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Ibuprofen Linked To Male Infertility, Study Says (theguardian.com)

An anonymous reader quotes a report from The Guardian: Men who take high doses of ibuprofen for months at a time may be at greater risk of fertility issues and also other health problems, such as muscle wastage, erectile dysfunction and fatigue, scientists have found. Research on healthy young men who took the common painkiller for up to six weeks showed that the drug disrupted the production of male sex hormones and led to a condition normally seen in older men and smokers. The 18 to 35-year-olds who took part in the study developed a disorder called "compensated hypogonadism" within two weeks of having 600mg of ibuprofen twice a day. The condition arises when the body has to boost levels of testosterone because normal production in the testes has fallen. Doctors in Copenhagen who led the study said that while the disorder was mild and temporary in the volunteers, they feared it could become permanent in long-term ibuprofen users. This would lead to continuously low levels of testosterone, because the body could no longer compensate for the fall. Details of the study are published in the Proceedings of the National Academy of Sciences.

131 comments

  1. Not tonight, I have a headache by Anonymous Coward · · Score: 2, Funny

    so much for that excuse gents.

  2. What about other NSAIDs? by Only+Time+Will+Tell · · Score: 5, Interesting

    I am curious if this effect is limited to ibuprofen or if other NSAIDs (non-steroidal anti-inflammatory drugs) such as Aleve (naproxen) or ketoprofen affect male reproduction as well. I'm sure there will be additional studies, but if these effects are repeated, they will likely be discontinued given they already have the propensity for stomach ulcers and other side effects.

    1. Re:What about other NSAIDs? by Anonymous Coward · · Score: 0

      Don't worry, there's going to be a study out sharpish espousing the effects of ibuprofen and suggesting to take more to counter the alleged negative effects.

    2. Re:What about other NSAIDs? by Mashiki · · Score: 1

      Nearly all pain killers effect testosterone levels to some degree, everything from ibuprofen to naproxen to tramadol, and mixes like acetaminophen/oxy, acetaminophen/tramadol, etc. The urologist I go to tells patients to avoid lyrica and won't prescribe it for example, since he saw large drops in testosterone in the blood. It was a go to medication a few years ago for boys who had testicular torsion, since it did a great job of dulling the nerves from the swollen testicle. I'm sure you can see the problems of lowering testosterone in boys in puberty and all that. Having had that ~30 years ago now, it ranks right there as an 11/10 for pain, I can't even describe it beyond it being so painful the world was a gigantic hallucination with a dream-haze effect. And the pain is with you for a long time, roughly 3 years in my case and that was considered "normal" in cases where the teste is saved.

      --
      Om, nomnomnom...
    3. Re:What about other NSAIDs? by burtosis · · Score: 1

      I am curious if this effect is limited to ibuprofen or if other NSAIDs (non-steroidal anti-inflammatory drugs) such as Aleve (naproxen) or ketoprofen affect male reproduction as well. I'm sure there will be additional studies, but if these effects are repeated, they will likely be discontinued given they already have the propensity for stomach ulcers and other side effects.

      If that was the case, we would no longer be taking asprin. Given the profit still left to be had here, and given the name recognition built up over years, I think we can safely say that we will be seeing ibuprofen and all the current NSAIDs for a long time no matter how bad it gets.

    4. Re:What about other NSAIDs? by DickBreath · · Score: 1

      Um, no. That would not be the first choice.

      --

      I'll see your senator, and I'll raise you two judges.
    5. Re:What about other NSAIDs? by Anonymous Coward · · Score: 0

      We're still waiting to for that to happen for lead, asbestos. Why don't you try drinking a glass of water with some extra lead in it ?

    6. Re:What about other NSAIDs? by hairyfeet · · Score: 4, Interesting

      People who are taking NSAIDs like Ibuprophen for a long period of time aren't doing it for fun or minor boo boos, they are in serious pain. So this is a "damned if you do, damned if you don't" situation.

      Take myself for example, I have to take NSAIDs because I bounced down a two lane at 65 MPH+ when a dog ran out in front of my bike when I was 16. The docs told me then that even though I didn't break any bones the amount of damage to the joints caused by the impact would mean later in life I would be seriously suffering and they are right, when the weather is cold or damp it feels like someone is jamming needles into my knees and wrists and the swelling makes even simple tasks seriously hard.

      Now do I like hearing this about Ibuprofen? No but frankly I'd rather go to my doc and ask her whether I should get testosterone than not be able to walk or use my hands. Without NSAIDs my knee and wrist joints simply do not work, even if you took away the pain the inflammation would keep me from doing much. Tylenol can help with the pain but does squat for the swelling, aspirin can cause serious bleeding, out of the current choices we have ibuprofen and naproxen are probably the safest bets for the millions of us who have serious joint damage and which are not good candidates for joint replacement.

      --
      ACs don't waste your time replying, your posts are never seen by me.
    7. Re:What about other NSAIDs? by jedidiah · · Score: 2

      NSAIDs aren't the thing you take for "serious" pain.

      They will also destroy your other organs if you treat them like candy over long periods of time.

      Pretty much any drug taken regularly will do this and you need to be under sufficient medical supervision to ensure this doesn't happen. Pretty much every drug needs to be treated as harmful by default and we tend to take the exact opposite view as a society.

