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Experimental Spit Test Could Identify Men Most At Risk of Prostate Cancer (gizmodo.com)

An anonymous reader quotes a report from Gizmodo: A test developed by scientists in the U.K. and U.S. might someday be able to pinpoint the men most likely to get prostate cancer. A new study published Monday in Nature Genetics suggests the test can detect the one percent of men who are genetically most vulnerable to developing prostate cancer, a leading cause of cancer deaths among American men. The international research team used a new DNA analysis technique to peer into the genes of more than 70,000 people enrolled in previous studies. Some 45,000 of the subjects had already developed prostate cancer, while 25,000 hadn't. So the researchers compared the two groups, singling out any inherited genetic variations that might have contributed to their cancer risk. According to the authors, they managed to find 63 new variants never before associated with prostate cancer.

These results were then integrated with nearly a hundred genetic variants linked to prostate cancer previously found among 60,000 people to create a total genetic risk score. And finally, the researchers devised a test that uses a person's saliva to detect these more than 150 variants. In the U.S., people over the age of 50 are generally screened for prostate cancer via the prostate-specific antigen (PSA) blood test. Those with a certain high level of PSA should be screened annually, while everyone else is advised to be screened every two years. But the saliva test could reveal especially high-risk people who need annual screening regardless of their PSA level, while ruling out low-risk people who don't need annual screening based on their genetic risk and PSA scores. Those people would only need screenings every two, five, and maybe even 10 years.

58 comments

  1. This is an option, I guess by Anonymous Coward · · Score: 0

    Or, someone could just poke a finger up your butt. Either way works.

    1. Re:This is an option, I guess by Anonymous Coward · · Score: 1

      90% of men who reach the age of 80 years have an enlarged prostate. It causes many problems.

      There is some evidence that consumption of soy (and possibly other sources of isoflavones) reduces that risk. And, contrary to stupid-but-popular-belief, it does not feminize men at all to eat soy.

    2. Re:This is an option, I guess by Anonymous Coward · · Score: 0

      Soy consumption causes farting.

    3. Re:This is an option, I guess by HornWumpus · · Score: 1

      Take your Ds, if you're a middle aged or older man. About 1000% RDA. It's toxic at extreem doses...reading amature docter magazine is no substitute for medical school + residency...don't listen to me...doctor, doctor, doctor.

      At this point it's been studied. Prostate cancer is unique, slow enough growing that normal treatment is 'watchful care' or some such weasel words for 'do nothing'.

      So they can do ethical studies with Vitamin D. Short version, it appears to work very well. 1000% RDA is the estimated dose a dark skinned person, with few clothes that spends most of the day in the tropical sun gets. Makes 'old man slow prostate cancer' just go away or slow way down, until they have time to die of something else.

      Talk to your doctor. Don't take medical advice from web forums.

      Soy may not feminzie, but soyboys are a bunch of girls.

      --
      John McAfee 'It was like that time I hired that Bangkok prostitute; to do my taxes, while I fucked my accountant'
    4. Re: This is an option, I guess by Anonymous Coward · · Score: 0

      That's a funny way of saying "pissing out your ass."

    5. Re:This is an option, I guess by PopeRatzo · · Score: 4, Funny

      Or, someone could just poke a finger up your butt. Either way works.

      I'm not going to read TFA, but I'm pretty sure that's what this new test is, except they spit on their finger first.

      --
      You are welcome on my lawn.
    6. Re:This is an option, I guess by Anonymous Coward · · Score: 0

      If anything, farting all the time is a masculine thing. Or maybe its the not caring that is masculine...

    7. Re:This is an option, I guess by Anonymous Coward · · Score: 0

      Did the original poster even read what they wrote? A random test "just to be on the safe side" in 10 years? Do they have no idea how fast AI is progressing? In 10 yeara, I'd bet you could tell with 90% certainty if you'll EVER get prostate cancer.

    8. Re: This is an option, I guess by Anonymous Coward · · Score: 0

      Shame on you for coming here as an agent of Big Soy (which is one of the biggest US exports).

    9. Re: This is an option, I guess by Nidi62 · · Score: 1

      You can do that now. The answer is yes. Most men who live long enough will get prostate cancer, but it will develop late enough and grow so slow that something else will kill you first. It's the people that get prostate cancer early that have to worry.

