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Brain Implants Allow Paralyzed Monkeys To Walk (nature.com)

An anonymous reader quotes a report from Nature: For more than a decade, neuroscientist Gregoire Courtine has been flying every few months from his lab at the Swiss Federal Institute of Technology in Lausanne to another lab in Beijing, China, where he conducts research on monkeys with the aim of treating spinal-cord injuries. The commute is exhausting -- on occasion he has even flown to Beijing, done experiments, and returned the same night. But it is worth it, says Courtine, because working with monkeys in China is less burdened by regulation than it is in Europe and the United States. And this week, he and his team report the results of experiments in Beijing, in which a wireless brain implant -- that stimulates electrodes in the leg by recreating signals recorded from the brain -- has enabled monkeys with spinal-cord injuries to walk. The treatment is a potential boon for immobile patients: Courtine has already started a trial in Switzerland, using a pared-down version of the technology in two people with spinal-cord injury. The team first mapped how electric signals are sent from the brain to leg muscles in healthy monkeys, walking on a treadmill. They also examined the lower spine, where electric signals from the brain arrive before being transmitted to muscles in the legs. Then they recreated those signals in monkeys with severed spinal cords, focusing on particular key points in the lower part of the spine. Microelectrode arrays implanted in the brain of the paralyzed monkeys picked up and decoded the signals that had earlier been associated with leg movement. Those signals were sent wirelessly to devices that generate electric pulses in the lower spine, which triggered muscles in the monkeys' legs into motion.

50 comments

  1. Cute sciencey talk by LesFerg · · Score: 4, Insightful

    ... monkeys with spinal-cord injuries ...

    Meaning: monkeys with spinal-cords we have slashed and butchered

    --
    If I had a DeLorean... I would probably only drive it from time to time.
    1. Re: Cute sciencey talk by Anonymous Coward · · Score: 0, Insightful

      Why the troll mod? How do you think they get a monkey with a spinal injury to experiment on? I was only stating a fact.

    2. Re: Cute sciencey talk by Anonymous Coward · · Score: 4, Funny

      Car accidents at the circus?

    3. Re: Cute sciencey talk by Oswald+McWeany · · Score: 1

      Spinal cord got broken from people spanking the monkey

      --
      "That's the way to do it" - Punch
    4. Re: Cute sciencey talk by LifesABeach · · Score: 1

      I can only wonder if the monkeys tasted good also?

  2. Score one for research using monkeys. by CrimsonAvenger · · Score: 4, Interesting

    Assuming this can be ported to humans, it's the beginning of something huge.

    Mind-bogglingly huge, in fact. Since it should be usable for arms, hands, and such as well....

    --

    "I do not agree with what you say, but I will defend to the death your right to say it"
    1. Re:Score one for research using monkeys. by Visarga · · Score: 1

      In other news, we can tap into the visual cortex and use it as a teaching system for machine vision: "Representational Distance Learning for Deep Neural Networks"

      https://arxiv.org/abs/1511.039...

      They use a neat little trick: instead of mapping brain states directly to neural network states, they measure the distances between the representations of pairs of objects in the source domain and then transfer the same structure to the target domain. They don't need to be similar architectures. Hence, the possible lead to mind uploading / downloading. Of course we need to capture much more than vision, there's also the language representations, and value representations (as in Reinforcement Learning) for behavior transfer.

      With a portable brain scanner a person could build a model of herself during life, then transfer to another body or to VR after death.

    2. Re:Score one for research using monkeys. by Lotana · · Score: 1

      Indeed! This is very exciting!

      Biotechnology is making some huge strides in the last decade. It is an interesting time to be alive.

    3. Re:Score one for research using monkeys. by scratchy_king · · Score: 2

      I've had a chance to be involved in the technical setup of the clinical trial. It is truly fascinating to see the system at work. It will be 8 patients in total by mid-2018, so we'll have to wait until then to see if it truly works.

      Restoring walking is a first step because it is also easiest to begin with because walking is largely based on reflexes. These reflex networks are typically preserved after spinal cord injury, but the person is no longer able to activate them voluntarily, thus losing the ability to walk. With electrical stimulation and an extensive rehabilitation program, the aim is that the person regains some of this voluntary control.

      Restoring arms and hands function will be the next step. Tasks involving these limbs however, require fine motor control and are less reliant on reflexes. This means that remnant reflexes cannot be exploited and relearning tasks will be much harder (if not impossible...).

      My hope is still that one day we can have a paralyzed patient compete in the cybathlon exoskeleton race but with the implanted electrical stimulator instead of an actual exoskeleton.

