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Experimental Drug Targeting Alzheimer's Disease Shows Anti-Aging Effects (nextbigfuture.com)
schwit1 writes with news that researchers at the Salk Institute have found that an experimental drug candidate aimed at combating Alzheimer's disease has a host of unexpected anti-aging effects in animals. Says the article:
The Salk team expanded upon their previous development of a drug candidate, called J147, which takes a different tack by targeting Alzheimer's major risk factor–old age. In the new work, the team showed that the drug candidate worked well in a mouse model of aging not typically used in Alzheimer's research. When these mice were treated with J147, they had better memory and cognition, healthier blood vessels in the brain and other improved physiological features.
"Initially, the impetus was to test this drug in a novel animal model that was more similar to 99 percent of Alzheimer's cases," says Antonio Currais, the lead author and a member of Professor David Schubert's Cellular Neurobiology Laboratory at Salk. "We did not predict we'd see this sort of anti-aging effect, but J147 made old mice look like they were young, based upon a number of physiological parameters."
"Initially, the impetus was to test this drug in a novel animal model that was more similar to 99 percent of Alzheimer's cases," says Antonio Currais, the lead author and a member of Professor David Schubert's Cellular Neurobiology Laboratory at Salk. "We did not predict we'd see this sort of anti-aging effect, but J147 made old mice look like they were young, based upon a number of physiological parameters."
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I've seen the documentaries. This can only lead to one thing.
The zombie apocalypse.
Worth looking at the actual article, especially the before and after pic they've included ...
I saw this movie.... it doesnt end well!
have you seen my sig? there are many others like it but none that are the same
Anti-aging! On my Slashdot? Cue the Luddites!
How do you keep niggers out of your back yard?
Hang one in the front yard.
Why do blacks stink?
So blind people can hate them too.
Did you hear of the new Black Barbie?
It comes with 12 kids, AIDS and a welfare check .
Whats Big, Long, Black and smelly?
The Welfare Line in Harlem.
Whats long and hard on a nigger?
The Fourth Grade.
How did the nigger break his leg raking the leaves?
He fell out of the tree.
What do you call a black woman who gets an abortion?
A member of Crimestoppers of America.
Whats the difference between a black and a snow tire?
A snow tire won't sing when you put chains on it.
What does PONTIAC stand for?
POOR OLD NIGGER THINKS ITS A CADILLAC.
Why do niggers keep chickens in there backyard?
To teach there kids how to walk.
Why did The Nigger from Nation of Islam wear his nicest Tuxedo to his vasectomy?
Cuz if I'ma gonsta Be Impotent I wants to look Impotent.
A White man and a Black man are arguing about which race God belongs to. They argue about this for hours, and finally they decide to ask the heavens for the answer. The black looks upwards and asks: 'God, I gotta know. Is you Black or is you White?' The answer booms down from above. 'I AM WHAT I AM'. Vindicated, the Black man says: 'There, you see, I told you he was a brother.' 'Not so,' replies the White. 'If he was Black, he would have said "I IS WHAT I IS".
Did you hear the NFL is switching to green balls next year?
Have you ever heard of a nigger dropping a watermelon?
What do you call a nigger with an IQ of 15?
Gifted.
What do you call a nigger with an IQ of 150?
Tribe.
Why don't niggers put Oder Eaters in their shoes?
Because it makes them dissapear!
What's the difference between a truckload of watermelons and a truckload of nigger babies?
You cant unload a truckload of watermelons with a pitchfork!
What's black and red, wears a high top Reeboks and cant go through a revolving door?
A nigger with a spear through his head!
How do we know that Adam and Eve were not black?
Have you ever tried to take a rib away from a nigger?
There is a 3 story apartment building with 1 apartment on each floor. A white family lives on the top floor. A mexican family lives on the second floor. A nigger family lives on the botom floor. At 2:00 PM in the afternoon a terrrible tornado hits the building, totally destroying it. Which family lived? The White family because both parents were at work and the kids were in school.
Two Georgia State Troopers are on duty watching for speeding truckers on the interstate. These 2 troopers hate truckers. They become bored and pull in behind a truck. The driver is hauling a load of bowling balls. He gets nervous with the cops behind him and pulls off onto a side street to see if the troopers will follow. On the side street, a little nigger kid standing in the street with a bicycle stops the truck to ask for a ride. The driver says OK, but you have to get in the trailer in back. The little nigger and his bike are now in the trailer. The driver says to himself, Well those troopers have gone by now, I'll get back on the highway. After a few minutes on the highway the troopers pull in behind the truck and stops him. The troopers give the driver a real hard time, they check his license, log book, etc. The troopers start to get back in their car when one says to the other, "We didn't check out the trailer, maybe we should." The one trooper says to the other, "OK, I'll take care of it." He goes back to the driver and tells him he wants the trailer doors opened. The driver thinks to himself, Now I'm really in trouble, they're going to think I kidnapped that little nigger kid. The trooper opens the trailer door to look in and slams it shut quickly! The trooper is all pale and shaken and starts screaming to the trucker, "Go NOW!, Get out of my city! Get out of my co
I can't wait for them to try this on Humans! Any idea why they named several of the mice 'Algernon'?