      --
      A Pirate and a Puritan look the same on a balance sheet.
    8. Re:What about other NSAIDs? by s122604 · · Score: 2

      I would doubt it very seriously. Yes this is a side effect, but many would not care. Women, men using it temporarily, men who simply would rather live with the side effect than remain in pain.
      As a side note, I think I remember reading some research that semi regular use of NSAIDs is actually linked to a lower risk of dementia

      There is no such thing, as a completely safe, non addicting, highly effective pain reliever. If such a thing is ever developed it would revolutionize medicine and make it's inventor billions.

    9. Re:What about other NSAIDs? by Impy+the+Impiuos+Imp · · Score: 1

      I have Tramadol, and it sucks compared to 800 ibuprofen, the prescription strength.

      2 weeks of that will kill bursitis in your shoulder. Try it out.

      Anyway I don't take 800 except rarely but I will take 200 or 400 once a day.

      --
      (-1: Post disagrees with my already-settled worldview) is not a valid mod option.
    10. Re: What about other NSAIDs? by Anonymous Coward · · Score: 0

      Only time will tell ;)

    11. Re:What about other NSAIDs? by Anonymous Coward · · Score: 0

      Testicular torsion was central to a story in the first season of the Venture Brothers. If you kidnap someone and they experience severe testicular pain, seek medical attention before pursuing further acts of evil.

    12. Re:What about other NSAIDs? by Anonymous Coward · · Score: 0

      Probably all of them. I believe all the NSAIDS cause hearing loss and/or tinnitis, and they all impact prostaglandins - thus SLOWING healing of soft tissue injuries.

    13. Re: What about other NSAIDs? by Anonymous Coward · · Score: 0

      I hear Cannabis does great things for people in pain. Too bad the stupid government outlaws it from most jurisdictions.

    14. Re: What about other NSAIDs? by GuB-42 · · Score: 1

      AFAIK, cannabis does nothing against inflammation. It doesn't seem there is a big overlap with NSAIDs like Ibuprofen.
      It may help reduce dependency on opioids though.

    15. Re: What about other NSAIDs? by Anonymous Coward · · Score: 0

      Pot has Cannabidiol(?) In it. CBD. Supposed to be awesome for inflammation. No high if just taking CBD either.

    16. Re:What about other NSAIDs? by piojo · · Score: 1

      Without NSAIDs my knee and wrist joints simply do not work, even if you took away the pain the inflammation would keep me from doing much.

      Have you looked into sub-psychoactive doses of certain old drugs, like DOM or DOI? These are being researched for their anti-inflammatory properties by Dr. Charles Nichols (interviewed about it here). I'd like to try it myself for some inflammatory injuries, and some drugs in that family aren't even scheduled! The problem is that they're not really used for anything except research, so they would be very hard to acquire.

      I'd feel somewhat safe taking them therapeutically, since they used to be used as party drugs, but are being tested against inflammation at much lower doses. Also, desperate times call for desperate measures.

      --
      A cat can't teach a dog to bark.
    17. Re:What about other NSAIDs? by volmtech · · Score: 1

      Better find a male doctor. Ten years ago at 55 I hurt all over and felt so depressed I had to quit work. I had been taking 1600 mg a day of ibuprofen. I told my female doctor I needed extra testosterone. Tests were done and she decided I was low but "within range". After eight years and another female doctor I finally was seen by a male doctor. It took him one minute to diagnose low testosterone. He explained I was on the low end but everone's reaction is different, I needed mid-range to function. Within minutes of the first shot I felt great, my depression was gone. I will not be taking anymore ibuprofen.

    18. Re:What about other NSAIDs? by Reziac · · Score: 2

      The symptom set described in TFS screams "thyroid impact" -- at a guess, it accelerates the natural decline of thyroid production, leading to the assorted side effects (including testosterone deficiency). Meaning it should be treatable the same way you'd deal with ordinary hypothyroidism.

      Anyone over 50 should have an annual thyroid profile anyway (the whole set, not just TSH test). Most of what we attribute to "aging" is actually age-related hypothyroidism. For any chronic condition, ALWAYS look at thyroid first, it affects *everything*, and fixing it will make a host of apparently-unrelated conditions go away without further treatment.

      [I sound like a broken record about this, but it's really frustrating to have read reams of research and realise that almost none of it has trickled down to medical practice, let alone been considered where it may impact other research.]

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    19. Re:What about other NSAIDs? by MercTech · · Score: 1

      Yes, Tramodol is for pain. You need something to reduce the inflammation and NOT more and more pain killer. My primary care needs to be beat up with a clue bat. They keep upping pain killer dosage and canceled the NSAID prescriptions. But, 600mg of ASA 4 times a day works.

      --
      NRRPT/RCT
  3. Ibuprofen helps in prostatisis by Anonymous Coward · · Score: 0

    So guys with prostatisis are now double screwed.

    Ibuprofen was a must for me when I had acute prostatisis.

    1. Re: Ibuprofen helps in prostatisis by Anonymous Coward · · Score: 0

      Have you tried Paleo, keto or fasting ?

