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The Mutant Genes Behind the Black Death
An anonymous reader writes: Each year, 4 million people visit Yosemite National Park in California. Most bring back photos, postcards and an occasional sunburn. But two unlucky visitors this summer got a very different souvenir. They got the plague. This quintessential medieval disease, caused by the bacterium Yersinia pestis and transmitted most often by fleabites, still surfaces in a handful of cases each year in the western United States, according to the Centers for Disease Control and Prevention. Its historical record is far more macabre. The plague of Justinian from 541 to 543 decimated nearly half the population in the Mediterranean, while the Black Death of the Middle Ages killed one in every three Europeans.
Now researchers are beginning to reveal a surprising genetic history of the plague. A rash of discoveries show how just a small handful of genetic changes — an altered protein here, a mutated gene there — can transform a relatively innocuous stomach bug into a pandemic capable of killing off a large fraction of a continent.
The most recent of these studies, published in June, found that the acquisition of a single gene named pla gave Y. pestis the ability to cause pneumonia, causing a form of plague so lethal that it kills essentially all of those infected who don't receive antibiotics. In addition, it is also among the most infectious bacteria known. "Yersinia pestis is a pretty kick-ass pathogen," said Paul Keim, a microbiologist at Northern Arizona University in Flagstaff. "A single bacterium can cause disease in mice. It's hard to get much more virulent than that."
Now researchers are beginning to reveal a surprising genetic history of the plague. A rash of discoveries show how just a small handful of genetic changes — an altered protein here, a mutated gene there — can transform a relatively innocuous stomach bug into a pandemic capable of killing off a large fraction of a continent.
The most recent of these studies, published in June, found that the acquisition of a single gene named pla gave Y. pestis the ability to cause pneumonia, causing a form of plague so lethal that it kills essentially all of those infected who don't receive antibiotics. In addition, it is also among the most infectious bacteria known. "Yersinia pestis is a pretty kick-ass pathogen," said Paul Keim, a microbiologist at Northern Arizona University in Flagstaff. "A single bacterium can cause disease in mice. It's hard to get much more virulent than that."
"decimated nearly half the population"
So it killed 5%?
"Decimated nearly half the population" means less than 5%. You can't just ignore the prefix 'deci' because everyone uses it incorrectly, dictionary.
"Decimate" hasn't meant "killed every tenth man by lot" for a lot of years. It's usually not used with exact percentages, but it's often used for percentages other than ten.
"You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
When Europeans arrived to colonize the New World, their small population should have been wiped out by the diseases unfamiliar to them in the New World. But they were not. Instead the much larger (than the colonists) New World population got devastated by the Old World diseases.
This explanation came out as a 12 page (The arrow of disease) article by Jared Diamond in 1992 in the Discover magazine. Later it was expanded into a Pulitzer winning book, Guns, Germs and Steel
sed -e 's/Chuck Norris/Rajnikant/g' joke > fact
Still easily treatable with antibiotics.
You have no idea what you're yacking on about. What you call a "European" circa 500 CE is some admixture of Mediterranean, Near Eastern, Middle Eastern, Eurasian, Russian , Ukrainian and Maikop. The LAST thing the European continent was ever is "isolated" at least not since 2500 BCE.
If you want to see what happens with genes when they're isolated, go to the Galapagos Islands.
Words mean what most of the speakers of the language mean. So your tirade is pointless, unoriginal, and wrong. Utterly wrong.
I am aware that any language's mapping of letters and sounds to meanings is completely arbitrary, and furthermore that these mappings evolve continuously. So yes, if enough people start thinking that "chartreuse" means "pink", then indeed it does, at least to them. But for the rest of it, it still means greenish-yellow. The end result is a failure of communication. What I and people like me--pedants--are trying to do is preserve the integrity of communication by nipping some of these uglier and less consistent forms in the bud, before they metastasize and spread throughout the meme pool, and we all just have to live with them. That is literally all I'm saying.
The reason Europeans were so susceptible to the plague is that they were Europeans, just as the reason Native Americans were so susceptible to small pox was that they were Native Americans. Inbreeding leads to weakness, crossbreeding leads to strength.
