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A Search For Insomnia Genes Involving 1.3 Million People is the Largest Genetic Study Ever (technologyreview.com)

In a genetic study of unprecedented size, scientists have searched for inherited causes of insomnia in the DNA 1,310,010 people. From a report: They found 956 different genes linked to the sleep disorder, drawing closer to an explanation of what causes it and, perhaps, to new ways to treat it. The study appears to be the first gene search to involve DNA collected from more than one million people. "It's amazingly massive," says Stuart Ritchie, a psychologist involved with genetics research at the University of Edinburgh. On Twitter, scientists let loose with superlatives: "Holy cr*p," "mammoth," and "Wow!" The project involved crunching genetic and medical information collected from the UK Biobank and the consumer DNA testing company 23andMe. It was led by Danielle Posthuma, a neuroscientist specializing in statistical genetics at Vrije University, in Amsterdam.

37 comments

  1. 23andme? by Anonymous Coward · · Score: 0

    when using 23andMe, do you give them permission to use your DNA for other purposes?

    1. Re:23andme? by Anonymous Coward · · Score: 0

      it's opt in

    2. Re:23andme? by TechyImmigrant · · Score: 2

      They ask for consent individually for each study.

      --
      I should use this sig to advertise my book ISBN-13 : 978-1501515132.
    3. Re:23andme? by Anonymous Coward · · Score: 0

      No, the NHS put it up in an semi-unsecured cloud for all to see.
      And now positive results for a Dutch concern. In the future they may even send out letters advising a cure for Scottish genes, and something to repress British soccer lout syndrome.

  2. Disorder? by Anonymous Coward · · Score: 0

    Is it really a disorder if so many people have it? Perhaps it's time for our social constructs such as work times, sleeping hours, etc. to catch up with evolution.

    1. Re:Disorder? by Anonymous Coward · · Score: 0

      You could be right. Insomnia may not be a disability but a super power, if only we could learn how to harness the power of it in some fashion.

    2. Re:Disorder? by Anonymous Coward · · Score: 5, Insightful

      Yes, it is *absolutely* a disorder.

      It is horrible. Fucking horrible. People who have never been afflicted have no concept of how shitty you feel all the time, and the overwhelming frustration of laying in bed, completely exhausted, and uncompromisingly wide awake.

      The strong medications are either tolerance-building, or cause problematic symptoms like sleep-walking, or both. And of course the weak medications are weak.

      And you are surrounded by people who know nothing about fucking anything giving you stupid and thoughtless advice as if they have just cured you.

    3. Re:Disorder? by Anonymous Coward · · Score: 0, Flamebait

      Cranky, cranky!

      Sounds like someone needs a nap.

    4. Re:Disorder? by Anonymous Coward · · Score: 0

      I just figure there's a lot of people out there with guilty consciences.

    5. Re:Disorder? by Anonymous Coward · · Score: 0

      I have anxiety induced insomnia. I can cope/manage it by better management of my anxiety. I've only had a few nights with 3 hours of sleep, and it was horrible. I've never felt so wide awake, even thought I was exhaustively tired. Insult to injury, the more tired I felt, the more difficult it was to get to sleep. An uncontrollable version would suck a big fat.....

      My biggest issue right now is feeling tired can trigger my anxiety.

    6. Re:Disorder? by subk · · Score: 1

      You're obviously either too dumb or too square to try weed... Nature solved this problem for us eons ago.

      --
      Now, if you'll excuse me, I have backups to corrupt.
    7. Re:Disorder? by asackett · · Score: 1

      I've Delayed Sleep Phase Disorder which I don't suffer because I'm self employed, but I get whacked by wicked insomnia every now and then that makes life pure shit. A week of sleeping zero to two of every 24 hours knocks me out of work, and at two weeks I can't follow idle chit-chat any more and have switched off the telephone ringers. At a month in, it's just a complete bummer and death seems an acceptable, though not preferable, resolution. (I'm not suicidal; don't need a hotline.)

      On the up side, being self employed means that I can better control the trigger conditions of the insomnia and don't have to worry about the DSPD getting me fired for being habitually late to work.

      --

      Warning: This signature may offend some viewers.

    8. Re: Disorder? by gweilo8888 · · Score: 1

      Oh, get over yourselves with the flamebait moderation on this post. I have suffered with chronic insomnia for between three and four decades, but you know what? I can still tell a joke when I see one. Parent post didn't deserve the downvote, just s quiet chuckle or a roll of the eyes.

    9. Re:Disorder? by Anonymous Coward · · Score: 0

      Could you elaborate? I'm assuming you're talking about CBD or CBN, not THC. I'm trying to find something that worked for others.

    10. Re:Disorder? by asackett · · Score: 1

      In my experience, weed reduces the frequency of it but once an episode begins all I get for smoking myself into a stupor is redundancy -- I'm already stupefied by the absence of sleep.

      --

      Warning: This signature may offend some viewers.