  4. Shit! by drinkypoo · · Score: 2

    That sounded great for a second, until they got to ED. I'd love to be cheaply infertile, but I want my pecker to work, if not my gonads.

    --
    "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    1. Re:Shit! by Anonymous Coward · · Score: 0

      ED drugs work well even if you take OTC and/or prescription NSAIDS for years.

    2. Re:Shit! by Aaden42 · · Score: 2

      One pill makes you larger, and one pill makes you small.

      (And if Mother's the one who's giving them to you, you have other problems.)

    3. Re:Shit! by david_thornley · · Score: 1

      And ED drugs are contraindicated for at least one fairly common health issue (heart attacks).

      --
      "When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
  5. Sex drive by Anonymous Coward · · Score: 0

    Maybe this is why I lost all my sex drive, low testosterone... taking Naproxen-EC 500mg twice a day since a year. I don't care for my fertility, I've a vasectomy :P

  6. Now What by Anonymous Coward · · Score: 0

    First, cell phones kill our sperm and now ibuprofen..

    1. Re:Now What by Anonymous Coward · · Score: 0

      Won't somebody please think of the sperm?

    2. Re:Now What by DickBreath · · Score: 2

      Since every sperm is sacred, you should not take NSAIDS, but just suffer with the pain. And get rid of your cell phone. Or only operate it in airplane mode -- I mean, your phone, not your, um, other equipment. Getting rid of your phone would take away the distraction from the toy that males are supposed to play with.

      --

      I'll see your senator, and I'll raise you two judges.
  7. Now you tell me? by Jethro · · Score: 2

    This would have been useful information 20 or so years ago...

    --


    In the land of the blind, the one-eyed man is kinky.
    1. Re:Now you tell me? by Anonymous Coward · · Score: 0

      I concur. The Army and subsequently the VA has had me on a large dose of ibuprofen for a while now.

    2. Re:Now you tell me? by DickBreath · · Score: 1

      It's a quality of life question. Does the use of ibuprofen, with its side effects, give you a better or worse quality of life?

      --

      I'll see your senator, and I'll raise you two judges.
    3. Re: Now you tell me? by Anonymous Coward · · Score: 0

      Well it helps with the inflammation and pain, but now my wife's become a pain in the ass. ;)

      Can't win. Lose lose.

  8. One can imagine the effect in Women by SigIO · · Score: 1

    With already lower testosterone levels than men, this sounds like a prescription for Vaginile Dysfunction.

    1. Re:One can imagine the effect in Women by omnichad · · Score: 1

      Actually, it makes it an even better ingredient in PMS drugs - since that's peak testosterone time.

  9. Did they use soldiers? by known_coward_69 · · Score: 1

    Motrin is a US Army joke going back decades that it cures everything. Also called Ranger Candy cause the joke is the Army Rangers train so hard they take it all the time for your normal injuries and aches

    1. Re:Did they use soldiers? by dwillden · · Score: 2

      Joke? That's no joke, it's medical care in the military. Go to the Medics, get Motrin. Who cares that it was for a cold or a sprain or a missing limb. The wonder drug cures all, or at least lets the medics feel like they did something.

      --
      I'm too lazy to compose a creative sig.
    2. Re:Did they use soldiers? by Anonymous Coward · · Score: 0

      Yep. Commenting as a military brat, the docs dole that shit out for everything. This would've been really nice info to know YEARS ago. I'm glad I stopped taking so much of this stuff last year due to my neurologist's recommendation though. Not that I care about infertility, the ED, testosterone production, and muscle wastage though...

    3. Re:Did they use soldiers? by Anonymous Coward · · Score: 0

      It wasn't just that they gave out Motrin for everything. They gave high dosage Motrin. 800mg if I remember correctly.

    4. Re:Did they use soldiers? by GingaFlash · · Score: 1

      Don't forget to change your socks and drink plenty of water for that missing limb! ;]

  10. Don't worry.... by MerlTurkin · · Score: 1

    Next month someone will say the opposite. Move along, nothing to see here.

    1. Re:Don't worry.... by Jason1729 · · Score: 1

      Of course someone will say the opposite. I'm sure Pfizer (owners of the Advil brand) already have their people writing the papers.

      While this study may or may not actually be right, you really aren't stupid enough to believe you can read an occasional headline in pop-media and think you know what is going on in the scientific community are you?

      And you aren't stupid enough to think most studies are published as pure unbiased science without pushing corporate agendas, are you?

  11. News for nerds... by Anonymous Coward · · Score: 0

    ... like me that nobody will date anyway?

  12. So, it works? by Anonymous Coward · · Score: 0

    Long term relief from an 18 year long headache? Sign me up, please.

  13. Long term use by SumDog · · Score: 1

    I knew someone in high school who took Ibuprofen all the time. I think she took it for headaches and then didn't realize just how much she was taking.

    No over the counter drug is probably safe for extended long term use. If you're seriously using it that long, you need to find out what else is wrong.

    1. Re:Long term use by DickBreath · · Score: 1

      An OTC drug can be perfectly safe for extended long term use -- but should only be done under a doctor's supervision.

      --

      I'll see your senator, and I'll raise you two judges.
    2. Re:Long term use by jedidiah · · Score: 1

      > An OTC drug can be perfectly safe for extended long term use -- but should only be done under a doctor's supervision.

