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Scientists Find A 'Weak Spot' In HIV That May Pave The Way To A Vaccine (futurism.com)
iONiUM quotes a report from Futurism: Research conducted by a team from the National Institutes of Health reported a new vulnerable site on HIV for vaccines to target. It is based on an antibody from the blood of an HIV-infected patient that binds with the virus and also prevents it from infecting a cell. A recent press release reports that a team of scientists led by the National Institutes of Health (NIH) has discovered a new "weak spot" in HIV that vaccines can target. The area, called the fusion peptide, is a simple structure of eight amino acids that helps the virus fuse with a cell. According to the study, the team used a particularly powerful antibody, called VRC34.01, taken from the blood of an unnamed HIV-positive patient that caught the weak spot in the virus. It's not only capable of binding with the virus through the fusion peptide but also preventing it from infecting an entire cell.
Sweeeeet! Now Slashdot nerds can have no sex but without a condom!
(-1: Post disagrees with my already-settled worldview) is not a valid mod option.
Can someone explain to me: If the person has an antibody that prevents HIV from binding to a cell, how are they HIV positive?
They found an HIV-patient exhibiting an effective (to what degree is unclear from TFS) immune response to the HIV virus.
Let's give credit to the patient or the patient's immune system.
... is the patient whose body produced this antibody going to get a cut, or is it just the researchers and their organizations who will gain?
That's good. I've been wearing the same condom since 2003.
You are welcome on my lawn.
Could have saved Nina from his madness.
The story's been out for an hour, and nary a comment about how it makes no sense to cure when they can keep profiting from ongoing treatment. I don't know whether to be relieved or disappointed. (oooh.... did I just really use the word 'nary' in a sentence???)
File under 'M' for 'Manic ranting'
Yeaaaaahh... about that... HIV isn't the only thing that casual unprotected sex spreads. See "herp, the."
We can't cure stupid, apparently, so what makes you think we could cure gay?
After initial infection, the virus will enter a long-dormant period, during which it will continue to mutate and wear down the immune system. In most people, this period will end after a decade or so, when the immune system "tires" and allows viral load to increase. The destruction of CD4 helper cells (most by induced apoptosis, a small percentage by infection) opens the body to oprotunistic infection, which (barring treatment) is usually the end of the story.
A small group of the infected, called "Long Term Non-Progressors," are able to create highly-effective antibodies in their B-cells. When they do this, the viral load never increases, and they remain in the latency period indefinitely.
The antibodies produced by such people have been studied with X-ray crystalography. Their B-cells can actually be used in the "monoclonal antibody" process to create antibody solutions for other people that can be injected and used in treatment.
In any case, these highly-effective antibodies are only produced after years of interaction of the virus with the immune system. They are not presented upon initial infection, and LTNP individuals don't differ from the normal immune reaction during the first six months.
The target area is only two microns wide. It's a small chemical heat exchange valve, right below the main nutrient valve. The passageway leads directly to the nucleotide system.
I think the most scary STD is hepatitis C. Cirrhosis is a very long, drawn out death.
Any idea how many children are born already infected with HIV? What sin did they commit?
I've abandoned my search for truth; now I'm just looking for some useful delusions.
And it has worked... I still haven't caught AIDS! It is a bit difficult to pee, however...
I've abandoned my search for truth; now I'm just looking for some useful delusions.
Jaundice, it turns you orange. Hey, is there anybody out there that's already orange?
I've abandoned my search for truth; now I'm just looking for some useful delusions.
Leave it the fuck alone! Otherwise, I'l mutate it myself to be more resilient.
Brec1 can actually cure people of HIV, by going into infected cells and removing the integrated provirus. I'm a software engineer, so I have no idea how this works, but it sounds more promising than this naturally-occurring antibody. Apparently BREC is evolved with a genetic algorithm; that part I understand.
I've abandoned my search for truth; now I'm just looking for some useful delusions.
Wait, you're supposed to wear it on your...? Oh, never mind.
You are welcome on my lawn.
Cause thats where I've been sticking them all these years. It took me a while to get turning my car good...once I switched to the ribbed kind I had much better finger traction on the wheel.
They are born with antibodies. They are not born with HIV.
sent HIV as punishment for homosexuality. Why do these doctors hate Jesus?
A "cure" or vaccine for HIV/AIDS has been possibly only 10 years away for the past 30 years.
We're always "closer than ever before" to nuclear fusion, and have been within 20 years of it for 50 years
We've been only 10 to 20 years away from a manned Mars mission for 40+ years
Flying cars? Jetpacks? the list is endless of the stuff lots of people wish for and that advocates are always promising "soon" if somebody (usually taxpayers) would just pony-up another pile of cash on top of the billions previously "invested". These things are unicorns. They either cannot exist, or they do not yet exist for very good reasons like humans not understanding some fundamental thing or lacking the ability to fabricate some widget etc.
With HIV, there's a basic fact people are expected to ignore:
Human beings have never truly defeated a virus. We do not know how, and may not know enough for another century or two, or twenty...
As individuals we only survive a virus by sheer luck of circumstance, general health, and so forth (not likely with things like HIV). The general population manages to survive viral exposure via innoculation with a vaccine (i.e. not an actual "cure" so much as an assist to the immune system to help us survive the exposure). The dream of an HIV vaccine is not a cure for HIV at all, but rather a play to expose the entire population to something that would then allow most people to survive exposure to HIV. Nobody is even pretending to want to actually eliminate HIV/AIDS, which would happen for free and in only 1 generation if we could just get people to stop IV drugs and stop sleeping around like animals. In other words: if in the 1980s society had treated HIV/AIDS as a communcable disease rather than a political cause and ignored all the AIDS and IV-drug addicts activists and done quarantines and contract tracing as had been done in so many earlier outbreaks of infectious diseases, HIV/AIDS would now be a distant dark memory and millions of people would not now be dead or dying.
