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Researchers Analyze DNA From 'Supercentenarians' Aged 110+ To Discover Secret To Longevity (nytimes.com)
biobricks writes: Scientists looking for clues to healthy longevity in people in their 90s and 100s haven't turned up a whole lot. It is thought that the DNA of the very old may be a good place to look, but people over 110 are one in five million in the United States. The New York Times chronicles one scientific quest to collect their DNA (Warning: source may be paywalled; alternative source). From the report: "James Clement, a self-described 'citizen-scientist,' has collected blood, skin and saliva samples from individuals aged 110-plus in 14 states and seven countries during the past six years, The New York Times reports. Mr. Clement has detected 2,500-plus differences between supercentenarian DNA and the general population. However, with a sample size of only some three dozen genomes, his team is still working to determine which genes are significant. One analysis suggested supercentenarians tended to inherit fewer genetic variations related to conditions like heart disease and Alzheimer's disease. However, since supercentenarians also tend to be more healthy than the general population, some researchers hypothesize there are other genetic benefits at play. For example, supercentenarians may boast genes that protect them from aspects of aging." Mr. Clement plans to release DNA sequences from the project, called the New England Centenarian Study, this month.
Don't Die.
Drink
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Ovaltine
There can be only one.
Have gnu, will travel.
I applaud your cleverness, but you don't actually have to cite fiction to find a written record of the existence of a blood line of the type to which you allude. The word you're looking for is Nephilim.
What are you on about? They didn't give them longevity. They just took samples from people who were already old.
I suspect it is reversed to a large extent.
That is, the super-centagarians are not healthy because of genetics, but instead it is impossible to become a supercetagarian unless you are lucky enough to be healthy.
If for example you get infected with pneumonia and survive, it would not surprise me that it would weaken your lungs by say 4% and you end up dying at 80. If you never got the pneumonia you might have lived to 101 merely because you had 100% lung functionality.
Being healthy makes you live longer, it is not always a sign of lack of bad mutations..
In fact, sometimes bad genetic mutations can make you live longer.
Good example are the dwarfs of Ecuador that have Laron Syndrome http://discovermagazine.com/20.... They are basically immune to cancer and diabetes, but suffer convulsive disorders (and also are short).
excitingthingstodo.blogspot.com
I'm entirely certain genetics help but anyone living past 100 is quite likely living off of dumb luck.
The universe is a chaotic place after all.
I ignore Anonymous Coward posts. If you want to discuss something, that's awesome. Log in.
I think this is an interesting avenue of study but when I read:
James Clement, a self-described 'citizen-scientist,'
I get wary to the point of being totally turned off. Pretty soon I would expect to start getting banner ads for some new "miracle supplement" or something like that after after reading it. It wouldn't be bad to be wrong about this but the track record...
Even Universities and well-funded corporation get huckster scientists. The guy doing it alone by definition doesn't have the institutional filters in place to keep pipe dreams and wishful thinking at bay.
Cuban cigars and 16+ year old single malt, I don't wanna live tp be that old...
And environment too.
Genetics is just a face of the coin.
Sent as ripples into the electromagnetic field. No single photon has been harmed in the process.
Excuse me but in most developed countries the older people are "supposed" to have paid into the system - Pensions, social security or whatever name-of-choice the country has, and are supposed to be taking the things they have been promised in exchange of paying into the system for over 4 decades.
If your country over-promised (...perhaps YOU let your politicians) and basic welfare turns into a ponzi scheme it's a problem with overspending and politicians that promised you the moon letting future generations hanging. Getting old is not a sin in itself.
And I'm not even to calling you out for your old vs. young people broad brush yet, the same can be said of those un/underemployed youngsters who receive more than they pay into the system. Are you ready to call low-income earners blood-suckers of the society?
There will certainly be genetic factors. To the comments about longevity being luck, of course that plays a role. Want to live to 100, don't get hit by a train, duh. Lot of illness is driven by luck. If you have a gene that makes you prone to cancer, that's no guarantee that you will get cancer. However, the fact remains that your chances of longevity are a lot better without that gene.
There have been some experiments with simpler life forms (fruit flies, iirc), where - in surprisingly few generations - they were able to triple the average lifespan through planned breeding. The selection criteria was simply to breed the critters as late as possible in their lives. In any case, the results are pretty clear proof that genetics play a decisive role in longevity.
Who has read Heinlein's novel Methusalah's Children? The premise of the book was that someone had created a legacy - a couple of centuries ago - to encourage certain people to marry and have children (selected, iirc, by their grandparents' longevity). Based on what we know today, this would be entirely possible and reasonable. Equally possible and reasonable was the inevitable resentment felt by the rest of the human race, towards people who lived for hundreds of years. No one wants their neighbor to be smarter, richer or healthier than they, themselves are - humans rejoice in Schadenfreude, but we don't even have a word for the reverse.