    4. Re:Score one for research using monkeys. by KingBenny · · Score: 1

      should be, as if humans arent overpopulating enough as is
      it is huge though although i doubt the monkeys have given explicit written permission prior to being implanted ... if regulation is that convenient, why not directly go for the real target i mean
      and pardon my apparent lack of humanity-moralism but i wouldnt mind to see the army of twelve monkeys decimate the human population
      people sell their own kidneys for money
      why not, if they agree to it to feed their family
      in the name of science ?

      --
      Free speech was meant to be free for all... how can anyone grow up in a nanny state ?
    5. Re:Score one for research using monkeys. by KingBenny · · Score: 1

      can i ... just mention that i actually mean this, its not a sneer at the chinese or something, im all up for experimenting on humans who agree to it in the name of science

      --
      Free speech was meant to be free for all... how can anyone grow up in a nanny state ?
    6. Re:Score one for research using monkeys. by Anonymous Coward · · Score: 0

      Does it feature WEP security ?

  3. Better secure that... by fuzzyfuzzyfungus · · Score: 2, Interesting

    So, what are the options for tinkering with the signal before passing it on?

    Remote control meat puppet? Real-world RealPlayer experience, with all your attempts at motion suffering from unpredictable stuttering and buffering? The possibilities for creative signal processing are endless!

  4. Pro Tip: Don't be a monkey in China. by fahrbot-bot · · Score: 2

    ... because working with monkeys in China is less burdened by regulation than it is in Europe and the United States ...

    Probably applies to people too.

    --
    It must have been something you assimilated. . . .
    1. Re:Pro Tip: Don't be a monkey in China. by Anonymous Coward · · Score: 0

      Don't worry, the monkeys raise to claim this planet is starting from Beijing instead of San Fransisco, like our future historical documents have revealed.

    2. Re:Pro Tip: Don't be a monkey in China. by deadweight · · Score: 1

      I think the issue here is *why* the monkeys are paralyzed. I am suspecting these are not unfortunate victims of climbing accidents.

    3. Re:Pro Tip: Don't be a monkey in China. by fahrbot-bot · · Score: 1

      I think the issue here is *why* the monkeys are paralyzed. I am suspecting these are not unfortunate victims of climbing accidents.

      Probably more likely to be falling accidents than climbing. :-)

      Although, it's not the fall that kills you, but the abrupt stop at the bottom...

      --
      It must have been something you assimilated. . . .
  5. Finally... by 110010001000 · · Score: 5, Funny

    Finally a story about Donald Trump!

    1. Re:Finally... by ChrisMaple · · Score: 1

      Trump isn't the one who needs help walking. Pay attention.

      --
      Contribute to civilization: ari.aynrand.org/donate
    2. Re:Finally... by Anonymous Coward · · Score: 0

      What are you babbling on about, faggot? She was clearly helping those two men up the stairs.

    3. Re:Finally... by 110010001000 · · Score: 0

      Obviously. He had the brain implant. Read the summary.

    4. Re:Finally... by mnemotronic · · Score: 0

      Implants allow monkeys to walk. And run. For political office no less. And win. I feel so good about the future for us all in the Divided States of Donald.

      --
      The Russians have won. They have made the world a cesspool of distrust, greed, fear and hate.
    5. Re:Finally... by Anonymous Coward · · Score: 0

      Ironic viewpoint considering it's the secular Left that has no differentiating characteristic delineating a category of "human", and never will.

      Might want to get one before throwing around questions of who are mere hominids.

  6. China "Monkees" being those serving time by Anonymous Coward · · Score: 0

    Here we come
    Walking down the street
    Hey-hey, we're the Monkees!
    Take a liver, take a lung,
    Shove your testilcles
    Up our rectums!

  7. life imitates fiction by Anonymous Coward · · Score: 0

    Stephenson, Neal; George, J. Frederick (2005) [1994]. Interface. Bantam Spectra. ISBN 9780553383430.

    go read it. there is all: brain implants, us presidential election, media manipulation... to quote wikipedia
    """
    a thriller, set in the then-future year of 1996 when a shadowy coalition bent on controlling the world economy attempts to manipulate a candidate for president of the United States through the use of a computer biochip brain implant.
    """

    spoiler: he wins. but, he was honest and likeable. (as tom clancy supposedly said: "The difference between reality and fiction? Fiction has to make sense.")

  8. Poor monkeys by Anonymous Coward · · Score: 2, Insightful

    I hate all animal testing. This kind of work should be done on volunteer humans with nothing to lose.

    1. Re:Poor monkeys by Anonymous Coward · · Score: 1

      This kind of work should be done on volunteer humans with nothing to lose.

      It's very hard to recruit volunteers for suicide experiments, and the first time you try something new, it's highly likely to end badly. As in, death may actually be a preferred outcome. The people you can recruit are going to be so sick and so few that any study outcomes will be indistinguishable from anecdotes.