I agree that crossbreeding builds a strong population and pure bloodlines (aka. inbreeding) leads to weak populations but the rest of your post is wrong. There was steady gene flow between Asia and Europe for millennia whereas the aboriginals of the Americas were isolated after the end of the last ice age and the submergence of Beringia which cut the land bridge between Asia and North America. There were some old-world diseases that caused devastation among Native American populations and there were some new world diseases that caused devastation in the Old World. However, some of the pandemics that wiped out the native populations of the Americas (and that were previously thought to have been introduced pathogens) would in the light of modern research seem to have been entirely home grown. For example the pandemic that wiped out the Aztecs after the Spanish invasion seems to have been a hemorrhagic fever endemic to the Americas. Scholars in the past wrote a whole lot of stuff about pandemics without having the foggiest notion of which pathogens had been involved and those writings unfortunately remained gospel until very recently. Until only a couple of decades ago we had only a limited idea of whether the Black Death pathogen was the same as the modern plague bacteria, there were divided opinions. Some thought he plague of 1346 was an influenza. The last time I looked plague DNA had indeed been found in ancient remains but we still do not know if the Black Death and the Justinian plague were the same or not, the Justinian plague could have been something else altogether. There is also this persistent myth, born out of the 19th and early 20th century fascination with the orient, that all culture flowed from the east (i.e. Ex oriente lux = From the east the light), that medieval Europeans were somehow dirtier, more ignorant and more primitive than oriental people and that that is why the plague spread so rapidly in Europe. Roman bathing culture did not just evaporate with the fall of the old empire and throughout the Middle Ages there were bathhouses in many cities and towns in Europe (in the 13th century Paris had 32 bathouses). If the Medieval European really was so dirty and Asians so clean why did a pandemic spread by fleas spread from Asia to the West? You'd think it would originate among the dirty Europeans and then travel east and dissipate when it reached Asia because of the supposedly superior hygiene of medieval period Asians who would not, or so the conventional theory goes, have had fleas. In actual fact the Plague ravaged Europe and Asia pretty much equally and Asians of the 14th century seem to have been just as flea ridden as their European contemporaries. For example in 1334, a pandemic that was probably the same black death that ravaged Europe a decade later killed 5 million people in Hebei Province China with a death toll of about 90%.
Exactly. To get some idea how well the democratization of knowledge serves as a defense against BadGuys, take a look at how we're doing on the internet. There we have full democratic access to a technology of mid-value intellectual difficulty. Do you feel like you can defend your computer against all created viruses trojans etc. or do you turn to professionals to provide you with tools to do that job?
And about those professionals. How are they doing?
Last I looked, they were basically getting a near zero-score for near zero-days.
That's because they're good at defending themselves against what they recognize and know about and can fingerprint but essentially terrible at recognizing the uncatalogued attack, the novel approach, the slightly innovative variation.
I point this out because I hear the argument that the more DIY biohacking we do, the better able we will be to defend ourselves. It really hasn't worked out that way. Things- people, cats dogs puzzles- go together one way. They can be taken apart in an infinity of ways.
The surface of attack is infinite within the bounds of the target's particular characteristics. That's not a good castle to have to defend. The fewer people who can attack the castle, the better.
Bacteria as a bioweapon probably won't ever work to wipe out populations. You certainly could wreck havoc in clusters of humans with poor infrastructure (refuge camps, slums, Trenton, New Jersey) but even without antibiotics we know enough to slow down the transmission to prevent mass catastrophe. Yes, it would be a good 'terror weapon' since at least the US population seems to be scared of it's own shadow much less any real boogy man (cf, the Ebola scare) but as far as a tactical weapon it has a lot of drawbacks.
Faster! Faster! Faster would be better!
there is nothing like a good joke and that's nothing like a good joke
"The hands that help are better far than lips that pray." - Robert Ingersoll (1833-1899)
Decimate must always mean a tenth, just like December is always the tenth month.
Red to red, black to black. Switch it on, but stand well back.
Survivors of the Back Death seem to acquire part of a beneficial genetic mutation that gets passed on in full if they breed with another Black Death survivor - resistance to most known forms of HIV.
http://www.eurekalert.org/pub_...
Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
But in the case of the "decimate" you'd be wrong. It absolutely does NOT mean killing a tenth of anything.
Meriam-Webster says:
Decimate: v
: to destroy a large number of (plants, animals, people, etc.)
: to severely damage or destroy a large part of (something)
Firstly there is a vaccine for Y. pestis, I know I've had it, and secondly a good stiff dose of Y. pseudotuberculosis is going to give you the shits, but most likely leave as immune to Y. pestis as you can get.
Apocalypse Cancelled, Sorry, No Ticket Refunds
I used to live in Tahoe.
Occasionally during the summer months, someone would contract bubonic plague after their house cats were outside and near ground squirrel burrows.
It is transmitted by fleas of the common ground squirrel in the area. Don't remember the species.
The infestation of infected fleas usually gets worse in drought years.
Plague fleas are found all over the sierras, Yosemite as well.
"Suppose you were an idiot...and suppose you were a member of Congress...but I repeat myself." Mark Twain