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New Immunotherapy Trial Cures Kids of Peanut Allergy For Up To Four Years (theguardian.com)
Using a new kind of immunotherapy treatment, Australian researchers have managed to cure a majority of the children in their study suffering from a peanut allergy. "The desensitization to peanuts persisted for up to four years after treatment," reports The Guardian. From the report: Tang, an immunologist and allergist, pioneered a new form of treatment that combines a probiotic with peanut oral immunotherapy, known as PPOIT. Instead of avoiding the allergen, the treatment is designed to reprogram the immune system's response to peanuts and eventually develop a tolerance. It's thought that combining the probiotic with the immunotherapy gives the immune system the "nudge" it needs to do this, according to Tang. Forty-eight children were enrolled in the PPOIT trial and were randomly given either a combination of the probiotic Lactobacillus rhamnosus with peanut protein in increasing amounts, or a placebo, once daily for 18 months. At the end of the original trial in 2013, 82% of children who received the immunotherapy treatment were deemed tolerant to peanuts compared with just 4% in the placebo group. Four years later, the majority of the children who gained initial tolerance were still eating peanuts as part of their normal diet and 70% passed a further challenge test to confirm long-term tolerance. The results have been published in the Lancet Child & Adolescent Health.
Four years later, the majority of the children who gained initial tolerance were still eating peanuts as part of their normal diet and 70% passed a further challenge test to confirm long-term tolerance.
That sounds much better than "up to four years". Very refreshing to see a headline that understates research results :)
nobody had a peanut allergy.
Now your kid can be suspended for even having a granola bar (ZERO TOLERANCE POLICY).
So sayeth The Lord.
Somehow a study that checked back on people 4 years after treatment get's converted to "works up to four years".
Do these people even english?
So, isolating children from a danger was making them lethally sensitive, and the solution is to gradually expose them to it. Surely, that strategy applies only to this specific case?
Is it just me or does giving any group of people especially kids who have a much lower level of understanding and a higher level of trust medicine that might be a placebo and then telling them this will let you eat that thing that could kill you seem like a bad idea?
Yes, it's a therapy.
No, it doesn't make your peanut bigger.
My snowflake is perfect as is. You need to check your peanut privilege.
... but at least you would die happy.
http://artesanatobrasil.net/09-receitas-de-doces-com-amendoim-para-festa-junina/
I'd get that treatment if not else just to be able to eat paçoquinha.
You know what else "cures" a peanut "allergy?"
Peanuts.
Desensitization works for peanut allergies nearly 100% of the time. In fact, isolation from allergens typically only makes allergies worse. I had a peanut allergy as an infant. I almost died once according to my parents. My mom, being a well-educated and smart woman, ignored the idiot doctor's orders to keep me away from all things peanut (doctors only say this to cover their asses, there is no medical research that supports evasive therapy for allergies) and instead would put a tiny amount of peanut on my lip every day. I would break out in hives at first, but after a couple of months, my reactions went away.
Now I eat peanut butter all the time and I have my mom to thank. Since learning of this when I was old enough to understand, I've never avoided allergens - and I've never had allergies of any kind, to anything.
BTW, if anyone tells you their kid will die at the slightest contact with something peanut, they're lying. Nobody is that allergic to peanuts. It's all in their heads.
His comment isn't form one of those people who are picking on someone for acting like it's the end of the World because their video game is broken.
He's right by the way - although the ultra cleanliness of first world countries is just a hypothesis. Plumpy'nut is distributed in Africa during famines and they have yet to see an allergic reaction.
The last flight I was on had to serve almonds instead of peanuts because a passenger had a peanut allergy. Here I am.. 30,000 feet.. and I'm eating almonds - like we're flying over Iran or something.
--- We need more Ron Paul!
. . . I can force others to keep them away from me ??
(OK, it was worth a shot. . . . )
If you can be killed by a peanut, your genes are weak and should be removed from the pool.
So... now kids can eat more?
I blame the liberals. Seriously. They raised entire generations that overreact to everything.
Really? Peanut allergies are political now? I find it amazing that so many conservatives seem to find a way to blame liberalism for anything that annoys them. That is called scapegoating and it says more about you than it does about them. I coach a high school sports team and I can assure you that conservative parents are just as obnoxious and over-reaction prone as liberal ones. I deal with both routinely and it has NOTHING to do with their political bent.
I remember being told (may or may not be true) that children who were allowed to play in the mud and get dirty were less likely to develop allergy to peanuts. Something about developing a tolerance. I forget the details. It's good to know we have a way of treating those who are affected, even if for a relatively short time.
"Imagination is more important than knowledge" - Einstein
If it is "up to four years" then it is not a CURE, it is a palliative, not a cure at all!