      --
      The only thing necessary for evil to triumph is for it to be pitted against a slightly greater evil
    10. Re:This is an option, I guess by Oswald+McWeany · · Score: 1

      Or, someone could just poke a finger up your butt. Either way works.

      My doctor seems over eager to stick his finger in my bum. Two years ago he said "OK, I need you to bend over the bed"- when I looked at him funny he said "Oh, you're not 40 yet- you don't need the prostate test yet." This year in a cheerful tone he told me, "and next year you get a prostate exam".

      I'm not opposed to correct medical procedures taking place. I am a bit disturbed at how enthusiastic my doctor appears to be.

      --
      "That's the way to do it" - Punch
    11. Re:This is an option, I guess by sexconker · · Score: 1

      And, contrary to stupid-but-popular-belief, it does not feminize men at all to eat soy.

      It absolutely does. There's a reason parents with newborn boys are told to avoid soy and lavender and all the other estrogen-like compounds swirling around us from plastics, pollutants, the birth control pill tainting our food and water supplies, etc.

    12. Re: This is an option, I guess by sexconker · · Score: 1

      No no no. Most men get an enlarged prostate. Not prostate cancer. If we diagnose prostate cancer as cancer we have to deal with the patient wanting to get it treated. Since they're typically old and on medicare, they're not profitable.

      Just let it slowly grow and hope they die of something else or have enough money to be profitable patients once they realize it's killing them and they need to get it treated. Then we can call it cancer.

    13. Re: This is an option, I guess by Anonymous Coward · · Score: 0

      You can do that now. The answer is yes. Most men who live long enough will get prostate cancer, but it will develop late enough and grow so slow that something else will kill you first. It's the people that get prostate cancer early that have to worry.

      Recent Australian radio program on proper surveillance of recently diagnosed prostate cancer. (transcript)

      http://www.abc.net.au/radionat...

  2. How about a test for pancratic cancer by Anonymous Coward · · Score: 0

    More men die of that than anal cancer, it's just easier to test for and doctors don't look for it. oh it's been 3 min in a dfferent threat well clearly am abusing AC and not giving slashdot enough resellable information

  3. This hurts women by Anonymous Coward · · Score: 0

    It distracts from breast cancer.

    1. Re:This hurts women by Anonymous Coward · · Score: 0

      It tests their spit after giving a BJ.

    2. Re:This hurts women by Anonymous Coward · · Score: 0

      https://www.smh.com.au/articles/2003/11/24/1069522535088.html

      TL;DR:
          - men can reduce their risk of prostate cancer through regular ejaculation.
          - regular sex helps to avoid colds

    3. Re:This hurts women by AbRASiON · · Score: 2

      I know you're being facetious but the attitude you're posting about, is becoming sadly common, including on this website.

    4. Re:This hurts women by AmiMoJo · · Score: 1

      Let's not let the trolls distract from how important this story is. Prostate cancer is one of the biggest causes of death for men, and like most cancer it's much easier to treat if caught early. Encouraging guys to self-check regularly is really important, but this test should be able to detect it even earlier.

      Fortunately if caught early there are effective treatments. Check yourself once a month and don't hesitate to see your doctor if you find something.

      --
      const int one = 65536; (Silvermoon, Texture.cs)
      SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
    5. Re:This hurts women by arth1 · · Score: 1

      Fortunately if caught early there are effective treatments.

      Care to back up that claim, especially the word "effective"?

    6. Re:This hurts women by Anonymous Coward · · Score: 0


      Encouraging guys to self-check regularly is really important, but this test should be able to detect it even earlier.

      The PSA tests havebeen show repeatedly to not reduced mortality. I'd expect "self checK" from an untrained person to also not reduce mortality. Also, women doing self breast exams (which is far easier than sticking a finger up your ass) hasn't shown to detect breast cancer earlier.

  4. Meh. So what else is new. by jedidiah · · Score: 1

    A simple spit test can determine your HLA markers and all sorts of stuff. The fact that you can also test for genetic vulnerabilities is pretty mundane. The consumer genetic testing services already do a great deal of this including much more obscure stuff.

    This isn't news. This is the dull side of a butter knife.

    --
    A Pirate and a Puritan look the same on a balance sheet.
  5. Wth scientists?!? by Anonymous Coward · · Score: 0

    This test is only for men who get prostate cancer? What about all those poor women who get prostate cancer? This is what is wrong with America.

