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Fasting Can Improve Overall Health By Causing Circadian Clocks In the Liver and Skeletal Muscle To Rewire Their Metabolism, Study Finds (sciencedaily.com)

An anonymous reader quotes a report from ScienceDaily: In a University of California, Irvine-led study, researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases. The study was published recently in Cell Reports. The research was conducted using mice, which were subjected to 24-hour periods of fasting. While fasting, researchers noted the mice exhibited a reduction in oxygen consumption (VO2), respiratory exchange ratio (RER), and energy expenditure, all of which were completely abolished by refeeding, which parallels results observed in humans.

"The reorganization of gene regulation by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression. In other words, fasting is able to essentially reprogram a variety of cellular responses. Therefore, optimal fasting in a timed manner would be strategic to positively affect cellular functions and ultimately benefiting health and protecting against aging-associated diseases." This study opens new avenues of investigation that could ultimately lead to the development of nutritional strategies to improve health in humans.

10 of 216 comments (clear)

  1. I have noticed by Beeftopia · · Score: 4, Interesting

    I have noticed that dropping my calories way down for a day leads to dramatically improved sleep. FWIW, YMMV, etc.

  2. Fasting worked wonders for my health. by Cobratek · · Score: 5, Interesting

    This was worth logging in for.

    I was overweight and staring down 50, so I did some research and decided to try it.

    I did a 7 day water fast followed by a mostly keto style diet, but really just sticking to food that's been on the planet for longer than 100 years, no processed chemical foods. I lost maybe 10 pounds during that week but the weight just kept falling off.  Down from 40's to 34's and even 32's after about 9 months of sticking to real food, cut back(not out) on sugar and bread.  My blood panels showed no problems with cholesterol etc after eating bacon and eggs for breakfast for months.  homemade soups etc for dinner.

    Fasting is part of a natural cycle, your body uses the time when digestion is shut down to heal itself.

    Don't believe me, prove me wrong.

    --
    DONT TREAD ON ME MOÎΩN ÎABÃ
    1. Re:Fasting worked wonders for my health. by doubledown00 · · Score: 4, Insightful

      Down from 40's to 34's and even 32's after about 9 months of sticking to real food 32 pounds = 14.5kg. Weight of a 8 years old kid.

      Don't believe me, prove me wrong. Unless one with a gene that growth no taller than 3 feets, 40 pounds basically spell mulnutritions.

      I could be wrong, but I gather the comment was referring to pant sizes.

  3. Re:Don't like the science? Wait a few years by Ichijo · · Score: 5, Informative

    500 years ago, everybody knew that the Earth was flat.

    False.

    --
    Any sufficiently unpopular but cohesive argument is indistinguishable from trolling.
  4. Re:Don't like the science? Wait a few years by Shaitan · · Score: 5, Informative

    It's a quote from the movie Men in Black

  5. Re:Look for the agenda by antek9 · · Score: 5, Informative

    I know you're trolling, but allow me to bite: Vegan doctrine doesn't include fasting, moreover, vegans love carbs and get fat if they don't also afford a nutrition coach. Muslims don't know the first thing about fasting, Ramadan is a joke: not even water during daytime, only to eat triple the normal daily amount all night long is NOT intermittent fasting, it's binge eating with a cooldown phase.

    Keto and fasting (comes naturally, the hunger just goes away) for the win, and you can keep eating those steaks. But throw away the potato.

    --
    A World in a Grain of Sand / Heaven in a Wild Flower,
    Infinity in the Palm of your Hand / And Eternity in an Hour.
  6. Re:Don't like the science? Wait a few years by jma05 · · Score: 5, Interesting

    The fasting traditions in religion didn't make health claims.
    Fasting causes acidosis, which leads to mild euphoria.
    People also fast to promote the odds of transcendental experiences.
    It was an act of discipline.

    But no religion had the liver, let alone circadian clocks in mind.
    I wouldn't say religion *knew* fasting. It used it for an entirely different purpose.

  7. Re:Don't like the science? Wait a few years by Kokuyo · · Score: 4, Insightful

    Today people still believe that people 500 years ago believed the world to be flat.

  8. Re: Don't like the science? Wait a few years by x0ra · · Score: 5, Insightful

    by definition, it *is*, as "breakfast" is litterally the "breaking of the period of fast" :-/

  9. Re:Don't like the science? Wait a few years by jma05 · · Score: 5, Insightful

    Most of what had been "known" for millennia was wrong. That is the whole point of doing science.
    But even a broken clock can be right twice a day.
    The scientific process for doing dietary studies though is less than stellar today. But that can be fixed.
    Science is working, not "struggling". Never before in human history has so much been uncovered in such a short time.

    > "religions" are just archetypes of human biology pattern

    If so, we would not have so many religions. Religions occasionally are codifications of natural human behavior - social, more than biological. Other times, they deny natural human behavior.