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Diet Sodas May Be Tied To Stroke, Dementia Risk (cnn.com)

Gulping down an artificially sweetened beverage not only may be associated with health risks for your body, but also possibly your brain, a new study suggests. From a report: Artificially sweetened drinks, such as diet sodas, were tied to a higher risk of stroke and dementia in the study, which published in the American Heart Association's journal Stroke on Thursday. The study sheds light only on an association, as the researchers were unable to determine an actual cause-and-effect relationship between sipping artificially sweetened drinks and an increased risk for stroke and dementia. Therefore, some experts caution that the findings should be interpreted carefully. No connection was found between those health risks and other sugary beverages, such as sugar-sweetened sodas, fruit juice and fruit drinks.

40 of 223 comments (clear)

  1. Huh? What? by Frosty+Piss · · Score: 5, Insightful

    the researchers were unable to determine an actual cause-and-effect relationship between sipping artificially sweetened drinks and an increased risk for stroke and dementia

    In other words, the headline is worthless click-bait. This is not a "study", it's a statistical analysis of a database set that proves nothing at all by itself.

    --
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    1. Re:Huh? What? by networkBoy · · Score: 5, Interesting

      Which sweetener was tested?

      IIRC aspartame was initially developed to be a drug for alzheimer's... but it was noticed that it tasted sweet, so it was marketed as an artificial sweetener.
      which... Kinda lends credence to this story.

      What about sucralose?
      Or Sodium saccharin?

      -nB

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    2. Re:Huh? What? by Anonymous Coward · · Score: 3, Insightful

      I understand how science is done. I also understand that while this suggests an appropriate avenue for further research, it's essentially meaningless by itself. Sure, green jelly beans may cause acne. But probably not. (Google if you don't get the reference but if you don't, what the hell are you doing reading this web site?)

    3. Re:Huh? What? by sinij · · Score: 5, Interesting

      Obligatory: https://xkcd.com/882/

    4. Re:Huh? What? by BarbaraHudson · · Score: 2

      Why take the possible risk? Diet soft drinks taste like crap if you haven't had one for a few weeks, and they may make you stupid. Regular soft drinks definitely make you fat.

      Mind you, if you get dementia, you won't give a shit. Pick your poison.

      --
      "Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
    5. Re:Huh? What? by Joce640k · · Score: 2

      It suggests a link.

      No it doesn't. It's just some dweeb massaging a dataset until he gets the results he was after.

      --
      No sig today...
    6. Re:Huh? What? by Ol+Olsoc · · Score: 5, Insightful

      It suggests a link. It will take further study to determine whether there is actual causation or whether other factors may be involved.

      It's almost like you don't know how science works.

      Agreed, but I'm even skeptical about the entire study. Remember - we live in an age where cane sugar is considered healthy. Micro, non angry rant follows.

      What is remarkable about this study is that apparently every single artificial sweetener has exactly the same association with stroke and dementia.

      This is truly groundbreaking, because different artificial sweeteners have wildly different compositions.

      Stevia, aspartame, sucralose, neotame, acesulfame potassium, saccharin, and advantame, Cyclamates, allulose, monk fruit, Sorbitol and xylitol. All artificial, and every single one is associated with stroke and dementia. I left out lead acetate because not many people think that is safe at all - although in the anti science age, perhaps the deniers want to try it.

      Back to the study, and lest I be accused of being sarcastic, the researchers are very, very clear about this. To wit:

      After adjustments for age, sex, education (for analysis of dementia), caloric intake, diet quality, physical activity, and smoking, higher recent and higher cumulative intake of artificially sweetened soft drinks were associated with an increased risk of ischemic stroke, all-cause dementia, and Alzheimer’s disease dementia. When comparing daily cumulative intake to 0 per week (reference), the hazard ratios were 2.96 (95% confidence interval, 1.26–6.97) for ischemic stroke and 2.89 (95% confidence interval, 1.18–7.07) for Alzheimer’s disease. Sugar-sweetened beverages were not associated with stroke or dementia.

      There is no distinction between the different types of artificial sweeteners, therefore they tested all of them. And sugar sweetened beverages ha no association. Which apparently means both sucrose and corn syrup.

      This sounds like a study where we might want to look into the money path, because the abstract is so remarkably bad that it is difficult to put much credence into any of it, and the skeptic in me finds some groups with a financial interest in the "results" might have a profit motive.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    7. Re:Huh? What? by llZENll · · Score: 3, Informative

      Stevia is not artificial.