    1. Re:Wth scientists?!? by HornWumpus · · Score: 1

      You are in luck.

      /. has both men with breasts and men who swallow cum. So elements of this population can test if swallowing cum prevents breast cancer in men, like it does in women.

      http://web.mit.edu/zoz/Public/...

      --
      John McAfee 'It was like that time I hired that Bangkok prostitute; to do my taxes, while I fucked my accountant'
    2. Re: Wth scientists?!? by Anonymous Coward · · Score: 0

      You joke, and yet...

      There are women who have prostates. Typically their PSA levels are minimal, so a genetic screening test could be very, very, useful.

  6. Screening not advised for ANYONE by Anonymous Coward · · Score: 0

    I thought the consensus was that screening for prostate cancer was not recommended for ANYONE because detection and treatment rarely leads to overall better outcomes.

    Maybe once they get the weaponized-immune-system thing down it will be a different story.

    1. Re:Screening not advised for ANYONE by arth1 · · Score: 1

      I thought the consensus was that screening for prostate cancer was not recommended for ANYONE because detection and treatment rarely leads to overall better outcomes.

      This is not true! Many a golf club membership and Lexus have been financed by detecting prostate cancer. Do you want to deprive the poor doctors and pharmaceutical investors from their honest source of income?

  7. Take your own advice and shaddap by Anonymous Coward · · Score: 0

    Agreed, you're not a fucking doctor and have no business giving any kind of medical advice.

  8. Re:Screening by harvey+the+nerd · · Score: 2

    The problem often is not the PSA screening per se, it's the prostate snatcher urologist eager to sell his "services" - old fashioned biopsies and surgery. There are many flavors of PSA related tests that can less invasively help enumerate your prostate cancer odds.

    We are at the threshold of diagnostic technologies that are less invasive, and early treatments that are not well recieved by all urologists.

  9. Do a AngJollie and cut the damn thing out already by Anonymous Coward · · Score: 0

    and ne'er worry about said appendage already.

  10. Re:Cryptofeces Lepidoptera Creimerus by Anonymous Coward · · Score: 0

    CROFLOL! here is some pictures in case some wonder:

    Before the sex change:
    https://ibb.co/cc7Ddw
    After the sex change:
    https://ibb.co/gVad65

  11. I contracted PROSTRATE cancer. by Anonymous Coward · · Score: 0

    You get it from lying down.

    1. Re:I contracted PROSTRATE cancer. by Anonymous Coward · · Score: 0

      You get it from being a faggot and having cocks put into your ass.

  12. Here... by Anonymous Coward · · Score: 0

    Here... Spit on my finger before I insert it.

  13. Re:Cryptofeces Lepidoptera Creimerus by Anonymous Coward · · Score: 0

    You shouldn't be dissing I.T. closet cleaners. They often volunteer to do jobs that everyone else spent years avoiding. For example, creimer cleared out a 600-sqft storage closet that no one had seen the floor in eight years. He did that in between tickets over a six week period. He also finished deploying 750 PCs and 1,500 monitors ahead of schedule, ending his 12-month contract after nine months.

  14. more importantly: by slashdice · · Score: 1

    Experimental spit test identifies men that just gave me a blow job.

    --
    Copyright (c) 1990 - 2014 Dice. All rights reserved. Use of this comment is subject to certain Terms and Conditions.
  15. Re:Cryptofeces Lepidoptera Creimerus by Anonymous Coward · · Score: 0

    I almost forgot! Here's the link. Don't forget to buy a Goat C shirt!

  16. If you live long enough by RogueWarrior65 · · Score: 1

    You're going to get it. So what good is a test if it can't tell you if you're going to get it early on?

    1. Re:If you live long enough by arth1 · · Score: 1

      You're going to get it. So what good is a test if it can't tell you if you're going to get it early on?

      It's good for those selling expensive MRI tests or $60,000/year cancer medication that makes minimal difference in longevity but often a severely degraded life quality. Incidentally, the same that fund studies like these...

    2. Re:If you live long enough by Bruce+Perens · · Score: 1

      I'm sure there are some bad oncologists in the world, but: 1) everyone gets cancer if they live long enough and 2) the most common response to a condition like this coming up is to keep watching it. Not to treat it. If I had this, I'd want imaging once in a while just to make sure it wasn't becoming a problem.