If you are too weak to survive the wrath of peanuts, you remove yourself from the pool. This is 100% effective in eradicating this blight.
As Darwin loving liberals, you should all support this.
I wonder if something like this could work with other allergies. My wife has a terrible latex allergy which really limits where she can go (you'd be surprised at the number of places that have balloons for no apparent reason or use latex gloves to prepare food). Maybe there's hope?
I can't help but think part of the whole 'peanut allergy' thing has to do with helicopter parents who micromanage their child's comfort beyond all rationality.
For parents like this (helicopter parents isn't the best term, can't think of a better one now), a doctor telling them their kid *cannot* have a single peanut is almost like crack to them. It gives them an outlet for their OCD: Guard child against deadly peanuts.
To these parents, the idea of sensitizing their kid over time is anathema..."I will not slowly poison my child!" I guess the only way to really see what I mean is to hop over to some of those "parenting" message boards about peanut allergy...
Thank you Dave Raggett
It can seem like it's working.....then suddenly you are in the emergency room wondering if your child will die.
It took my daughter more than 1 year to recover the ability to eat normal food after this treatment failed and put her in the emergency room.
If your child has an anaphylaxis level allergy, siimply keep them away from the allergen. It's 100% effective.
OIT https://www.oit101.org/ (oral immuno therapy) AIMT (Aimmune Theraputics) http://www.aimmune.com/clinica... https://clinicaltrials.gov/ct2... 500 person trial ending i november CODIT oral therapy for PN DBVT (ViaSkin Patches) https://www.dbv-technologies.c... Skin patch therapy for peanuts. Go invest in them FWIW... DS
I agree arresting kids who had no ill intent with their food is overboard. Use of peanuts as a deadly weapon is quite another issue.
However, the British have > 90% effective treatments for desensitizing people with peanut allergies. Since 2009-ish.
https://blogs.scientificameric...
and other articles. Why is the FDA not jumping on this treatment and allowing it in the USA? Is it because we can't give credit to the results of other first world countries' studies? If so, this is dumb as rocks.
Treatments exist today that could relieve as much as 90% of the severe peanut allergy burden in this country.
--PeterM
This is how the Dread Pirate Roberts developed an immunity to the deadly poison iocane.
the preceding comment is my own and in no way reflects the opinion of the Joint Chiefs of Staff
Took 4 years, over the course of 6 months per year, they give you shots of the things you are allergic to. After that, I'm pretty much allergy free from flowers, trees, weeds (ragweed is the killer!). Oh, if the pollen count gets stupid, it might bother me a bit, but nothing like it did. Once when I was 18, I ended up in the hospital ER, with anaphylaxis. Couldn't breathe, heart rate nuts, eyes swelling. After a treatment, was good as new. Use to keep an epi-pen with me for a while. The shots were WORTH it. The doctor was a customer of mine, and so I knew the staff pretty well. When they would usher me into the room right off the lobby, I would have some "fun" if there were kids in the lobby. As I came out, to sit in the lobby (required for 20-30 minutes after the shot), I would hold my arm and say OUCH and rub my arm...Looks on the kids eyes. The staff kept saying they would stash all their "rusty dirty, bent" needles if I didn't stop it.
It's true, it's called the Hygiene Hypothesis.
https://en.wikipedia.org/wiki/Hygiene_hypothesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841828/
As a hypothesis it has been experimentally supported and is very respectable. In short there is truth in this idea. There has even been research that suggests pets in the home (cats & dogs mainly) also help train the immune system of children living in that home.
The underlying theory is that your immune system is extremely powerful and is perfectly capable of killing you if it goes off track. Immune system components like antibodies are responses to immune challenges you've had; you don't have antibodies for things your immune system has never seen (there is a minor exception for infants who are breast fed). Therefore it is essential to train and regulate your immune system to properly distinguish Friend from Foe.
However there's more to it than that. Allergies are to Non-Self materials but those allergens typically pose a minor threat or even no threat at all. Allergies are an immune system over-reaction. Therefore the idea is that training your immune system to respond appropriately, is key to tamping down allergic reactions. You want a modulated immune response, not a five alarm fire reaction to everything.
Now, this isn't a suggestion to avoid medical care, to neglect wounds, or even to stop vacuuming! It just suggests that exposure to the environment is good, and more exposure to the environment tends to be better.
I'd be happy if they just cured it for ONE PLANE RIDE!
Mombies with these defective kids are the absolute worst. They think their precious spawn are the most important thing in the whole world and should inconvenience the entire plane full of people instead of, you know...driving.
If the alergies go away for a While, be it four years, be it longer, then the treatment does not CURE the Alergies.
The alegies are on Remission. Is slightly different.
*** Suerte a todos y Feliz dia!