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Woolly Mammoth On Verge of Resurrection, Scientists Reveal (theguardian.com)

An anonymous reader quotes a report from The Guardian: The woolly mammoth vanished from the Earth 4,000 years ago, but now scientists say they are on the brink of resurrecting the ancient beast in a revised form, through an ambitious feat of genetic engineering. Speaking ahead of the American Association for the Advancement of Science (AAAS) annual meeting in Boston this week, the scientist leading the "de-extinction" effort said the Harvard team is just two years away from creating a hybrid embryo, in which mammoth traits would be programmed into an Asian elephant. "Our aim is to produce a hybrid elephant-mammoth embryo," said Prof George Church. "Actually, it would be more like an elephant with a number of mammoth traits. We're not there yet, but it could happen in a couple of years." The creature, sometimes referred to as a "mammophant," would be partly elephant, but with features such as small ears, subcutaneous fat, long shaggy hair and cold-adapted blood. The mammoth genes for these traits are spliced into the elephant DNA using the powerful gene-editing tool, Crispr. Until now, the team have stopped at the cell stage, but are now moving towards creating embryos -- although, they said that it would be many years before any serious attempt at producing a living creature.

34 of 169 comments (clear)

  1. Why not go the whole nine yards? by muecksteiner · · Score: 4, Interesting

    The only bit I don't quite understand is why they don't piece together some completely mammoth DNA, and try to grow that in an artificial uterus? What would the additional complications be, beyond hacking together an elephant-mammoth hybrid like they propose?

    1. Re:Why not go the whole nine yards? by WindBourne · · Score: 4, Interesting

      mammoth DNA is pretty badly broken up. Chances are they are going to use these hybrids as models to figure out which genes of the mammoth cell lineage is viable.

      --
      I prefer the "u" in honour as it seems to be missing these days.
    2. Re:Why not go the whole nine yards? by umafuckit · · Score: 2

      The only bit I don't quite understand is why they don't piece together some completely mammoth DNA, and try to grow that in an artificial uterus? What would the additional complications be, beyond hacking together an elephant-mammoth hybrid like they propose?

      I think because there is no confidence that we have an error-free mammoth genome. So it seems much more likely that modifying the elephant genome will yield success.

    3. Re:Why not go the whole nine yards? by thinkwaitfast · · Score: 2

      Maybe because artificial uteruses don't exist yet?

    4. Re:Why not go the whole nine yards? by jandersen · · Score: 3, Informative

      As others have already said, we don't really have a whole, undamaged genome for a mammoth, but an artificial uterus is technologically still very far beyond our capabilities. The only option is to implant the fetus in an existing animal, in which case there may be compatibility issues - the fetus has to be a reasonably close match to the mother, immunologically speaking. A hybrid may be close enough for it to be feasible, and perhaps it is possible to get closer and closer to 100% mammoth by adding more and more for each generation, who knows.

    5. Re:Why not go the whole nine yards? by Quakeulf · · Score: 5, Funny

      You mean why not make a wholly wooly mammoth?

    6. Re:Why not go the whole nine yards? by dreamchaser · · Score: 2

      It still begs the question. Why? It's a waste of money and resources that could be focused on actually contributing to society. "Because we can" is not a good justification.

    7. Re:Why not go the whole nine yards? by religionofpeas · · Score: 5, Funny

      mammoth DNA is pretty badly broken up

      Just use some frog DNA to fix the bad parts.

    8. Re:Why not go the whole nine yards? by dbIII · · Score: 3, Insightful

      Oh yes, the end of Science. Thank you Lord Kelvin.
      For one thing we still don't have a clue how owls fly so silently but there are some people working on it with very simplified wing models, so relatively simple stuff from the world around us is still outside our grasp without a lot of time, effort and dead ends. The idea of "that if we throw enough money at something we can make virtually anything we want" is an incredibly toxic cargo cult piece of shit that you should cure yourself of if before it backfires on you (that's if it wasn't an attempt at a joke). I've met people that disconnected from reality and they kept lurching from one fuckup to the next.
      Dreaming is great, taking fantasy from granted not so much.

    9. Re:Why not go the whole nine yards? by Deadstick · · Score: 2

      Ooo, yeah, let's see them do that right. Here's your spear, here's your rock...now you stand over here with the long spear. Plant the end right there...

    10. Re:Why not go the whole nine yards? by Kierthos · · Score: 2

      Didn't you ever listen to that song by Loverboy?

      Frog and mammoth DNA just won't splice.

      --
      Mr. Hu is not a ninja.
    11. Re:Why not go the whole nine yards? by Enigma2175 · · Score: 4, Insightful

      Really? There have been instances of almost intact mammoths being found in receding glaciers, how bad does DNA get degraded from freezing? Heck, in this find blood was actually flowing out of the carcass as it thawed. If we can sequence the neanderthal genome using much older samples I don't see a reason we couldn't sequence the much more recent mammoth genome.

      --

      Enigma

    12. Re:Why not go the whole nine yards? by greythax · · Score: 2

      First of all, bullshit: https://asknature.org/strategy... And secondly, it is really odd that you choose something like an owl wing to base your scientific musings off of, rather than the fantastic examples of us throwing enough money at something and figuring it out, such as nuclear weaponry or traveling to the moon. Money = resources. If you throw enough resources at science, you will indeed see results. The vast majority of scientific achievements have been from people who knew what they wanted to do and kept plugging away at it until they made it happen. Eureka moments are very rare in the grand scheme of things.

  2. Re:Mammoth steak, vat-grown by fustakrakich · · Score: 2

    When do we get our brontosaurus burgers?