      Those two statements are inherently contradictory.

      A drug by definition is meant to "mess you up". It should be pretty obvious that anything that can have a useful effect on your body will also likely disturb it as well.

      Assuming that things are harmless is very dangerous.

      --
      A Pirate and a Puritan look the same on a balance sheet.
    3. Re:Long term use by david_thornley · · Score: 1

      A drug by definition is meant to "mess you up". It should be pretty obvious that anything that can have a useful effect on your body will also likely disturb it as well.

      Probably, but the body also has self-healing capability, and if the amount of damage the drug causes is well below the healing ability it's likely to be safe.

      --
      "When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
  14. Done on purpose. by Anonymous Coward · · Score: 0, Funny

    I have heard a LOT about how nsaids combine with flouride to make men infertile and feminine. This shit is being done on purpose to destroy male power and bring about a new world order.

    1. Re:Done on purpose. by Anonymous Coward · · Score: 1

      You really think the people in charge are able to do something like that? They're bumbling idiots who can't even pass a budget without screwing up the country. You're an idiot.

      Estrogen in the water supply that gets there from women's urine after they take birth control pills is having the effect you're talking about. And it's not a conspiracy it's just the sheer stupidity and incompetence of the people in power.

      Soy products also have that effect on men, and you see how the left lobby pushes soy milk and tofu on the population. But again it's not a conspiracy just stupidity and incompetence.

    2. Re:Done on purpose. by Anonymous Coward · · Score: 0

      Found the libtard.

    3. Re:Done on purpose. by sexconker · · Score: 1

      You really think the bumbling idiots paraded on stage are the people in charge?

      You really think those in charge are people?

  15. Therapeutic Dosage Range by gazelam · · Score: 1

    Ibuprofen has had several advantages because it has such a wide dosage range between minimally effective, maximally effective, and toxic/damaging. Even taking 2400 mg per day (maximally effective prescribed dosage) seems to be well below the point where any organ damage is generally observed. OTOH, for acetaminophen, taking the maximum effective prescribed dosage of 3250 mg/day seems pretty close to the level at which damaging effects are observed in kidneys and perhaps the liver. Now, with this result, are we back to aspirin? **I am not a doctor, but I am willing to have a look. Put your feet in the stirrups.**

    1. Re:Therapeutic Dosage Range by burtosis · · Score: 5, Interesting

      Now, with this result, are we back to aspirin?

      You must be new to American healthcare and pharmaceutical industries, you simply don't stop taking something like ibuprofen just because your testosterone levels may become permanently damaged. That would be stupid, but more impotently, it would wreak havoc on stockholder returns. No, the impudent thing to do is to simply keep taking it and add an additional drug to block the side effects that is patented and protected. Being able to skyrocket the price of a 12 cent generic medication, that nearly all Americans take and many rely on, to over 17 dollars is sheer financial genius and a winning example of what you can achieve with capitalism in charge of healthcare.

    2. Re:Therapeutic Dosage Range by jittles · · Score: 0

      Now, with this result, are we back to aspirin?

      You must be new to American healthcare and pharmaceutical industries, you simply don't stop taking something like ibuprofen just because your testosterone levels may become permanently damaged. That would be stupid, but more impotently...

      I see what you did there...

    3. Re:Therapeutic Dosage Range by Anonymous Coward · · Score: 0

      Ibuprofen has had several advantages because it has such a wide dosage range between minimally effective, maximally effective, and toxic/damaging. Even taking 2400 mg per day (maximally effective prescribed dosage) seems to be well below the point where any organ damage is generally observed. OTOH, for acetaminophen

      FYI, acetaminophen is not an NSAID, it's a COX-2 blocker, and has different usages.

    4. Re:Therapeutic Dosage Range by 93+Escort+Wagon · · Score: 1, Redundant

      ... but more impotently, ...

      Please tell me that wasn’t a typo!

      --
      #DeleteChrome
    5. Re:Therapeutic Dosage Range by Anonymous Coward · · Score: 0

      (Score: 5, Socialist Manure)

    6. Re:Therapeutic Dosage Range by Rande · · Score: 1

      12cents? Damn, here in the UK it costs 53p for a box of 16 which I previously thought was cheap. And 10 times more in Ireland.

    7. Re:Therapeutic Dosage Range by s122604 · · Score: 1

      It's not 12c, at least not in bulk
      Generic ibuprofen can be bought for less than 1 cent a pill
      https://www.costco.com/Kirkland-Signature-Ibuprofen%2C-200-mg.%2C-1%2C000-Tablets.product.11489095.html

    8. Re:Therapeutic Dosage Range by cmseagle · · Score: 1

      What on earth are you talking about? Is your point that this study is bogus, and that patients should continue taking ibuprofen because it's cheap? That pharmaceutical companies shouldn't do research into compounds that would offset this apparent side effect? That such a drug wouldn't be worth giving to patients, no matter what the monetary cost?

      There's an interesting conversation to be had in weighing the cost of drugs against their efficacy. Your comment, a logically incoherent rant that seems primarily aimed at hitting all the squares of "mod me up!" buzzword bingo, does not contribute to it.

