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Vitamin D Deficiency During Pregnancy Linked To Autism (newatlas.com)

New submitter future guy quotes a report from New Atlas: The researchers examined around 4,200 blood samples from pregnant women and their children and discovered a link between autism and low levels of vitamin D. More specifically, they found that pregnant women who were vitamin D deficient at 20 weeks gestation were more likely to have a child with autistic traits by the age of six. Rather than taking in more sunlight and the heightened risk of skin cancer that it carries, the researchers suggest that making inexpensive and safe vitamin D supplements available to at-risk groups may be a better path forward. "This study provides further evidence that low vitamin D is associated with neurodevelopmental disorders," says Professor John McGrath from the University of Queensland. "Just as taking folate in pregnancy has reduced the incidence of spina bifida, the result of this study suggests that prenatal vitamin D supplements may reduce the incidence of autism." The research was published in the journal Molecular Psychiatry.

29 of 216 comments (clear)

  1. Re:Shots by Anonymous Coward · · Score: 2, Funny

    That's the recipe for Aspergers!

  2. Where is the news? by quenda · · Score: 4, Interesting

    Where is the news?
    This seems to just confirm previous data, which is important to researchers, but not that interesting to the public.

    The vitamin-D hypothesis has been around for years. It would be interesting if a causal link, or treatment, could be demonstrated,
    e.g. a randomised placebo controlled trial of supplements during pregnancy. But there seems to be none of that yet.

    1. Re:Where is the news? by jandersen · · Score: 5, Informative

      Where is the news?
      This seems to just confirm previous data, which is important to researchers, but not that interesting to the public.

      Well, this is how science works. Overall, it is extremely rare to make astounding, new discoveries; most scientific research is about confirming what we already know or improving our observations - even the Higgs boson was just a confirmation of what we already knew, really. It is easy to get the idea that all science is making sensational finds, if you only read the popular science stuff, and it gives you the completely wrong picture. Important science is mostly routine. It has to be - the scientific method dictates that you must keep testing, because the only certainty you can achieve lies in falsifying predictions. That is why there still are people who keep finding new ways of testing that gravity still works as predicted; next time it might not - that is of course taking it to the extreme, but it is scientifically very valid to keep asking the question.

      The vitamin-D hypothesis has been around for years. It would be interesting if a causal link, or treatment, could be demonstrated, e.g. a randomised placebo controlled trial of supplements during pregnancy. But there seems to be none of that yet.

      I think you are getting things mixed up a bit. Randomised trials are meant specifically for testing the efficacy of new medicines. The method would work for vitamin D, of course, but it would be ethically unsound to deliberately expose groups of people to the well-documented risks that this deficiency would cause, and it would be extremely difficult to control the parameters, I think; you get vitamin D from many sources, such as exposure to sunlight, and you would have to keep large groups of pregnant women confined indoors for 9 months, and so on. Can't be done practically.

      But it isn't really necessary. Firstly, I think we have confirmed that the correlation is real, not spurious, so presumably we now have a confirmed pattern of vitamin D deficiency correlating to a certain increase in the risk of developing autism. Secondly, other research seems to point to plausible mechanisms - we know something about what goes on in an autistic brain, and we know that vitamin D probably plays an important role in the development of certain features that appear to be important in connection with autism.

      But you are right, this is not a surprising, new discovery; we are simply inching closer to understanding how autism develops.

    2. Re:Where is the news? by Ol+Olsoc · · Score: 3, Insightful

      Bullshit, with a large enough cohort, and without telling them it's vitamin D just a new drug, you would have baseline control probably close enough to the average rate of autism that you could discern any potential benefits from vitamin D. That assumes, of course, that this report itself doesn't spur a large amount of mothers to start taking large vitamin D supplements, thus changing the average prior to any trials if the link actually exists.

      Its rather amusing that a person who calls bullshit is so full of it.

      You weren't by any chance involved in the Tuskegee syphilis experiments were you?

      And just how many experimental trials were you involved in?

      This isn't the 1940's any more. Any medical experimentation is subject to ethical review, and before you get to even start the experiment. There is absolutely no way that a trial that involves purposefully causing a vitamin deficiency in a selected group will ever make it through an ethics review.

      Sorry Dr Mengele, you can't do your twin vivisection experiments any more.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    3. Re:Where is the news? by Ol+Olsoc · · Score: 4, Informative

      It would be 'ethical' to find a population that's already deficient, then supplement half of them.

      Okay, let me give you a few cites so that you know where I'm coming from.

      https://sciencebasedmedicine.o...

