Slashdot Mirror


New Study Shows Marijuana Users Have Low Blood Flow To the Brain (eurekalert.org)

cold fjord writes: State level marijuana legalization efforts across the U.S. have been gaining traction driven by the folk wisdom that marijuana is both a harmless recreational drug and a useful medical treatment for many aliments. However, some cracks have appeared in that story with indications that marijuana use is associated with the development of mental disorders and the long-term blunting of the brain's reward system of dopamine levels. A new study has found that marijuana appears to have a widespread effect on blood flow in the brain. EurekAlert reports: "Published in the Journal of Alzheimer's Disease, researchers using single photon emission computed tomography (SPECT), a sophisticated imaging study that evaluates blood flow and activity patterns, demonstrated abnormally low blood flow in virtually every area of the brain studies in nearly 1,000 marijuana users compared to healthy controls, including areas known to be affected by Alzheimer's pathology such as the hippocampus. According to Daniel Amen, M.D., 'Our research demonstrates that marijuana can have significant negative effects on brain function. The media has given the general impression that marijuana is a safe recreational drug, this research directly challenges that notion. In another new study just released, researchers showed that marijuana use tripled the risk of psychosis. Caution is clearly in order.'"

22 of 560 comments (clear)

  1. Here come the science deniers by Anonymous Coward · · Score: 5, Interesting

    Interesting how science denial has a per-subject ideological bent.

    1. Re:Here come the science deniers by BitZtream · · Score: 5, Insightful

      On the contrary, I want to see real science on the subject. I want to know what the REAL dangers are.

      Unfortunately, the down side is that getting any real research on pot in the USA is pretty much impossible. If you give any hint that you don't INTEND to find something wrong with pot, good luck getting approval and funding for your study.

      If you want actual research on pot you have to leave the US. You'll find a different view in any country outside the US, so you have to approach any study in the US with very very high skepticism. I'm not saying its wrong, but you know its biased from the start, so you have to be careful to pick out the facts from the implications.

      When the people who make money off Alzheimer's studies start saying pot causes Alzheimer's type affects on the brain, you have to determine if thats true in any meaningful form or if its just another scary title to get more research money, or if its being promoted by others who don't want pot to be legal.

      Remember, legalized pot destroys MANY industries. The prison business is fucked in states that legalize pot, thats half their population right there. Illegal pot growers ... they don't want it legal either, and invest LARGE sums of money keeping it illegal, as silly as that might sound cause legalization kills their sole reason to exist. California, as an example, doesn't have legalized recreational pot because THE GROWERS DON'T WANT IT TO BE LEGAL, its not as profitable that way. Police in certain places don't care, so legalizing it would kill profit.

      I have no delusions about the dangerous side effects of inhaling smoke, but I would like some facts about what the end results are, from people who aren't biased by a preconception.

      I.E. I want real science, not bullshit spewed by people like you who have made up your mind before you even read the summary. You don't know what science is, you treat science like a religion.

      --
      Persistent Volume manager for Kubernetes - https://github.com/dwimsey/openshift-pvmanager
    2. Re:Here come the science deniers by jenningsthecat · · Score: 4, Insightful

      I agree with everything you said, but recommend caution with regard to the following:

      ... If you want actual research on pot you have to leave the US. You'll find a different view in any country outside the US, so you have to approach any study in the US with very very high skepticism. I'm not saying its wrong, but you know its biased from the start, so you have to be careful to pick out the facts from the implications...

      I would say that you have to approach any study ANYWHERE in the world with high skepticism. Yes, the US has a huge economic stake, (and the concomitant ideological stake), in proving the evils of pot. On the other hand, other jurisdictions have ideological stakes in proving pot's harmlessness. They also have economic stakes; for example, here in Canada where we're about to legalize pot, the government stands to make a lot of money from its controlled sale and distribution.