I'm not saying this is true, but just imagine if it was. What would pharmaceutical companies charge for something like this? Who gets access to what will at first be a limited supply? What are the social implications? It boggles the mind.
End of life care is expensive and ineffectual because it is targeting the symptoms of the problem, not the underlying problem, which is age. Eventually, the technology will be at the point that it will just make more economic sense to have people preemptively reduce aging instead of going to the doctor for an age related illness.
Yes, people will have to work longer but you will not work yourself to death to save up for retirement (just for the occasional break). There are plenty of problems in the world, so having more able people to address those problems is probably a good thing. Also, people will put off having kids longer and everyone is going to start to care a lot more about the "longterm" of things. Seems like a positive direction for humanity. . .
Sdelat' Ameriku velikoy Snova!
What do you call a racist neckbeard loser nerd who's posting -1 crap on Slashdot?
Racist neckbeard loser nerd.
Actually a true racist thinks that black people are inherently inferior due to genetics that are naturally beyond their control. To put that another way, a true racist believes that there is no difference between "black folk" and "niggers".
I, the poster of the nigger jokes above, hereby certify that I agree with the stand-up comic Chris Rock, in that I "Love black people, but hate me some niggers!" I have met and and truly enjoyed knowing some really fine, intelligent, wise, motivated, hard-working folks who happened to be of African descent. They were an extremely diverse group, in terms of interests, religious beliefs (or lack of), hobbies, political views, career paths, etc. But they all had one thing in common: none of them thought that being a street thug was a really good idea. All of them would have been disgusted and ashamed of anyone they know who thought that being a street criminal was just great.
That's why they are black -- and I do mean, some of them are darker than ink -- but none of them qualify as niggers. See the difference? It's not genetics. It's trashy people raised by trashy (single) parents in a trashy culture that glorifies trashy failings in life. That's what a nigger is. DNA has nothing to do with it. Racism is strictly defined as a matter of genetics. Look it up in multiple dictionaries if you don't believe me (though OF COURSE you wouldn't use a word like that without knowing what it does and doesn't mean, RIGHT?!). Thus, loving black folk and valuing their company while hating niggers is not remotely racist.
Incidentally you really have no idea what color my own skin is. Did you have a preconceived notion of what it would be? Do you ever try looking in the mirror before making judgments against someone else? Didn't think so. I have no idea why you think this kind of bias and prejudice is terrible if it's done for $SOME_REASON, but perfectly acceptable when you do it for $OTHER_REASON (more like, $HOLY_TO_YOU_REASON). The hypocrisy is disgusting. Most humans in the world are not white.
Are you in your Safe Zone? Call 911 to report a Bias Incident...
"You are not ready for immortality."
This drug is just a synthetic curcumin (turmeric) derivative and the statistics show that the natural substance does protect Indians, who eat a lot of it. (Old news.)
Check the patent... they improved it but they developed it from Curcumin.
https://en.wikipedia.org/wiki/...
From the published paper:
Salk has an issued patent on J147 licensed to Abrexa Pharmaceuticals.
It will be interesting to see if this makes its way through the labyrinth of FDA testing within the next 40 years.
Apparently it is the mice that are running the planet and they got us trained to solve their health problems.
She's the closest we humans have to the mouse!
Ally? McBeal? Have you been living in a cave?
I'll bet the folks at Google's anti-aging company (whatever it's called) are growing old real fast right now.
Ha
Ha
Schmucks
Firstly, race should be off topic for this web site.
Secondly, everything in the media is airbrushed. There are minimal ugly, or fat people on TV, movies, or magazines. See "Last Action Hero". That's the way it is.
Thirdly, children born out of wedlock is >40% for whites. So, yes things are getting worse for both races...
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I can't wait for them to try this on Humans!
Note that the anti-ageing effects were seen in a strain of mutated mice that "exhibit rapid ageing". It may turn out that the drug's effects are specific for the pathway affected by the mouse line's particular genetic fault, rather than against ageing in general.
But even if that's the case, I expect it would retard SOME aspects of age-related debilitation in normal mice and in humans. I await the results of the upcoming human trials.
Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
Here's some well-thought critique regarding the "anti-aging effects":
https://www.fightaging.org/arc...
(The whole site is a goldmine for those interested in serious anti-aging research.)
Here you go: http://www.alzheimersweekly.co...
Dateline: Nov 16th, 2015
Lede: FDA Saves Seniors from Themselves
When a delegation of seniors with severe memory problems presented themselves at the FDA requesting immediate availability of J147, FDA representative Ben Dover told the supplicants to "forget about it", and that they should "remember that the FDA is there to protect them."
This reporter asked Brian Toomore, an older gentleman in the group asking the FDA to allow this treatment, what he thought of Mr. Dover's remarks. He had this to say: "Where am I? Who? Are the Japanese winning?"
--fyngyrz
Rather than target amyloid, the lab decided to zero in on the major risk factor for the disease–old age. Using cell-based screens against old age-associated brain toxicities, they synthesized J147.
If they're targeting "old age", why would anti-aging effects be surprising?
Does anyone understand exactly what this drug is doing? I'm not able to parse that second sentence, possibly because my brain is too old.
-- sudon't
Air-ride Equipped
He who controls the spice controls the universe.