      There was a time when we had a pretty awful approach to medical experimentatino on humans. The Tuskegee syphilis experiment is one of the worst examples. There was another STD experiment called the Guatamalan syphilis Experiment. And by the way, given the nature of the experiments, good luck in getting cooperation from dark pigmented people as they have a well earned distrust of medical experimentation. And Black women in northern climates are probably the number one risk group.

      You will probably really stand up for the experiments on children during the mid-1960's At the Willwbrook State School in Staten Island, a school for the mentally deficient, they intentionally injected children with Hepatitis in order to see if Gamma Globulin could cure it. That's pretty sweet and kindly.

      http://ethics.iit.edu/eelibrar...

      Anyhow, they rationalized it by declaring that since so many of the children became infected with Hep, it wasn't a big deal. Oddly enough, it was never made clear why they didn't test Gamma Globulin on the children who already contracted hepatitis.

      In 1948 REsearchers gave over 800 pregnant women "vitamin drinks" that contained radioactive iron to examine the placental/ mother's blood transfer. At the Massachusetts based Walter E. Fernald State School, the AEC and Quaker Oats performed a experiment of given them oatmeal with radioactive Calcium in it to track digestion of Calcium. The students were told they were joining a science club.

      There are a lot more, but when these abuses - and I seriously hope you would also consider them abuses, a lot of ethical concerns, and eventually ethics committees and regulations came into existence.

      While there might be some clandestine stuff still going on, any program such as one that is aimed at studying autism causes is going to be closely studied for three reasons. One is that it's an obvious one, to possibly help children avoid becoming autistic. The second one is that it involves mothers and children at all, so it will have ahigh priority. The thirs is a bit of an embarrassment, because people who for some reason are heavily invested in the belief that vaccines cause autism, will want to debunk the experiments in any way possible. If you don't believe me, just look at what happened when they removed the original "cause of autism" th emerthiolate from vaccines, and it had no effect. So without any proof, the anti vaxxers just decided it was "something else".

      Test it with existing data. If it's true, populations more likely to be vitamin D deficient (darker skins at higher latitudes) will already have higher autism rates. Do black folks in Chicago have higher autism rates than in the south? (Where we know the population migrated from, mostly less than 100 years ago.)

      Data will be called racist, so compare dark skinned folks at different latitudes.

      Good luck with African descent people to agree with any test like you suggest. They don't trust the medical profession in that way, and they have a good reason not to.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
  3. Another possibility by Anonymous Coward · · Score: 2, Interesting

    1. Autism is primarily genetic

    2. Autistic individuals seem to have real problems metabolizing some vitamins and minerals from food. Vitamin B-12 is one well-known example... basically, autistic individuals aren't able to adequately metabolize forms like cyanocobalamin into something that can cross the blood-brain barrier, but giving them injectable methylcobalamin (which CAN cross the BBB) can reduce some symptoms of autism by giving their brain access to a vitamin it would otherwise be deficient in.

    3. By extension of 1 and 2, aspie mothers might show vitamin D deficiencies and, for reasons completely independent of their own vitamin D deficiency, be more likely to have kids who are themselves on the autism spectrum.

  4. Re:Autistic People Not Needed by brantondaveperson · · Score: 5, Insightful

    No, you look after them for the rest of their lives, just like any responsible society does for those not able to look after themselves.

  5. Re: Tell mom's to drink their milk. by TheConway · · Score: 4, Insightful

    Maybe something crazy like taking inexpensive vitamin D pills

  6. And schizophrenia. by nbritton · · Score: 5, Interesting

    Don't forget schizophrenia too. Vitamin D3 deficiency (Calcitriol) is why black mothers who give birth in winter months have a significantly high percentage of having a child that develops schizophrenia. D3 has a strong catalytic effect on glutathione production in the brain (PMID 10428085), and without adequate glutathione the body will not have a way to control reactive oxygen species. This oxidative stress then irrevocably damages the brain during fetal development and you end up with a wide range of problems down the road like Autism and mental health problems.

    Also don't forget that the half-life for the active metabolite of vitamin D is on the order of 21 days. That means it takes about 5 months to reach steady state. One of the best advice I can recommend is that all pregnant women take at least 2,000 IU of D3 per day, with a 21 day 4,000 I.U. loading dose.

    1. Re:And schizophrenia. by jbmartin6 · · Score: 4, Informative

      Where is the racism? Africans synthesize a less D than Europeans, it's a particular problem in the winter with a lot less sun exposure.

      --
      This posting is provided 'AS IS' without warranty of any kind, implied or otherwise.
    2. Re:And schizophrenia. by Ol+Olsoc · · Score: 2

      It affects all mothers, but black mothers more. Scientific research supports that conclusion. I'll admit it was odd in this context to single out black mothers in the GP's comment (the schizophrenia link to vitamin d deficiency was the interesting part), but you'll have to provide an argument as to why it's racist.