    11. Re: Disorder? by Anonymous Coward · · Score: 0

      Must have been Sativa. Try Indica next time.

    12. Re:Disorder? by subk · · Score: 1

      Yes, good question. I have found CBD-rich Indica strains work well. THC doesn't hurt, but Sativa is usually counter-productiive. The best is straight CBD oil dropped sublingually.

      --
      Now, if you'll excuse me, I have backups to corrupt.
    13. Re: Disorder? by subk · · Score: 1

      Put a few drops of CBD oil under your tongue and thank me when you wake up 15 hours later. :P

      --
      Now, if you'll excuse me, I have backups to corrupt.
    14. Re: Disorder? by asackett · · Score: 1

      Don't tell me, let me guess: You're a budtender.

      --

      Warning: This signature may offend some viewers.

    15. Re: Disorder? by Anonymous Coward · · Score: 0

      This hopeless insomniac LOL'ed.

    16. Re: Disorder? by Anonymous Coward · · Score: 0

      It's true, but the cohort with the biggest burden of guilty feelings isn't even approximately equal to the cohort that has done the most wrong.

  3. A study ? Made by scientists ? by Anonymous Coward · · Score: 0

    But aren't all scientists untrusworthy bastards part of a global conspiracy of evil to suck always more grant money from not-at-all-evil governements ?

    If you don't trust scientists when they tell you that global warming is caused by human activity, or that diversity of life on earth is the product of evolution through natural selection, or that the universe is 15 billion years old and not six thousand, or that vaccines don't cause autism, then why would you trust them when they tell you that there may be a link between genes and insomnia ?

    1. Re:A study ? Made by scientists ? by Anonymous Coward · · Score: 0

      Believing one thing a person says does not automatically mean you have to believe everything a person says.

      People can be right about one thing and yet wrong about another.

      This applies to groups of people, as well.

    2. Re:A study ? Made by scientists ? by Anonymous Coward · · Score: 0

      Yes, and belief or disbelief must be based on objective, rational criteria, not on the fact that some studies or scientists contradict a 2000 year old book, or displease some big oil and gaz corporations.

  4. Professional scientists on Twitter? by Anonymous Coward · · Score: 0

    Doubt it.

  5. Chosen because you can call at any time by mykepredko · · Score: 1

    Makes sense - if you're doing a study, you should pick a group of people you can ask questions of at any time.

  6. This article makes me tired. by xxxJonBoyxxx · · Score: 1

    Time for a nap.

  7. how do they know? by Anonymous Coward · · Score: 0

    disclaimer: i did read the very short article and have some questions.
    how do they know which genes cause insomnia?
    presumably the genes these sleep-deprived people share could be completely unrelated to sleeping.
    especially if "30% of the population" suffers from the disorder.

  8. Evolution in action by nospam007 · · Score: 1

    Younger people sleep well at night, because they need to be alert during the day for hunting mammoths and stuff.
    Older people sleep lightly or hardly at night, so to be able to hear predators, enemies and sick young ones. Since they don't participate in hunts anymore, they can do naps during the day.

    1. Re:Evolution in action by Anonymous Coward · · Score: 0

      Older people sleep lightly or hardly at night, so to be able to hear predators, enemies and sick young ones. Since they don't participate in hunts anymore, they can do naps during the day.

      I am so using that on the wife ...

      Me: But I have to nap, honey, it's an evolutionary imperative.
      Wife: Huh?
      Me: See, I have to be alert for predators ... and, um, sneak attacks ... and, err, sick youngn's.
      Wife: Predators? We live in the burbs. In a house. What predators?
      Me: Yeah, but ...
      Wife: Sneak attacks by who, exactly?
      Me: Ummm ...
      Wife: Sick children? We don't have children? We don't even have a dog.
      Me: Honey, it's evolution, and I read it on the interwebs ... you can't argue with science, honey.
      Wife: *glares*
      Me: I'll see you in a few hours ...

      Thanks! I can't wait to try that out!!

  9. What an interesting name... Danielle Posthuma(n) by Anonymous Coward · · Score: 0

    What an interesting name... Danielle Posthuma(n).

    I wonder if she's (oops I'm assuming gender) one of those technocrat weirdos who want to merge with machines and control/kill the rest of us. If so, she (oops there I go again) should be a little more subtle.

  10. Colour Television is rubbish by Anonymous Coward · · Score: 0

    You can track increased reports of insomnia and the adoption of colour television.

  11. I guess they are searching for those genes by Anonymous Coward · · Score: 0

    TIRELESSLY!

  12. Judi Bola by Anonymous Coward · · Score: 0
  13. Physical exertion by iamacat · · Score: 1

    Seriously, if you can't sleep, maybe that's because you are not tired. Of course if you do a one off work out, sore muscles will keep you awake. But else, do what nature intended and take a sufficiently challenging hike to be TIRED. You'll sleep like you probably don't remember. Seeing that people sit on their butts these days, I am not surprised they can't sleep at night.