    9. Re:Therapeutic Dosage Range by burtosis · · Score: 2

      Your comment, a logically incoherent rant that seems primarily aimed at hitting all the squares of "mod me up!" buzzword bingo, does not contribute to it.

      Thank you for your droll review of my word craft. The OP really did seem to be unaware of how things work here, and an incoherent rant primarily aimed at hitting all the squares of "mod me up!" buzzword bingo, as it relates to the article, was not only what I intended, but is actually succinct, only slightly hyperbolic simile.

    10. Re:Therapeutic Dosage Range by burtosis · · Score: 1

      True, but it also sells 2 pills for us$ 1.79 in gas stations or other convenience locations. Further, it costs $10-20 per pill in hospital settings like an ER. An ER bill for Ibuprofen could easily run $300 for a single visit, patients may be responsible for paying the full amount in America if they don't have the right coverage.

  16. Possible research by gurps_npc · · Score: 1

    I bet they can find a bio-similar drug that avoids the more permanent/serious issues and simply prevents fertility.

    --
    excitingthingstodo.blogspot.com
    1. Re:Possible research by Opportunist · · Score: 0

      If so, rest assured the religious nutjobs will try what they can to keep it from becoming widespread. You can't just screw around without fearing at least consequences if you can't be swayed to fear their imaginary buddy.

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    2. Re:Possible research by AmiMoJo · · Score: 1

      It's called soy. Apparently.

      --
      const int one = 65536; (Silvermoon, Texture.cs)
      SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
    3. Re:Possible research by PPH · · Score: 1

      I think they'd need to find something more targeted than just interfering with testosterone production. That hormone does a lot of other desirable things besides generate baby seed.

      --
      Have gnu, will travel.
    4. Re:Possible research by drinkypoo · · Score: 1

      It's called soy. Apparently.

      Several studies suggest that eating too much soy will cause cancer in men though, especially prostate cancer. I, for one, simply cannot digest it, so I won't try to eat it anyway.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    5. Re:Possible research by AmiMoJo · · Score: 0

      Unfortunately it seems to be a vital component of Brain Force Plus, which I consume in industrial qualities. That's why I'm, like, a genus and very stable.

      --
      const int one = 65536; (Silvermoon, Texture.cs)
      SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
  17. LITERALLY, ADVIL TURNED ME INTO A NEUT! by Anonymous Coward · · Score: 0

    But it let me show my feminine side.

    Inmate 0132812
    Fort Redmond

  18. Ranger Candy by geekmux · · Score: 1

    There's a reason those large 800mg Motrin pills are called "Ranger Candy". I've seen MDs "prescribe" those horse pills scooped out of a cardboard box and into a plastic bag with a large metal scoop. Looked exactly like a kid buying jelly beans in bulk from a candy store.

    Wonder if this latest research will affect the mentality in those high-speed low-drag military units where they tend to eat these things like candy.

    Sadly, infertility is probably a better alternative than getting hooked on opium from Dr. Pharma.

    1. Re:Ranger Candy by TJ_Phazerhacki · · Score: 1

      Not just Ranger Candy - it's been the cure-all for aches and pains among athletes for YEARS, since the only 'real' side effects have been Stomach/Intestinal problems for older people. When I was actively playing Football in HS/College, I was taking 2400mg/day (with a doctor's blessing) without *any* concern. It's been my go-to treatment for knee and back problems as I entered my 30's (albeit at a much lower dose.) Stacking it and CBD is almost as effective for me as stacking it and Percocet for short-term heavy-duty acute pain relief.

      I haven't hoped that a study was retracted quite so much in a long time... :(

      --
      Physics is nothing like religion. If it was, we'd have an easier time trying to raise money!
  19. I think it has less to do with stockholders by rsilvergun · · Score: 1

    then it does with people taking excessive amounts of OTC drugs to cope with pain instead of seeing a doctor about that pain. In America unless you're in the top 5% you don't just go see a doctor. You weigh the cost in terms of co-pay, deductibles, time off work (we don't get very much of it) etc, etc. With all those costs you just pop another Advil and hope for the best.

    --
    Hi! I make Firefox Plug-ins. Check 'em out @ https://addons.mozilla.org/en-US/firefox/addon/youtube-mp3-podcaster/
    1. Re:I think it has less to do with stockholders by Anonymous Coward · · Score: 0

      And when you DO go see a doctor you'll probably pass some hot girl on her way out that just got done pitching said doctor on the safety of oxycontin. Best thing to fix this whole situation is to put a CEO of a drug company in charge of deregulating and eliminating all criminal liability for abuse. Oh and lets crack down on weed while we're at it. We all know that legal weed has turned CO and WA into states with...less marijuana and alcohol abuse.

    2. Re:I think it has less to do with stockholders by Anonymous Coward · · Score: 0

      then it does with people taking excessive amounts of OTC drugs to cope with pain instead of seeing a doctor about that pain. In America unless you're in the top 5% you don't just go see a doctor. You weigh the cost in terms of co-pay, deductibles, time off work (we don't get very much of it) etc, etc. With all those costs you just pop another Advil and hope for the best.

