mark Twain
  5. No combining by Anonymous Coward · · Score: 0

    "the answer combines new technology with old remedies"

    Where is this combining ?
    The links mention using old remedies OR using the genetics. Not combined.

    Slashdot Editors: EIDT ! FFS !

  6. Funny you mention that... by Ol+Olsoc · · Score: 1, Interesting
    As someone who gets earaches fairly often, once upon a time, I would get a course of antibiotics, and occasionally needed a second course.

    Then a very smart lady told me about hydrogen peroxide. A bit of that in your ear for a day or so would knock those little buggers on their ass.

    It was very interesting the first time you put some in your ear - tickles a little and is loud as it releases the oxygen it kills the germs with.

    21st century US litigation disclaimer:

    This is not medical advice. Do not ever do this. Always consult a trained medical professional with the proper certifications for any and all medical treatments including antiseptics and band-aids. Do not use any other treatments than prescribed medicine. Always visit a trained professional for every physical ailment.

    --
    The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    1. Re:Funny you mention that... by TimSSG · · Score: 1

      As someone who gets earaches fairly often, once upon a time, I would get a course of antibiotics, and occasionally needed a second course.

      Then a very smart lady told me about hydrogen peroxide. A bit of that in your ear for a day or so would knock those little buggers on their ass.

      It was very interesting the first time you put some in your ear - tickles a little and is loud as it releases the oxygen it kills the germs with.

      21st century US litigation disclaimer:

      This is not medical advice. Do not ever do this. Always consult a trained medical professional with the proper certifications for any and all medical treatments including antiseptics and band-aids. Do not use any other treatments than prescribed medicine. Always visit a trained professional for every physical ailment.

      I might try this, once more, I forgot I used to do this when I was younger. And, it was very loud when I last did it.
      Did you every gargle with hydrogen peroxide diluted with water?
      I am trying to decide if I want to try that again.

      Tim S.

    2. Re:Funny you mention that... by Ol+Olsoc · · Score: 1

      I might try this, once more, I forgot I used to do this when I was younger. And, it was very loud when I last did it. Did you every gargle with hydrogen peroxide diluted with water? I am trying to decide if I want to try that again. Yes, its a weird peppery laste, and you're stuck with a foamy mouth for while. If I have a bad sore throat, I'll use it, but no way every day like some do.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    3. Re:Funny you mention that... by hackwrench · · Score: 1

      I used the hydrogen peroxide in the ear bit when I had earaches too. Don't recommend gargling with hydrogen peroxide, but gargling with salt water helps.

    4. Re:Funny you mention that... by luis_a_espinal · · Score: 1

      As someone who gets earaches fairly often, once upon a time, I would get a course of antibiotics, and occasionally needed a second course.

      Then a very smart lady told me about hydrogen peroxide. A bit of that in your ear for a day or so would knock those little buggers on their ass.

      It was very interesting the first time you put some in your ear - tickles a little and is loud as it releases the oxygen it kills the germs with.

      21st century US litigation disclaimer:

      This is not medical advice. Do not ever do this. Always consult a trained medical professional with the proper certifications for any and all medical treatments including antiseptics and band-aids. Do not use any other treatments than prescribed medicine. Always visit a trained professional for every physical ailment.

      To the readers, the disclaimer above also applies to my post.

      With the cover-your-ass part done, I'll add that I've done something similar. I've used a mix of alcohol (or water peroxide) mixed with tea tree oil and iodine. Hurts as hell, but that has knocked out ear infections that would make me go see a doc to get prescription antibiotics.

      First time I tried and showed my PCP she was actually quite surprised. She even told me "man you did nuke those suckers" (not that she was approving of it.)

      Same with my sinuses. I spent thousands of dollars in medicine (even going under the knife). Then someone told me to try neti pots. Then someone else suggested alkalol in the neti pot solution. Then another person suggested I use borax in the saline solution. That last part, the borax, within a week, that shit completely cured me of the sinus infection that have been plaguing me for 25 years.

      Again, medical disclaimer - don't try it. I'm not a doctor. For all I know I could be developing a tumor for doing this stuff. And if you do, you are on your own.

    5. Re:Funny you mention that... by Ol+Olsoc · · Score: 1

      With the cover-your-ass part done, I'll add that I've done something similar. I've used a mix of alcohol (or water peroxide) mixed with tea tree oil and iodine. Hurts as hell, but that has knocked out ear infections that would make me go see a doc to get prescription antibiotics.

      First time I tried and showed my PCP she was actually quite surprised. She even told me "man you did nuke those suckers" (not that she was approving of it.)

      Strange world, where we're here on slashdot trading health tips!

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    6. Re:Funny you mention that... by WolfWithoutAClause · · Score: 2

      Um, unless you have a hole in your eardrum, that doesn't work; or at least it cannot work by disinfection.

      Peroxide in your ear can help get rid of earwax, but the kind of earache you get that needs antibiotics is on the other side of the eardrum, which is sealed from that side.

      Unless the earwax was building up to the point it blocked your Eustachian tube or unless the tickling on your eardrum cleared your Eustachian tube then it could just be a coincidence.

      --

      -WolfWithoutAClause

      "Gravity is only a theory, not a fact!"
    7. Re:Funny you mention that... by Ol+Olsoc · · Score: 0

      Um, unless you have a hole in your eardrum, that doesn't work; or at least it cannot work by disinfection.

      As I said, do not use this method. Before teh age of modern medicine, with properly trained doctors making prescriptions for properly tested pprescription medicines, the death rte from ear infections was 100 percent.

      Seriously my dear fellow, it does indeed work, and you are entitled to your opinion, but you are not entitled to your own facts.