      I would say that the American government's position on marijuana has the same level of ignorance, fear, and fervor as the typical fundamentalist religion. That doesn't mean that other more liberal, more moderate countries are neutral and without agendas on this issue.

      --
      'The Economy' is a giant Ponzi scheme whose most pitiable suckers are the youngest among us and the yet-unborn.
    3. Re:Here come the science deniers by The+Real+Dr+John · · Score: 4, Insightful

      Agreed, and I expect that as more states legalize pot the more the opioid and alcohol industries will fund "studies" to show the horrible dangers of THC. Forget about the facts that alcohol and opioids kill tens of thousands of people each year in the US. Forget about all the traffic accidents and domestic violence tied to alcohol abuse. Everyone knows pot is safer than alcohol, opioids and tobacco. But that won't stop the research into the "dangers" of pot.

      --
      A brain is a terrible thing to waste... Mind? That's debatable.
    4. Re: Here come the science deniers by cayenne8 · · Score: 5, Insightful
      And how do these findings compare to the effects of alcohol on the brain and rest of the body?

      C'mon, a little common sense says that ANYTHING that alters consciousness likely isn't that good for the human body. But there is a trade off, for occasional use and enjoyment vs the potential harmful effects.

      It is YOUR body, the govt really shouldn't have a say in what you can do with it....

      --
      Light travels faster than sound. This is why some people appear bright until you hear them speak.........
    5. Re:Here come the science deniers by MrKaos · · Score: 4, Interesting

      I've been on opiates after spine surgery, I can't stand them. I discussed with my doctor that I use THC to control pain and happy to put me me onto a lower opiate dose. I had previous experience using it when I had to recover from achillies tendon snapped playing soccer (It was a fucking awesome goal though and the decider in the last minute).

      As I've been withdrawing from opiates I've been using THC to calm the symptoms that oscillate through many unpleasantries - sweating (like breaking a flu), headaches, nausea, waking up suddenly from not having my autonomous breathing working which really scares the shit out of me, clawing from inside my chest, weird emotions, it's taken almost 6 weeks to get this far. symptoms last from 3-6 hours twice a day. Almost there.

      I also experienced a head injury where it went the other way and my body simply rejected THC, I could not put that to my lips. My use of THC for pain control is much higher than my recreational use was and as I find myself healing I come to a point where I don't want it anymore and then I stop. The withdrawal symptoms are a few weeks of crazy dreams (which can be a little fun) headaches, moody.

      I can completely accept that there might be consequences for using THC as much as I accept them for alcohol for recreation. Tobacco kills, when used as directed but people can still choose that. It's so frustrating, like being treated like a child.

      If they legalise it maybe we can take it apart and find out what other things it is useful for and what the dangers are.

      --
      My ism, it's full of beliefs.
    6. Re: Here come the science deniers by Anonymous Coward · · Score: 5, Funny

      C'mon, a little common sense says that ANYTHING that alters consciousness likely isn't that good for the human body.

      Yoga. Meditation. Masturbation.

    7. Re:Here come the science deniers by cayenne8 · · Score: 4, Insightful

      And, we also have solid scientific evidence about the harmful and addictive nature of ethanol... coupled with a relatively recent social experiment showing what happens when you ban its distribution, sale and consumption nationwide.

      The marijuana ban has been longer term, and the repeal of the ban is more phased, and not yet complete, but it will be very interesting to see how history views the repeal of the marijuana ban 20 years after it happened, assuming current trends continue.

      I've often wondered, how that it took a constitutional amendment to prohibit alcohol in the US, and then ANOTHER constitutional amendment to repeal said alcohol prohibition....BUT it only took a few strokes of a pen for laws to ban other intoxicants, like pot????

      I wonder why no one has challenged the constitutionality of said "scheduling" of drugs and their prohibition?

      I've often wished we could get our presidents and politicians to chime in on that one....on camera, as a surprise question to see how they'd address that one.