      The top 5% of the intelligence pool does not go to a white coat opium dealer. They can only offer addiction in a bottle, and you're better off staying at home and finding another way to manage your pain.

      When looking at the root cause of pain, obesity plays a supersized role in this fucking mess. And you can fix lazy about as easily as you can fix stupid. It hurts me just looking at those dealing with pain caused by ignorance.

    3. Re:I think it has less to do with stockholders by Impy+the+Impiuos+Imp · · Score: 1

      top 5% only see doctors

      How is the work down on the docks, comrade?

      --
      (-1: Post disagrees with my already-settled worldview) is not a valid mod option.
    4. Re: I think it has less to do with stockholders by Anonymous Coward · · Score: 0

      Energy is a little low since our rations of freedom coffee and saccharine tablets hasn't arrived yet.

    5. Re:I think it has less to do with stockholders by burtosis · · Score: 1

      We all know that legal weed has turned CO and WA into states with...less marijuana and alcohol abuse.

      Its about time someone thought of those poor prison systems. Legalize weed and suddenly you lose out on all kinds of profit and jobs for those prisons, people start to abuse drugs less - even alcohol, you can't use it as an easy excuse to hassle minorities and most importantly - permanently ruin their lives, but the biggest loss here is the the billions of dollars that is going to be lost to big pharma when they are faced with a free alternative to many of their products. Get a grip, let's make America great again by making those few individuals who deserve it ludicrously wealthy and those god damn minorities pay.

  20. clickbait headline by TheGratefulNet · · Score: 4, Insightful

    look, 1200mg is VERY high dosage!

    I take 2 200mg pills every day, matter of course, for joint pain (I'm over 50) and at first, I was concerned, but when I read the dosage they were taking, I 'stopped reading there' (as the kids say).

    slash is getting so sleazy these days.

    the correct headline is: MASSIVE dosage of advil can cause problems. leave out the adjective and the article is a lie.

    typical of slash and media these days. accuracy never matters anymore, just clicks. sigh.

    --

    --
    "It is now safe to switch off your computer."
    1. Re:clickbait headline by hawkfish · · Score: 2

      look, 1200mg is VERY high dosage!

      I take 2 200mg pills every day, matter of course, for joint pain (I'm over 50) and at first, I was concerned, but when I read the dosage they were taking, I 'stopped reading there' (as the kids say).

      slash is getting so sleazy these days.

      the correct headline is: MASSIVE dosage of advil can cause problems. leave out the adjective and the article is a lie.

      typical of slash and media these days. accuracy never matters anymore, just clicks. sigh.

      It depends on how sensitive you are to the drug. When I broke my collarbone about 30 years ago, they gave me some codeine, which made me throw up. The fallback was to take 100mg of ibuprofen every hour (2400mg/day) for about a week. Ever since then, I've had to take 800mg just to get rid of a headache. I've tried 600mg and it doesn't work (FWIW I weigh about 190# and am pretty active).

      So while you may be lucky enough to get by on 400mg/day, not everyone can.

      --
      You will not drink with us, but you would taste our steel? - Walter Matthau, The Pirates
    2. Re:clickbait headline by xfade551 · · Score: 4, Informative

      That number 1200mg sounds like ridiculously high dosage, until you realize it's typical for U.S. military physicians to prescribe a dosage of an 800mg pill x 3-4 times/day. Same goes for discharged veterans getting medical care from VA hospitals.

    3. Re:clickbait headline by Anonymous Coward · · Score: 0

      Ibuprofen in 600+ on a regular basis will form a habit where you will get headaches unless you keep taking it. The only way out is to switch to something like tylenol and wean yourself off of the ibuprofen. I know someone who was in this habit and the headaches slowly became worse over the years until they were hospitalized because of the pain. Now they don't take any ibuprofen at all, and no headaches.

    4. Re:clickbait headline by Anonymous Coward · · Score: 0

      200mg is only 3x less.

      Low dose pills are 81mg, 7x times less. Much better.

    5. Re:clickbait headline by Anonymous Coward · · Score: 1

      1200mg per day is "massive"? Hardly. It's just 2 pills taken 3 times a day (once each meal). Not only is that perfectly normal, but I've been told by doctors to take at least that much, if not more (e.g., 3-4 pills taken 3 times a day) for weeks on end in various cases. It's well within the accepted range.

    6. Re:clickbait headline by Anonymous Coward · · Score: 1

      If by MASSIVE you mean the recommended maximum dosage on the package?
      I have a packet of generic ibuprofen right here: 2 x 200mg 3 times a day = 1200mg

    7. Re:clickbait headline by Anonymous Coward · · Score: 0

      hahahaha of Ibuprofen?

    8. Re:clickbait headline by Anonymous Coward · · Score: 0

      And, if you read up on ibuprofen serum levels, you'll see that 800mg was considered the maximum effective dose for a nominal adult male. Giving anything more seemed to just be a risky waste, while giving less could have lower therapeutic levels of the drug in the blood.

      My body reacts to most narcotics with an "I am poisoned!" response full of nausea, so I settled on ibuprofen as my go-to medicine for pain many years ago. I'll alternate with acetomeniphen, but since I'd like to reserve my liver for drinking beer, I favor the NSAIDs. However, I was a believer in the "Excederin" blend of acetomeniphen, aspirin, and caffiene back when I had recurring migraine headaches. In recent years, I've seen that naproxen works better for aching joints from over-work.

