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Study: Mice Gain Weight In Cold Temperatures Due To Gut Changes (economist.com)

Beeftopia writes with the results of a study described in The Economist: Mice were separated into two groups, one temperature maintained at 6C, the other at 22C. Researchers expected the cold mice to lose weight as they burned stored fat to stay warm. And for the first few days they did. But after five to ten days, in spite of their rations not increasing, the cold mice begain to put on weight. When scientists examined the gut microbiome of the previously identical mice, they found they were radically different. Additionally, the intestine had grown villi 50% larger than those of the warm temperature mice. Finally, after transplanting the gut microflora into a new batch of aseptic mice kept at warm temperatures, those mice showed the increased insulin sensitivity, cold tolerance, and villi length of the cold mice.

16 of 132 comments (clear)

  1. I'm not sure what conclusions to draw from here by mrsam · · Score: 2

    Scratching my head here. What's the conclusion to be drawn, from these experiments? That if we don't want to gain weight, we should all move to Florida?

    1. Re:I'm not sure what conclusions to draw from here by Ungrounded+Lightning · · Score: 5, Informative

      What's the conclusion to be drawn, from these experiments? That if we don't want to gain weight, we should all move to Florida?

      How about: "The mouse gut bacteria that flourish in cold weather conditions signal the mouse to take more nutrition from the gut. They're throwing more of their own potential food supply to the mouse than the summer-time bugs, in order to keep their house intact and warm (rather than starved to death) over the winter months."

      Yet another instance of life forms involved in a symbiosis evolving better mutual-survival strategies.

      --
      Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
    2. Re:I'm not sure what conclusions to draw from here by 110010001000 · · Score: 4, Funny

      But it is a simple matter of calories in/out. The study even says so. They looked at the calorific value left in the faeces.

    3. Re:I'm not sure what conclusions to draw from here by MDMurphy · · Score: 2

      I've wondered the same thing, but also is a "cure" for obesity good? Would it better for the world if people could eat more and not gain extra weight? Aren't people who can eat less and still put on weight actually more efficient? While I'd seen some similar studies, I'd like to know how this affects how much work you can do on a given caloric intake. While it would be nice if all of a sudden I could eat what I want and not gain weight, I can't help that thinking that doing so is not much different than binge and purge at a Roman feast.

      Maybe thin people in areas with less food availability should get transplants of gut flora from those who gain weight when eating less food?

    4. Re:I'm not sure what conclusions to draw from here by __aaclcg7560 · · Score: 2

      [...] who knew they'd be buying into a worthless investment.

      A smart speculator would look at the scientific data for rising water levels and buy worthless properties that will eventually become new water front properties.

    5. Re:I'm not sure what conclusions to draw from here by Cyberax · · Score: 2

      Yes, it's thermodynamics. The "warm-temperature" mice simply don't burn food as completely as the "cold-temperature" mice. If you restrict calorie intake further then they WILL lose weight.

    6. Re:I'm not sure what conclusions to draw from here by slashping · · Score: 2

      I know it's silly, but some people are interested in the details.

    7. Re:I'm not sure what conclusions to draw from here by Applehu+Akbar · · Score: 2

      And I for one am not going to try the stool-flavored yogurt.

  2. Explanations! by dohzer · · Score: 4, Funny

    This explains why I gain weight when pouring beer after cold beer into my gut.

  3. Gained weight despite unchanged diet by Beeftopia · · Score: 3, Interesting

    I found that interesting. Identical mice placed in different environments, on the same diets. One set gets fat, the other stays normal weight.

    Certainly obese humans should eat healthier and exercise, but perhaps it's not all moral failing that make them fatter than normal weight types.

    Also, something like this might suggest further areas of human research. Instead of just saying that the naturally skinny differ "in the genes", researchers might start investigating different subsystems, such as the digestive, to see how changes in them might mitigate weight gain.

