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Scientists 3D-Print Ovaries To Allow Infertile Mice To Mate and Give Birth (theguardian.com)
An anonymous reader quotes a report from The Guardian: Infertile mice have given birth to healthy pups after having their fertility restored with ovary implants made with a 3D printer. Researchers created the synthetic ovaries by printing porous scaffolds from a gelatin ink and filling them with follicles, the tiny, fluid-holding sacs that contain immature egg cells. In tests on mice that had one ovary surgically removed, scientists found that the implants hooked up to the blood supply within a week and went on to release eggs naturally through the pores built into the gelatin structures. The work marks a step towards making artificial ovaries for young women whose reproductive systems have been damaged by cancer treatments, leaving them infertile or with hormone imbalances that require them to take regular hormone-boosting drugs. Of seven mice that mated after receiving the artificial ovaries, three gave birth to pups that had developed from eggs released by the implants. The mice fed normally on their mother's milk and went on to have healthy litters of their own later in life. Writing in the journal Nature Communications, the scientists describe how they printed layered lattices of gelatin strips to make the ovary implants. The sizes and positions of the holes in the structures were carefully controlled to hold dozens of follicles and allow blood vessels to connect to the implants. Mature eggs were then released from the implants as happens in normal ovulation.
Unfortunately, your lopsided view of things does not always work well. Take for instance if we were going to engineer a better human race, tools like this would be useful to promote the genes. Or if there were a mistake with sterilization, maybe it could be reversed. Your trolling here is not appreciated.
--Beau
- to young women whose ovaries have been damaged by cancer treatments. Should we be restoring fertility to women who develop cancer at an early age? Unless they spend a lot of time around cancer-causing agents, it would be indicative of an hereditary condition.
Whatsa woman gonna do with mouse ovaries?!? Shes gonna giva da birth to mice!!! Oh, help us president Trumpa. Pleeeeeeeesa!!!
How exactly was the gelatin engineered to respond to estrogen and release an egg only upon estrus? I'm guessing it wasn't, and this printed ovary just periodically released eggs. The article also contains this gem: "an ovary implant could also help cancer survivors whose eggs are so damaged that they need hormone replacement therapy to trigger puberty". My understanding is that eggs don't cause puberty; and this 'ovarian prosthetic' does nothing to grow new follicles, so if your eggs are damaged, you're still sterile.
Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
File it with the one about the economist with a headline that suggested he said there would be no oil burning vehicles on the road in eight years - only he didn't.
Headlines have to be short I suppose but so short they are misleading is a bit annoying.
While I understand where you are coming from and agree with some of your statements (exploitation for profit), there are people in this world that could emotionally benefit if this research leads to applicability in humans.
My wife and I adopted because we couldn't have children naturally (even medically assisted). We received worse news after, when due to a life threatening medical condition, my wife's ovaries had to be surgically removed. Our women in the world face this situation more often than we think (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913114/).
The ovaries are quite important to the health and wellbeing of women. Hormones get produced, and, if removed early in life, require nasty, side-effect bearing hormone supplement therapy. Early menopause is an unpleasant thing to young women (N.B.: as a man, I cannot put this in proper words - I only experience this as a partner to a woman).
If there were a way to restore my wife's womb and ovaries, we would - even though we wouldn't use this for procreation. It would be for her mental and physical wellbeing.
If I drew a parallel to male conditions, like testicular cancers requiring the removal of a ball or two and researchers found a way to 3-D print a set, people would applaud their efforts. So, you can STFU!
Two, "hard reality" when it comes to biomedical science? "Adopt rather than have a baby" is a weird place to draw the line. "The hard reality is if you get cancer, you should probably just accept there are more than enough people on earth, so just hurry up and die and be glad you get time to make peace with it rather than in a car accident."
Three, TFA specifically points out, in case high school biology fails you, that the ovary does more than just poop out eggs.
The goal of the project is to be able to restore fertility and endocrine health to young cancer patients
A woman in her 20s gets ovarian cancer and is unable to reproduce ever again, that's bad enough, but there's also the added awfulness of menopause. Osteoporosis, heart disease, a bunch of other shit that cancer survivors really shouldn't have to deal with.
Fourth, tissue engineering like this is really in it's infancy. Successfully duplicating an organ should be exciting to you even if you don't happen to have that organ and you aren't convinced the organ's function is really so important. You like your testicles functional? How about having a non-diabetic pancreas? Odds aren't bad you'll have problems with some organ some day and could benefit from a new one. Lessons learned here won't be strictly confined to ovaries, it makes it more likely an organ you'll want to replace will be possible. Plus, what the fuck? Slashdot is news for nerds who are supposed to like technology. Just because it's wet, squishy, and feminine, we've decided we don't like THIS technology?
Fifth, how much time and money were "wasted" on this? From NIH reporter, it looks like $300,000 was spent specifically on this project. About a third of a single tomahawk missile, like the 60 we used to do fuck all in Syria in a vain attempt to boost Trump's ratings. Or less than three times as much as has been raised to make onesies for fully grown manchildren.
In conclusion, leave questions about science and priorities to the adults.
"better human race"... only hind-sight will decide the "better" part. "Be careful what you wish for..."
This issue is a bit more complicated than you think.
Crap. Thanks for reminding me to renew my Science License!
Infertile females don't produce the "follicles, the tiny, fluid-holding sacs that contain immature egg cells" which are implanted. They would have to come from a fertile donor. Am I missing something?
"The hard reality is if you get cancer, you should probably just accept there are more than enough people on earth, so just hurry up and die and be glad you get time to make peace with it rather than in a car accident." hmmm...this sounds suspiciously like the current GOP healthcare bill...
