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Despite CRISPR Baby Controversy, Harvard University Will Begin Gene-Editing Sperm (technologyreview.com)
Even as a furious debate broke out in China over gene-edited babies, some scientists in the US are also hoping to improve tomorrow's children. From a report: [...] Amid the condemnation, though, it was easy to lose track of what the key experts were saying. Technology to alter heredity is for real. It is improving very quickly, it has features that will make it safe, and much wider exploratory use to create children could be justified soon. That was the message delivered at a gene-editing summit in Hong Kong on Wednesday, by Harvard Medical School dean George Daley, just ahead of He's own dramatic appearance on the stage (see video starting at 1:15:30).
Astounding some listeners, the Harvard doctor and stem-cell researcher didn't condemn He but instead characterized the Chinese actions as a wrong turn on the right path (see video). "The fact that it is possible that the first instance of human germ-line editing came forward as a misstep should in no way lead us to stick our heads in the sand," Daley said. "It's time to ... start outlining what an actual pathway for clinical translation would be."
Astounding some listeners, the Harvard doctor and stem-cell researcher didn't condemn He but instead characterized the Chinese actions as a wrong turn on the right path (see video). "The fact that it is possible that the first instance of human germ-line editing came forward as a misstep should in no way lead us to stick our heads in the sand," Daley said. "It's time to ... start outlining what an actual pathway for clinical translation would be."
Practice makes perfect so if you are going to start making improvements over a baseline then I think it would be logical to practice gene editing on something that isn't human and could really be improved. What fits the bill here is dog breeds. For the unaware, pure breed dogs have significant genetic defects because they are inbred which results in the expression of recessive traits. The current trend of buying cute dogs that are a genetic disaster doesn't seem to be receding so they seem like a prime target for genetic editing. When we've learned some important lessons (or succeeded beyond all expectations) then we should use what we learned on humans.
If you think it's a waste then you haven't considered the annual cost of animal surgeries that are a consequence of a small gene pool.
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