    1. Re:Gained weight despite unchanged diet by Beeftopia · · Score: 3, Insightful

      It's also paradoxical. Cold weather should speed up the metabolism, and thus, on the same diet, the organism should lose weight, not gain it. Yet the adaptation to gain fat to likely protect body temperature kicks in, generating changes in the digestive subsystem to achieve that end.

    2. Re:Gained weight despite unchanged diet by nullchar · · Score: 2, Interesting

      Or anticipated need for large stores of energy to burn when it's really cold, even if you have more calories available to eat.

    3. Re:Gained weight despite unchanged diet by Anonymous Coward · · Score: 4, Insightful

      What IS it about fat people where they get enraged when someone points out they're fat?

      What IS it about skinny people that they appoint themselves as self-righteous pricks by offering unsolicited, and often inappropriate, advice to fat people? A friend insisted that I run seven miles a day even though it would blow out my knees. A coworker insisted that I drink water all the time even though I drink more water than him. Another coworker insisted in front of other coworkers at a meeting that I get lap-band surgery even though we weren't talking about my weight.

      Everyone can not only see, but see exactly how fat you are as well.

      I don't have a problem with being fat. I'm on a low carb diet, work out at the gym and drink plenty of water. I'm doing what I can do without killing myself in the process. Seems like skinny people are insecure around me because I'm not insecure or ashamed of being fat. I put that nonsense behind me years ago.

      I get the same type of self righteous crap from people about my diabetes, which I have had for about 18 years, and I usually let them tell me all the shit about what I should and shouldn't eat, and how it is all my fault.. and I wait about a beat and smile and tell them that I have type 1 diabetes not the type that you get from insulin resistance and the non alcoholic fatty liver syndrome effects.

      People are dicks, unless they work not to be. It is more about them and their insecurities and inferiority complexes and confirmation biases than it is about you. Pay those idiots no mind is my advice. The lady that suggested lap-band surgery out of the blue needs to be complimented on her lack of people skills and have an HR complaint filed it sounds like. I would have just laughed and said something like "I can get on a treadmill, what can you do about just being ugly? Bag over the head much?"

      Not everyone is the same, has the same habits or conditioning or gut flora and all of it matters to one degree or another. I have a fucked up mean immune system is my problem and it is no ones fault. It just happened. This does not stop idiots who don't have a problem ascribing to their skill or moral superiority, something that has happened by chance. This is a cognitive bias on their part and nothing to do with you, let them be morons.. rest assured that people around within earshot don't think those people are smart or witty or anything but ugly bags of mostly water.

      Carry on with your exercise and build some muscle .. and someday kick their ass when they mouth off.. :)

      And most importantly, be happy!

    4. Re:Gained weight despite unchanged diet by Antique+Geekmeister · · Score: 2

      Morbid obesity is a real health risk for many American children. Whether cause or effect, it's correlated with diabetes, heart trouble, and sleep apnea, to name only a few conditions that can kill a child.

  4. The new frontier by nullchar · · Score: 2

    Exactly! Our microbiomes are the new frontier of health for all sorts of things, obesity being number one for the general western population.

    It's only a matter of time, and IP law, that engineered bacteria will be sold as designer probiotics to counter all sorts of maladies. Could we easily create a grassroots organization to distribute colon flora? Sure! But the fat, sterile westerners will say "Ew, gross!", but happily pay for Monsanto Microbiome Enhancement Plus for a premium. (it's a fictional drug to counter the bacterial imbalance created by eating processed, industrialized food.)

    Just as the finding of lead in our environment is bad for humans, perhaps so will antibiotics from medicines to soaps, along with polymers such as BPA (commonly found in most thermal paper receipts that people handle on a daily basis), be found to cause harm to our microbiome.

    If you count cells in the human body, there are more bacterial cells than human cells; of course the human cells are much larger, but human individuals are complex organisms living with lots of other living "things".

  5. Re: I'm not sure what conclusions to draw from he by qbast · · Score: 2

    No. They should simply account for what they have no control over and adjust their calories intake.