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Wheelchair-Bound Stroke Victim Walks Again After 'Unprecedented' Stem Cell Trial At Stanford (washingtonpost.com)
An anonymous reader quotes a report from The Washington Post: Stanford researchers studying the effect of stem cells injected directly into the brains of stroke patients said Thursday that they were "stunned" by the extent to which the experimental treatment restored motor function in some of the patients. The results, published in the journal Stroke, could have implications for our understanding of an array of disorders including traumatic brain injury, spinal cord injury and Alzheimer's if confirmed in larger-scale testing. The work involved patients who had passed the critical six-month mark when recoveries generally plateau and there are rarely further improvements. Each participant in the study had suffered a stroke beneath the brain's outermost layer and had significant impairments in moving their arms and-or legs. The one-time therapy involved surgeons drilling a hole into the study participants' skulls and injecting stem cells in several locations around the area damaged by the stroke. These stem cells were harvested from the bone marrow of adult donors. They suffered minimal adverse effects such as temporary headaches, nausea and vomiting. "Their recovery was not just a minimal recovery like someone who couldn't move a thumb now being able to wiggle it. It was much more meaningful. One 71-year-old wheelchair-bound patient was walking again," said Steinberg, the study's lead author and chair of neurosurgery at Stanford who personally performed most of the surgeries. Steinberg said that the study does not support the idea that the injected stem cells become neurons, as has been previously thought. Instead, it suggests that they seem to trigger some kind of biochemical process that enhances the brain's ability to repair itself. "Patients improved by several standard measures, and their improvement was not only statistically significant, but clinically meaningful," Steinberg said. "Their ability to move around has recovered visibly. That's unprecedented. At six months out from a stroke, you don't expect to see any further recovery."
This could save not just suffering but money - round-the-clock care isn't cheap.
"Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
Not taking sides in any "stem cell war," but adult stem cells do seem to be the ones we hear about having these miraculous effects.
It was truly a Miracle from God! Praise Jesus!
Is this report based on real research, or is someone just binge-watching Arrow right now?
Was the patient's name "F. Smoak"?
#DeleteChrome
And "OH" -- the most interesting part (I didn't read the article cited in TFA, but I've read a few on this subject and know one of the folks in the trial) is that the stem cells die off pretty quick. They just seem to "spark" brain cells to go "Hey guys! Lets hold hands" and magically make new connections.
Embryonic stem cells (and any kind of pluripotent stem cells) are hard to work with and haven't produced many results. Adult stem cells are much cheaper to work with and have produced a lot of good results. This isn't a PR issue, it's a technical issue.
Well, part of that is likely because it would be a public relations nightmare trying to do trials with fetal stem cells.
... only in America. It is less of a issue in Europe, and a non-issue in China.
Question: Instead of harvesting the stem cells from the bone marrow of donors, why didn't they harvest the stem cells from the bone marrow of the patients themselves? That would eliminate any immune reaction. Stroke victims generally still have healthy marrow.
Way before its time.
https://www.youtube.com/watch?v=TRtlkcQ6brE
I donate blood every eight weeks (over 10 gallons so far). I have been on the marrow donor list for several years, but have never been matched with anyone. If/when the call comes, I will donate, and have no expectation of compensation. The procedure is very low risk and usually harmless.
Embryonic stem cells (or pluripotent stem cells -- meaning they can become any type of cell) are hard to get.
Adult stem cell transfers have been around for a while (~50 years)...and most of it was based on the older Bone Marrow Transfers.
Note: Adult stem cell transfers (non Autologous (Self)) still have to deal with Host vs. Graft disease.... it's great when it works...but it's also a die roll and can flat out kill you.
IANAD - It's my limited understand that the 'blood-brain-barrier' - while protects the brain - also inhibits the immune system from gaining access to it too. Perhaps it's not the stem cells. Perhaps, just a though, that the act of drilling holes is breaking the blood-brain-barrier enough for the immune system to go in a cleanup and make way for natural repair.
Any thoughts on this supposition; false or otherwise?
Life is not for the lazy.
"Question: Instead of harvesting the stem cells from the bone marrow of donors, why didn't they harvest the stem cells from the bone marrow of the patients themselves? That would eliminate any immune reaction. Stroke victims generally still have healthy marrow."
