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Diabetes Is Actually Five Separate Diseases, Research Suggests (bbc.com)

An anonymous reader quotes a report from the BBC: Scientists say diabetes is five separate diseases, and treatment could be tailored to each form. Diabetes, or uncontrolled blood sugar levels, is normally split into type 1 and type 2. But researchers in Sweden and Finland think the more complicated picture they have uncovered will usher in an era of personalized medicine for diabetes. The study, by Lund University Diabetes Centre in Sweden and the Institute for Molecular Medicine Finland, looked at 14,775 patients including a detailed analysis of their blood. The results, published in The Lancet Diabetes and Endocrinology, showed the patients could be separated into five distinct clusters:

Cluster 1 - severe autoimmune diabetes is broadly the same as the classical type 1 -- it hit people when they were young, seemingly healthy and an immune disease left them unable to produce insulin
Cluster 2 - severe insulin-deficient diabetes patients initially looked very similar to those in cluster 1 -- they were young, had a healthy weight and struggled to make insulin, but the immune system was not at fault
Cluster 3 - severe insulin-resistant diabetes patients were generally overweight and making insulin but their body was no longer responding to it
Cluster 4 - mild obesity-related diabetes was mainly seen in people who were very overweight but metabolically much closer to normal than those in cluster 3
Cluster 5 - mild age-related diabetes patients developed symptoms when they were significantly older than in other groups and their disease tended to be milder

7 of 114 comments (clear)

  1. And Potentially Alzheimerâ(TM)s as an additio by pollarda · · Score: 2

    There is more and more information coming out that Alzheimerâ(TM)s may be its own form of diabetes. https://www.ncbi.nlm.nih.gov/p...

  2. Re:And yet... by Ries · · Score: 2, Funny

    And you are an expert on this because...

    Certified internet WebMD doctor here, can vouch for demonlapin.

  3. Re:And yet... by Darinbob · · Score: 2

    He could just be American, where we insist on our right to express outrage at a story after only reading the headline.

  4. Re:More medical failure isn't news by ghoul · · Score: 2

    Same here. Got acute attack of pancreatitis and then got diagnosed as diabetic. Never ate sugar even in coffee as both parents had adult onset. Doctor keeps prescribing meds but nothing works except insulin. I have a weight of 170 pounds on a 5 7 frame so not morbidly obese but the general advice is lose weight. Hell I am taking Insulin 50 units a day and insulin makes you fat. How are you supposed to lose weight when you are barely 10 pounds above normal for the height and the insulin injections you take make you gain weight.

    It sucks when the efficiency of your body of changing food into food stores and cell energy is to high that your own body is trying to kill you
    BTW its almost impossible to find store bought food with no sugar in it. Even Morton's salt has sugar(dextrose) as an anti caking agent.
    All soups have sugar. The low fat stuff is the worst. Once you take fat out stuff tastes like crap so the companies add sugar to the brew to make it taste better.

    Scientists really need to figure out metabolic syndrome. its not as easy as taking a drug to affect one pathway as the body has multiple pathways and hyperactivates other pathways when you try to shutdown one. Take Insulin? The Liver starts converting sugar to fat and dumping it into the bloodstream or starts taking up the insulin to convert sugar to triglycerides and adding it to your belly. As opposed to the insulin being used by cells to take sugar in for burning which was the prescribed aim
    Try to eat less, body thinks its in starvation mode and slows down metabolism.
    Try to exercise a lot, the cells start using lactic acid instead of sugar.
    I also have super high triglycerides like 3000 (150 is normal).
    Dont drink and eat a low carb , high meat diet but the triglycerides never go down.
    Fixing diabetes is not easy and not every diabetic is grossly overweight or pigging on sugar.

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    **Life is too short to be serious**
  5. Re:Modern science treat the disease not symptom by Sique · · Score: 3, Interesting

    You know that 75-80% of your example potato is water, while the bag of chips is nearly free of water? A fair comparisation thus would be to compare 40 oz of potato to 8 oz of chips + 32 oz of water.

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    .sig: Sique *sigh*
  6. Re:And yet... by techno-vampire · · Score: 2

    I'm a diabetic. LADA to be exact. If I cut out all (or almost all) carbs from my diet, I'd be dead. I have to have some, and it's a balancing act: not to many, not too little. I may not be an expert on the subject, but I'm writing from personal experience.

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    Good, inexpensive web hosting
  7. Re:And yet... by Impy+the+Impiuos+Imp · · Score: 2

    "Just lose weight" has a 95% failure rate as a treatment. It is so bad the FDA would have rejected it.

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