Enjoy life! This is not a dress rehearsal.
Stay thin. I see a lot more pictures of old healthy thin people than of old healthy fat people.
My father in law is in his 90s and all he does is sit around and watch Judge Judy. If you find a way to extend your 30s maybe sign me up.
I am related to Henny van Andel-Schipper
When she was born, the doctors told her she would not be older than 6 weeks and her mother should forget about her. She was held warm by her grand mother. She lived at home till in her 40-ies and ran away from home then with a man that was divorced.
As a kid she was often sick. When she became older (80), she decided to give her body to the local University, so not to bother family and/or friends with a funeral.
When she became older than 100, there was a change in interest. It was not anymore about just another body for autopsy lessons. It became serious. She was looked at on a regular basis and when she died at the age of 115, there was a process to replace her blood as soon as possible.
Not only did they discover that their was no trace of Alzheimer anywhere, they found some other stuff about aging as well.
She was also the reason why they started a centenarian process in The Netherlands to as more people who are older than 100 to donate their bodies.
Her real answer on getting old where : keep breathing and don't die. Somebody has to be the oldest and this time it is me. As if she was saying that correlation was not the same as causation.
I have read a bit about real old people and what is evident is that all are positive minded.
So think about donating your body to science or, to put it in a way you would better understand: Open Source your remains. Because why not?
Don't fight for your country, if your country does not fight for you.
They should analyze the Millenials. 1000 is greater than 100.
There's no profit to you, a person so shallow you only think of other people in terms of how they benefit you. There's plenty of benefit to the person living longer.
Contribute to civilization: ari.aynrand.org/donate
There have been animal studies in which multiple copies of certain genes correlate with longer life.
Looked at another way, giant turtles live much longer than mayflies. The difference is genetic.
Genes that contribute to improved refolding of proteins, genes that cause a better immune system, and all sorts of other possibilities are waiting to be discovered.
Contribute to civilization: ari.aynrand.org/donate
That's why no one survives. ~ QotSA
I tend to rant.
Old people are a drain on society. They suck up social security and medicare that young people have siphoned from their paychecks.
To express the idea of Social Security in a way that you young whippersnappers will understand, it's just like those times when you're at Starbucks and you pay for the person in line behind you.
Its Google rolling out a "23 and Me" option to tell you about your telomeres and that its getting shorter each year.
Jeanne Calment lived to be 122... outlived her husband, Daughter and Grandson .. her Daughter and Grandson died at 36
She was almost never ill, was active her entire life, smoked but only one or two cigarettes a day, and had a healthy diet
No-one else in her family was long lived
Puteulanus fenestra mortis
non-genetic circumstances (inheritance, lottery, lucky investment)
One could argue that the likelihood of getting an inheritance is genetic.
Enigma
The idea that all you need to do is eat well is pseudo religious. Of course eating well is a good idea, but thinking that the key to your longevity is in your conscious control is a coping mechanism against existential dread as much as a belief in heaven is.
My grandpa died in his 80s to lung cancer from asbestos. In order for the payout from the company regarding asbestos, there was an autopsy. They said his heart was like a 20 year old athlete. Fit as a fiddle. What'd he eat? Sausage, beef, eggs, and cheese. A typical northern USA Polish diet.
My friend's grandpa died at the age of 95 while plowing his field. He stopped to investigate something when he made some sort of mistake and got ran over. His diet was also heavy in meat and cheese and he was a chain smoker since the age of 11.
My wife's grandpa, also has a typical northern USA diet, he's 93 years old and recently was in a competition where he pulled off 100 push ups.
My uncle is in his 70s, also eats the same way as the rest of us, and he runs about 10 miles a day. He's very spry and quick witted.
Nearly every one of my great aunts and uncles are either alive or died in their 90s or early 100s. At least at family functions, we all eat the polar opposite of vegan. I am not sure how much diet plays a role vs genetics.
To express the idea of Social Security in a way that you young whippersnappers will understand, it's just like those times when you're at Starbucks and you pay for the person in line behind you.
No, because that would be your choice. Social Security is more like when you're at Starbucks and the person in line in front of you leaves you their bill, justifying it on the basis that the person in front of them did the same.
"The state is that great fiction by which everyone tries to live at the expense of everyone else." - Bastiat
It may be more important that your diet suit your genetics and flora than that it conform to any particular diet fad. It may be an urban legend, but my understanding is that Native Americans generally don't tolerate a diet high in saturated fat as well as Europeans, for example. Glucose tolerance and intolerance would be another example.
I've heard similar about diets possibly needing to be tailored to your genes. I can't wait to see what the research shows on this topic over the next decade or two. Regardless of the exact results, my guess is diet, flora, genetics, and health relations are a lot more complex than anyone ever imagined.