    8. Re:Huh? What? by istartedi · · Score: 2

      What if the common factor is that all of these artificial sweeteners stimulate the "sweet taste" centers of the brain but don't supply any energy? So then one part of your system says, "hey sugar coming" but the pancreas says "no dummy, this ain't sugar". They then proceed to duke it out, smashing bottles and breaking chairs all over the circulatory system.

      It could be like virtual reality. Driving a car doesn't make you sick because your eyes and your balance system provide congruent information. Now put on a VR system and driving games can give you a headache because they only feed information to your eyes.

      It's virtual sugar, only feeding information to your taste buds. It doesn't matter who makes the VR, they're all deficient.

      --
      For all intensive purposes, "whom" is no longer a word. That begs the question, "who cares"?
    9. Re:Huh? What? by F.Ultra · · Score: 2

      And let me guess that caloric intake, diet quality, physical activity and smoking where determined by people filling out forms. I.e the kind of input that is known to be fatally flawed (i.e there are ward studies where they fed people exactly the food and amounts that they filled in their forms that they ate and they all lost weight).

    10. Re:Huh? What? by Ol+Olsoc · · Score: 2

      Stevia, Xylitol, and Monk Fruit are not artificial. there are probably some others on your list too but these were the ones I knew of offhand.

      I suppose it depends on how you classify natural. Looking up how Stevia is made you put the leaves of the plant in hot water, then pas it through a resin, which traps the glycosides, after which you wash it with alcohol, then heat it to remove the alcohol.

      It's natural in the same way that cocaine is natural.

      As a side note, Stevia is a member of the chrysanthemum family, which is the source of pyrethrum insecticide. Also a natural substance.

      Here's a link about the different alternative sweeteners https://cspinet.org/new/201312...

      We can scare ourselves out of eathing if we try hard enough.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
  2. For fuck sakes by nightfire-unique · · Score: 4, Informative

    It's bad enough having to wade through all of the uneducated mouthbreathers and their "HEALTH GOODNESS WELLNESS NOW!!11" anti-science garbage sites.

    Do we really need to see more garbage science on /.?

    If you want to know the risks of aspartame (spoiler alert: there are none unless you've been diagnosed with phenylketonuria), consult legitimate scientific bodies, like the NHS or Health Canada.

    --
    A government is a body of people notably ungoverned - AC
  3. Something doesn't sound right... by GrumpySteen · · Score: 3, Interesting

    "They also found that those who drank one a day were nearly three times as likely to be diagnosed with dementia."

    "Those who drank one to six artificially sweetened beverages a week were 2.6 times as likely to experience an ischemic stroke but were no more likely to develop dementia"

    So if you drink six a week, there's no change to risk of dementia, but somehow the seventh triples your risk?

    1. Re:Something doesn't sound right... by dslauson · · Score: 5, Informative

      So if you drink six a week, there's no change to risk of dementia, but somehow the seventh triples your risk?

      These are two distinct groups:

      • group A drinks less than one a day.
      • group B drinks more than one a day.

      Crossing from group A into group B doesn't magically triple your risk, but group B, collectively, has a much higher risk.

      Because group B does not have a cap, (7 to infinity sodas), it's intuitive that the collective risk jumps dramatically. That group includes people who are drinking a fucking ridiculous amount of diet soda.

    2. Re:Something doesn't sound right... by Gilgaron · · Score: 2

      I haven't reviewed their data, but sometimes biology works like that. You'll see a buffered response where nothing happens until the buffer is saturated and then effects increase linearly, followed by a plateau where you've saturated the target. You can think of it as sipping alcohol: nothing happens until you have absorbed more than your liver can eliminate per unit time, then you have a linear drunkenness response until you plateau by blacking out and being unable to continue drinking.

    3. Re:Something doesn't sound right... by denzacar · · Score: 2

      If they are drinking caffeinated sodas (can't be bothered to look up the study, which is probably worthless weakly correlated crap anyway and as for the click-bait link - fuck it up its stupid ass) - 24/7 caffeine intake might be causing them continuous inadequate rest and sleeping disorders, causing increased mental and physical stress.
      Not to mention that the cause of so much caffeine might be workplace stress, compounding the effects.

      Working oneself into an early grave IS after all tied to stroke, dementia, cancer, cardiac arrest, divorce, alcoholism, drug use, office shootings and looting the company accounts before flying away to Paraguay with Candy.

