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After Century of Removing Appendixes, Docs Find Antibiotics Can Be Enough (arstechnica.com)

After more than a century of slicing tiny, inflamed organs from people's guts, doctors have found that surgery may not be necessary after all -- a simple course of antibiotics can be just as effective at treating appendicitis as going under the knife. From a report: The revelation comes from a large, randomized trial out of Finland, published Tuesday, September 25, in JAMA. Despite upending a long-held standard of care, the study's finding is not entirely surprising; it follows several other randomized trials over the years that had carved out evidence that antibiotics alone can treat an acute appendicitis. Those studies, however, left some dangling questions, including if the antibiotics just improved the situation temporarily and if initial drug treatments left patients worse off later if they did need surgery. The new JAMA study, with its full, five-year follow-up, effectively cauterised those remaining issues. Nearly two-thirds of the patients randomly assigned in the study to get antibiotics for an uncomplicated appendicitis didn't end up needing surgery in the follow-up time, the Finnish authors, based at the University of Turku, report. And those drug-treated patients that did end up getting an appendectomy later were not worse off for the delay in surgery. "This long-term follow-up supports the feasibility of antibiotic treatment alone as an alternative to surgery for uncomplicated acute appendicitis," the authors conclude. The finding suggests that many appendicitis patients could be spared the risks of surgical procedures, such as infections.

12 of 77 comments (clear)

  1. Not as profitable by Anonymous Coward · · Score: 5, Interesting

    This will never fly in the USA; a surgical procedure will generate much more profit than a simple prescription. Our medical system is based on a for-profit model.

    1. Re:Not as profitable by DaFallus · · Score: 2

      Agreed. I had my appendix removed about 6 years ago. After waiting in the ER for over 5 hours in intense pain, morphine, anesthetic, surgery, and 3 days in the hospital the bill was over $40,000 before my insurance kicked in. I was just over the 3 month mark at my new job when I qualified for health insurance, so I was incredibly lucky.

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    2. Re:Not as profitable by commodore64_love · · Score: 4, Insightful

      I understand your cynicism, but it is misplaced. More-and-more surgeries that used to require multiple days of recovery, are now being replaced by minimally-invasive procedures that only require a single afternoon. The same will be true with appendicitis treatment.

      --
      "I disapprove of what you say, but I will defend to the death your right to say it." - historian Evelyn Beatrice Hall
  2. Re:biotics backup by olsmeister · · Score: 4, Insightful

    You don't need to nuke it; just assist enough that the body can get a handle on the infection.

  3. Until by Zorro · · Score: 3, Insightful

    Antibiotics no longer work.

  4. Books about poor medical management by Futurepower(R) · · Score: 4, Informative

    The badly named and poorly edited book, Natural Causes: An Epidemic of Wellness, the Certainty of Dying, and Killing Ourselves to Live Longer lists numerous ways in which medical procedures in the United States are poor.

    On page 8, that book recommends another book, Overdiagnosed: Making People Sick in the Pursuit of Health. I haven't read that one yet.

  5. 90% of what we do is make-work by alternative_right · · Score: 3, Interesting

    When I first read a similar line in Houellebecq's writing, I was skeptical. Since that time, I have seen that in every profession, humans have invented ways of following procedure instead of doing what is necessary. This rewards the individual humans involved with more money but makes them weak because they spend their time on wastage. This bloat affects all human societies once they reach a certain level of internal division.

  6. Re:Finish folks take a long time to recover by petermgreen · · Score: 3

    Remember averages include a wide range of cases. At one extreme you have someone who is young and fit, has an occupation that doesn't involve much physical stress and where they succeed in doing the procedure keyhole. At the other extreme you have someone who is old, works a manual job and has some complications during surgery that require them to fully open the abdomen.

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  7. Appendix by PopeRatzo · · Score: 3, Funny

    I don't care if they remove appendixes, but I really wish they'd get rid of endnotes. They're just a hassle.

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  8. Gut-buster? by MAXOMENOS · · Score: 2

    Wait....what's this?

    Those studies, however, left some dangling questions...

    Oh...oh dear. Was that a pun?

    ...effectively cauterised those remaining issues.

    Was that ANOTHER surgery pun?

  9. Re: Recovery time varies by TimMD909 · · Score: 2

    Can confirm. Good news is that it gets easier with each surgery. I'm up to three (appendicitis and some hernias). If I get 2 more, I'll have my punch card filled out for a free one.

  10. This is already being done in the US by porges · · Score: 2

    My cousin had appendicitis less than a year ago, in NYC, and they gave him the choice of surgery or antibiotics; he chose the antibiotics and all went fine. (Interestingly he says they offered him to be in a study where they'd randomly assign him to one or the other; he declined in favor of avoiding surgery.)