Something like 40% of gay men are HIV positive.
I wonder what happens if we only half-way beat this and some pandemic comes along to make use of the compromised immune systems? Combine it with some of the anti-vaxxers types and...
You're an idiot.
Vaccines do not cause learning disabilities. Asthma has increased in correlation but it's not causative - working in schools I can assure you that asthma and allergies are on the rise because of LACK OF EXPOSURE to things like grass, pollen, nuts, etc. No asthma in unvaccinated? Bollocks. Healthier? Bollocks. Disease resistance? Bollocks. Safety studies, stop making up criteria that they don't meet because that's BOLLOCKS.
The Dr you quote thought that Vitamin C cured lots of things that it doesn't. The guy published only in the 70's and 80's, things have moved on.
Though I'm not in the "YOU MUST HAVE YOUR CHILDREN VACCINATED OR YOU'RE EVIL AND KILLING THE WHOLE WORLD" camp, I disagree with almost everything you quoted here even more.
Vaccination, like ANY MEDICAL PROCEDURE, it not without statistical outliers, mistakes, and risks. Nothing medical is risk-free. 99.9999% of all medicine is working out if what you take and might end up with is better than what you already have. Drug interactions are difficult and people work differently.
Like the HIV story at the moment - a patient, of their own accord, formed an antibody that stopped HIV. Now scientists are taking that antibody and hopefully forming a vaccine or kinds. But HIV is different in every person and evolution relies on something, completely by chance, working differently in one animal to every other animal of the same species. That's how it works, and that's why vaccines cannot be "safe".
But, as a mathematician, the overwhelming, massively tested, calculated, verified and best odds are that vaccination will help an individual, and a population, more than they will harm it. Nobody can guarantee that for any individual, because we're playing biology roulette. But we're making sure we're playing on a table with only one tiny "you die" against a myriad "you never get the disease, or die from it" slots.
Stop being an idiot, Dr. M.D. PhD means nothing. Ask my geneticist girlfriend who's qualified to tell half of London if they have cancer, or if their unborn child is likely to have a crippling genetic disease or not and works with lots of wackos, or my multiple-Dr PhD father-in-law who has PhD's in everything from chemistry to physics to sports science. One wacko Dr doesn't make everything he said 30 years ago true just because he has letters on his name.
The overwhelming, peer-reviewed, best-guess of established science nowadays is that people should be vaccinated. And, in fact, one British doctor with a similar amount of letters was SO WRONG in his autism/vaccination link that he went to jail for it. Not just a slap on a wrist. Not just "Oh, his science is poor". But "Your assessment and scaremongering was so damn incorrect, and you knew it, and you faked results and made up numbers, and you went so public and scared so many people incorrectly, that it was criminal."
I can find a wacko PhD in any field, from astrophysics to maths (so many claimed to have proven Fermat's Last Theorem etc. and ALL of them were wrong until the 1990's and that took nearly 10 years to prove right even though it actually LOOKED right for a change), biology to environmental studies. A sound-bite from a wacko is not science.
I would think that if cells can not become infected that over time the virus might cease to exist within the body.
No. Mother to child transmission is quite common. The virus can be transferred through maternal blood or breast milk to the infant.
The Sin of Adam.
As long as it's not your ass, how's that your business?
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
They're born with HIV. And they die of HIV. Before they're even old enough to think about fucking.
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
But me and my hand are faithful to each other!
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
Some kids that overdid it with the tanning cream usually end up looking bright orange. Like this goofball.
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
Another vaccine. Just what everybody needs.
Thankfully we nailed a guy to a cross 2000 years ago to pay for all our sins. So we can keep doing what we want.
Being born wrong is indeed considered a sin in the eyes of conservatives.
Proof is in their actions, not their words.
They chose the wrong parents. That's the same reason that all children of a religion different to your parent's religion will burn in the hell of your parent's religion - they too chose the wrong parents.
Birds are not dinosaur descendants;birds are dinosaurs, for all useful meanings of "birds", "are" and "dinosaurs"
It's the sin of the parent visiting itself upon the child.
It's also a "sin" of evolution. The biologically strong survive. Just don't reproduce with an infected (or weak) organism and you'll be able to pass along your genes.
Remember, if you don't get out there and sin, then Jesus died for nothing!!!
I've abandoned my search for truth; now I'm just looking for some useful delusions.
Social Darwinist? Don't tell me, let me guess... you're a Trump supporter?
I've abandoned my search for truth; now I'm just looking for some useful delusions.
You mean the rebels found a fatal flaw in HIV? A thermal exhaust port with a shaft that leads directly to the HIV reactor core? A simple proton torpedo could take out the whole virus! It's a one-in-a-million shot, kid!
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See subject & LMAO (@ how stupid you are Mr. menial nobody "ne'er-do-well") https://slashdot.org/comments....
APK
P.S.=> You never answered my question after your "ministry of UNTRUTH" there too, lol... apk
See subject & https://slashdot.org/comments.... LMAO!
* What's it LIKE being an "outism" brain-damaged do-nothing menial nobody on your end?
(Talking behind my back now to top it all off only shows EVERYONE how much of a reject retarded bitch you are...)
APK
P.S.=> Lastly also - what's it like having to "EAT YOUR WORDS" too, stupid? apk