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Brains of Overweight People Look Ten Years Older Than Those of Lean Peers, Says Report (theguardian.com)

An anonymous reader quotes a report from The Guardian: The brains of people who are obese or overweight appear to have aged an extra 10 years compared to their lean peers from middle age onwards, brain scanning research has revealed. The difference, scientists say, corresponds to a greater shrinkage in the volume of white matter, although they don't know the cause. It might be down to genes causing both brain-shrinking and obesity, or it could be that changes occurring in the brain lead to overeating. Either way, it does not appear to affect cognitive performance. White matter is tissue, composed of nerve fibers, that aids communication between different regions of the brain. The volume of white matter in a human brain increases during youth and then decreases with age for both lean people and those who are overweight or obese. But researchers have discovered that this shrinkage differs depending on a subject's BMI. "The overall message is that brains basically appear to be 10 years older if you are overweight or obese," said Lisa Ronan, first author of the study from the University of Cambridge. Despite a higher BMI being linked to a smaller volume of white matter, it did not appear to have any link to mental prowess, with no difference seen between lean and overweight or obese participants when they were subjected to IQ tests. Scientists from the University of Cambridge and Yale University have published their findings in the journal Neurobiology of Aging.

17 of 184 comments (clear)

  1. Wisdom of the elders by bruce_the_loon · · Score: 4, Funny

    Well since you're supposed to get wiser with age, does this accelerate the wising-up process?

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    1. Re:Wisdom of the elders by The+Real+Dr+John · · Score: 4, Informative

      As the article mentioned, they could not measure a difference in intellectual functioning, just a loss of white matter (nerve fibers) without a significant effect on cortex. They did not look at other brain structures, which are also involved in cognition. The loss of white matter may not relate directly to cognitive functioning because it can happen, for example, by a reduction in fiber thickness, without a loss of fiber number. Therefore, if being fatter affects nerve fiber diameter (or myelin sheath thickness) then this would show up as reduced white matter volume. But all the connections would still be there.

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      A brain is a terrible thing to waste... Mind? That's debatable.
  2. Re:Or... by CrimsonAvenger · · Score: 3, Informative

    Or it could be that overconsumption, especially of certain nutrients like animal fats, processed meats or refined sugars, also leads to a decline in brain health and tissue-loss. There is in fact research which demonstrates that, eg eating animal fat has a direct impact on people's congnitive performance

    Since they said specifically that there seemed to be no differences in cognitive performance between the skinny subjects and the fat ones, this is unlikely to be the cause of the difference.

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    "I do not agree with what you say, but I will defend to the death your right to say it"
  3. Wait a sec... by meglon · · Score: 4, Funny

    So now, on top of missing dark matter, we're missing white matter too? Frak. Who the hell is in charge of keeping track of where this shit goes?!!!

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    Fascism: An authoritarian and nationalistic right-wing system of government and social organization. See also: NAZI's
  4. Re:Starving is good? by gtall · · Score: 3, Insightful

    More aptly, who wants to torture themselves just to get old.

  5. Re:Or... by Anonymous Coward · · Score: 5, Informative

    Having lost 150lbs over the past few years, I have read innumerable articles over that time about nutrition and have come to a conclusion: Nobody has any fucking idea what they're talking about. Carbs are bad for you, fat is bad for you, refined sugar is bad for you, all sugar is bad for you, processed food of any kind is bad for you, artificial sweeteners are bad for you, and on and on. I can find an article and a study to back up just about any claim you care to make about nutrition. It's all bullshit pseudo science.

    Here's the consensus: Burn more calories than you consume and you will lose weight, and try to eat some vegetables every once in a while to ensure you get some vitamins. That's about it.

    If you're having trouble gaining weight, you're not eating enough. Simple as that. Here's what you do: Eat what you normally would every day, then eat an entire loaf of bread and a jar of peanut butter every night. That's an extra 10000 Calories or so every day. If you can't gain weight on that then you're a medical marvel or an Olympiad in training. Will it be hard to force yourself to eat all that? You bet it will. It's at least as hard for people on the opposite end of the spectrum who have to force themselves not to eat, trust me. So it's really just a matter of how bad you want it, isn't it?

  6. Re:Starving is good? by Opportunist · · Score: 4, Funny

    Like in the old joke:

    Doc, what do I have to do to get old?
    You smoke?
    Nope
    You drink?
    Nope
    You sleeping around?
    Nope
    Then why the hell you wanna get old?

    --
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  7. Re:Or... by tomhath · · Score: 4, Interesting

    Your claim of lower cognitive performance due to diet choices is not related to the premature aging the scientists found.

    My guess is that the brain matter loss has more to do with the sedentary life style which often goes along with obesity. Lack of exercise, watching too much TV, etc.

  8. Re:BMI != obesity by tomhath · · Score: 4, Informative

    When looking at an entire populate, the very muscular athletes are outliers. High BMI almost always indicates obesity.

  9. Re:Or... by JamesTRexx · · Score: 4, Informative

    It's all bullshit pseudo science.

    That's what I concluded from years of following discussions, and I never even tried to start any fad diet.