  17. PSA test doesn't reduce mortality. by Anonymous Coward · · Score: 0

    There's one problem with the PSA test. It doesn't actually lengthen anyones life. It seems to detect a lot of very slow growing cancers. So slow growing that by the time the prostate cancer kills you, you'd be far more likely to do of something else.

    https://www.medscape.com/viewarticle/893458

  18. 'People' by rickb928 · · Score: 2

    'people over the age of 50 are generally screened for prostate cancer'

    Are we so PC that we can't specify the gender that actually has prostate glands, but have to be inclusive and all, and avoid excluding those genders that do not?

    --
    deleting the extra space after periods so i can stay relevant, yeah.
    1. Re:'People' by Bruce+Perens · · Score: 1

      You've never heard of Skene's gland.

    2. Re:'People' by rickb928 · · Score: 1

      And yet, it's not a prostate gland. Prostate-like? And the incidence or carcinoma is truly small.

      No, it's really not.

      --
      deleting the extra space after periods so i can stay relevant, yeah.
  19. Overhyped math! What about the other 99%? by mileshigh · · Score: 1

    OP says " one percent of men ..., a leading cause of cancer deaths"

    So the 1% is a "leading" cause?! What about the 99%?

  20. Nice but useless by nospam007 · · Score: 1

    That specific cancer has mostly 2 variants, the one that kills you quickly, no matter how many dangerous operations you do and one that won't be a problem, since it grows so slowly that you can ignore it, because you'll be dead from old age before it can possibly kill you.

    But nonetheless, the medical industry wants to radiate, operate and make you piss your pants the rest of your life.

    1. Re:Nice but useless by Anonymous Coward · · Score: 0

      Early detection generally results in better outcomes. Good detection practices will be very valuable once there is a treatment for aggressive prostate cancer.

      It doesn't matter whether the treatment or the detection gets good first. You want both.

  21. Re:Omfg by Anonymous Coward · · Score: 0

    Clearly this joke went right over everyone's head.
      i.e. She's back in the news raising capital for a new 'venture'. Get it?

    Fucking aspergers syndrome must sap the humor right out of folks hereabouts, huh. Lol.

  22. Re:Cryptofeces Lepidoptera Creimerus by Anonymous Coward · · Score: 0

    He also finished deploying 750 PCs and 1,500 monitors ahead of schedule, ending his 12-month contract after nine months.

    You delusional piece of lard!

    I had to redeploy those 750 PCs by myself after paying you to do it. That's why I let you go early so you wouldn't be in the way!

    I redeployed everything in 3 months and met the deadline but the money we gave you is a total lost.

    You also threw away a bunch of valuable spare parts in your genius closet cleaning and we had to buy new ones, further adding to the bill. You are a disaster.

    Fuck you!

  23. Re:Cryptofeces Lepidoptera Creimerus by Anonymous Coward · · Score: 0

    You also threw away a bunch of valuable spare parts in your genius closet cleaning and we had to buy new ones, further adding to the bill. You are a disaster.

    CROFLOL! He most probably ate those spare parts and farted as he was going...

    we should be ditching the creimers...

  24. Re:Cryptofeces Lepidoptera Creimerus by Anonymous Coward · · Score: 0

    There you are spamming amazon and youtube affiliate links with yet another fake account, you revenue stream hogging disgusting fat sexist tube of lard, Christopher Dale Reimer!

    You can be sure I will be watching this fake account too. I know this is you because you told me you were working on your freepass 11 file server and you are so dumb that you can't even masquerade yourself properly.

    Now, I told you I was out of meds last week and you didn't even care to contact me you lazy fucker.

    How many times do I have to express the emergency of the situation??????

    The python click script you wrote for my pheromone revenue stream web site suddenly stopped to work!!!!!!

    You fucking incompetent python script writer!!!

    When it works, I get 4000+ clicks a day on my pheromone revenue stream web site but only 5 or 6 without it!!!!

    Now, it seems like you dont care and that you have abandoned me you heartless fucking pig!

    Bonus:
    Here is a story that creimer told me when convincing me what a hard life he had:

    The tree was him and the tree knot was his butt hole!

    So, his uncle packed his fat ass with lard and with his cock! Not that it makes much of a difference but anyway, there it is!

    Signed:
    Ethell, The girl that used to love you and now hates you, burn in hell where you belong you sexist pig!