      I realize it's impossible to have a rational discussion about animal research, but every scientist I know makes a serious effort to use the simplest species possible and to minimize its discomfort. For example, the Courtine group developed their technology in rodent models before even trying it in primates. Even "chronic" animal studies are brief relative to the human lifespan, and the time that an animal model has to live with the consequences of an experiment gone bad are much shorter than a human volunteer.

    2. Re:Poor monkeys by La+Gris · · Score: 1

      I realize it's impossible to have a rational discussion about animal research, but every scientist I know makes a serious effort to use the simplest species possible and to minimize its discomfort. For example, the Courtine group developed their technology in rodent models before even trying it in primates. Even "chronic" animal studies are brief relative to the human lifespan, and the time that an animal model has to live with the consequences of an experiment gone bad are much shorter than a human volunteer.

      In best case these monkeys will be, or are already euthanasied.
      In worst case they will be maintained a miserable life of a paralyzed animal and recycled for other unrelated testing to some other lab facility for a discount.

      The only rational question is weather there is really no other alternatives.
      Since we discuss this after the facts, I only hope those involved into these experiments and taking care of the lab monkeys had enough ethics to keep the rational question in mind with no definitive answer.

      --
      Léa Gris
    3. Re:Poor monkeys by Duhavid · · Score: 2

      Thought experiment:

      Very advanced aliens come to earth.  ( they got lost ( not very advanced, eh? ), wrong turn at Aldebaran )
      They are ( i would not argue ethically, but ) advanced beyond us.  Lets concentrate on the power/technology aspect of this.
      They have power to dominate us as individuals and as a civilization.  And they live about 1000 years, so our ~100 year span is "brief" to them.
      They are biologically similar to us, so the things that go wrong in us also go wrong in them.
      So, they decide that we make good test subjects for research into various research topics ( regrowing limbs, how long can the brain live without a body, without sensory input, hair loss, etc ).

      They land here, and pick *you* for something that will benefit them tremendously, but will require things be done to your person.
      It may be painful, but they will have some pity for your state, and pump you up on painkillers where this does not harm the experiment.
      Your mental state will not be considered.  Addicted is OK for them, you are a test subject.
      Your connections to fellow human beings will not be considered, unless that is part of the test, and staying with your loved ones is very unlikely.
      You will also be put down painlessly at the conclusion of their test, even if the test is a success.
      You will, in no case, receive any benefits of this research, nor will humanity as a whole.
      Your body will be disposed of after, probably as food for other experiments.

      Has the ethical landscape changed for you?
      If you say "no", I ask "really?"

      --
      emt 377 emt 4
    4. Re:Poor monkeys by Anonymous Coward · · Score: 0

      Nice propaganda piece. Fanatics like you cause a lot of human deaths, grief, and misery. Save the tapeworms - they're animals too!

      Medical techniques developed on animals have helped non-human animals as well as the human ones. Veterinarians today routinely use such techniques - including those that work with animals injured in the wild. There is a benefit for animals here.

      Some human beings wouldn't mind being experimental subjects, either - but our legal structure isn't set up to permit that in many cases. Read the medical literature and you'll find lots of cases where human being volunteered for experimental treatments, but the government wouldn't allow it.

      By the time this happens the people are usually older and have serious physical problems (which is why they're not as concerned about what happens to them, losing all of one's friends and loved ones' one after another is also really bad). Unfortunately, the older humans also tend to have so many problems that they make poor subjects - it's difficult to assess the true causes of failures.

      Still, if you put some effort into fixing the regulatory and legal problems, there would be more opportunities for human beings to volunteer as test subjects.

      In the best cases, animals that already have injuries are used - animals that wouldn't even be alive without human intervention.

  9. Talk talk talk by krray · · Score: 0

    I first read, and would be MUCH MORE impressed, "Brain Implants Allow Paralyzed Monkeys To Talk."
    Let me know when that happens. Get back to me.

    1. Re:Talk talk talk by Anonymous Coward · · Score: 3, Funny

      The first thing they would say is "thanks for severing my spinal cord you fucking assholes!"

    2. Re:Talk talk talk by Oswald+McWeany · · Score: 1

      They can't conquer the world if they're paralyzed. It's the non paralyzed monkeys, or rather non-human apes, that you don't want to talk.

      --
      "That's the way to do it" - Punch
  10. Step on his crack... by Anonymous Coward · · Score: 0

    Break your monkey's back.

    Or was it... "Spank that monkey with a base.. ball.. bat!"?

    Seems rather evil in any way shape or form. Funny, but evil.