      No go eat some antibiotic fed beef, it will keep you very healthy.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
  7. Wizard's 2nd Rule by Jahat · · Score: 2

    “The greatest harm can result from the best intentions.” Stone of Tears: Chapter 63, page 886 and Legend of the Seeker: Marked If you artifically mess with genetics of an organism, it no longer is that organism. There will be unintended consequences.

    --
    Sola Scriptura Sola Fide Sola Gratia Sola Christus
    1. Re:Wizard's 2nd Rule by cyberchondriac · · Score: 1

      Actually, it's "Sword of Truth", that was the name of the book series.. Legend of the Seeker was its television name.

      --

      Look back up at my post, now look back down, you're on the Internet. Now look back up. I'm a signature.
    2. Re:Wizard's 2nd Rule by penguinoid · · Score: 1

      If you artifically mess with genetics of an organism, it no longer is that organism. There will be unintended consequences.

      Oh, does that mean that if you catch a virus you're no longer human?

      --
      Don't waste your vote! Vote for whoever you want, unless you live in a swing state it won't matter anyways
  8. Don't discount ancient tech by Jahat · · Score: 1

    “After you have stitched it, you should bind fresh meat upon it the first day. If you find the stitching of the wound is loose, draw it together and treat it with grease and honey every day until the patient recovers.” http://www.surgerysupplements....

    --
    Sola Scriptura Sola Fide Sola Gratia Sola Christus
    1. Re:Don't discount ancient tech by tomhath · · Score: 2

      Ah yes, "salubrious pus". A massive infection is always the best treatment for an injury; unless it kills you.

    2. Re:Don't discount ancient tech by TheCarp · · Score: 1

      Yes but isn't that kind of the point here? Even today studies are done that turn out wrong, we find treatments that turn our later to not work.... so why not recreate and evaluate old methods that may have some promise now that we have far better means of evaluation.

      Its not like we shouldn't expect to find things like this, hell, there have been interesting studies with butterflies where it was found that individuals with mite infestations would selectively prefer individual plants that made toxins which treat their infestation. Humans had a long time to try things out, why not re-examine our own old practices?

      Can't always blame our ancestors for thinking some things worked when pesky patients often get better on their own and ruin your data.

      --
      "I opened my eyes, and everything went dark again"
    3. Re:Don't discount ancient tech by Agent0013 · · Score: 1

      We have the old treatment with leaches that was found to work very well for reattaching body parts or other blood flow problems. It is now a modern medical procedure that can save you from gang green. Only a couple of decades ago it would have been considered a quack treatment that people did in the ancient times.

      --

      -- ssoorrrryy,, dduupplleexx sswwiittcchh oonn.. -Quote found on actual fortune cookie.
  9. "mixed in with a lot of cruft" by Anonymous Coward · · Score: 0

    Equals, "Hey, there's stuff here that actually works! How did we miss that? Ah well, we'll "invent" this now and go back to demonizing everything else we haven't bothered looking closely at yet."

  10. Be careful of unintended consequences... by Anonymous Coward · · Score: 1

    I'm sure there were things that were practiced in medicine in the past that worked to some degree and have been abandoned. That really can't be doubted. However, there was also a lot of well-intentioned snake oil and many potentially dangerous treatments. It's very hard to distinguish a legitimate treatment from the snake oil, and now a huge business has sprung up around peddling mostly snake oil (supplements, homeopathy, etc...). My concern is people turning to alternative medicine when they really need to seek medical treatment.

    About antibiotics, there are some bacteria that have evolved to be antibiotic resistant through no fault of our own. However, abuse of antibiotics is a big problem, both in terms of overprescribing them and giving them unnecessarily to animals. Furthermore, people don't always finish a course of antibiotics, which can lead to the bacteria that are left developing resistance. People need well-developed immune systems, through generally healthy habits and not being unnecessarily clean. Within reason, some exposure to germs is good! The other thing we can do is develop more vaccinations that protect against bacterial infections, make them cheap and affordable, and remove exemptions that allow children to not be vaccinated. If we vaccinate more, we won't have to use antibiotics as frequently. Gene therapy is also a promising avenue for eliminating antibiotic resistant bacteria.

    I'm not opposed to alternative remedies being supervised by a doctor when antibiotics aren't required. That's a good thing because it prevents overuse. But I don't want people to think they can avoid vaccines and treat themselves by shopping in the homeopathy aisle at whole foods. We also need to properly study these treatments with rigorous clinical trials. It's a great idea if done right, but I don't think it will be as long as people can't tell the difference between legitimate treatment supervised by a doctor and over snake oil.

  11. Evolution my ass. by Anonymous Coward · · Score: 0

    Seriously people, stop giving the creationists ammo. It has been shown multiple times that antibiotic resistance was around before the development of modern antibiotics. The use of antibiotics is a form of artificial selection that eliminates the portion of a population that is susceptible and leaves the rest. No super bugs, no new genetic information, a reduced gene pool; in short no evolution.

    1. Re:Evolution my ass. by Anonymous+Cow+Ward · · Score: 2

      You have correct, wrong, and not even wrong statements in your comment, which is sort of rare - congrats!

      First, yes, antibiotic resistance was around before humans used modern antibiotics. However, it was much less common and much less strong.

      Second, artificial selection is still evolution. Eliminating a less fit portion of the population is Evolution 101, regardless of whether it's artificial or natural selection.

      Lastly, new antibiotic resistance genes are showing up; sometimes they're heavily modified versions of the ones that already existed, but in other cases they seem not to be. However, more effective resistance genes are selected for, which definitely qualifies as new genetic information.

      --
      Examine even your most deeply held beliefs. Nobody is always right.