      Good grief! The issue is race based, but it surely isn't racist.

      It all has to do with skin pigmentation. Groups who evolved in areas with a lot higher sun exposure were capable of generating enough vitamin D from insolation. When they move to an area with a lot less insolation, they tend to have trouble generating enough Vitamin D.

      I caught a report on NPR that noted that people with dark pigmentation (note this can be either African or Indian) living in a northern city like Detroit, Michigan cannot create enough Vitamin D metabolically from solar exposure, and should always take supplements.

      Conversely, people who are predominantly light skin will often have problems when living in tropical or sub tropical areas. In this case, their skin has difficulty handing the increased insolation.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    3. Re:And schizophrenia. by MattskEE · · Score: 2

      There is a world of difference between bias based on prejudice and scientific observation based on fact.

      The truth is there are certain medically significant differences between races. In this case, the increased skin melanin in black individuals is well known to lead to increased incidence of Vitamin D deficiency, which can be linked with certain other problems. Also people of Asian decent are more likely to be lactose intolerant. There are probably more differences but these are commonly known ones.

      It doesn't mean that we practice eugenics, it means we study the problem and try to help everybody be as health as they can be. One treatment does not fit all. If some groups of people are more susceptible to certain health problems then those specific problems should be addressed.

    4. Re:And schizophrenia. by Ol+Olsoc · · Score: 2

      That being said, it is kind of a misnomer, it seems like there should be better ways of accurately speaking about genetic profiles that are tied to specific geographic origins.

      Which is why I try to refer to it as skin pigmentation. Because you don't have to be African to have a lot of melanin.

      After all I there are quite a few 3rd and 4th generation African's of European descent.

      Race is an entirely made up construct , it just doesn't exist and the sooner everyone starts acting that way the better off we will all be.

      But there are important issues of genetics involved, many people of African descent and some Mediterraneans have a genetic profilee that allowed them to be resistant to Malaria. Obviously a good evolutionary trait in an area where Malaria is common. However, it also leaves them susceptible to Sickle cell anemia. Now My ass is so lily white that no one owuld ever consider testing me for SSA. So I would disagree that race is an artificial construct.

      You can't just say that race doesn't exist. Well you can, but you'd be throwing away a lot of genetic variations like Vitamin D shortages, sickle cell anemia, melanoma and other issues that have life and death implications. Knowledge and acknowledgement of these things does not equalte to racism.

      This isn't to say that there aren't stupid preconceptions. I was listening to a woman being interviewed on NPR sometime this past year She was of Kenyan descent, but lived in Germany. The woman interviewing her asks her how she felt about some issue as an "African American" A couple second delay, then the woman answered " I'm not certain how to answer that, because I'm a German".

      It was hilarious to listen to the interviewer stumble all over herself for a while.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
  7. 3-4X autism in Somali immigrant childern in Sweden by Anonymous Coward · · Score: 5, Interesting

    This is consistent with studies going back to the late 1990's.

    https://www.scientificamerican.com/article/vitamin-d-and-autism/

    >... Swedish researchers published a study in Developmental Medicine and Child Neurology that found the prevalence of autism and related disorders was three to four times higher among Somali immigrants than non-Somalis in Stockholm. The study reviewed the records of 2,437 children, born between 1988 and 1998 in Stockholm, in response to parents and teachers who had raised concerns about whether children with a Somali background were overrepresented in the total group of children with autism.
    >
    > In Sweden, the 15,000-strong Somali community calls autism "the Swedish disease," says Elisabeth Fernell, a researcher at the Karolinska Institute in Stockholm and a co-author of the study.

      In Minnesota, where there are an estimated 60,000 Somali immigrants, the situation was quite similar: There, health officials noted reports of autism among Somali refugees, who began arriving in 1993, comparable to those found in Sweden. Within several years of arrival, dozens of the Somali families whose children were born in the U.S. found themselves grappling with autism, says Huda Farah, a Somali-born molecular biologist who works on refugee resettlement issues with Minnesota health officials. The number of Somali children in the city's autism programs jumped from zero in 1999 to 43 in 2007, says Ann Fox, director of special education programs for Minneapolis schools. The number of Somali-speaking children in the Minneapolis school district increased from 1,773 to 2,029 during the same period.

  8. Re:Autistic People Not Needed by ShanghaiBill · · Score: 5, Informative

    No, you look after them for the rest of their lives, just like any responsible society does for those not able to look after themselves.