    --
    “He’s not deformed, he’s just drunk!”
  3. Hardly by nospam007 · · Score: 2

    As I read ion all the other articles, the result will be a hairy elephant with a beard, that's all.

    1. Re: Hardly by cyber-vandal · · Score: 4, Funny

      So the pachyderm version of a Unix sysadmin

  4. Re:wonder why asian elephant? by geantvert · · Score: 5, Informative

    The answer is likely in there: http://news.nationalgeographic...

    The relevant bit is "At that time African elephants branched off first. Then just 440,000 years later, a blink of an eye in evolutionary time, Asian elephants and mammoths diverged into their own separate species."

  5. Re:All fun and games by Black+Parrot · · Score: 4, Funny

    until they break out of their cages and go berserk.

    But if you survive you can write your memoirs and they'll make it into a major motion picture.

    --
    Sheesh, evil *and* a jerk. -- Jade
  6. Re:how selfish, how unethical by Black+Parrot · · Score: 2

    Zoo? The scientists are going to *eat* it!

    --
    Sheesh, evil *and* a jerk. -- Jade
  7. First to go extinct twice? by Anonymous Coward · · Score: 2, Funny

    National Geographic reported that extinction rates are 1,000 times faster due to human activity[1]. So I predict that the woolly mammoth will be the first species to go extinct twice. #f1RST

    [1]: http://news.nationalgeographic.com/news/2014/05/140529-conservation-science-animals-species-endangered-extinction/

  8. Re:vanity project by religionofpeas · · Score: 4, Insightful

    Different people, different interests. If you would rather help existing species, go right ahead.

  9. Re:Not to be egotistic, but... by Anonymous Coward · · Score: 3, Insightful

    It's news for NERDS dude. If you don't think this is at least interesting you can hand in your nerd card.

  10. Re:All fun and games by Applehu+Akbar · · Score: 2

    until they break out of their cages and go berserk.

    A good place for Pleistocene Park would be one of those large uninhabited islands off the Siberian coast. It would promote tourism in a region that badly neeeds it.

  11. Great idea by kbg · · Score: 2

    Hey I have an idea. Why don't we create a park on an island...we could call it Jurassic Mammoth Park or something...where mammoths roam free and you could go on safari tours to see them. What could possibly go wrong with that.

    1. Re:Great idea by religionofpeas · · Score: 2

      Will it have Unix system? I ask because I know those.

  12. Re:how selfish, how unethical by Anonymous Coward · · Score: 2, Funny

    Not that unethical - just a necessary step towards merging electric eels with sharks. How else are they going to power the lasers?

  13. Stupid naming by famebait · · Score: 4, Funny

    The creature, sometimes referred to as a "mammophant,"

    Way to waste an opportunity.
    "Heffalump" FTW!

    --
    sudo ergo sum
  14. Re:Mammoth steak, vat-grown by tepples · · Score: 2

    Not on Sundays.

  15. Re:Not to be egotistic, but... by robinsonne · · Score: 2

    I'd rather read about genetic modifications of mammoth DNA and elephants to try to reintroduce a species than see yet another phone/tablet/phablet story personally.

    There's more to be geeky about than just programming languages. Biology is cool. CRISPR is cool (and slightly scary).

    But ok, lets talk about how awesome vi is. Emacs is for losers. Am I doing it right?

  16. CRISPR for the masses by mi · · Score: 4, Informative

    Why? It's a waste of money and resources that could be focused on actually contributing to society.

    The technique they are using — CRISPR — is what we just discussed as applicable to humans. If splicing mammoth into elephant yields a viable organism, some day it may be possible to splice useful features of Neanderthals and other extinct human species, or even apes into humans — yielding strength, resistance to diseases, or adaptability to uncomfortable conditions (think Antarctica or even Mars).

    Eugenics became a dirty word because of Nazis, who would improve humanity by killing off the "degenerates". But there is nothing wrong with improving the human stock per se... For example, Heinlein in "Beyond This Horizon" describes a society, where this was done successfully — while also explaining, how it can be done (very) wrong as well.

    --
    In Soviet Washington the swamp drains you.
    1. Re:CRISPR for the masses by Oswald+McWeany · · Score: 2

      That's an interesting thought- I hadn't thought of giving humans genes for cold-hardiness, but certainly, even beyond increased Mars/Antarctica survivability, cold-resistant humans would require less energy costs in deep space exploration. If we ever got advanced enough to send a ship off to another star system, having humans that have lower energy requirements could allow us to send more humans further.

      --
      "That's the way to do it" - Punch
    2. Re:CRISPR for the masses by mi · · Score: 2

      it's just a story

      It still provides a lot more details — and answers a lot more questions — than a Slashdot post can be expected to. If it is Ok to outline one's vision of solution in the latter, it is certainly Ok to refer people to the former. As I did...

      Sure, it is "just a story", but until such things are implemented for real, all discussions will have to deal with the hypotheticals.

      --
      In Soviet Washington the swamp drains you.
  17. Re:wonder why asian elephant? by T.E.D. · · Score: 2

    That's very interesting. Among other things, it implies that Mammoths and Asian elephants are closer related to each other than either is to African elephants (but not by much).

    Another way of putting this is that its probably more accurate to consider Mammoths as just another species of Elephant.

    There used to (in historic times) be another relatively small North African Elephant species (Hannibal used them in his war with Rome), that is also now extinct. There were quite recently lots of island-based pygmy elephants and pygmy mammoths too. If you could bring back a Mammoth, those might be equally recoverable.

  18. Asian elephants are endangered by Nkwe · · Score: 2

    While the science around this is indeed interesting, there are ethical questions beyond just those involved with gene editing. Specifically around if it is appropriate to risk reduction of one endangered population of animals to attempt to revive an extinct one.