      --
      Mit der Dummheit kämpfen Götter selbst vergebens
  4. That's not really a statistic by Anonymous Coward · · Score: 2, Interesting

    "We studied 2888 participants aged >45 years for incident stroke (mean age 62 [SD, 9] years; 45% men) and 1484 participants aged >60 years for incident dementia (mean age 69 [SD, 6] years; 46% men). Beverage intake was quantified using a food-frequency questionnaire at cohort examinations 5 (1991–1995), 6 (1995–1998), and 7 (1998–2001). We quantified recent consumption at examination 7 and cumulative consumption by averaging across examinations. Surveillance for incident events commenced at examination 7 and continued for 10 years. We observed 97 cases of incident stroke (82 ischemic) and 81 cases of incident dementia (63 consistent with Alzheimer’s disease)."

    Not a lot of people and with questionaires you get such accurate data.

    "the hazard ratios were 2.96 (95% confidence interval, 1.26–6.97) for ischemic stroke and 2.89 (95% confide"nce interval, 1.18–7.07)"
    the error bars are huge and the value is close to a ratio of 1.

    So nothing to see here.

    1. Re:That's not really a statistic by sinij · · Score: 4, Insightful

      I would also point out that you are sending questionnaires to a population of people who suffered a stroke. This would make such data even less reliable than a typical not that reliable survey data.

  5. Sponsors? by ITRambo · · Score: 2

    This reeks of being sponsored by the sugar industry. Those bastards paid Harvard researches in the 1960's to leave out sugar's being a cause of obesity and to shift the blame to fat. The result is a diabetes "epidemic", likely fueled by excessive sugar consumption taxing the pancreas until it no longer controls insulin levels properly. Any "study' like this should be suspect. How can an artificial sweetener that is not absorbed by the body, like sucralose, have any physical effect, unless the brain hates being tricked and is getting even.

    1. Re:Sponsors? by iggymanz · · Score: 2

      false, 2-8% of sucralose consumed is metabolized.

      https://en.wikipedia.org/wiki/...

    2. Re:Sponsors? by Just+Some+Guy · · Score: 2

      How can an artificial sweetener that is not absorbed by the body, like sucralose, have any physical effect, unless the brain hates being tricked and is getting even.

      Nailed it. From Wash U med school:

      The elevated insulin response could be a good thing, she pointed out, because it shows the person is able to make enough insulin to deal with spiking glucose levels. But it also might be bad because when people routinely secrete more insulin, they can become resistant to its effects, a path that leads to type 2 diabetes.

      Basically, the part of your digestive tract that identifies incoming sugar and triggers an insulin release can't tell the difference between sugar and sweeteners. That's not a shocker: if our taste buds can be tricked, it's not crazy to imagine that our sugar-detecting circuits are also fallible. When your body is continually flooded with elevated insulin, it becomes resistant to it. Another term for insulin resistance is type 2 (adult onset) diabetes.

      --
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  6. Re:Oops by hviezda14 · · Score: 3, Insightful

    Not exactly. Also slim people drink diet sodas, to stay slim. Best way to avoid this, is to drink - water.

  7. Re:Correlation does not imply causation by BillCable · · Score: 2

    So you're saying it was done so they can beg for funds to do the "real" study.

    You can manipulate statistics to show a link between just about any pair of variables. Massage this. Try a dozen different formulas to calculate significance. And tada! You have the link you were digging for.

    The article I read about this study this morning stated: "But after accounting for all lifestyle factors, the researchers found the link to dementia was statistically insignificant." Despite their best efforts, I'm sure. Yet the clickbait headline and lead still blare out "dementia!!"

  8. "Follow the Money" by hillbluffer · · Score: 2

    Has anybody looked at who FUNDED this "study"?... could it have been https://www.sugar.org/ ???
    For example, people have been trying to demonize Aspertame for YEARS.
    But the American Cancer Society finds no ill effects https://www.cancer.org/cancer/...
    There are other examples if you search.

  9. Re:Oops by NatasRevol · · Score: 5, Insightful

    it's drunk by fat people.

    You're going to need some real data to back that up. All the 'normal' sized people I know who drink soda drink diet soda.

    --
    There are two types of people in the world: Those who crave closure
  10. 24 cans by DumbSwede · · Score: 3, Interesting

    So don't drink more than 24 cans of Diet Coke a day (125mg) or 52 cans of Diet Mountain Dew (57mg).
    Good to know

  11. Re:Oops by cayenne8 · · Score: 2, Insightful

    All the 'normal' sized people I know who drink soda drink diet soda.

    But, the "normal" person today, is pretty much obese as compared to someone as recent as maybe 20 years ago or so....

    But heaven forbid you say that to people....you cannot "fat shame" people, and everyone is to feel good about themselves.