  11. Great but is it ethical? by Anonymous Coward · · Score: 0

    Hi,
    this is great news and I am sure it will be useful to humans as well but I am wondering how he found all the monkeys with spinal cord injuries. Unless...

  12. Honor these slave monkeys by Anonymous Coward · · Score: 0

    Their sacrifice will make human walks again. I support this researchs but I pray the monkey has the best possible treatment before they are paralyzed and end their days in as little pain as possible, and as rich lives as possible.

  13. Re:Hasn't it gone on in the U.S. for some time? by Anonymous Coward · · Score: 0

    http://www.aquilaarts.com/bush...

    Orangoutangs have orange hair??

  14. Human Clinical Trial by scratchy_king · · Score: 1

    In case you're interested in the details, or know someone who would be willing to try.

    https://clinicaltrials.gov/ct2...

  15. e mail marketing by Disparo · · Score: 0

    e mail marketing Turbine suas vendas com e-mail marketing e potencialize suas oportunidades de negócio!

  16. Scientific Concept, TED Talk by scratchy_king · · Score: 1

    Some years ago, Prof. Courtine gave a TED talk when they were still doing the experiments in rats.

    The underlaying mechanism is that the electrical stimulation brings the remaining neural structures in the spinal cord into an active state (i.e. where neurons can transmit electrical information). If you can time the stimulations correctly with the rat's own intention to walk, you facilitate neural plasticity (the ability of neurons to create new connections). This means that after an extensive training, the rat's remaining neural structures rewire and give the animal the ability to walk again by itself, in certain cases even without electrical stimulation.

    The monkeys in the current paper have a completely severed spinal cord and so there are no remaining neural structures. The "therapy" paradigm was thus changed and instead relies on a permanently active neurostimulation system, that links the brain directly to the region below the injury in the spinal cord.

  17. Why wireless? by bytesex · · Score: 1

    That has absolutely no bearing to this research. In fact, I'd probably prefer mine to be wired. I'll carry the wire and not the extra battery. And not worry about missing packets.

    --
    Religion is what happens when nature strikes and groupthink goes wrong.
  18. inflammatory no ? by Brigadier · · Score: 1

    All medicine requires testing, likewise personal products. Your blood pressure medicine, cholesterol, and the compound which will likely save your life one day. My sister was a research scientist for a pharma, she performed tests on mice which as you would put it had there brains sliced and butchered in order to test a drug which could save someone's life during a stroke. My grandmother died from a stroke. So I respect your opinion, this being said your only entitled to it you refuse any help in the form of compounds which will one day save your life.

    I hate what slashdot has become a bunch of people with opinions that aren't personally vetted and thought through. No one thinks, reads the article does additional research then comments with pertinent and thoughtful responses.

    1. Re:inflammatory no ? by LesFerg · · Score: 1

      I guess my main problem was with the wording. Saying this guy "fixed" an "injured" monkey is all just a little to sugar coated for my liking. Lets just say when we have prepared a specific test-case, so people who don't think things through so well can be made aware of the actual circumstances.

      --
      If I had a DeLorean... I would probably only drive it from time to time.
  19. NUCLEAR WAR Allows Paralyzed SCIENTISTS To Walk by WheezyJoe · · Score: 1

    Feh. Monkeys. Try mine-shafts filled with "stimulating" females for re-populating the Earth. No implants, gets 'em right on their feet.
    Mein Führer... I CAN WALK !!

    --
    Take it easy, Charlie, I've got an Angle...
  20. Because control by xarragon · · Score: 1

    Haven't you read the short story "Manna", at the end of which the protagonist gets taken to "paradise" (Australia) by beautiful women traveling in transparent, futuristic airplanes?
    Once in paradise you get your spinal cord cut and spliced with a remote-controlled implant, wirelessly connected to a central authority that monitors what you do. Whenever an infraction is detected, they just paralyze your body. It was a long time since I read it, but I think the author was sincere in his belief about this "paradise". As frightening as that seems.

    CAPTCHA: "locator"

  21. Once again bigotry and making fun of disabled by Anonymous Coward · · Score: 0

    Once again bigotry and making fun of the disabled is fine if you are a leftist.

    What Trump's calculated non-politically correct jibes demonstrated is the fundamental hypocrisy and hate that the left nurtures within its ranks.

    That is why many of us who voted for Obama TWICE, went for Trump this time. And not the criminal.

    Listen and Learn, or be doomed to lose over and over again.

  22. My brother is paraplegic so . . . by rhyous · · Score: 1

    My brother is paraplegic so, to me, this sounds freaking awesome.

  23. You know the evil plan. by Anonymous Coward · · Score: 0

    It happened.
    Surrender your thoughts.
    For state safety.