      --
      Light travels faster than sound. This is why some people appear bright until you hear them speak.........
    8. Re: Here come the science deniers by ShanghaiBill · · Score: 5, Informative

      Since you love science so much, I'm sure you'll be willing to pay the 27.50 Euro fee to get a copy of the paper so that you can see all the details.

      If you love science, you will help fight for open access to all publicly funded research. If my tax dollars paid for the research, I shouldn't have to pay again to see the results.

    9. Re:Here come the science deniers by TheCarp · · Score: 4, Insightful

      More than that, even if you are not trying to do bad science, there is always incentive to report bad science. I saw a great example myself a while back, big headline about marijuana use increasing the risk of heart attack.....as a pot smoker I was concerned, so I dig in....

      First, it wasn't the main point of the study. Pot smokers made up a small portion of their study population. The overall study was good.

      So out of a study of many hundreds, the big headline was on a small sub-population of somewhere around 20 people. The main metric they used was how many hours it had been since a person last smoked.... 24 hours being the lowest.

      So basically.... a small number of pot smokers who had heart attacks before and had new ones, had them within 24 hours of smoking pot. Totally disregarding that if they had another heart attack at all, the likelyhood of it being within 24 hours of smoking was high, even if there is no connection.

      It wasn't even a large difference, it was a small anomaly from a small population.

      In the end, the result wasn't worth reporting, much less a headline, but reporting it like they did got their names int he paper and a big national headline.

      --
      "I opened my eyes, and everything went dark again"
    10. Re:Here come the science deniers by Qzukk · · Score: 4, Informative

      The original banning of cannabis was from The Marihuana Tax Act of 1937, where the government declared that any sold in the US had to have the appropriate tax stamp, and then did not print any tax stamps.

      This law review from 1968 covers a lot of the early cases such as how the supreme court decided whether or not American Indians can use drugs for their ceremonies and such, as well as somewhat-related cases like regulation of LSD under the Food, Drug and Cosmetic Act. It concludes that the most likely avenue for a successful challenge would be a freedom of religion argument, but would require an established religion to have a sincerely held belief in the use of cannabis specifically (as a person claiming to use it independently of a recognized, established religion for the religious/spiritual experience lost their appeal because they were held not to have a sincere belief requiring its use).

      --
      If I have been able to see further than others, it is because I bought a pair of binoculars.
  2. Re:No, just no by xtal · · Score: 5, Insightful

    Drugs are fun. That's why.

    You're going to die, I'm going to die, everyone dies from something. Life is about having fun.

    Drugs aren't for everybody, but people like drugs; treat drug abuse as a medical condition, not crime; that approach has failed.

    Alcohol, caffeine.. all drugs.

    You do what you want. Stop telling other people what's good for them.Live free (and die anyway).

    --
    ..don't panic
  3. Source of information is questionable by ebrandsberg · · Score: 5, Informative

    The Amen clinics have been accused of using questionable techniques (https://www.quackwatch.org/06ResearchProjects/amen.html and others, just google for information on them). This isn't to say that the data isn't true, but this result hasn't been confirmed by replication of the results by other researchers or more accurate scanning methods.

  4. selection bias and general quackery by Mr.+Slippery · · Score: 5, Informative
    The usual Reefer Madness bad science of prohibitionists:

    All data were obtained for analysis from a large multisite database, involving 26,268 patients who came for evaluation of complex, treatment resistant issues to one of nine outpatient neuropsychiatric clinics across the United States

    But "people with serious neuropsychiatric people who used cannabis have low blood flow to the brain" is both less clickworthy and less politically useful than "OMG pot rots yr brain!"

    And I love this: "As a physician who routinely sees marijuana users..." Yeah, that's called "a physician". Cannabis use is common, every physician has seen patients who has used it.