    Many of them can look after themselves, especially if they get some help to get started. In America, 80% of autistic people are not employed. But with coaching, and targeted help, most autistic people are employable. Some countries do a far better job of this than others. The Economist recently had an article about the effectiveness of education and employment policies for autistic people.

  9. Re:So what about peoples who live at the poles? by ShanghaiBill · · Score: 2

    Presumably peoples who live at the extreme latitudes near the poles, who would get a lot less sunlight in winter, would have a seasonally higher incidence of autism?

    People who live near the poles tend to each a lot of oily fish that have a plenty of vitamin D.

  10. Re:Autistic People Not Needed by Anonymous Coward · · Score: 2, Interesting

    As an autistic person I find your comment far more offensive and ignorant than the obvious flamebait above it. Autistic people who cannot take care of themselves are a minority of a minority of a minority.

  11. Re:And this is why blacks... by ShanghaiBill · · Score: 4, Informative

    Physics was not one of your best subjects in high school, was it?

    Melanin make skin dark, and does indeed cause more light to be absorbed, but the light is absorbed before it generates vitamin D. People with darker skin living in northern climates are more likely to be vitamin D deficient.

  12. Re: Tell mom's to drink their milk. by thegarbz · · Score: 5, Insightful

    Because the amount of vitamin D available in food sources is piss poor in general. The effective natural way to get it is to go on the sun. This has orders of magnitude more effect than diet.

  13. Re: Autistic People Not Needed by ChristW · · Score: 2

    Not everyone with autism is an 'antisocial nerd' that's living in the gutter, thank you very much. People with autism may be even more productive in some areas than neurotypical people.

    --
    09 F9 11 02 9D 74 E3 5B D8 41 56 C5 63 56 88 C0
  14. Re:MMR Virus by mrbester · · Score: 4, Informative

    And the vaccine contains mercury...

    Oh wait, both those statements are bollocks.

    --
    "Wait. Something's happening. It's opening up! My God, it's full of apricots!"
  15. Re:Autistic People Not Needed by Anonymous Coward · · Score: 2, Funny

    Eventually, the Market will sort all that out. People with autism will choose to be born in countries that have better public health care, which will bankrupt themselves by subsidizing the weak and useless. America will become greater by not having so many autistic people born here. Of course, once they're born, we won't let them in, unless they can get an H1B visa.

  16. Re: Tell mom's to drink their milk. by NoNonAlphaCharsHere · · Score: 3, Informative

    There's plenty of sunlight on Vega, so, problem solved.

  17. Re: Tell mom's to drink their milk. by Anonymous Coward · · Score: 2, Funny

    Have you noticed how civilizations in history have most of the time been located near waters abundant in fish?
    Did you know fish is very important for health, especially for the health of our brains?
    Have you wondered what would happen to a human population where fish is all but cut out from their diets?
    Why people living inland away from seas, lakes and great rivers seem stupider on average?

    Yes, I have noticed this. Thankfully, those advanced Polynesian islanders will use their advanced techno-wizardry to bring their fishy goodness to backward, impoverished places like Switzerland in the near future.

  18. Re:Autistic People Not Needed by Anonymous Coward · · Score: 2, Funny

    Well, as an austenitic person I find your sub-912C body temperature and non-FCC crystal structure to be disturbing and unnatural.

  19. Re: Tell mom's to drink their milk. by Rei · · Score: 2

    What "people living inland away from seas, lakes and great rivers"? The reason you see populations of people near bodies of water is because water is essential for life, not because it contains fish. Ancient Egyptian civilization was by the Nile because its floods provided water and nutrients to their crops, not because some lack of fish would have transformed them into blithering idiots. Same with Mesopotamia. Same with the Indus valley. Same with the early Chinese civilizations.

    --
    Sometimes I doubt your commitment to Sparkle Motion.
  20. Re: Tell mom's to drink their milk. by Maritz · · Score: 2

    Given that you think eating fish is directly linked to being smart, I'm assuming you're from an inland region.

    --
    I do not want your cheap brainburning drugs. They are useless for work. And I am a working man today.
  21. Taking supplements insufficient by laughingskeptic · · Score: 2

    Blood draws are required to measure efficacy. For instance, most vitamin D supplements did not improve my wife's vitamin D levels. Science requires measurement and the science people should care the most about is the science of their own health. Doctors telling patients to take supplements without follow up are poor practitioners of medicine.

  22. All I can think of... by ilsaloving · · Score: 2

    Reading this, all I can think of is how much sooner would we have figured this out if we hadn't wasted millions of man-hours and 10s of millions of dollars fighting against all the anti-vaccine idiocy.