    Hence, overweight is now the accepted new normal.

    While that might help peoples' self image, it won't ever help their physical health.

    --
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  12. Re:Oops by Joce640k · · Score: 2, Insightful

    It's not even that. This is just another "study" by somebody with an agenda against sweeteners.

    There's no data, no evidence, just a guy manipulating numbers with excel until he finds a result he likes.

    --
    No sig today...
  13. Tea is the Solution by Yergle143 · · Score: 5, Insightful

    This story is probably relevant to /. because I've known many coders who suck down sugar soda or Aspartame soda like no tomorrow. Having followed the dementia research I put it to ya'll that a nice hot cup of tea most probably the best way to a slake thirst and keep those neurons chugging away. A bit of cream or sugar is just fine. There is a growing body of evidence correlating Alzheimers/Dementia to diabetes and metabolic imbalance and our choice of drinks is likely to be a contributing factor. Plus it is so civilized.

  14. The wrong order by irrational_design · · Score: 2

    The dementia lead to drinking diet soda, not the other way around.

  15. Re:Read the main article. by religionofpeas · · Score: 2

    Actually, they also found a correlation between strokes and diabetes, plus they found a correlation between diabetes and artificial sweetener consumption.

    So, most likely, it goes like this: people eat too much carbs, they develop diabetes, and the diabetes causes stroke. At the same time, their doctor tells them they are diabetic, and should switch to diet soda.

  16. Re:Oops by Khashishi · · Score: 2

    Did you even read the study before criticizing it? My guess is no. The study does take into account "waist/hip ratio", which is similar for the sugar soda and diet soda groups, among other parameters.

  17. Re:Oops by sexconker · · Score: 2

    But lots of people do live in California, including a lot of Asians, a lot of obese people, and a lot of people who follow shitty Hollywood-style "cleanse" fads.

    He referred to slim people with his generalization.
    You referred to Asians with yours.

    His was less inaccurate.

  18. Re:Oops by Khashishi · · Score: 5, Insightful

    facepalm

    That's not how science works. A lot of studies do turn out to be false, but that's not because some guy is fudging numbers. It does happen sometimes, but it's a serious allegation, and for you to simply dismiss a peer reviewed study without evidence puts you in the anti-science crowd.

  19. Re:Simple rule for all by sexconker · · Score: 2

    Soda pop is poison. You don't need a study to prove that. There are only four safe drinks in this world. Water, milk, orange juice, and beer. Wait, there are only five safe drinks in this world. Water, milk, orange juice, wine and beer.

    You forgot butter. There's nothing like a nice hot mug of butter to start your day.

  20. Personal Anecdatum - sample size of one by Cyberpunk+Reality · · Score: 2

    Consuming as much as single packet of aspartame gives me a splitting headache. I tested pretty extensively (on myself) several years ago when I was in my mid-20s, and re-confirm my finding when I (rarely) inadvertently consume some. I was (and am) in pretty good health and physically fit, with no known relevant health issues. (Although similar quantities of thujone result in scintillating scotoma for me.)

    --
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  21. Re:Oops by Rei · · Score: 2

    Indeed. There's a lot of skepticism here. When you factor in confounding factors:

    Crucially, the association with stroke and dementia disappeared after adjusting for diabetes and vascular risk factors, such as high blood pressure and prior heart attack

    The study appears to be an excellent example of the reverse causality effect. For example, let's say I was doing a study on on the effects of taking a heart medication on heart attacks. So I randomly collect thousands of people and study their incidence of heart attacks, and compare which people who had heart attacks were taking a heart medication and which weren't. Lo and behold, the people taking heart medication are far more likely to have a heart attack! Does that mean the medication is to blame? Not at all; it means that the people who are on heart medication are already more likely to be taking heart medication. It's the risk of a heart attack that's causing the taking of heart medication, not the heart medication that's causing the risk of heart attack.

    --
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  22. Re:Oops by filesiteguy · · Score: 2

    I drank (past tense) diet soda often. I wasn't fat. Still am not. I'd read correlative evidence of dementia as well as insulin resistance so I gave up. Coffee (unsweetened) is way better.

  23. Re:Oops by magarity · · Score: 2

    it's drunk by fat people.

    You're going to need some real data to back that up. All the 'normal' sized people I know who drink soda drink diet soda.

    My anecdotal response to your anecdote is that I mainly see obese people drinking diet soda... along with entire pizzas, supersized fries, etc.

  24. Re:Oops by radarskiy · · Score: 2

    I agree that someone who is drinking pizza has gone too far.