    Both Amen and this methodology are poorly regarded. He's in the addiction treatment industry -- look at this is an old marketing pitch of his quoted in a Quackwatch article:

    How your brain and soul work together determines how happy you feel, how successful you become, and how well you connect with others. The brain-soul connection is vastly more powerful than your conscious will. Will power falters when the physical functioning of the brain and the health of your soul fail to support your desires, as seen by illogical behaviors like overeating, smoking, drug and alcohol abuse, and compulsive spending.

    OHOH, Officials at major psychiatric and neuroscience associations and research centers say his SPECT claims are no more than myth and poppycock, buffaloing an unsuspecting public.

    --
    Tom Swiss | the infamous tms | my blog
    You cannot wash away blood with blood
  5. Re:Should be obvious to everyone by TheRealMindChild · · Score: 4, Insightful

    There is a reason we are particularly squeamish about handing out legal medicine that works on brain chemistry

    I don't think so, bud. Tell your primary physician that you don't feel like yourself and are depressed a lot, and they have ABSOLUTELY NO PROBLEM giving you a antidepressant/re-uptake inhibitor. Hell, they even perscribe such to help stop smoking. That is just antidepressants. Make your way to a psychiatrist and there is no end to the antidepressants, mood stabalizers, antipsychotics, benzodiazapines, etc not to mention drugs like depakote that not only treat seizures and mania, but also migraines. Do you like coffee? Do you know how caffeine "works on brain chemistry"? Get your agenda straight here

    --

    "When life gives you lemons, don't make lemonade. Make life take the lemons back!" -- Cave Johnson
  6. Re:No, just no by Maritz · · Score: 4, Funny

    You do what you want. Stop telling other people what's good for them.Live free (and die anyway).

    Yeah but they want to tell other people what's good for them. So you see their problem now.

    --
    I do not want your cheap brainburning drugs. They are useless for work. And I am a working man today.
  7. Does This Relate To Personal Drive? by kackle · · Score: 5, Interesting

    Anecdotal, I know, but the few marijuana users I have known had little drive in their lives (career, education, hobbies). I always wondered whether their personality type caused the use of marijuana or vice versa (or neither). I wonder if this study might explain that.

    1. Re:Does This Relate To Personal Drive? by jittles · · Score: 4, Insightful

      Anecdotal, I know, but the few marijuana users I have known had little drive in their lives (career, education, hobbies). I always wondered whether their personality type caused the use of marijuana or vice versa (or neither). I wonder if this study might explain that.

      My guess is their personality, but again my experience is just as anecdotal as yours. I only know a few people who went from smoking weed every day to full-blown pothead. And I know a few people who smoke every day but work incredibly hard. I have never personally tried the stuff, I've never had any inclination, but these kinds of studies should be taken with a grain of salt strictly because we allow people to legally drink alcohol, which is by all appearances far more deadly than marijuana, so why all the hate for people who want to smoke weed from time to time? Society deals with alcoholics, I suspect we can openly deal with potheads, too.

  8. Re:Should be obvious to everyone by Maritz · · Score: 4, Insightful

    The ban on marijuana in the US was, from day one, a completely ad-hoc political decision. It never had anything to do with the drug's effect on the brain. Ban alcohol before you talk about the disadvantages of marijuana legalisation with a straight face.

    --
    I do not want your cheap brainburning drugs. They are useless for work. And I am a working man today.
  9. Re:Don't let them do any research on alcohol! by tbannist · · Score: 4, Informative

    There are also some indications of health benefits of small intake, but they tend to not be conclusive.

    Actually, the "health benefits" have, may have been debunked and found to be systemic failures in the studies that originally found them. To put it simply, the drinking group in every test, by necessity, does not include anyone who no longer consumes alcohol due to health concerns, while the non-drinking groups may contain such individuals. This biases the health results on the non-drinking group in a negative manner. It seems when those participants who's health is compromised to the point where they no longer consume alcohol are excluded from both groups, the health benefits are either greatly reduced or vanish entirely.

