New Immunotherapy Trial Cures Kids of Peanut Allergy For Up To Four Years (theguardian.com)

Using a new kind of immunotherapy treatment, Australian researchers have managed to cure a majority of the children in their study suffering from a peanut allergy. "The desensitization to peanuts persisted for up to four years after treatment," reports The Guardian. From the report: Tang, an immunologist and allergist, pioneered a new form of treatment that combines a probiotic with peanut oral immunotherapy, known as PPOIT. Instead of avoiding the allergen, the treatment is designed to reprogram the immune system's response to peanuts and eventually develop a tolerance. It's thought that combining the probiotic with the immunotherapy gives the immune system the "nudge" it needs to do this, according to Tang. Forty-eight children were enrolled in the PPOIT trial and were randomly given either a combination of the probiotic Lactobacillus rhamnosus with peanut protein in increasing amounts, or a placebo, once daily for 18 months. At the end of the original trial in 2013, 82% of children who received the immunotherapy treatment were deemed tolerant to peanuts compared with just 4% in the placebo group. Four years later, the majority of the children who gained initial tolerance were still eating peanuts as part of their normal diet and 70% passed a further challenge test to confirm long-term tolerance. The results have been published in the Lancet Child & Adolescent Health.

Comments

Re:When I was in school

[Kjella]

Peanut allergies are a first world problem. They are rare in developing countries, where kids grow up around chickens, pigs, and goats, so they develop strong immune systems that don't overreact.

Part of why it seems like such a huge first world problem is the gross over-reaction to "casual" allergy to protect a few hyper-allergics. I'm allergic to peanuts. I don't care if you eat a peanut bar in the adjacent seat or if the kitchen used the same spoon. Hell, I could eat that peanut bar and though it might cause me a bit of discomfort it wouldn't actually be dangerous. But if I tell anyone I have peanut allergy that tends to invoke "faint traces of nuts = lethal danger" levels of paranoia. Don't get me wrong, they exist and it's nice that we accomodate them so they don't die or anything but you sometimes feel those with a common cold and ebola are put in the same box labeled "sick".