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Belgian Scientists Inhibit Protein Responsible For Allergic Reactions (ugent.be)
lhunath writes: Scientists at the University of Gent exposed the TSLP protein's function in triggering allergic reactions such as asthma and eczema. The team then developed a protein-based inhibitor used to capture TSLP and prevent its bioactivity as it associates with its natural receptors. Using this method, allergic reactions can be inhibited before they are triggered.
The team's results were recently published in Nature, where they share a vision that their work "will guide therapeutic approaches that manipulate human TSLP-mediated signalling to treat allergic diseases."
The team's results were recently published in Nature, where they share a vision that their work "will guide therapeutic approaches that manipulate human TSLP-mediated signalling to treat allergic diseases."
I am not on this study but it is a close colleague of mine (in the same lab) that has made the TSLP trap. It is NOT an antibody. Basically, he fused the extracellular parts of the receptor and the co-receptor into a single fusion protein, which binds TSLP very efficiently and does not release it for a very long time. This recombinant protein can be produced in large quantities, so the production costs will especially depend on the manufacturing standards for biologicals The "golden standard" benchmark that they compare their fusion protein TSLP trap with is an antibody though.