    9. Re:clickbait headline by pots · · Score: 1

      1200 mg/day is the standard dosage for over-the-counter ibuprofen. Prescription can be more than 2.5 times that.

    10. Re:clickbait headline by hawkfish · · Score: 1

      Ibuprofen in 600+ on a regular basis will form a habit where you will get headaches unless you keep taking it. The only way out is to switch to something like tylenol and wean yourself off of the ibuprofen. I know someone who was in this habit and the headaches slowly became worse over the years until they were hospitalized because of the pain. Now they don't take any ibuprofen at all, and no headaches.

      I have heard of this (I had a Health teacher in the 1970s who had the same problem), but I don't take such doses on a regular basis. I get headaches maybe about once a month, so I don't get hooked. But I also suspect that your anecdote has a lot of individual variation - which is why I gave my weight in my OP.

      --
      You will not drink with us, but you would taste our steel? - Walter Matthau, The Pirates
  21. Male Birth Control pill? by rsilvergun · · Score: 1

    just wondering if the mechanism that makes this work could be used elsewhere. Not that you could just prescribe a tone of ibuprofen, it's got as ton more (and worse) side effects than this in high doses. But I don't think there's been nearly enough research on a male pill.

    --
    Hi! I make Firefox Plug-ins. Check 'em out @ https://addons.mozilla.org/en-US/firefox/addon/youtube-mp3-podcaster/
    1. Re:Male Birth Control pill? by Anonymous Coward · · Score: 0

      just wondering if the mechanism that makes this work could be used elsewhere. Not that you could just prescribe a tone of ibuprofen, it's got as ton more (and worse) side effects than this in high doses. But I don't think there's been nearly enough research on a male pill.

      It reduces testosterone levels. We already have ways to do that or to block the action of testosterone. Most people who want birth control still want to have sex. If you bothered to read even the first sentence of the summary you'd see it also causes "muscle wastage, erectile dysfunction and fatigue".

  22. What about effect on females? by lamer01 · · Score: 1

    Lots of women take ibuprofen during their period for cramps.

  23. wtf druggies by Anonymous Coward · · Score: 0

    who the fuck takes 1200mg of ibuprofen a day? if you need that much, you need to see a doctor.

    1. Re: wtf druggies by Anonymous Coward · · Score: 0

      You are right, if you SEE a doctor he will prescribe more than 1200 a day. 1200 a day is the recommended amount by manufacturers. Doctors do routinely prescribe much higher doses.

      You sir aren't informed at all. Doctors routinely prescribe 800mg tablets. 2 per dose. That's 1600 right there bunk.

  24. Comment removed by account_deleted · · Score: 0

    Comment removed based on user account deletion

  25. Re:Oh, dang! by Anonymous Coward · · Score: 0

    If anyone needs pain relief it's the people tricked into watching your videos or reading your bullshit stories!

  26. Finally ... by CaptainDork · · Score: 1

    ... a Pill for men.

    --
    It little behooves the best of us to comment on the rest of us.
  27. Re:Oh, dang! by Anonymous Coward · · Score: 0

    A creimer erect
    heart couldn't take it
    don't send flowers

  28. Alternatives for inflammation by TimTucker · · Score: 1

    There are some non-drug alternatives for dealing with inflammation that have seen positive results from research, namely foods with high amounts of anthocyanins.

    As an example: "Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial":
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874510/

    1. Re:Alternatives for inflammation by Anonymous Coward · · Score: 0

      And hypnosis is seriously effective for pain management. If you practice enough at it (it's a skill just like everything else in life), you can use it instead of being knocked out during surgery.

  29. I win by slashmydots · · Score: 1

    Joke's on you all. I'm allergic to Ibuprofen. Take that.

  30. Re:Oh, dang! by Anonymous Coward · · Score: 0

    1) Why are you taking pain meds when after one look at you, you're obviously a rare specimen of physical fitness? (Think football player)
    2) What does impotence have to do with infertility? Granted, you're both, but still?

  31. Two birds with one stone by mschuyler · · Score: 2

    Sounds like it takes care of two headaches at once.

    --
    How about a moderation of -1 pedantic.
  32. More about long term usage than actual dosage. by DarthVain · · Score: 1

    No its the highest recommended dosage by manufactures. At the recommendation of doctors I have taken dosages even larger than that.

    However when I've taken it at such high dosages it was for acute temporary pain (i.e. injury trauma). However once past the hump which is probably measured in days, or perhaps a week, dosage down to more reasonable levels for a few weeks.

    Sure if you take it for months at a time it probably isn't so good for you. Though at a guess if you are, likely the alternative isn't great either. I recall asking my doctor if it was really OK to go beyond the recommended maximum dosage on the bottle, and she said that it happens in the military all the time, so long as your young and healthy (outside of your current injury), and don't do it for any long period of time it shouldn't be a problem.

    That said, as a guy, it isn't really all that great to hear this kind of news anyway...