    The one thing I started with after reducing my working days to just a few hours was only eat when I'm really hungry.
    Not when I feel peckish or something looks good. No, my stomach gives a clear signal that the body needs food and then I eat. And with just a little restraint at first and stop eating when I feel full enough, my portions became automatically smaller.
    Since the start of the year I've gone down from 110kg to hitting 96kg on the scale as of last week. With the increased energy I also did a bit more weightlifting.

    Even my girl who's overweight has followed my lead and only started eating when really hungry has lost 4 to 5 kg in just over 1 month (with light exercise). She now has more energy and feels much better.

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  10. Pick Your Poison - by Anonymous Coward · · Score: 3, Interesting

    From The Guardian:

    Underweight people face significantly higher risk of dementia, study suggests
    ==========
    https://www.theguardian.com/society/2015/apr/10/underweight-people-face-significantly-higher-risk-of-dementia-study-suggests
    ==========
    Research involving health records of 2 million people condradicts current thinking, sparking surprise among authors and health experts
    It has been wrongly claimed that obese people have a higher risk of dementia, say the authors from the London School of Hygiene and Tropical Medicine.

  11. Re:Or... by Jaime2 · · Score: 3, Interesting

    Here's the consensus: Burn more calories than you consume and you will lose weight, and try to eat some vegetables every once in a while to ensure you get some vitamins. That's about it.

    Even this is a little bullshit. I lost 100 pounds last year and I had similar experiences to yours. My weight has now been stable for about eight months. This year, I suffered an injury which changed my routine, causing me to burn about 7000 fewer calories per week than my pre-injury routine (I was completely bedridden). With my reduced calorie burn and no significant changes in intake, I lost about five pounds in a few weeks. Here I am six weeks later, and the weight loss was real and permanent. This weight loss completely baffles me and can't be explained by my mental model of weight management.

  12. Re:Alcohol by JonnyCalcutta · · Score: 3, Funny

    I'm already on it - no need to nag!

  13. Re:Or... by Anonymous Coward · · Score: 3, Informative

    Thanks for the most insightful post on Slashdot on this matter ever. Damn that I don't have any modpoints to give you. The only reason that "don't eat fat" or "don't eat carbs" work is because they make people eat less, i.e if you skip carbs then there is a lot of calories on a lunch plate that you suddenly don't eat anymore. Also if you skip fat or carbs you automatically don't eat a lot of the junk food. Myself I started to calculate calories and so far have lost 180lbs.

    While that is true, one of the things that is a marker of healthy aging is higher than average insulin sensitivity, which a certain number of general things are known about:

    1- Centenarians consistently have excellent insulin sensitivity, resulting in lower heart disease, cancer and chronic degenerative brain disorder numbers.
    2- One way of improving insulin sensitivity is to lower carbohydrate intake in relation to total calories, for some this works for others it needs to be balanced by exercise.
    3- Ketogenic diets originally were formulated to provide relief in seizures for children who suffered from epilepsy. The ketogenic diet, while not for everyone is well studied and it is known and well documented that it does not cause heart disease and promotes good cholesterol numbers.

    4- Once people lose a lot of body fat through diet or exercise by restricting dietary carbs or overall calories (or both) they can titrate in more carbohydrates and in the presence of better insulin sensitivity tend to do better in keeping the fat weight down, all other things being equal.

  14. Re:BMI != obesity by serviscope_minor · · Score: 5, Insightful

    When looking at an entire populate, the very muscular athletes are outliers. High BMI almost always indicates obesity.

    Except on slashdot. You see on any youth thread we complain about how all the millennials think they are special snowflakes. But on BMI threads, everyone with an obese level BMI is one of the few special snowflakes for whom the prediction is not accurate.

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    SJW n. One who posts facts.
  15. Re:Duh. by goose-incarnated · · Score: 4, Interesting

    No one should be overreacting on this subject. On TFA, the researcher already stated that weight may not really be the cause (just a possibility and may need further research)

    If there's a correlation it could be the other way around: perhaps people with those specific brain characteristics are prone to eating more.

    --
    I'm a minority race. Save your vitriol for white people.
  16. Re:Or... by DoofusOfDeath · · Score: 3, Insightful

    This. There are several insights I've found useful for keeping my weight down:

    (1) Learn to recognize the difference between hunger and craving. When one's body seems to "be trying" to get back to your set-point weight, you'll be hit with all kinds of cravings that are unaccompanied by hunger. It takes less discipline to ignore cravings than to ignore the cravings+hunger.

    (2) Keep a mental tally of (approximately) how many calories you've eaten so far in the day, vs. how active you have been / will be. It helps you decide if it's worth eating food ${X} or doing activity ${Y}.

    (3) Poor sleep ==> { extra appetite, worse self-control, and less desire to get exercise }. So place a high premium on good sleep.

    (4) Carbs seem to be somewhat addictive, in terms of cravings. In my experience, it takes ~ 1-2 months of not eating a lot of carbs in order for the cravings to go away.

    (5) If I'm hungry, or even have cravings for fattening foods, it's better to eat something filling (meat, yogurt, etc.) rather than let myself get so hungry / craving that I say "screw it" and make brownies.

    (6) For some reason, people who eat a lot of yogurt seem to be skinny. Correlation isn't causation, but it's perhaps a sign of it. So consider eating more yogurt. IMHO the yucky low-fat stuff with aspartame isn't worth it; just get something really yummy like Liberte and accept the calories as a worthwhile investment.