Fifth, how much time and money were "wasted" on this? From NIH reporter, it looks like $300,000 [nih.gov] was spent specifically on this project.
Best investment this year.
"First they came for the slanderers and i said nothing."
Or maybe you should not reproduce and give your ticket to them?
At some point someone do any of you creeps who thinks we are overpopulated wonder what yourselves are doing by staying alive? Hell of a thing to ask other people not to reproduce. What about your own self?
I'm sure SuperKendall will be along shortly to tell you that it's socialised medicine that has the death panels.
Confucius say, "Find worm in apple - bad. Find half a worm - worse."
There are enough people in this world we don't need to be continuing the propogation of people that have defective genes!! If they can't have a kid naturally then there are hundreds and thousands of kids that need someone to take care of them... selfish pricks...
So if it can be done in mice, surely this will work for humans. Is there an STL for it?
Hmmm... That sounded like an uninformed snark.
Right, they should have researched a cure for baldness. Or impotence. Or something to make my armpits less sweaty. Or make my feet smell good.
But yes, I agree, the last thing we need is more people. We already have way too many and we'd be better off if some just vanished. You and your post just reminded me of this.
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
Actually I was more concerned that the GOP healthcare bill goes along the lines of having more young people die young so we can harvest and sell their organs to rich people to prolong their lives.
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
A better human trap, maybe? I wonder what to use as bait, the trolling may commence now!
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
If your life comes crashing down at the announcement of infertility, you were not emotionally stable enough to have a family in the first place.
hehheheh
ur dum
Okay, I could have gone into more detail, but it seemed redundant. Other people have done eloquent justice to your pitifully idiotic post.
lol
Just renewed myself. I can carry science concealed too!
"I can haz moar mices???"
- My Lazy, Overweight Cat -
Like we don't have enough mice in the world...or people, for that matter.
I've calculated my velocity with such exquisite precision that I have no idea where I am.
Does that mean men can give birth too any time soon?
Not saying I wish to bear children. But it'd stifle a few abject misandry opinions.
I hadn't the slightest objection to his spending his time planning massacres for the bourgeoisie... (P.G. Wodehouse)
When the human race suddenly fails to reproduce, and the population gets down to say 1% of the current count, maybe then scientists would have a reason for doing this kind of research.
Right now it sounds like making up a new way to get money from distressed people. The hard reality is if somebody is unable to reproduce, they should get a sympathy card and the offer to adopt.
Says the Greenpeacer who thinks that the human species is an infestation to be erased from the environment.
Congratulations on deciding not to have any children of your own. May your ideas die with you and not be transmitted to a new generation.
I'm pretty sure synthetic ovaries are the first step in making better traps.
Yay the Feminist Dystopian Fantasy comes closer to reality! Men be gone!
Next Hearts and kidneys
Hi, I am not originally part of the thread but just to interject on first-hand experience with female anatomy I must disclose that: Ovaries are a gland not a follice, menopause is a lack of nutrient in diet to keep that gland flowing where similarly if a woman had consumed strawberry roots durring her period then she would rxperience uterine orgasms dor ejecting the unused egg and factory workers, and last too much estrogen causes the health problems you speak of in such matter as fat cell mismanagement invents hormones stored in bodily fat that will time-release as a does a gland.
I suggest an equator diet for optimal genital health.
So, btw, iorn, iirc: go fuck yourself and say the same to your wife that this wouldnt be a problem if she ate right and exchanged her aerobics and yoga class for 2 hours of trampoline sex with you.
Get permission from each mouse before experimenting on it. Scientists should falsify their assumption that mice can't communicate before killing them in experiments. Science must have a code of ethics that prevents experimentation on anyone including animals without their express consent. If you can get the mice to voluntarily come into your experimental setup, when they have a free choice to run away, then maybe you can test them but they should always be free to leave.
I wish it were, but the GOP is legitimately intent on bringing down quality of coverage simply because a black man brought it up.
There's no real order: Hearts and kidney efforts are well underway. Liver might be a bigger priority than kidneys actually. Dialysis is terrible compared to where we need to be with kidney function, but IIRC it's much further than where we are with liver dysfunction. Plus livers seem to have a better ability to organize and repair itself. The kidney would need a lot higher architectural precision, so it's a more distant goal unfortunately.
Spoken like a true anonymous coward.
Trans men can already have babies, as they are typically born with ovaries.
This, however, is a great hope for trans women.
I hope you're not stupid enough to think that. Hey why don't you look back to the 1994 midterm and tell me why the Democrats lost control of the House for the first time in 50 years.
Oh yeah. HillaryCare.
Keep believing your racist sh!t and see where it gets you,
(Racist because you assume the only reason I, and others like me, are against ObamaCare is because Obama is black.)
If you're scared of your govt then you need to further restrict its powers
Vote 3rd Party in 2016 and beyond
1994 is really too recent to be doing revisionist history like that. It was because of the economy and NAFTA.
Give me a different reason other than race why people are so infuriated that health care insurance companies need to cover sick people with pre-existing conditions then. Bonus points if you can explain why it's totally unrelated that the GOP continues to have so many racist gaffes, or why the openly racist southern strategy isn't still in effect, or why Jeff Sessions is trying to get back to the racist war on drugs.
You, and others like you, suffer from the dunning kruger effect when it comes to race.
No dude. I was around at the time. The energy was over health care. And by the way the economy was doing just fine in 1994. We came out of the recession in early 1992 and the economy was humming along. Just checked. GDP was a healthy 4.0.
If you're scared of your govt then you need to further restrict its powers
Vote 3rd Party in 2016 and beyond