    --
    Fanatically anti-fanatical
  10. Cannabis cured my stage-IV cancer by Anonymous Coward · · Score: 4, Interesting

    (Posted anonymously for obvious reasons)

    I was diagnosed 4 years ago with stage IV colon cancer. I did all the traditional treatments (12 rounds of intense chemo, 6 weeks of radiation daily coupled with an oral form of chemo, multiple surgeries, etc.). When it spread to my lungs I had yet more surgery (biopsies, which with lungs is major surgery), and more rounds of chemo. The tumors were at that point widespread, inoperable, and unresponsive to the chemo that was otherwise killing me. Finally my oncologist agreed I had to stop chemo or die, and I was given less than six months to live.

    I did 5 months of intesnse Rick Simpson Oil treatment (http://phoenixtears.ca/), mostly because my wife wanted me to not give up and there really was nothing left to try. I didn't expect it to work, and if my wife and my oncologist hadn't both been encouraging me to give it a go, I wouldn't have. It was a miserable experience, being "beyond high" for more than five months (because of the damage 18 rounds of chemo had done, it took 150 grams rather than the 60 it usually takes).

    But, I've now had three scans that show the cancer is GONE, I am in complete ("full") remission. The nodules throughout my lungs are dead, there is no sign of other cancer anywhere in my body, and in a few months, if it continues, I go from full remission to officially cured.

    By marijuana.

    If this were widespread, it would spell the end of several lucrative pharma industries. Oh, by the way, my oncologist admitted that they're required to sign numerous contracts forbidding them from mentioning any treatments other than chemo, radiation, surgery, or hospital-approved drug trials to any patient, and even though more and more of them are aware of the curative value of cannabis oils (especially in the palliative care area where they've given up all hope, and people are going into full remission), they are forbidden from telling their patients.

    Unfortunately stories like mine are all anectdotal. The FDA absolutely refuses to consider any study that might indicate a curative value for marijuana. And guess who's running the FDA these days ... yup, that's right. Big Pharma insiders.

    Until politics gets out of the way of science, and stops preventing research, there will be no true science on this subject (in the United States anyway). Meanwhile opioids are approved for widespread use on the basis of one article,written by a Big Pharma employee, claiming with no evidence, and no peer review. that opioids are "non-addictive," and how the rest of the industry pounces on that, cites it, and pushes their agenda forward. Funny how big pharma has such a ridiculously low bar for their "science," while real cures for numerous severe deseases, including most late-stage cancers, are held to an impossible standard ("prove it, but we won't allow any studies!") and then dismissed as "not scientific."

    I'm alive today because of cannabis, specificlly highly concentrated cannabis oils. Hopefully someone out there who needs it will read this, and not be dissuaded by those wh will no doubt quote doctrine (with no evidence of their own), dismissing this amazing medicine.

  11. Legalization not about absolute safety by swb · · Score: 4, Insightful

    This is just another attempt to define, in threatening terms, another risk for smoking marijuana. We already *know* that smoking marijuana isn't risk free and for some people can be even riskier.

    But all of this is a distraction -- marijuana prohibitionists want, and actually need, the debate for legalization to be oriented around the *safety* of marijuana use, both demanding an artificial high standard of safety not applied to other substances and trying to demonstrate unique and insidious risks from marijuana use.

    But this isn't really what legalization should be about. We have ample scientific and more importantly, long-term public use, evidence of the relative safety of marijuana. The debate about legalization is about the *failed* nature of criminal prohibition as public policy. Prohibition has been an utter failure, costing trillions of dollars, sacrificing civil liberties, poisoning the relationship between the police and the public, discrediting public health warnings on more dangerous drugs, and all the the while totally and utterly failing to deliver anything remotely resembling the elimination of marijuana use.

    It doesn't work. It costs a fortune. Trying to make it work erodes civil liberties. Nobody believes anyone who spins scare stories about marijuana. Prohibition of marijuana is one of the worst public policies advanced by every possible measure.