I don't think it's an issue. The study noted that the stem cells die off pretty quick. They just appear to make the brain cells go "Hey guys! Lets hold hands!" and the patients brain just starts making new connections.
Also: Ugh, the 'faux computer nerd' crap they're pushing on TV now. Also the ideal of magically injecting a chip with no other prepwork to magically make people walk again. (Not that it can't be done, but I REALLY doubt any that could actually be made prepless and injectable would also be REUSABLE.)
So you've apparently watched Arrow, and don't have issues with all the magical talismans and tattoos, super-powered metahumans, ATOM shrinking suits, Lazarus pits and whatnot else ... but object to the depiction of faux computer nerd crap? :-D
#DeleteChrome
Since I am alive and cancer-free today thanks to a bone marrow transplant, George (my new bone marrow) and I thank you and commend you for doing so.
Oh, and I encourage everyone else to do so as well. It's not difficult, painful, or time-consuming, and it just might save a life....
"I do not agree with what you say, but I will defend to the death your right to say it"
It needs a little salt, but OK as is.
And "OH" -- the most interesting part (I didn't read the article cited in TFA, but I've read a few on this subject and know one of the folks in the trial) is that the stem cells die off pretty quick. They just seem to "spark" brain cells to go "Hey guys! Lets hold hands" and magically make new connections.
I'm glad you pointed that out; I didn't have a chance to get to this discussion sooner. As a scientist - though not one involved in the study - I find myself wondering if this was a kind of apoptotic response. The stem cells probably found themselves in an unfamiliar environment (they were bone stem cells no longer subjected to bone cell transcription factors, bone cell extracellular matrix, etc) so they may have found themselves with nothing left to do but die. Apoptosis tends to leave tidy little packages in the wake of cell death (as opposed to cells going straight-up necrotic) which may have made some of their contents accessible to other cells. Neurons do live much more dynamic lives than we tend to give them credit for, so they may well have picked up these post-apoptotic packages and then responded to their contents.
:)
One neat thing about such an approach is it should be fairly short lived on the molecular level, which seems to be just what we wanted here. The proteins and mRNA from the stem cells likely was degraded fairly quickly and almost certainly did not form a self-feedback loop. It sounds like magic, but it's really more like a crude attempt at gene hacking
Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
I've been on a marrow donor list since '94, when a volunteer practically accosted me while I was walking to the school cafeteria and begged me to sign up since they were desperately short of Asian donors. They took a cheek swab and two blood samples; that was it.
A decade later, I got a call saying I was a preliminary match, and they needed my permission to unthaw one of the blood samples so they could run a more thorough compatibility test on it. I would receive a letter I'd need to sign consenting to further testing of my blood, plus some additional questions, which I filled out, signed, and returned. Sadly, the second test revealed my marrow wasn't a good enough match to warrant the risk of a transplant. But it did give me some insight into the process.
Donors and recipients are kept anonymous. You won't get to meet each other. There is no compensation, but as the donor you won't have to foot any of the medical bills. If you think about it, this is more like insurance than it is a donation. Because who knows, it could be you who needs the bone marrow transplant in the future. The procedure is low-risk, but they did say the area would be really sore for a week or two, like you'd run a marathon (they take the marrow from your hip). Which I thought was a funny analogy to use since I and I suspect most people have never run a marathon.
Anyway, it's a small price to pay for potentially saving someone's life. Go do it if you haven't yet.
https://bethematch.org/support-the-cause/
Not taking sides in any "stem cell war," but adult stem cells do seem to be the ones we hear about having these miraculous effects.
A great deal of effort went into making adult stem cells work like fetus ones, thanks to a couple of true geniuses. How much sooner would we have gotten here without that delay?
(-1: Post disagrees with my already-settled worldview) is not a valid mod option.
They did these trials with fetal stem cells years ago. You can google for teeth growing inside head and other untoward results with fetal stem cells. Adult stem cells are less apt to do the surprising and undesirable things. [And more likely to be available.]
They are one step closer to not have to worry about being wheelchair-bound for the rest of their lives.
Forget magic. Any technology distinguishable from divine power is insufficiently advanced.