  33. So in other words... by balbeir · · Score: 1
    Painkillers make you a girly wuss

    Suck it up, be a man

    Pain is just weakness leaving the body

  34. Re:Oh, dang! by Anonymous Coward · · Score: 0

    Yes, wouldn't want to disappoint all those women lusting after you. One look at those chins and it's Dirty Grandpa time!

  35. Need that handle... by Anonymous Coward · · Score: 0

    Chris is 400 pounds of dead weight in bed. Without his morning wood, no one can pull him out of bed.

  36. Who cares? by Anonymous Coward · · Score: 0

    Single study positing a potential risk to male reproductive health? Time to pump more money into pre-natal care and breast cancer research.

  37. Re:Oh, dang! by Anonymous Coward · · Score: 0

    Shut up man. One Indonesian lady who said she wanted him purely for a green card was all up on his jock. However, in the end creimer decided he didn't want to go to India.

  38. Re:Oh, dang! by Anonymous Coward · · Score: 0

    https://slashdot.org/~Joe_Drag... is a creimer sockpuppet for karma.

  39. Downplay and distract. by Anonymous Coward · · Score: 0

    Downplay and distract.

  40. Re:Oh, dang! by Anonymous Coward · · Score: 0

    Same lame humor, yes. What other evidence do you have?

  41. Re:Oh, dang! by Anonymous Coward · · Score: 0

    I don't think it's creimer. He never talks about any of creimer's favorite topics. No compulsive hyperlinking.
    He's not causing trouble anyhow.

  42. Re:Oh, dang! by Anonymous Coward · · Score: 0

    1) Endless posts that are about two lines long (20 of them in the past two days). This is also creimer's usual style of posting.

    2) Repeatedly brings up creimer's pet subjects ("Send mulder and scully to the apple spaceship!"). Granted there's obviously other nerds on slashdot who enjoy these statements, and are socially awkward enough that they throw them out as LOL SO RANDOM humor (like his recent MiB post), but he does it over and over.

    3) Poor grammar ("Now with AMD EYPC maybe get 5-7 gpu per node with the rest of the PCI-e for network / disk / ipmi / etc.")

    No I am not 100%. But 90%, sure.

  43. Re:Oh, dang! by Anonymous Coward · · Score: 0

    Yeah it does smell of creimer's usual open-mouth burp at a social event, doesn't it?

  44. Re:Oh, dang! by Anonymous Coward · · Score: 0

    Holy shit, now I KNOW it's you, Chris! You don't even need to burp your foulness, I can smell your stale BO through the screen!

    I really truly wonder what drives you, what is your motivation? Did you grow up in such an adverse environment that you simply can't do anything else but be contrarian?

  45. Re:Oh, dang! by Anonymous Coward · · Score: 0

    Indonesia and India are ... two different countries, Chris. And how many decades ago was this? You're a geriatric loner who spends his free time making videos about coins and delaying the publication of your haiku.

    So the only woman who ever interacted with you just wanted a green card. Hard to believe a football player 4.0 GPA star programmer would be single.

  46. Comment removed by account_deleted · · Score: 0

    Comment removed based on user account deletion

  47. Why are you taking it for that long? by whitroth · · Score: 1

    That's the real question: why are men taking high dosages for that long? If they're in that much pain, they're not going to be real interested in sex, anyway.

    On the other hand, if you're taking it for bad headaches... and you regularly work 60+ hour weeks, perhaps you should consider cutting back to 40 hours, and getting enough sleep.... (Or are you actually an indentured servant?)

    1. Re:Why are you taking it for that long? by Zeekort · · Score: 1

      I agree. It really depends on what they're taking it for. If it's just headaches and they work too much, they should consider a different job if they can't cut back the hours. I know several guys that need to rethink their life because they work themselves to death everyday and they aren't in a position to where they need to do so with family and kids to take care of for example.

      It's good to shoot for the sky (or space), but you need to be able to enjoy life too. It's usually younger guys that make the mistake of overworking but it can happen to anyone.

  48. Re:Oh, dang! by Anonymous Coward · · Score: 0

    hahaha I'm not creimer, if some guy on a tech site is full of creimer non-humor autism I'm not really surprised.
    I only looked for a second but I only see normal nerd autism and none of creimer's bullshit. I don't even care if it is creimer as long as he's not constantly making up flimsy excuses to post a referrer link.

    As far as creimer's motivation? Dude he's full of get rich quick schemes, he gets off on chasing piddly dollars it's one of his autistic obsessions. Anything where he gets a reward and it's tightly coupled with the action that got him it. Like staring at the ground all day for lotto tickets. He reads about all these stupid ways to get rich on the web and then carries that shit back to slashdot where people LOATHE that kind of shit and long for the days when it wasn't a normal part of the internet.

  49. Re:Oh, dang! by Anonymous Coward · · Score: 0

    You're some AC switching between 1st and 3rd person mid-sentence, which isn't really very convincing one way or the other.

  50. Re:Oh, dang! by Anonymous Coward · · Score: 0

    Plenty of ACs are trolling you and they're all name Chris. Or Lilly. Maybe Joe?

  51. Re:Oh, dang! by Anonymous Coward · · Score: 0

    "and they're all name Chris"

    creimer-like grammar detected. Chris, try to put some effort into your posts.